Vaccination with protein-transduced dendritic cells elicits a sustained response to hepatitis C viral antigens

Gastroenterology

Volumn 130, Issue 2, 2006, Pages 453-464

  Kuzushita, Noriyoshi ^a   Gregory, Stephen H ^a   Monti, Nola A ^a   Carlson, Rolf ^a   Gehring, Stephan ^a   Wands, Jack R ^a,b  

^a RHODE ISLAND HOSPITAL   (United States)

^b Liver Research Center Brown University Medical School   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORE PROTEIN; CYTOKINE; DENDRITIC CELL VACCINE; GAMMA INTERFERON; GLYCOPROTEIN P 15095; HEPATITIS C ANTIGEN; HEPATITIS C VACCINE; INTERLEUKIN 4; LIGAND; NAKED DNA; PLASMID DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ANTIVIRAL ACTIVITY; ARTICLE; CD4+ T LYMPHOCYTE; CELL POPULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; IN VITRO STUDY; IN VIVO STUDY; INOCULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN; SPLEEN CELL; STAINING; T LYMPHOCYTE ACTIVATION; VACCINATION; VIRUS CORE; VIRUS RECOMBINANT;

EID: 32044443616     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2005.10.048     Document Type: Article

References (55)

1. M.J. Alter, H.S. Margolis, K. Krawczynski The natural history of community-acquired hepatitis C in the United States. The Sentinel Counties Chronic non-A, non-B Hepatitis Study Team N Engl J Med 327 1992 1899 1905
2. N. Boyer, P. Marcellin Pathogenesis, diagnosis and management of hepatitis C J Hepatol 32 2000 98 112
3. H.B. El-Serag Hepatocellular carcinoma and hepatitis C in the United States Hepatology 36 2002 S74 S83
4. G.L. Davis, R. Esteban-Mur, V. Rustgi, J. Hoefs, S.C. Gordon, C. Trepo, M.L. Shiffman, S. Zeuzem, A. Craxi, M.H. Ling, J. Albrecht International Hepatitis Interventional Therapy Group Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C N Engl J Med 339 1998 1493 1499
5. J.G. McHutchison, S.C. Gordon, E.R. Schiff, M.L. Shiffman, W.M. Lee, V.K. Rustgi, Z.D. Goodman, M.H. Ling, S. Cort, J.K. Albrecht Hepatitis Interventional Therapy Group Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C N Engl J Med 339 1998 1485 1492
6. Q.L. Choo, K.H. Richman, J.H. Han Genetic organization and diversity of the hepatitis C virus Proc Natl Acad Sci U S A 88 1991 2451 2455
7. G. Inchauspe, S. Zebedee, D.H. Lee, M. Sugitani, M. Nasoff, A.M. Prince Genomic structure of the human prototype strain H of hepatitis C virus comparison with American and Japanese isolates Proc Natl Acad Sci U S A 88 1991 10292 10296
8. A. Grakoui, C. Wychowski, C. Lin, S.M. Feinstone, C.M. Rice Expression and identification of hepatitis C virus polyprotein cleavage products J Virol 67 1993 1385 1395
9. H.M. Diepolder, R. Zachoval, R.M. Hoffmann, E.A. Wierenga, T. Santantonio, M.C. Jung, D. Eichenlaub, G.R. Pape Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection Lancet 346 1995 1006 1007
10. G. Missale, R. Bertoni, V. Lamonaca, A. Valli, M. Massari, C. Mori, M.G. Rumi, M. Houghton, F. Fiaccadori, C. Ferrari Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response J Clin Invest 98 1996 706 714
11. F. Lechner, D.K. Wong, P.R. Dunbar, R. Chapman, R.T. Chung, P. Dohrenwend, G. Robbins, R. Phillips, P. Klenerman, B.D. Walker Analysis of successful immune responses in persons infected with hepatitis C virus J Exp Med 191 2000 1499 1512
12. J. Encke, J. zu Putlitz, M. Geissler, J.R. Wands Genetic immunization generates cellular and humoral immune responses against the nonstructural proteins of the hepatitis C virus in a murine model J Immunol 161 1998 4917 4923
13. S. Calarota, G. Bratt, S. Nordlund, J. Hinkula, A.C. Leandersson, E. Sandstrom, B. Wahren Cellular cytotoxic response induced by DNA vaccination in HIV-1-infected patients Lancet 351 1998 1320 1325
14. R. Wang, D.L. Doolan, T.P. Le, R.C. Hedstrom, K.M. Coonan, Y. Charoenvit, T.R. Jones, P. Hobart, M. Margalith, J. Ng, W.R. Weiss, M. Sedegah, C. de Taisne, J.A. Norman, S.L. Hoffman Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine Science 282 1998 476 480
