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Volumn 10, Issue 4, 2008, Pages 334-342

Stem-cell based therapies for brain tumors

Author keywords

Brain tumor; Molecular imaging; Stem cell; Therapeutic; Viral vector

Indexed keywords

ANTINEOPLASTIC AGENT; BETA INTERFERON; BEVACIZUMAB; CAMPTOTHECIN; CEDIRANIB; CYTOSINE DEAMINASE; FLUCYTOSINE; FLUOROURACIL; GANCICLOVIR; INTERLEUKIN 12; INTERLEUKIN 23; INTERLEUKIN 4; IRINOTECAN; PEROXISOMAL ASSEMBLY FACTOR; THYMIDINE KINASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

EID: 49249120070     PISSN: 14648431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (16)

References (95)
  • 6
    • 33747173765 scopus 로고    scopus 로고
    • Gene therapy for glioblastoma
    • Aghi M, Chiocca EA: Gene therapy for glioblastoma. Neurosurg Focus (2006) 20(4):E18.
    • (2006) Neurosurg Focus , vol.20 , Issue.4
    • Aghi, M.1    Chiocca, E.A.2
  • 8
    • 0034712047 scopus 로고    scopus 로고
    • Gage FH: Mammalian neural stem cells. Science (2000) 287(5457):1433-1438. •• A classic review on the developmental biology of neural stem cells.
    • Gage FH: Mammalian neural stem cells. Science (2000) 287(5457):1433-1438. •• A classic review on the developmental biology of neural stem cells.
  • 9
    • 0034619328 scopus 로고    scopus 로고
    • Aboody KS, Brown A, Rainov NG, Bower KA, Liu S, Yang W, Small JE, Herrlinger U, Ourednik V, Black PM, Breakefield XO, Snyder EY: Neural stem cells display extensive tropism for pathology in adult brain: Evidence from intracranial gliomas. Proc Natl Acad Sci USA (2000) 97(23):12846-12851. •• The first comprehensive demonstration of gliomatrophic migration of murine and human NSCs toward glioma cells and the successful delivery of their therapeutic payload to tumor deposits in vivo.
    • Aboody KS, Brown A, Rainov NG, Bower KA, Liu S, Yang W, Small JE, Herrlinger U, Ourednik V, Black PM, Breakefield XO, Snyder EY: Neural stem cells display extensive tropism for pathology in adult brain: Evidence from intracranial gliomas. Proc Natl Acad Sci USA (2000) 97(23):12846-12851. •• The first comprehensive demonstration of gliomatrophic migration of murine and human NSCs toward glioma cells and the successful delivery of their therapeutic payload to tumor deposits in vivo.
  • 11
    • 19544362405 scopus 로고    scopus 로고
    • Adult neurogenesis and repair of the adult CNS with neural progenitors, precursors, and stem cells
    • Emsley JG, Mitchell BD, Kempermann G, Macklis JD: Adult neurogenesis and repair of the adult CNS with neural progenitors, precursors, and stem cells. Prog Neurobiol (2005) 75(5):321-341.
    • (2005) Prog Neurobiol , vol.75 , Issue.5 , pp. 321-341
    • Emsley, J.G.1    Mitchell, B.D.2    Kempermann, G.3    Macklis, J.D.4
  • 12
    • 0019826665 scopus 로고
    • Establishment in culture of pluripotential cells from mouse embryos
    • Evans MJ, Kaufman MH: Establishment in culture of pluripotential cells from mouse embryos. Nature (1981) 292(5819):154-156.
    • (1981) Nature , vol.292 , Issue.5819 , pp. 154-156
    • Evans, M.J.1    Kaufman, M.H.2
  • 16
    • 1442354188 scopus 로고    scopus 로고
    • Sanai N, Tramontin AD, Quiñones-Hinojosa A, Barbaro NM, Gupta N, Kunwar S, Lawton MT, McDermott MW, Parsa AT, Manuel-Garcia Verdugo J, Burger MS et al: Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration. Nature (2004) 427(6976):740-744. • This study confirmed the presence of NSCs in the adult human brain and showed that the lack of an established migratory path could affect endogenous migration of NSCs to the tumor.
