Progress in mechanisms of visceral hypersensitivity in irritable bowel syndrome

World Chinese Journal of Digestology

Volumn 16, Issue 14, 2008, Pages 1554-1558

  Kang, Ming Xiang ^a   Jia, Hong ^a  

^a SOUTHWEST MEDICAL UNIVERSITY   (China)

Author keywords

Brain gut axis; Irritable bowel syndrome; Visceral hypersensitivity

Indexed keywords

ABDOMINAL DISCOMFORT; CENTRAL NERVOUS SYSTEM; CLINICAL FEATURE; DEFECATION HABIT; GASTROINTESTINAL MOTILITY DISORDER; GASTROINTESTINAL SECRETION; HUMAN; HYPERSENSITIVITY REACTION; INTESTINE INNERVATION; IRRITABLE COLON; REVIEW; SOCIAL PSYCHOLOGY; SPINAL CORD; STRESS; VISCERAL HYPERSENSITIVITY;

EID: 49149130633     PISSN: 10093079     EISSN: None     Source Type: Journal    
DOI: 10.11569/wcjd.v16.i14.1554     Document Type: Review

References (67)

1. Wood JN. Recent advances in understanding molecular mechanisms of primary afferent activation. Gut 2004; 53 Suppl 2: ii9-ii12
2. Ritchie J. Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome. Gut 1973; 14: 125-132
3. Holzer P, Schicho R, Holzer-Petsche U, Lippe IT. The gut as a neurological organ. Wien Klin Wochenschr 2001; 113: 647-660
4. Boeckxstaens GE. Understanding and controlling the enteric nervous system. Best Pract Res Clin Gastroenterol 2002; 16: 1013-1023
5. Gebhart GF. Pathobiology of visceral pain: molecular mechanisms and therapeutic implications IV. Visceral afferent contributions to the pathobiology of visceral pain. Am J Physiol Gastrointest Liver Physiol 2000; 278: G834-G838
6. Corsetti M, Gevers AM, Caenepeel P, Tack J. The role of tension receptors in colonic mechanosensitivity in humans. Gut 2004; 53: 1787-1793
7. Poitras P, Riberdy Poitras M, Plourde V, Boivin M, Verrier P. Evolution of visceral sensitivity in patients with irritable bowel syndrome. Dig Dis Sci 2002; 47: 914-920
8. Munakata J, Naliboff B, Harraf F, Kodner A, Lembo T, Chang L, Silverman DH, Mayer EA. Repetitive sigmoid stimulation induces rectal hyperalgesia in patients with irritable bowel syndrome. Gastroenterology 1997; 112: 55-63
9. Defilippi GC, Quera PR, Madrid SAM, Defilippi CC, Valenzuela EJ. Rectal barostat in irritable bowel syndrome. Rev Med Chil 2006; 134: 1524-1529
10. Posserud I, Agerforz P, Ekman R, Björnsson ES, Abrahamsson H, Simrén M. Altered visceral perceptual and neuroendocrine response in patients with irritable bowel syndrome during mental stress. Gut 2004; 53: 1102-1108
11. Basilisco G. Pathogenesis of irritable bowel syndrome: current understanding. Recenti Prog Med 2007; 98: 543-547
12. Lucas A, Cobelens PM, Kavelaars A, Heijnen CJ, Holtmann G, Haag S, Gerken G, Langhorst J, Dobos GJ, Schedlowski M, Elsenbruch S. Disturbed in vitro adrenergic modulation of cytokine production in inflammatory bowel diseases in remission. J Neuroimmunol 2007; 182: 195-203
13. Heitkemper M, Burr RL, Jarrett M, Hertig V, Lustyk MK, Bond EF. Evidence for autonomic nervous system imbalance in women with irritable bowel syndrome. Dig Dis Sci 1998; 43: 2093-2098
14. Barbara G, Wang B, Stanghellini V, de Giorgio R, Cremon C, Di Nardo G, Trevisani M, Campi B, Geppetti P, Tonini M, Bunnett NW, Grundy D, Corinaldesi R. Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome. Gastroenterology 2007; 132: 26-37