15. O. Akbari, N. Panjwani, S. Garcia, R. Tascon, D. Lowrie, B. Stockinger DNA vaccination transfection and activation of dendritic cells as key events for immunity J Exp Med 189 1999 169 178
16. K.J. Maloy, I. Erdmann, V. Basch, S. Sierro, T.A. Kramps, R.M. Zinkernagel, S. Oehen, T.M. Kundig Intralymphatic immunization enhances DNA vaccination Proc Natl Acad Sci U S A 98 2001 3299 3303
17. J. Banchereau, R.M. Steinman Dendritic cells and the control of immunity Nature 392 1998 245 252
18. J. Banchereau, B. Schuler-Thurner, A.K. Palucka, G. Schuler Dendritic cells as vectors for therapy Cell 106 2001 271 274
19. J.F. Arthur, L.H. Butterfield, M.D. Roth, L.A. Bui, S.M. Kiertscher, R. Lau, S. Dubinett, J. Glaspy, W.H. McBride, J.S. Economou A comparison of gene transfer methods in human dendritic cells Cancer Gene Ther 4 1997 17 25
20. A.S. Irvine, P.K. Trinder, D.L. Laughton, H. Ketteringham, R.H. McDermott, S.C. Reid, A.M. Haines, A. Amir, R. Husain, R. Doshi, L.S. Young, A. Mountain Efficient nonviral transfection of dendritic cells and their use for in vivo immunization Nat Biotechnol 18 2000 1273 1278
21. L. Jenne, G. Schuler, A. Steinkasserer Viral vectors for dendritic cell-based immunotherapy Trends Immunol 22 2001 102 107
22. M. Herraiz, N. Beraza, A. Solano, B. Sangro, J. Montoya, C. Qian, J. Prieto, M. Bustos Liver failure caused by herpes simplex virus thymidine kinase plus ganciclovir therapy is associated with mitochondrial dysfunction and mitochondrial DNA depletion Hum Gene Ther 14 2003 463 472
23. D.A. Mann, A.D. Frankel Endocytosis and targeting of exogenous HIV-1 Tat protein EMBO J 10 1991 1733 1739
24. A.D. Frankel, C.O. Pabo Cellular uptake of the tat protein from human immunodeficiency virus Cell 55 1988 1189 1193
25. S.R. Schwarze, A. Ho, A. Vocero-Akbani, S.F. Dowdy In vivo protein transduction delivery of a biologically active protein into the mouse Science 285 1999 1569 1572
26. M.C. Morris, J. Depollier, J. Mery, F. Heitz, G. Divita A peptide carrier for the delivery of biologically active proteins into mammalian cells Nat Biotechnol 19 2001 1173 1176
27. Y. He, A.A. Pimenov, J.V. Nayak, J. Plowey, L.D. Falo Jr, L. Huang Intravenous injection of naked DNA encoding secreted flt3 ligand dramatically increases the number of dendritic cells and natural killer cells in vivo Hum Gene Ther 11 2000 547 554
28. S.H. Gregory The viability of mononuclear phagocytes in vitro is diminished by the interaction of cells with serum proteins bound to the culture substratum Immunol Lett 20 1989 155 162
29. X. Jiang, S.H. Gregory, E.J. Wing Hepatocytes can serve as accessory cells in the response of immune T lymphocytes to heat-killed Listeria monocytogenes Infect Immun 63 1995 926 933
30. X. Jiang, S.H. Gregory, E.J. Wing Immune CD8+ T lymphocytes lyse Listeria monocytogenes-infected hepatocytes by a classical MHC class I-restricted mechanism J Immunol 158 1997 287 293
31. S.H. Gregory, A.J. Sagnimeni, N.B. Zurowski, A.W. Thomson Flt3 ligand pretreatment promotes protective immunity to Listeria monocytogenes Cytokine 13 2001 202 208
32. S. Gallucci, M. Lolkema, P. Matzinger Natural adjuvants endogenous activators of dendritic cells Nat Med 5 1999 1249 1255
33. B. Pulendran, K. Palucka, J. Banchereau Sensing pathogens and tuning immune responses Science 293 2001 253 256
34. T. Kanto, N. Hayashi, T. Takehara, T. Tatsumi, N. Kuzushita, A. Ito, Y. Sasaki, A. Kasahara, M. Hori Impaired allostimulatory capacity of peripheral blood dendritic cells recovered from hepatitis C virus-infected individuals J Immunol 162 1999 5584 5591
35. C. Bain, A. Fatmi, F. Zoulim, J.P. Zarski, C. Trepo, G. Inchauspe Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection Gastroenterology 120 2001 512 524
36. S. Auffermann-Gretzinger, E.B. Keeffe, S. Levy Impaired dendritic cell maturation in patients with chronic, but not resolved, hepatitis C virus infection Blood 97 2001 3171 3176