    • Sanai N, Tramontin AD, Quiñones-Hinojosa A, Barbaro NM, Gupta N, Kunwar S, Lawton MT, McDermott MW, Parsa AT, Manuel-Garcia Verdugo J, Burger MS et al: Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration. Nature (2004) 427(6976):740-744. • This study confirmed the presence of NSCs in the adult human brain and showed that the lack of an established migratory path could affect endogenous migration of NSCs to the tumor.
  • 18
    • 0031771599 scopus 로고    scopus 로고
    • Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes
    • This study showed that exogenous NSCs respond to and develop according to the local microenvironmental milieu, •
    • Flax JD, Aurora S, Yang C, Simonin C, Wills AM, Billinghurst LL, Jendoubi M, Sidman RL, Wolfe JH, Kim SU, Snyder EY: Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes. Nat Biotechnol (1998) 16(11):1033-1039. • This study showed that exogenous NSCs respond to and develop according to the local microenvironmental milieu.
    • (1998) Nat Biotechnol , vol.16 , Issue.11 , pp. 1033-1039
    • Flax, J.D.1    Aurora, S.2    Yang, C.3    Simonin, C.4    Wills, A.M.5    Billinghurst, L.L.6    Jendoubi, M.7    Sidman, R.L.8    Wolfe, J.H.9    Kim, S.U.10    Snyder, E.Y.11
  • 19
    • 0033929434 scopus 로고    scopus 로고
    • Ostenfeld T, Caldwell MA, Prowse KR, Linskens MH, Jauniaux E, Svendsen CN: Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell proliferation with extensive axonal outgrowth following transplantation. Exp Neurol (2000) 164(1):215-226.
    • Ostenfeld T, Caldwell MA, Prowse KR, Linskens MH, Jauniaux E, Svendsen CN: Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell proliferation with extensive axonal outgrowth following transplantation. Exp Neurol (2000) 164(1):215-226.
  • 23
    • 3042753986 scopus 로고    scopus 로고
    • Efficient generation of neural precursors from adult human skin: Astrocytes promote neurogenesis from skin-derived stem cells
    • Joannides A, Gaughwin P, Schwiening C, Majed H, Sterling J, Compston A, Chandran S: Efficient generation of neural precursors from adult human skin: Astrocytes promote neurogenesis from skin-derived stem cells. Lancet (2004) 364(9429):172-178.
    • (2004) Lancet , vol.364 , Issue.9429 , pp. 172-178
    • Joannides, A.1    Gaughwin, P.2    Schwiening, C.3    Majed, H.4    Sterling, J.5    Compston, A.6    Chandran, S.7
  • 24
    • 2342491483 scopus 로고    scopus 로고
    • Characterization of neuronal/glial differentiation of murine adipose-derived adult stromal cells
    • Safford KM, Safford SD, Gimble JM, Shetty AK, Rice HE: Characterization of neuronal/glial differentiation of murine adipose-derived adult stromal cells. Exp Neurol (2004) 187(2):319-328.
    • (2004) Exp Neurol , vol.187 , Issue.2 , pp. 319-328
    • Safford, K.M.1    Safford, S.D.2    Gimble, J.M.3    Shetty, A.K.4    Rice, H.E.5
  • 25
    • 0026501444 scopus 로고
    • Multipotent neural cell lines can engraft and participate in development of mouse cerebellum
    • Snyder EY, Deitcher DL, Walsh C, Arnold-Aldea S, Hartwieg EA, Cepko CL: Multipotent neural cell lines can engraft and participate in development of mouse cerebellum. Cell (1992) 68(1):33-51.
    • (1992) Cell , vol.68 , Issue.1 , pp. 33-51
    • Snyder, E.Y.1    Deitcher, D.L.2    Walsh, C.3    Arnold-Aldea, S.4    Hartwieg, E.A.5    Cepko, C.L.6
  • 28
    • 34250370523 scopus 로고    scopus 로고
    • Ectopic telomerase expression inhibits neuronal differentiation of NT2 neural progenitor cells
    • Richardson RM, Nguyen B, Holt SE, Broaddus WC, Fillmore HL: Ectopic telomerase expression inhibits neuronal differentiation of NT2 neural progenitor cells. Neurosci Lett (2007) 421(2):168-172.