15. Greenwood-van Meerveld B. Importance of 5-hydroxytryptamine receptors on intestinal afferents in the regulation of visceral sensitivity. Neurogastroenterol Motil 2007; 19 Suppl 2: 13-18
16. Coates MD, Mahoney CR, Linden DR, Sampson JE, Chen J, Blaszyk H, Crowell MD, Sharkey KA, Gershon MD, Mawe GM, Moses PL. Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology 2004; 126: 1657-1664
17. Zou BC, Dong L, Wang Y, Wang SH, Cao MB. Expression and role of 5-HT7 receptor in brain and intestine in rats with irritable bowel syndrome. Chin Med J (Engl) 2007; 120: 2069-2074
18. Wang GD, Wang XY, Hu HZ, Fang XC, Liu S, Gao N, Xia Y, Wood JD. Angiotensin receptors and actions in guinea pig enteric nervous system. Am J Physiol Gastrointest Liver Physiol 2005; 289: G614-G626
19. Dunlop SP, Jenkins D, Neal KR, Spiller RC. Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS. Gastroenterology 2003; 125: 1651-1659
20. Wu HG, Jiang B, Zhou EH, Shi Z, Shi DR, Cui YH, Kou ST, Liu HR. Regulatory Mechanism of Electroacupuncture in Irritable Bowel Syndrome: Preventing MC Activation and Decreasing SP VIP Secretion. Dig Dis Sci 2007
21. Moskwa A, Boznanska P. Role of serotonin in the pathophysiology of the irritable bowel syndrome. Wiad Lek 2007; 60: 371-376
22. Spiller R. Recent advances in understanding the role of serotonin in gastrointestinal motility in functional bowel disorders: alterations in 5-HT signalling and metabolism in human disease. Neurogastroenterol Motil 2007; 19 Suppl 2: 25-31
23. Gershon MD. Nerves, reflexes, and the enteric nervous system: pathogenesis of the irritable bowel syndrome. J Clin Gastroenterol 2005; 39: S184-S193
24. Barbara G, Stanghellini V, De Giorgio R, Cremon C, Cottrell GS, Santini D, Pasquinelli G, Morselli-Labate AM, Grady EF, Bunnett NW, Collins SM, Corinaldesi R. Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 2004; 126: 693-702
25. Chinese source
26. Park JH, Rhee PL, Kim HS, Lee JH, Kim YH, Kim JJ, Rhee JC. Mucosal mast cell counts correlate with visceral hypersensitivity in patients with diarrhea predominant irritable bowel syndrome. J Gastroenterol Hepatol 2006; 21: 71-78
27. Wheatcroft J, Wakelin D, Smith A, Mahoney CR, Mawe G, Spiller R. Enterochromaffin cell hyperplasia and decreased serotonin transporter in a mouse model of postinfectious bowel dysfunction. Neurogastroenterol Motil 2005; 17: 863-780
28. Dunlop SP, Coleman NS, Blackshaw E, Perkins AC, Singh G, Marsden CA, Spiller RC. Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome. Clin Gastroenterol Hepatol 2005; 3: 349-357
29. Rijnierse A, Nijkamp FP, Kraneveld AD. Mast cells and nerves tickle in the tummy: implications for inflammatory bowel disease and irritable bowel syndrome. Pharmacol Ther 2007; 116: 207-235
30. Palsson OS, Morteau O, Bozymski EM, Woosley JT, Sartor RB, Davies MJ, Johnson DA, Turner MJ, Whitehead WE. Elevated vasoactive intestinal peptide concentrations in patients with irritable bowel syndrome. Dig Dis Sci 2004; 49: 1236-1243
31. Simrén M, Stotzer PO, Sjövall H, Abrahamsson H, Björnsson ES. Abnormal levels of neuropeptide Y and peptide YY in the colon in irritable bowel syndrome. Eur J Gastroenterol Hepatol 2003; 15: 55-62
32. Xu JR, Luo JY, Shang L, Kong WM. Effect of change in an inhibitory neurotransmitter of the myenteric plexus on the pathogenetic mechanism of irritable bowel syndrome subgroups in rat models. Chin J Dig Dis 2006; 7: 89-96
