Design and optimization of lentiviral vectors for transfer of GALC expression in Twitcher brain

Journal of Gene Medicine

Volumn 8, Issue 8, 2006, Pages 962-971

  Dolcetta, Diego ^a   Perani, L ^a   Givogri, M I ^a   Galbiati, F ^a   Amadio, S ^b   Del Carro, U ^b   Finocchiaro, G ^c   Fanzani, A ^d   Marchesini, S ^d   Naldini, L ^a,e   Roncarolo, M G ^a   Bongarzone, Ernesto ^a  

^a SAN RAFFAELE SCIENTIFIC INSTITUTE   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c DEPARTMENT OF NEUROSURGERY   (Italy)

^d UNIVERSITY OF BRESCIA   (Italy)

^e VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

Galactocerebrosidase; Krabbe; Lentiviral; Lysosomes; Myelin; Twitcher

Indexed keywords

COMPLEMENTARY DNA; GALACTOSYLCERAMIDASE; HEMAGGLUTININ; LENTIVIRUS VECTOR;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BIOACCUMULATION; BIOCHEMISTRY; BLAST CELL; BRAIN TISSUE; BRAIN VENTRICLE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG ACCUMULATION; DRUG DIFFUSION; DRUG EFFICACY; ELECTROPHYSIOLOGY; ENZYME ACTIVITY; ENZYME RECONSTITUTION; ENZYME RELEASE; EPENDYMA; GENE EXPRESSION; GENETIC ENGINEERING; GENETIC TRANSDUCTION; GLIA CELL; GLOBOID CELL LEUKODYSTROPHY; HISTOLOGY; IN VITRO STUDY; IN VIVO STUDY; LIFESPAN; LYSOSOME; MOTOR NERVE CONDUCTION; MOUSE; NERVE CELL; NERVE CELL CULTURE; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRAL GENE THERAPY;

ACTION POTENTIALS; ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BIOLOGICAL ASSAY; BRAIN; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; DISEASE MODELS, ANIMAL; DNA, COMPLEMENTARY; GALACTOSYLCERAMIDASE; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GENETICS; HELA CELLS; HEMAGGLUTININS; HOMOZYGOTE; HUMANS; IMMUNOHISTOCHEMISTRY; LENTIVIRUS; LEUKODYSTROPHY, GLOBOID CELL; LYSOSOMES; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; NEURONS; OLIGODENDROGLIA;

ANIMALIA;

EID: 33747842839     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.924     Document Type: Article

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