    • (2007) Neurosci Lett , vol.421 , Issue.2 , pp. 168-172
    • Richardson, R.M.1    Nguyen, B.2    Holt, S.E.3    Broaddus, W.C.4    Fillmore, H.L.5
  • 29
    • 33745684551 scopus 로고    scopus 로고
    • The therapeutic potential of neural stem cells
    • Martino G, Pluchino S: The therapeutic potential of neural stem cells. Nat Rev Neurosci (2006) 7(5):395-406.
    • (2006) Nat Rev Neurosci , vol.7 , Issue.5 , pp. 395-406
    • Martino, G.1    Pluchino, S.2
  • 30
    • 1542290150 scopus 로고    scopus 로고
    • Telomerase immortalization of human neural progenitor cells
    • Bai Y, Hu Q, Li X, Wang Y, Lin C, Shen L, Li L: Telomerase immortalization of human neural progenitor cells. Neuroreport (2004) 15(2):245-249.
    • (2004) Neuroreport , vol.15 , Issue.2 , pp. 245-249
    • Bai, Y.1    Hu, Q.2    Li, X.3    Wang, Y.4    Lin, C.5    Shen, L.6    Li, L.7
  • 31
    • 34748919514 scopus 로고    scopus 로고
    • A novel, immortal, and multipotent human neural stem cell line generating functional neurons and oligodendrocytes
    • De Filippis L, Lamorte G, Snyder EY, Malgaroli A, Vescovi AL: A novel, immortal, and multipotent human neural stem cell line generating functional neurons and oligodendrocytes. Stem Cells (2007) 25(9):2312- 2321.
    • (2007) Stem Cells , vol.25 , Issue.9 , pp. 2312-2321
    • De Filippis, L.1    Lamorte, G.2    Snyder, E.Y.3    Malgaroli, A.4    Vescovi, A.L.5
  • 32
    • 6944232374 scopus 로고    scopus 로고
    • Robust in vivo gene transfer into adult mammalian neural stem cells by lentiviral vectors
    • This study demonstrated successful lentiviral transfections of NSCs in vivo, •
    • Consiglio A, Gritti A, Dolcetta D, Follenzi A, Bordignon C, Gage FH, Vescovi AL, Naldini L: Robust in vivo gene transfer into adult mammalian neural stem cells by lentiviral vectors. Proc Natl Acad Sci USA (2004) 101(41):14835-14840. • This study demonstrated successful lentiviral transfections of NSCs in vivo.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.41 , pp. 14835-14840
    • Consiglio, A.1    Gritti, A.2    Dolcetta, D.3    Follenzi, A.4    Bordignon, C.5    Gage, F.H.6    Vescovi, A.L.7    Naldini, L.8
  • 36
    • 30844443267 scopus 로고    scopus 로고
    • Lentivirus-mediated gene transfer to the central nervous system: Therapeutic and research applications
    • Wong LF, Goodhead L, Prat C, Mitrophanous KA, Kingsman SM, Mazarakis ND: Lentivirus-mediated gene transfer to the central nervous system: Therapeutic and research applications. Hum Gene Ther (2006) 17(1):1-9.
    • (2006) Hum Gene Ther , vol.17 , Issue.1 , pp. 1-9
    • Wong, L.F.1    Goodhead, L.2    Prat, C.3    Mitrophanous, K.A.4    Kingsman, S.M.5    Mazarakis, N.D.6
  • 39
    • 33845956281 scopus 로고    scopus 로고
    • Intravascular administration of tumor tropic neural progenitor cells permits targeted delivery of interferon-β and restricts tumor growth in a murine model of disseminated neuroblastoma
    • Dickson PV, Hamner JB, Burger RA, Garcia E, Ouma AA, Kim SU, Ng CY, Gray JT, Aboody KS, Danks MK, Davidoff AM: Intravascular administration of tumor tropic neural progenitor cells permits targeted delivery of interferon-β and restricts tumor growth in a murine model of disseminated neuroblastoma. J Pediatr Surg (2007) 42(1):48-53.
    • (2007) J Pediatr Surg , vol.42 , Issue.1 , pp. 48-53
    • Dickson, P.V.1    Hamner, J.B.2    Burger, R.A.3    Garcia, E.4    Ouma, A.A.5    Kim, S.U.6    Ng, C.Y.7    Gray, J.T.8    Aboody, K.S.9    Danks, M.K.10    Davidoff, A.M.11
  • 43
    • 11144231673 scopus 로고    scopus 로고
    • Shah K, Bureau E, Kim DE, Yang K, Tang Y, Weissleder R, Breakefield XO: Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression. Ann Neurol (2005) 57(1):34-41. •• The first demonstration of the potential of NSCs as an advanced diagnostic imaging tool in gliomas.
