Silent ischemia as a central problem: Regional brain activation compared in silent and painful myocardial ischemia

Annals of Internal Medicine

Volumn 124, Issue 11, 1996, Pages 939-949

  Rosen, Stuart D ^a   Paulesu, Eraldo ^b   Nihoyannopoulos, Petros ^a   Tousoulis, Dimitris ^a   Frackowiak, Richard S J ^c   Frith, Christopher D ^c   Jones, Terry ^a   Camici, Paolo G ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DOBUTAMINE; WATER O 15;

ADULT; AGED; ANGINA PECTORIS; ARTICLE; BRAIN BLOOD FLOW; BRAIN DEPTH STIMULATION; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; FEMALE; FRONTAL CORTEX; HEART MUSCLE ISCHEMIA; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PRIORITY JOURNAL; THALAMUS;

AFFERENT PATHWAYS; AGED; ANGINA PECTORIS; BRAIN; CEREBROVASCULAR CIRCULATION; DOBUTAMINE; FEMALE; HEART; HEMODYNAMIC PROCESSES; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL ISCHEMIA; PAIN; SYMPATHOMIMETICS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0030317286     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-124-11-199606010-00001     Document Type: Article

References (54)

1. Heberden W. Some account of a disorder of the breast. Medical Transactions of the Royal College of Physicians of London. 1772;2:59-67.
2. Warren J. Remarks on angina pectoris. New England Journal of Medicine and Surgery. 1812;1:1-11.
3. Babey AM. Painless acute infarction of the heart. N Engl J Med. 1939;220: 410-12.
4. Kannel WB. Abbott RD. Incidence and prognosis of unrecognized myocardial infarction. An update on the Framingham study. N Engl J Med. 1984; 311:1144-7.
5. Epstein SE, Quyyumi AA, Bonow RO. Myocardial ischemia - silent or symptomatic. N Engl J Med. 1988;318:1038-43.
6. Schang SJ Jr, Pepine CJ. Transient asymptomatic S-T segment depression during daily activity. Am J Cardiol. 1977;39:396-402.
7. Deanfield JE, Maseri A, Selwyn AP, Ribeiro P, Chierchia S, Krikler S, et al. Myocardial ischaemia during daily life in patients with stable angina: its relation to symptoms and heart rate changes. Lancet. 1983;2:753-8.
8. Quyyumi AA, Mockus L, Wright C, Fox KM. Morphology of ambulatory ST segment changes in patients with varying severity of coronary artery disease. Investigation of the frequency of nocturnal ischaemia and coronary spasm. Br Heart J. 1985;53:186-93.
9. Gottlieb SO, Weisfeldt ML, Ouyang P, Mellits ED, Gerstenblith G. Silent ischemia as a marker for early unfavorable outcome in patients with unstable angina. N Engl J Med. 1986;314:1214-9.
10. Tzivoni D, Gavish A, Zin D, Gottlieb S, Moriel M, Keren A, et al. Prognostic significance of ischemic episodes in patients with previous myocardial infarction. Am J Cardiol. 1988;62:661-4.
11. Gottlieb SO, Gottlieb SH, Achuff SC, Baumgardner R, Mellits ED, Weisfeldt ML, et al. Silent ischemia on Holter monitoring predicts mortality in high risk postinfarction patients. JAMA. 1988;259:1030-5.
12. Wames CA, Roberts WC. Sudden coronary death: relation of amount and distribution of coronary narrowing at necropsy to previous symptoms of myocardial ischemia, left ventricular scarring and heart weight. Am J Cardiol. 1984;54:65-73.
13. Hong RA, Bhandari AK, McKay CR, Au PK. Rahimtoola SH. Life-threatening ventricular tachycardia and fibrillation induced by painless myocardial ischemia during exercise testing. JAMA. 1987;257:1937-40.
14. Glazier JJ, Chierchia S, Brown MJ, Maseri A. Importance of generalized defective perception of painful stimuli as a cause of silent myocardial ischemia in chronic stable angina pectoris. Am J Cardiol. 1986;58:667-72.