37. A. Ulsenheimer, J.T. Gerlach, N.H. Gruener, M.C. Jung, C.A. Schirren, W. Schraut, R. Zachoval, G.R. Pape, H.M. Diepolder Detection of functionally altered hepatitis C virus-specific CD4+ T cells in acute and chronic hepatitis C Hepatology 37 2003 1189 1198
38. A. Grakoui, N.H. Shoukry, D.J. Woollard, J.H. Han, H.L. Hanson, J. Ghrayeb, K.K. Murthy, C.M. Rice, C.M. Walker HCV persistence and immune evasion in the absence of memory T cell help Science 302 2003 659 662
39. P. Sarobe, J.J. Lasarte, N. Casares, A. Lopez-Diaz de Cerio, E. Baixeras, P. Labarga, N. Garcia, F. Borras-Cuesta, J. Prieto Abnormal priming of CD4(+) T cells by dendritic cells expressing hepatitis C virus core and E1 proteins J Virol 76 2002 5062 5070
40. M. Lechmann, T.J. Liang Vaccine development for hepatitis C Semin Liver Dis 20 2000 211 226
41. H. Wedemeyer, S. Gagneten, A. Davis, R. Bartenschlager, S. Feinstone, B. Rehermann Oral immunization with HCV-NS3-transformed salmonella induction of HCV-specific CTL in a transgenic mouse model Gastroenterology 121 2001 1158 1166
42. P. Sarobe, J.J. Lasarte, A. Zabaleta, L. Arribillaga, A. Arina, I. Melero, F. Borras-Cuesta, J. Prieto Hepatitis C virus structural proteins impair dendritic cell maturation and inhibit in vivo induction of cellular immune responses J Virol 77 2003 10862 10871
43. P. Pancholi, M. Perkus, N. Tricoche, Q. Liu, A.M. Prince DNA immunization with hepatitis C virus (HCV) polycistronic genes or immunization by HCV DNA priming-recombinant canarypox virus boosting induces immune responses and protection from recombinant HCV-vaccinia virus infection in HLA-A2.1-transgenic mice J Virol 77 2003 382 390
44. R.M. Steinman, M. Pack, K. Inaba Dendritic cells in the T-cell areas of lymphoid organs Immunol Rev 156 1997 25 37
45. D. Vremec, K. Shortman Dendritic cell subtypes in mouse lymphoid organs cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes J Immunol 159 1997 565 573
46. R. Maldonado-Lopez, T. De Smedt, P. Michel, J. Godfroid, B. Pajak, C. Heirman, K. Thielemans, O. Leo, J. Urbain, M. Moser CD8alpha+ and CD8alpha- subclasses of dendritic cells direct the development of distinct T helper cells in vivo J Exp Med 189 1999 587 592
47. D. Traver, K. Akashi, M. Manz, M. Merad, T. Miyamoto, E.G. Engleman, I.L. Weissman Development of CD8alpha-positive dendritic cells from a common myeloid progenitor Science 290 2000 2152 2154
48. K. Inaba, M. Inaba, N. Romani, H. Aya, M. Deguchi, S. Ikehara, S. Muramatsu, R.M. Steinman Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor J Exp Med 176 1992 1693 1702
49. S.D. Lyman Biologic effects and potential clinical applications of Flt3 ligand Curr Opin Hematol 5 1998 192 196
50. H.E. Toldbod, R. Agger, L. Bolund, M. Hokland Potent influence of bovine serum proteins in experimental dendritic cell-based vaccination protocols Scand J Immunol 58 2003 43 50
51. E. Maraskovsky, K. Brasel, M. Teepe, E.R. Roux, S.D. Lyman, K. Shortman, H.J. McKenna Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice multiple dendritic cell subpopulations identified J Exp Med 184 1996 1953 1962
52. B. Pulendran, J. Lingappa, M.K. Kennedy, J. Smith, M. Teepe, A. Rudensky, C.R. Maliszewski, E. Maraskovsky Developmental pathways of dendritic cells in vivo distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice J Immunol 159 1997 2222 2231
53. R.K. Mathur, A. Awasthi, P. Wadhone, B. Ramanamurthy, B. Saha Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses Nat Med 10 2004 540 544
54. S. Ward, G. Lauer, R. Isba, B. Walker, P. Klenerman Cellular immune responses against hepatitis C virus the evidence base 2002 Clin Exp Immunol 128 2002 195 203
55. A.M. Wertheimer, C. Miner, D.M. Lewinsohn, A.W. Sasaki, E. Kaufman, H.R. Rosen Novel CD4+ and CD8+ T-cell determinants within the NS3 protein in subjects with spontaneously resolved HCV infection Hepatology 37 2003 577 589