    • Shah K, Bureau E, Kim DE, Yang K, Tang Y, Weissleder R, Breakefield XO: Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression. Ann Neurol (2005) 57(1):34-41. •• The first demonstration of the potential of NSCs as an advanced diagnostic imaging tool in gliomas.
  • 44
    • 43749114031 scopus 로고    scopus 로고
    • Novel bimodal viral vectors and in vivo imaging reveal the fate of human neural stem cells in experimental glioma model
    • Shah K, Hingtgen S, Kasmieh R, Figueiredo JL, Breakefield XO, Martinez-Serrano A, Weissleder R: Novel bimodal viral vectors and in vivo imaging reveal the fate of human neural stem cells in experimental glioma model. J Neurosci (2008) 28(17):4406-4413.
    • (2008) J Neurosci , vol.28 , Issue.17 , pp. 4406-4413
    • Shah, K.1    Hingtgen, S.2    Kasmieh, R.3    Figueiredo, J.L.4    Breakefield, X.O.5    Martinez-Serrano, A.6    Weissleder, R.7
  • 45
    • 0037022618 scopus 로고    scopus 로고
    • Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells
    • Teng YD, Lavik EB, Qu X, Park KI, Ourednik J, Zurakowski D, Langer R, Snyder EY: Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells. Proc Natl Acad Sci USA (2002) 99(5):3024-3029.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.5 , pp. 3024-3029
    • Teng, Y.D.1    Lavik, E.B.2    Qu, X.3    Park, K.I.4    Ourednik, J.5    Zurakowski, D.6    Langer, R.7    Snyder, E.Y.8
  • 46
    • 4544290431 scopus 로고    scopus 로고
    • Human neural stem cell transplantation reduces spontaneous recurrent seizures following pilocarpine-induced status epilepticus in adult rats
    • Chu K, Kim M, Jung KH, Jeon D, Lee ST, Kim J, Jeong SW, Kim SU, Lee SK, Shin HS, Roh JK: Human neural stem cell transplantation reduces spontaneous recurrent seizures following pilocarpine-induced status epilepticus in adult rats. Brain Res (2004) 1023(2):213-221.
    • (2004) Brain Res , vol.1023 , Issue.2 , pp. 213-221
    • Chu, K.1    Kim, M.2    Jung, K.H.3    Jeon, D.4    Lee, S.T.5    Kim, J.6    Jeong, S.W.7    Kim, S.U.8    Lee, S.K.9    Shin, H.S.10    Roh, J.K.11
  • 47
    • 28444476599 scopus 로고    scopus 로고
    • Neural stem cell grafts reduce the extent of neuronal damage in a mouse model of global ischaemia
    • Wong AM, Hodges H, Horsburgh K: Neural stem cell grafts reduce the extent of neuronal damage in a mouse model of global ischaemia. Brain Res (2005) 1063(2):140-150.
    • (2005) Brain Res , vol.1063 , Issue.2 , pp. 140-150
    • Wong, A.M.1    Hodges, H.2    Horsburgh, K.3
  • 48
    • 33744522789 scopus 로고    scopus 로고
    • Role of endogenous neural stem cells in neurological disease and brain repair
    • Dietrich J, Kempermann G: Role of endogenous neural stem cells in neurological disease and brain repair. Adv Exp Med Biol (2006) 557:191-220.
    • (2006) Adv Exp Med Biol , vol.557 , pp. 191-220
    • Dietrich, J.1    Kempermann, G.2
  • 52
    • 34648821254 scopus 로고    scopus 로고
    • Making a tumour's bed: Glioblastoma stem cells and the vascular niche
    • Gilbertson RJ, Rich JN: Making a tumour's bed: Glioblastoma stem cells and the vascular niche. Nat Rev Cancer (2007) 7(10):733-736.