15. Chierchia S, Lazzari M, Freedman B, Brunelli C, Maseri A. Impairment of myocardial perfusion and function during painless myocardial ischemia. J Am Coll Cardiol. 1983;1:924-30.
16. Klein J, Chao SY, Berman DS, Rozanski A. Is "silent" myocardial ischemia really as severe as symptomatic ischemia? The analytical effect of patient selection biases. Circulation. 1994;89:1958-56.
17. Langer A, Freeman MR, Josse RG, Steiner G, Armstrong PW. Detection of silent myocardial ischemia in diabetes mellitus. Am J Cardiol. 1991;67: 1073-8.
18. Shakespeare CF, Katritsis D, Crowther A, Cooper IC Coltart JD, Webb-Peploe MW. Differences in autonomic function in patients with silent and symptomatic myocardial ischaemia. Br Heart J. 1994;71:22-9.
19. Woolf CJ, Wall PD. Endogenous opioid peptides and pain mechanisms: a complex relationship [News]. Nature. 1983;306:739-40.
20. Sheps DS, Maixner W, Hinderliter AL. Mechanisms of pain perception in patients with silent myocardial ischemia. Am Heart J. 1989;119:983-7.
21. Droste C Roskamm H. Pain perception and endogenous pain modulation in angina pectoris. In: Kellerman JJ, Braunwald E, eds. Silent Myocardial Ischemia: A Critical Appraisal. New York: Karger; 1990:142-64.
22. van Rijn T, Rabkin SW. Effect of naloxone on exercise-induced angina pectoris: a randomized double-blind crossover trial. Life Sci. 1986;38:609-15.
23. Ellestad MH, Kuan P. Naloxone and asymptomatic ischemia: failure to induce angina during exercise testing. Am J Cardiol. 1984;54:982-4.
24. Heller GV, Garber CE, Connolly MJ, Allen-Rowlands CF, Siconolfi SF, Gann DS, et al. Plasma β-endorphin levels in silent myocardial ischemia induced by exercise. Am J Cardiol. 1987;59:735-9.
25. Falcone C, Specchia G, Rondanelli R, Guasti L, Corsico G, Codega S, et al. Correlation between beta-endorphin plasma levels and anginal symptoms in patients with coronary artery disease. J Am Coll Cardiol. 1988;11:719-23.
26. Barsky AJ, Hochstrasser B, Coles NA, Zisfein J, O'Donnell C, Eagle KA. Silent myocardial ischemia. Is the person or the event silent? JAMA. 1990; 264:1132-5.
27. White JC. Cardiac pain. Anatomic pathways and physiologic mechanisms. Circulation. 1957;16:644-55.
28. Malliani A, Pagani M, Lombardi F. Visceral versus somatic mechanisms. In: Wall PD, Melzack R, eds. Textbook of Pain. New York: Churchill Livingstone; 1989:128-40.
29. Meller ST, Gebhart GF. A critical review of the afferent pathways and the potential chemical mediators involved in cardiac pain. Neuroscience. 1992;48: 501-24.
30. Fox PT, Raichle ME, Mintun MA, Dence C. Nonoxidative glucose consumption during focal physiologic neural activity. Science. 1988;241:462-4.
31. Raichle M. Circulatory and metabolic correlates of brain function in normal humans. In: Mountcastle VB, Brookhart JM, Geiger SR, eds. The Nervous System. Bethesda, MD: Amer Physiological Soc; 1987:643-74.
32. Mata M, Fink DJ, Gainer H, Smith CB, Davidsen L, Savaki H, et al. Activity-dependent energy metabolism in rat posterior pituitary primarily reflects sodium pump activity. J Neurochem. 1980;34:213-5.
33. Fristen KJ, Frackowiak RS. Imaging functional anatomy. In: Lassen NA, Ingvar DH, Raichle ME, Friberg L, eds. Brain Work and Mental Activity: Quantitative Studies with Radioactive Tracers. Proceedings of the Alfred Benzon Symposium 31 held at the premises of the Royal Danish Academy of Sciences and Letters, Copenhagen, August 12-16, 1990. Copenhagen: Munksgaard; 1991:267-79.