33. Coffin B, Bouhassira D, Sabate JM, Barbe L, Jian R. Alteration of the spinal modulation of nociceptive processing in patients with irritable bowel syndrome. Gut 2004; 53: 1465-1470
34. Gonçalves L, Almeida A, Pertovaara A. Pronociceptive changes in response properties of rostroventromedial medullary neurons in a rat model of peripheral neuropathy. Eur J Neurosci 2007; 26: 2188-2195
35. Carlson JD, Maire JJ, Martenson ME, Heinricher MM. Sensitization of pain-modulating neurons in the rostral ventromedial medulla after peripheral nerve injury. J Neurosci 2007; 27: 13222-13231
36. Viisanen H, Pertovaara A. Influence of peripheral nerve injury on response properties of locus coeruleus neurons and coeruleospinal antinociception in the rat. Neuroscience 2007; 146: 1785-1794
37. Kohn A, Prantera C, Pera A, Cosintino R, Sostegni R, Daperno M. Anti-tumour necrosis factor alpha (infliximab) in the treatment of severe ulcerative colitis: result of an open study on 13 patients. Dig Liver Dis 2002; 34: 626-630
38. Chinese source
39. Anand P, Aziz Q, Willert R, van Oudenhove L. Peripheral and central mechanisms of visceral sensitization in man. Neurogastroenterol Motil 2007; 19: 29-46
40. Järnerot G, Hertervig E, Friis-Liby I, Blomquist L, Karlén P, Grännö C, Vilien M, Ström M, Danielsson A, Verbaan H, Hellström PM, Magnuson A, Curman B. Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: a randomized, placebo-controlled study. Gastroenterology 2005; 128: 1805-1811
41. Mönnikes H, Rüter J, König M, Grote C, Kobelt P, Klapp BF, Arnold R, Wiedenmann B, Tebbe JJ. Differential induction of c-fos expression in brain nuclei by noxious and non-noxious colonic distension: role of afferent C-fibers and 5-HT3 receptors. Brain Res 2003; 966: 253-264
42. Chinese source
43. Chinese source
44. Zuo XL, Li YQ, Huang KM, Kuang RG, Lv GP, Lu XF, Li JM, Desmond PV. Alterations in cerebral potentials evoked by rectal distention and drinking ice water in patients with irritable bowel syndrome. J Gastroenterol Hepatol 2006; 21: 1844-1849
45. Sinhamahapatra P, Saha SP, Chowdhury A, Chakrabarti SK, Ghosh A, Maiti B. Visceral afferent hypersensitivity in irritable bowel syndrome--evaluation by cerebral evoked potential after rectal stimulation. Am J Gastroenterol 2001; 96: 2150-2157
46. Chan YK, Herkes GK, Badcock C, Evans PR, Bennett E, Kellow JE. Alterations in cerebral potentials evoked by rectal distension in irritable bowel syndrome. Am J Gastroenterol 2001; 96: 2413-2417
47. Van Oudenhove L, Demyttenaere K, Tack J, Aziz Q. Central nervous system involvement in functional gastrointestinal disorders. Best Pract Res Clin Gastroenterol 2004; 18: 663-680
48. Casey KL, Minoshima S, Berger KL, Koeppe RA, Morrow TJ, Frey KA. Positron emission tomographic analysis of cerebral structures activated specifically by repetitive noxious heat stimuli. J Neurophysiol 1994; 71: 802-807
49. Rainville P, Duncan GH, Price DD, Carrier B, Bushneil MC. Pain affect encoded in human anterior cingulate but not somatosensory cortex. Science 1997; 277: 968-971
50. Rosen SD, Paulesu E, Nihoyannopoulos P, Tousoulis D, Frackowiak RS, Frith CD, Jones T, Camici PG. Silent ischemia as a central problem: regional brain activation compared in silent and painful myocardial ischemia. Ann Intern Med 1996; 124: 939-949