    • (2007) Nat Rev Cancer , vol.7 , Issue.10 , pp. 733-736
    • Gilbertson, R.J.1    Rich, J.N.2
  • 53
    • 2442687810 scopus 로고    scopus 로고
    • Glioma tropic neural stem cells consist of astrocytic precursors and their migratory capacity is mediated by CXCR4
    • Ehtesham M, Yuan X, Kabos P, Chung NH, Liu G, Akasaki Y, Black KL, Yu JS: Glioma tropic neural stem cells consist of astrocytic precursors and their migratory capacity is mediated by CXCR4. Neoplasia (2004) 6(3):287-293.
    • (2004) Neoplasia , vol.6 , Issue.3 , pp. 287-293
    • Ehtesham, M.1    Yuan, X.2    Kabos, P.3    Chung, N.H.4    Liu, G.5    Akasaki, Y.6    Black, K.L.7    Yu, J.S.8
  • 54
    • 33750224707 scopus 로고    scopus 로고
    • Neural stem cells and armed derivatives: Fate and therapeutic potential in the brain
    • Shah K: Neural stem cells and armed derivatives: Fate and therapeutic potential in the brain. Gene Ther Regulat (2007) 3(1):91-109.
    • (2007) Gene Ther Regulat , vol.3 , Issue.1 , pp. 91-109
    • Shah, K.1
  • 55
    • 33747065539 scopus 로고    scopus 로고
    • Stem cells for targeting CNS malignancy
    • Freese A, Simeone FA, Leone P, Janson C Eds, Karger Publishers, Basel, Switzerland
    • Yip S, Sidman RL, Snyder E: Stem cells for targeting CNS malignancy. In: Principles of Molecular Neurosurgery. Freese A, Simeone FA, Leone P, Janson C (Eds), Karger Publishers, Basel, Switzerland (2005) 18:624-644.
    • (2005) Principles of Molecular Neurosurgery , vol.18 , pp. 624-644
    • Yip, S.1    Sidman, R.L.2    Snyder, E.3
  • 56
    • 33747076690 scopus 로고    scopus 로고
    • Neural stem cells as novel cancer therapeutic vehicles
    • Yip S, Sabetrasekh R, Sidman RL, Snyder EY: Neural stem cells as novel cancer therapeutic vehicles. Eur J Cancer (2006) 42(9):1298-1308.
    • (2006) Eur J Cancer , vol.42 , Issue.9 , pp. 1298-1308
    • Yip, S.1    Sabetrasekh, R.2    Sidman, R.L.3    Snyder, E.Y.4
  • 57
    • 0034117480 scopus 로고    scopus 로고
    • Gene therapy of experimental brain tumors using neural progenitor
    • An early study that demonstrated the gliomatropic behavior of NSCs and their potential as a therapeutic tool, •
    • Benedetti S, Pirola B, Pollo B, Magrassi L, Bruzzone MG, Rigamonti D, Galli R, Selleri S, Di Meco F, De Fraja C, Vescovi A et al: Gene therapy of experimental brain tumors using neural progenitor. Nat Med (2000) 6(4):447-450. • An early study that demonstrated the gliomatropic behavior of NSCs and their potential as a therapeutic tool.
    • (2000) Nat Med , vol.6 , Issue.4 , pp. 447-450
    • Benedetti, S.1    Pirola, B.2    Pollo, B.3    Magrassi, L.4    Bruzzone, M.G.5    Rigamonti, D.6    Galli, R.7    Selleri, S.8    Di Meco, F.9    De Fraja, C.10    Vescovi, A.11
  • 58
    • 0037115671 scopus 로고    scopus 로고
    • Induction of glioblastoma apoptosis using neural stem cell-mediated delivery of tumor necrosis factor-related apoptosis-inducing ligand
    • Ehtesham M, Kabos P, Gutierrez MA, Chung NH, Griffith TS, Black KL, Yu JS: Induction of glioblastoma apoptosis using neural stem cell-mediated delivery of tumor necrosis factor-related apoptosis-inducing ligand. Cancer Res (2002) 62(24):7170-7174.
    • (2002) Cancer Res , vol.62 , Issue.24 , pp. 7170-7174
    • Ehtesham, M.1    Kabos, P.2    Gutierrez, M.A.3    Chung, N.H.4    Griffith, T.S.5    Black, K.L.6    Yu, J.S.7
  • 59
    • 0037108871 scopus 로고    scopus 로고
    • The use of interleukin 12-secreting neural stem cells for the treatment of intracranial glioma
    • Ehtesham M, Kabos P, Kabosova A, Neuman T, Black KL, Yu JS: The use of interleukin 12-secreting neural stem cells for the treatment of intracranial glioma. Cancer Res (2002) 62(20):5657-5663.