34. Friston KJ, Frith CD, Liddle PF, Dolan RD, Lammertsma AA, Frackowiak RS. The relationship between local and global changes in PET scans. J Cereb Blood Flow Metab. 1990;10:458-66.
35. Friston KJ, Frith CD, Liddle PF, Frackowiak RS. Comparing functional (PET) images: the assessment of significant change. J Cereb Blood Flow Metab. 1991;11:690-9.
36. Rosen SD, Paulesu E, Frith CD, Frackowiak RS, Davies GJ, Jones T, et al. Central nervous pathways mediating angina pectoris. Lancet. 1994;344: 147-50.
37. Wall PD. The gate control theory of pain mechanisms. A re-examination and a re-statement. Brain. 1978;101:1-18.
38. Spinks TJ, Jones T, Bailey DL, Townsend DW, Grootoonk S, Bloomfield PM, et al. Physical performance of a positron tomograph for brain imaging with retractable septa. Phys Med Biol. 1992;37:1637-55.
39. Takao Y, Kamisaki Y, Itoh T. Beta-adrenergic regulation of amine precursor amino acid transport across the blood-brain barrier. Eur J Pharmacol. 1992; 215:245-51.
40. Opie LH. Drugs and the Heart. 3d ed. Philadelphia: WB Saunders; 1991:143.
41. Talairach J, Tournoux P. Co-planar stereotaxic atlas of the human brain: 3-dimensional proportional system. An approach to cerebral imaging. New York: Thieme Med Publishers; 1988.
42. Friston KJ, Passingham RE, Nutt JG, Heather JD, Sawle GV, Frackowiak RS. Localisation in PET images: direct fitting of the intercommissural (AC-PC) line. J Cereb Blood Flow Metab. 1989;9:690-5.
43. 18F-fluorodeoxyglucose in postischemic myocardium of patients with exercise-induced angina. Circulation. 1986;74:81-8.
44. Neafsey EJ, Terreberry RR, Hurley KM, Ruit KG, Frysztak RJ. Anterior cingulate cortex in rodents: connections, visceral control functions and implications for emotion. In: Vogt BA, Gabriel M, eds. Neurobiology of Cingulate Cortex and Limbic Thalamus: A Comprehensive Handbook. Boston: Birkhäuser; 1993:206-23.
45. Terreberry RR, Neafsey EJ. Rat medial frontal cortex: a visceral motor region with a direct projection to the solitary nucleus. Brain Res. 1983;278: 245-9.
46. Hurley KM, Herbert H, Moga MM, Saper CB. Efferent projections of the infralimbic cortex of the rat. J Comp Neurol. 1991;308:249-76.
47. Vogt BA, Pandya DN. Cingulate cortex of the rhesus monkey: II. Cortical afferents. J Comp Neurol. 1987;262:271-89.
48. Van Hoesen GW, Morecraft RJ, Vogt BA. Connections of the monkey cingulate cortex. In: Vogt BA, Gabriel M, eds. Neurobiology of Cingulate Cortex and Limbic Thalamus: A Comprehensive Handbook. Boston: Birkhäuser: 1993:249-84.
49. Malliani A. Pathophysiology of ischemic cardiac pain. In: von Arnim T, Maseri A, eds. Silent Ischemia: Current Concepts and Management. New York: Springer-Verlag; 1987:19-24.
50. Jones AK, Brown WD Friston KJ, Qi LY, Frackowiak RS. Cortical and subcortical localization of response to pain in man using positron emission tomography. Proc R Soc Lond B Biol Sci. 1991;244:39-44.
51. Talbot JD, Marrett S, Evans AC, Meyer E, Bushnell MC, Duncan GH. Multiple representations of pain in human cerebral cortex. Science. 1991;251: 1355-8.
52. Channer KS. Central nervous pathways mediating angina pectoris [Letter]. Lancet. 1994;344:964-5.
53. Cronin CC. Central nervous pathways mediating angina pectoris [Letter]. Lancet. 1994;344:965.
54. Ahn J, Jarmukli NF, Iranmanesh A, Russell DC. Modulation of beta endorphin levels alters peripheral pain threshold but not anginal threshold in patients with stable angina [Abstract]. Circulation. 1994;90:1-57.