51. Aziz Q, Andersson JL, Valind S, Sundin A, Hamdy S, Jones AK, Foster ER, Långström B, Thompson DG. Identification of human brain loci processing esophageal sensation using positron emission tomography. Gastroenterology 1997; 113: 50-59
52. Devinsky O, Morrell MJ, Vogt BA. Contributions of anterior cingulate cortex to behaviour. Brain 1995; 118 (Pt 1): 279-306
53. Saper CB. Convergence of autonomic and limbic connections in the insular cortex of the rat. J Comp Neurol 1982; 210: 163-173
54. Miller MW, Alevizos A, Cropper EC, Vilim FS, Karagogeos D, Kupfermann I, Weiss KR. Localization of myomodulin-like immunoreactivity in the central nervous system and peripheral tissues of Aplysia californica. J Comp Neurol 1991; 314: 627-644
55. Wilder-Smith CH, Robert-Yap J. Abnormal endogenous pain modulation and somatic and visceral hypersensitivity in female patients with irritable bowel syndrome. World J Gastroenterol 2007; 13: 3699-3704
56. Moshiree B, Price DD, Robinson ME, Gaible R, Verne GN. Thermal and visceral hypersensitivity in irritable bowel syndrome patients with and without fibromyalgia. Clin J Pain 2007; 23: 323-330
57. Wilder-Smith CH, Schindler D, Lovblad K, Redmond SM, Nirkko A. Brain functional magnetic resonance imaging of rectal pain and activation of endogenous inhibitory mechanisms in irritable bowel syndrome patient subgroups and healthy controls. Gut 2004; 53: 1595-1601
58. Andresen V, Bach DR, Poellinger A, Tsrouya C, Stroh A, Foerschler A, Georgiewa P, Zimmer C, Mönnikes H. Brain activation responses to subliminal or supraliminal rectal stimuli and to auditory stimuli in irritable bowel syndrome. Neurogastroenterol Motil 2005; 17: 827-837
59. Silverman DH, Munakata JA, Ennes H, Mandelkern MA, Hoh CK, Mayer EA. Regional cerebral activity in normal and pathological perception of visceral pain. Gastroenterology 1997; 112: 64-72
60. Mertz H, Morgan V, Tanner G, Pickens D, Price R, Shyr Y, Kessler R. Regional cerebral activation in irritable bowel syndrome and control subjects with painful and nonpainful rectal distention. Gastroenterology 2000; 118: 842-848
61. Bonaz B, Baciu M, Papillon E, Bost R, Gueddah N, Le Bas JF, Fournet J, Segebarth C. Central processing of rectal pain in patients with irritable bowel syndrome: an fMRI study. Am J Gastroenterol 2002; 97: 654-661
62. Lackner JM, Jaccard J, Krasner SS, Katz LA, Gudleski GD, Blanchard EB. How does cognitive behavior therapy for irritable bowel syndrome work? A mediational analysis of a randomized clinical trial. Gastroenterology 2007; 133: 433-444
63. Rask CU, Thomsen PH. Cognitive behavioural therapy of functional recurrent abdominal pain in children. Ugeskr Laeger 2007; 169: 3839-3845
64. Dinan TG, Quigley EM, Ahmed SM, Scully P, O'Brien S, O'Mahony L, O'Mahony S, Shanahan F, Keeling PW. Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker? Gastroenterology 2006; 130: 304-311
65. von Mentzer B, Murata Y, Ahlstedt I, Lindström E, Martinez V. Functional CRF receptors in BON cells stimulate serotonin release. Biochem Pharmacol 2007; 73: 805-813
66. Fukudo S. Role of corticotropin-releasing hormone in irritable bowel syndrome and intestinal inflammation. J Gastroenterol 2007; 42 Suppl 17: 48-51
67. Delgado-Aros S, Camilleri M. Visceral hypersensitivity. J Clin Gastroenterol 2005; 39: S194-S203