    • (2002) Cancer Res , vol.62 , Issue.20 , pp. 5657-5663
    • Ehtesham, M.1    Kabos, P.2    Kabosova, A.3    Neuman, T.4    Black, K.L.5    Yu, J.S.6
  • 60
    • 0036841825 scopus 로고    scopus 로고
    • Treatment of intracranial glioma with in situ interferon-γ and tumor necrosis factor-α gene transfer
    • Ehtesham M, Samoto K, Kabos P, Acosta FL, Gutierrez MA, Black KL, Yu JS: Treatment of intracranial glioma with in situ interferon-γ and tumor necrosis factor-α gene transfer. Cancer Gene Ther (2002) 9(11):925-934.
    • (2002) Cancer Gene Ther , vol.9 , Issue.11 , pp. 925-934
    • Ehtesham, M.1    Samoto, K.2    Kabos, P.3    Acosta, F.L.4    Gutierrez, M.A.5    Black, K.L.6    Yu, J.S.7
  • 61
    • 34247592355 scopus 로고    scopus 로고
    • Genetically engineered neural stem cells migrate and suppress glioma cell growth at distant intracranial sites
    • Li S, Gao Y, Tokuyama T, Yamamoto J, Yokota N, Yamamoto S, Terakawa S, Kitagawa M, Namba H: Genetically engineered neural stem cells migrate and suppress glioma cell growth at distant intracranial sites. Cancer Lett (2007) 251(2):220-227.
    • (2007) Cancer Lett , vol.251 , Issue.2 , pp. 220-227
    • Li, S.1    Gao, Y.2    Tokuyama, T.3    Yamamoto, J.4    Yokota, N.5    Yamamoto, S.6    Terakawa, S.7    Kitagawa, M.8    Namba, H.9
  • 63
    • 12844258193 scopus 로고    scopus 로고
    • Migratory neural stem cells for improved thymidine kinase-based gene therapy of malignant gliomas
    • Uhl M, Weiler M, Wick W, Jacobs AH, Weller M, Herrlinger U: Migratory neural stem cells for improved thymidine kinase-based gene therapy of malignant gliomas. Biochem Biophys Res Commun (2005) 328(1):125-129.
    • (2005) Biochem Biophys Res Commun , vol.328 , Issue.1 , pp. 125-129
    • Uhl, M.1    Weiler, M.2    Wick, W.3    Jacobs, A.H.4    Weller, M.5    Herrlinger, U.6
  • 64
    • 32044432090 scopus 로고    scopus 로고
    • Potent bystander effect in suicide gene therapy using neural stem cells transduced with herpes simplex virus thymidine kinase gene
    • Li S, Tokuyama T, Yamamoto J, Koide M, Yokota N, Namba H: Potent bystander effect in suicide gene therapy using neural stem cells transduced with herpes simplex virus thymidine kinase gene. Oncology (2005) 69(6):503-508.
    • (2005) Oncology , vol.69 , Issue.6 , pp. 503-508
    • Li, S.1    Tokuyama, T.2    Yamamoto, J.3    Koide, M.4    Yokota, N.5    Namba, H.6
  • 66
    • 5644291973 scopus 로고    scopus 로고
    • Cytokine gene therapy for malignant glioma
    • Okada H, Pollack IF: Cytokine gene therapy for malignant glioma. Expert Opin Biol Ther (2004) 4(10):1609-1620.
    • (2004) Expert Opin Biol Ther , vol.4 , Issue.10 , pp. 1609-1620
    • Okada, H.1    Pollack, I.F.2
  • 67
    • 33747204065 scopus 로고    scopus 로고
    • The IL-4 and IL-13 Pseudomonas exotoxins: New hope for brain tumor therapy
    • Shimamura T, Husain SR, Puri RK: The IL-4 and IL-13 Pseudomonas exotoxins: New hope for brain tumor therapy. Neurosurg Focus (2006) 20(4):E11.
