Recent advances in understanding molecular mechanisms of primary afferent activation

Gut

Volumn 53, Issue SUPPL. 2, 2004, Pages

  Wood, J N ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

RECEPTOR SUBTYPE; SODIUM CHANNEL;

ACIDITY; CHEMOSENSITIVITY; COLD; EXPERIMENTAL MOUSE; HEAT; IN VITRO STUDY; MECHANICAL STIMULATION; MUSCLE SPINDLE AFFERENT NERVE; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PAIN RECEPTOR; PAIN THRESHOLD; PRIORITY JOURNAL; REVIEW; SENSORY NERVE; SENSORY NERVE CONDUCTION; SPINAL GANGLION; THERMAL STIMULATION; VISCERAL PAIN;

EID: 1242292940     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2003.033423     Document Type: Review

References (17)

1. Wood JN. The Molecular Basis of Pain Induction. New York: John Wiley, 2000.
2. Caterina MJ, Schumacher MA, Tominaga M, et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 1997;389:816-24.
3. Peier A, Moqrich A, Hergarden A, et al. A TRP channel that senses cold stimuli and menthol. Cell 2002;108:705-15.
4. McKemy DD, Neuhausser WM, Julius D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 2002;416:52-8.
5. Story GM, Peier AM, Reeve AJ, et al. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 2003;112:819-29.
6. Kellenberger S, Schild L. Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure. Physiol Rev 2002;82:735-67.
7. Nakamura F, Strittmatter SM. P2Y1 purinergic receptors in sensory neurons: contribution to touch-induced impulse generation. Proc Natl Acad Sci USA 1996;93:10465-70.
8. Price MP, McIlwrath SL, Xie J, et al. The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice. Neuron 2001;32:1071-83.
9. Drew LJ, Wood JN, Cesare P. Distinct mechanosensitive properties of capsaicin-sensitive and -insensitive sensory neurons. J Neurosci 2002;22:RC228.
10. Suzuki M, Mizuno A, Kodaira K, et al. Impaired pressure sensation with mice lacking TRPV4. J Biol Chem 2003;278:22664-8.
11. Akopian AN, Sivilotti L, Wood JN. A tetrodotoxin-resistant sodium channel expressed by C-fibre associated sensory neurons. Nature 1996;379:257-62.
12. Akopian AN, Souslova V, England S, et al. The tetrodotoxin-resistant sodium channel SNS plays a specialised role in pain pathways. Nat Neurosci 1999;2:541-8.
13. Bielefeldt K, Ozaki N, Gebhart GF. Experimental ulcers alter voltage-sensitive sodium currents in rat gastric sensory neurons. Gastroenterology 2002;122:394-405.
14. Baker MD, Chandra SY, Ding Y, et al. GTP-induced tetrodotoxin-resistant Na+ current regulates excitability in mouse and rat small diameter sensory neurones. J Physiol 2003;548:373-82.
15. Rugiero F, Mistry M, Sage D, et al. Selective expression of a persistent tetrodotoxin-resistant Na+ current and NaV1.9 subunit in myenteric sensory neurons. J Neurosci 2003;23:2715-25.
16. Laird JM, Martinez-Caro L, Garcia-Nicas E, et al. A new model of visceral pain and referred hyperalgesia in the mouse. Pain 2001;92:335-42.
17. Laird JM, Souslova V, Wood JN, et al. Deficits in visceral pain and referred hyperalgesia in Nav1.8 (SNS/PN3)-null mice. J Neurosci 2002;22:8352-6.