Pathobiology of visceral pain: Molecular mechanisms and therapeutic implications. IV. Visceral afferent contributions to the pathobiology of visceral pain

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 278, Issue 6 41-6, 2000, Pages

  Gebhart, G F ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Ion channels; Mechanosensitive; Polymodal; Visceral hyperalgesia

Indexed keywords

ION CHANNEL;

HYPERALGESIA; MECHANORECEPTOR; NERVE INJURY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RECEPTOR SENSITIVITY; REVIEW; SENSITIZATION; SENSORY NERVE; VISCERAL PAIN;

EID: 0033935566     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2000.278.6.g834     Document Type: Review

References (25)

1. Al-Chaer ED and Pasricha PJ. Transient colorectal irritation in the neonatal period produces long lasting visceral sensitization in rats: a potential model for IBS and other painful functional bowel disorders (Abstract). Gastroenterology 116: G4139, 1999.
2. Blumberg H, Haupt P, Jänig W, and Kohler W. Encoding of visceral noxious stimuli in the discharge patterns of visceral afferent fibers from the colon. Pflügers Arch 398: 33-40, 1983.
3. Buéno L, Fioramonti J, Delvaux M, and Frexinos J. Mediators and pharmacology of visceral sensitivity: from basic to clinical investigations. Gastroenterology 112: 1714-1743, 1997.
4. Cervero F. Afferent activity evoked by natural stimulation of the biliary system in the ferret. Pain 13: 137-151, 1982.
5. Cervero F and Sann H. Mechanically evoked responses of afferent fibers innervating the guinea-pig's ureter: an in vitro study. J Physiol (Lond) 412: 245-266, 1989.
6. Collins SM. The immunomodulation of enteric neuromuscular function: implications for motility and inflammatory disorders. Gastroenterology 111: 1683-1699, 1996.
7. Fiocchi C. Intestinal inflammation: a complex interplay of immune and nonimmune cell interactions. Am J Physiol Gastrointest Liver Physiol 273: G769-G775, 1997.
8. + current in nociceptors. Proc Natl Acad Sci USA 93: 1108-1112, 1996.
9. Häbler J, Jänig W, and Koltzenburg M. Activation of unmyelinated afferent fibers by mechanical stimuli and inflammation of the urinary bladder of the cat. J Physiol (Lond) 425: 545-562, 1990.
10. Häbler J, Jänig W, and Koltzenburg M. Myelinated primary afferents of the sacral spinal cord responding to slow filling and distension of the cat urinary bladder. J Physiol (Lond) 463: 449-460, 1993.
11. Hammer K, Sann H, and Pierau FK. Functional properties of mechanosensitive units from the chicken ureter in vitro. Pflügers Arch 425: 353-361, 1993.
12. Holzer P. Neural emergency system in the stomach. Gastroenterology 114: 823-839, 1998.
13. Holzer P and Maggi CA. Dissociation of dorsal root ganglion neurons into afferent and efferent-like neurons. Neuroscience 86: 389-398, 1998.
14. Hong SK, Han HC, Yoon YW, and Chung JM. Response properties of hypogastric afferent fibers supplying the ureter in the cat. Brain Res 622: 215-225, 1993.
15. Mayer EM and Gebhart GF. Basic and clinical aspects of visceral hyperalgesia. Gastroenterology 107: 271-293, 1994.
16. Raybould HE. Does your gut taste? Sensory transduction in the gastrointestinal tract. News Physiol Sci 13: 275-280, 1998.
17. Sengupta JN and Gebhart GF. Characterization of mechano-sensitive pelvic nerve afferent fibers innervating the colon of the rat. J Neurophysiol 71: 2046-2060, 1994.
18. Sengupta JN and Gebhart GF. Mechanosensitive properties of pelvic nerve afferent fibers innervating the urinary bladder of the rat. J Neurophysiol 72: 2420-2430, 1994.
19. Sengupta JN and Gebhart GF. Gastrointestinal afferent fibers and sensation. In: Physiology of the Gastrointestinal Tract (3rd ed.), edited by Johnson LR. New York: Raven, 1994, p. 483-519.
20. Sengupta JN, Saha JK, and Goyal RK. Stimulus-response function studies of esophageal mechanosensitive nociceptor in sympathetic afferents of opossum. J Neurophysiol 64: 796-812, 1990.
21. Sengupta JN, Saha JK, and Goyal RK. Differential sensitivity of bradykinin to esophageal distension-sensitive mechanoreceptor in vagal and sympathetic afferents of the opossum. J Neurophysiol 68: 1053-1067, 1992.
22. Su X and Gebhart GF. Mechanosensitive pelvic nerve afferent fibers innervating the colon of the rat are polymodal in character. J Neurophysiol 80: 2632-2644, 1998.
23. Su X, Wachtel RE, and Gebhart GF. Capsaicin sensitivity and voltage-gated sodium currents in colon sensory neurons from rat dorsal root ganglia. Am J Physiol Gastrointest Liver Physiol 277: G1180-G1188, 1999.
24. Su X, Wachtel RE, and Gebhart GF. Rat colon sensory neurons contain mechanosensitive channels (Abstract). Soc Neurosci Abstr 25: 410, 1999.
25. Torebjörk HE, Schmelz M, and Handwerker HO. Functional properties of human cutaneous nociceptors and their role in pain and hyperalgesia. In: Neurobiology of Nociceptors, edited by Belmonte C and Cervero F. New York: Oxford, 1996, p. 349-369.