    • (2006) Neurosurg Focus , vol.20 , Issue.4
    • Shimamura, T.1    Husain, S.R.2    Puri, R.K.3
  • 69
    • 33846842322 scopus 로고    scopus 로고
    • Prolonged survival of mice with established intracerebral glioma receiving combined treatment with peroxisome proliferator-activated receptor-γ thiazolidinedione agonists and interleukin-2-secreting syngeneic/allogeneic fibroblasts
    • Spagnolo A, Glick RP, Lin H, Cohen EP, Feinstein DL, Lichtor T: Prolonged survival of mice with established intracerebral glioma receiving combined treatment with peroxisome proliferator-activated receptor-γ thiazolidinedione agonists and interleukin-2-secreting syngeneic/allogeneic fibroblasts. J Neurosurg (2007) 106(2):299-305.
    • (2007) J Neurosurg , vol.106 , Issue.2 , pp. 299-305
    • Spagnolo, A.1    Glick, R.P.2    Lin, H.3    Cohen, E.P.4    Feinstein, D.L.5    Lichtor, T.6
  • 70
    • 3042740895 scopus 로고    scopus 로고
    • Gene therapy of rat malignant gliomas using neural stem cells expressing IL-12
    • Yang SY, Liu H, Zhang JN: Gene therapy of rat malignant gliomas using neural stem cells expressing IL-12. DNA Cell Biol (2004) 23(6):381-389.
    • (2004) DNA Cell Biol , vol.23 , Issue.6 , pp. 381-389
    • Yang, S.Y.1    Liu, H.2    Zhang, J.N.3
  • 73
    • 0034906370 scopus 로고    scopus 로고
    • Direct stimulation of apoptotic signaling by soluble Apo2L/tumor necrosis factor-related apoptosis-inducing ligand leads to selective killing of glioma cells
    • Pollack IF, Erff M, Ashkenazi A: Direct stimulation of apoptotic signaling by soluble Apo2L/tumor necrosis factor-related apoptosis-inducing ligand leads to selective killing of glioma cells. Clin Cancer Res (2001) 7(5):1362-1369.
    • (2001) Clin Cancer Res , vol.7 , Issue.5 , pp. 1362-1369
    • Pollack, I.F.1    Erff, M.2    Ashkenazi, A.3
  • 74
    • 2342583529 scopus 로고    scopus 로고
    • Inducible release of TRAIL fusion proteins from a proapoptotic form for tumor therapy
    • Shah K, Tung CH, Yang K, Weissleder R, Breakefield XO: Inducible release of TRAIL fusion proteins from a proapoptotic form for tumor therapy. Cancer Res (2004) 64(9):3236-3242.
    • (2004) Cancer Res , vol.64 , Issue.9 , pp. 3236-3242
    • Shah, K.1    Tung, C.H.2    Yang, K.3    Weissleder, R.4    Breakefield, X.O.5
  • 75
    • 19444363758 scopus 로고    scopus 로고
    • In vivo imaging of S-TRAIL-mediated tumor regression and apoptosis
    • Shah K, Tung CH, Breakefield XO, Weissleder R: In vivo imaging of S-TRAIL-mediated tumor regression and apoptosis. Mol Ther (2005) 11(6):926-931.
    • (2005) Mol Ther , vol.11 , Issue.6 , pp. 926-931
    • Shah, K.1    Tung, C.H.2    Breakefield, X.O.3    Weissleder, R.4
  • 76
    • 35148900227 scopus 로고    scopus 로고
    • Corsten MF, Miranda R, Kasmieh R, Krichevsky AM, Weissleder R, Shah K: MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas. Cancer Res (2007) 67(19):8994-9000. • The first study of combinatorial therapy using TRAIL-secreting NSCs and miRNA inhibitors in a mouse model of brain tumors.
    • Corsten MF, Miranda R, Kasmieh R, Krichevsky AM, Weissleder R, Shah K: MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas. Cancer Res (2007) 67(19):8994-9000. • The first study of combinatorial therapy using TRAIL-secreting NSCs and miRNA inhibitors in a mouse model of brain tumors.
  • 77
    • 34249034598 scopus 로고    scopus 로고
    • Tumor therapy mediated by lentiviral expression of shBcl-2 and S-TRAIL
    • Kock N, Kasmieh R, Weissleder R, Shah K: Tumor therapy mediated by lentiviral expression of shBcl-2 and S-TRAIL. Neoplasia (2007) 9(5):435-442.
