Inhibition of oxidative metabolism of tocopherols with ω-N-heterocyclic derivatives of vitamin E

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 16, 2008, Pages 7631-7638

  Ohnmacht, Stephan ^a   Nava, Phillip ^a   West, Ryan ^a   Parker, Robert ^b   Atkinson, Jeffrey ^a  

^a BROCK UNIVERSITY   (Canada)

^b Department of Obstetrics Gynecology   (United States)

Author keywords

CYP3A4; CYP4F2; Enzyme inhibition; Oxidative metabolism; Tocopherol; Tocotrienol; Vitamin E

Indexed keywords

2 (9 (1H 1,2,3 TRIAZOL 1 YL)NONYL) 2,5,7,8 TETRAMETHYLCHROMAN 6 OL; 2 (9 (1H 1,2,4 TRIAZOL 1 YL)NONYL) 2,5,7,8 TETRAMETHYLCHROMAN 6 OL; 2 (9 (1H BENZO[D][1,2,3]TRIAZOL 1 YL)NONYL) 2,5,7,8 TETRAMETHYLCHROMAN 6 OL; 2 (9 (1H BENZO[D]IMIDAZOL 1 YL)NONYL) 2,5,7,8 TETRAMETHYLCHROMAN 6 OL; 2 (9 (1H IMIDAZOL 1 YL)NONYL) 2,5,7,8 TETRAMETHYLCHROMAN 6 OL; 2 (9 (2H 1,2,3 TRIAZOL 1 YL)NONYL) 2,5,7,8 TETRAMETHYLCHROMAN 6 OL; 2 (9 (2H BENZO[D][1,2,3]TRIAZOL 1 YL)NONYL) 2,5,7,8 TETRAMETHYLCHROMAN 6 OL; ALPHA TOCOPHEROL; ALPHA TOCOPHEROL DERIVATIVE; CYP4F2M ENZYME; DELTA TOCOPHEROL; IMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG DESIGN; DRUG INHIBITION; DRUG METABOLISM; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROXYLATION; LIVER; LIVER MICROSOME; MALE; MOUSE; NONHUMAN;

ANIMALS; BENZIMIDAZOLES; BILE; CELL LINE; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICE; MIXED FUNCTION OXYGENASES; TOCOPHEROLS; TOCOTRIENOLS; TRIAZOLES; VITAMIN E;

ANIMALIA; MUS;

EID: 49149119190     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.07.020     Document Type: Article

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