    • (2007) Neoplasia , vol.9 , Issue.5 , pp. 435-442
    • Kock, N.1    Kasmieh, R.2    Weissleder, R.3    Shah, K.4
  • 84
    • 0033536064 scopus 로고    scopus 로고
    • Global cell replacement is feasible via neural stem cell transplantation: Evidence from the dysmyelinated shiverer mouse brain
    • Yandava BD, Billinghurst LL, Snyder EY: "Global" cell replacement is feasible via neural stem cell transplantation: Evidence from the dysmyelinated shiverer mouse brain. Proc Natl Acad Sci USA (1999) 96(12):7029-7034.
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.12 , pp. 7029-7034
    • Yandava, B.D.1    Billinghurst, L.L.2    Snyder, E.Y.3
  • 85
    • 0028951119 scopus 로고
    • Neural progenitor cell engraftment corrects lysosomal storage throughout the MPS VII mouse brain
    • Snyder EY, Taylor RM, Wolfe JH: Neural progenitor cell engraftment corrects lysosomal storage throughout the MPS VII mouse brain. Nature (1995) 374(6520):367-370.
    • (1995) Nature , vol.374 , Issue.6520 , pp. 367-370
    • Snyder, E.Y.1    Taylor, R.M.2    Wolfe, J.H.3
  • 86
    • 0036844019 scopus 로고    scopus 로고
    • Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons
    • Ourednik J, Ourednik V, Lynch WP, Schachner M, Snyder EY: Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons. Nat Biotechnol (2002) 20(11):1103-1110.
    • (2002) Nat Biotechnol , vol.20 , Issue.11 , pp. 1103-1110
    • Ourednik, J.1    Ourednik, V.2    Lynch, W.P.3    Schachner, M.4    Snyder, E.Y.5
  • 88
    • 34547550177 scopus 로고    scopus 로고
    • Neural stem cells for Parkinson's disease: To protect and repair
    • Sanberg PR: Neural stem cells for Parkinson's disease: To protect and repair. Proc Natl Acad Sci USA (2007) 104(29):11869-11870.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.29 , pp. 11869-11870
    • Sanberg, P.R.1
  • 89
    • 0036842501 scopus 로고    scopus 로고
    • The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue
    • Park KI, Teng YD, Snyder EY: The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue. Nat Biotechnol (2002) 20(11):1111-1117.
    • (2002) Nat Biotechnol , vol.20 , Issue.11 , pp. 1111-1117
    • Park, K.I.1    Teng, Y.D.2    Snyder, E.Y.3
  • 90
    • 0034006169 scopus 로고    scopus 로고
    • Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking recovery of progenitor cells
    • Lewin M, Carlesso N, Tung CH, Tang XW, Cory D, Scadden DT, Weissleder R: Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking recovery of progenitor cells. Nat Biotechnol (2000) 18(4):410-414.
    • (2000) Nat Biotechnol , vol.18 , Issue.4 , pp. 410-414
    • Lewin, M.1    Carlesso, N.2    Tung, C.H.3    Tang, X.W.4    Cory, D.5    Scadden, D.T.6    Weissleder, R.7
  • 91
    • 34547851774 scopus 로고    scopus 로고
    • Cellular multiparametric MRI of neural stem cell therapy in a rat glioma model
    • Brekke C, Williams SC, Price J, Thorsen F, Modo M: Cellular multiparametric MRI of neural stem cell therapy in a rat glioma model. Neuroimage (2007) 37(3):769-782.
    • (2007) Neuroimage , vol.37 , Issue.3 , pp. 769-782
    • Brekke, C.1    Williams, S.C.2    Price, J.3    Thorsen, F.4    Modo, M.5
  • 93
    • 33645095181 scopus 로고    scopus 로고
    • Interleukin-23- expressing bone marrow-derived neural stem-like cells exhibit antitumor activity against intracranial glioma
    • Yuan X, Hu J, Belladonna ML, Black KL, Yu JS: Interleukin-23- expressing bone marrow-derived neural stem-like cells exhibit antitumor activity against intracranial glioma. Cancer Res (2006) 66(5):2630- 2638.
    • (2006) Cancer Res , vol.66 , Issue.5 , pp. 2630-2638
    • Yuan, X.1    Hu, J.2    Belladonna, M.L.3    Black, K.L.4    Yu, J.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.