메뉴 건너뛰기




Volumn 1031, Issue , 2004, Pages 13-21

Discovery, characterization, and significance of the cytochrome P450 ω-hydroxylase pathway of vitamin E catabolism

Author keywords

Cytochrome P450; Cytotoxicity; Hepatocytes; Macrophage; Metabolism; Microsomes; Omega oxidation; Tocopherols; Vitamin E

Indexed keywords

4 CHROMANONE DERIVATIVE; ALKANE 1 MONOOXYGENASE; ALPHA TOCOPHEROL; CARBOXYCHROMANOL DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 4F2; CYTOCHROME P450 ISOENZYME; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

EID: 14944341755     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1331.002     Document Type: Conference Paper
Times cited : (53)

References (12)
  • 1
    • 0032933234 scopus 로고    scopus 로고
    • Measurement of the 2,7,8-trimethyl-2-(β-carboxyethyl)-6- hydroxychroman metabolite of γ-tocopherol in human urine: Evidence for urinary excretion as a major route of elimination of γ-tocopherol
    • SWANSON, J., R. BEN, G. BURTON & R. PARKER. 1999. Measurement of the 2,7,8-trimethyl-2-(β-carboxyethyl)-6-hydroxychroman metabolite of γ-tocopherol in human urine: evidence for urinary excretion as a major route of elimination of γ-tocopherol. J. Lipid Res. 40: 665-671.
    • (1999) J. Lipid Res. , vol.40 , pp. 665-671
    • Swanson, J.1    Ben, R.2    Burton, G.3    Parker, R.4
  • 2
    • 0034673567 scopus 로고    scopus 로고
    • A novel 5′-carboxychroman metabolite of γ-tocopherol secreted by HepG2 cells and excreted in human urine
    • PARKER, R. & J. SWANSON. 2000. A novel 5′-carboxychroman metabolite of γ-tocopherol secreted by HepG2 cells and excreted in human urine. Biochem. Biophys. Res. Commun. 269: 580-583.
    • (2000) Biochem. Biophys. Res. Commun. , vol.269 , pp. 580-583
    • Parker, R.1    Swanson, J.2
  • 3
    • 0037067711 scopus 로고    scopus 로고
    • Cytochrome P450 w-hydroxylase pathway of tocopherol catabolism: Novel mechanism of regulation of vitamin E status
    • SONTAG, T. & R. PARKER. 2002. Cytochrome P450 w-hydroxylase pathway of tocopherol catabolism: novel mechanism of regulation of vitamin E status. J. Biol. Chem. 277: 25290-25296.
    • (2002) J. Biol. Chem. , vol.277 , pp. 25290-25296
    • Sontag, T.1    Parker, R.2
  • 4
    • 0036791124 scopus 로고    scopus 로고
    • Identities and differences in the metabolism of tocotrienols and tocopherols in HepG2 cells
    • BIRRINGER, M., P. PFLUGER, D. KLUTH, et al. 2002. Identities and differences in the metabolism of tocotrienols and tocopherols in HepG2 cells. J. Nutr. 132: 31113-31118.
    • (2002) J. Nutr. , vol.132 , pp. 31113-31118
    • Birringer, M.1    Pfluger, P.2    Kluth, D.3
  • 5
    • 0344938358 scopus 로고    scopus 로고
    • Inhibition and induction of human cytochrome P450 (CYP) enzymes
    • PELKONEN, O., J. MAENPAA, P. TAAVITSAINEN, et al. 1998. Inhibition and induction of human cytochrome P450 (CYP) enzymes. Xenobiotica 28: 1203-1253.
    • (1998) Xenobiotica , vol.28 , pp. 1203-1253
    • Pelkonen, O.1    Maenpaa, J.2    Taavitsainen, P.3
  • 6
    • 0034597750 scopus 로고    scopus 로고
    • Cytochrome P4503A-dependent metabolism of tocopherols and inhibition by sesamin
    • PARKER, R., T. SONTAG & J. SWANSON. 2000. Cytochrome P4503A-dependent metabolism of tocopherols and inhibition by sesamin. Biochem. Biophys. Res. Commun. 277: 531-534.
    • (2000) Biochem. Biophys. Res. Commun. , vol.277 , pp. 531-534
    • Parker, R.1    Sontag, T.2    Swanson, J.3
  • 8
    • 0025893459 scopus 로고
    • Sesamin is a potent and specific inhibitor of Δ5 desaturase in polyunsaturated fatty acid biosynthesis
    • SHIMIZU, S., K. AKIMOTO, Y. SHINMEN, et al. 1991. Sesamin is a potent and specific inhibitor of Δ5 desaturase in polyunsaturated fatty acid biosynthesis. Lipids 26: 512-516.
    • (1991) Lipids , vol.26 , pp. 512-516
    • Shimizu, S.1    Akimoto, K.2    Shinmen, Y.3
  • 9
    • 0346158205 scopus 로고    scopus 로고
    • Effects of sesamin and capsaicin on the mRNA expressions of D6 and D5 desaturases in rat primary cultured hepatocytes
    • UMEDA-SAWADA, R., Y. FUIIWARA, H. ABE & Y. SEYAMA. 2003. Effects of sesamin and capsaicin on the mRNA expressions of D6 and D5 desaturases in rat primary cultured hepatocytes. J. Nutr. Sci. Vitaminol. 49: 442-446.
    • (2003) J. Nutr. Sci. Vitaminol. , vol.49 , pp. 442-446
    • Umeda-Sawada, R.1    Fuiiwara, Y.2    Abe, H.3    Seyama, Y.4
  • 10
    • 12144291047 scopus 로고    scopus 로고
    • Cereal alkylresorcinols elevate γ-tocopherol levels in male Sprague-Dawley rats and inhibit γ-tocopherol metabolism in vitro
    • ROSS, A., Y. CHEN, J. FRANK, et al. 2004. Cereal alkylresorcinols elevate γ-tocopherol levels in male Sprague-Dawley rats and inhibit γ-tocopherol metabolism in vitro. J. Nutr. 143: 506-510.
    • (2004) J. Nutr. , vol.143 , pp. 506-510
    • Ross, A.1    Chen, Y.2    Frank, J.3
  • 11
    • 0028799969 scopus 로고
    • Sesame seed and its lignans produce marked enhancement of vitamin E activity in rats fed a low α-tocopherol diet
    • YAMASHITA, K., Y. LIZUKA, T. IMAI & M. NAMIKI. 1995. Sesame seed and its lignans produce marked enhancement of vitamin E activity in rats fed a low α-tocopherol diet. Lipids 30: 1019-1028.
    • (1995) Lipids , vol.30 , pp. 1019-1028
    • Yamashita, K.1    Lizuka, Y.2    Imai, T.3    Namiki, M.4
  • 12
    • 0029045399 scopus 로고
    • Sesamin (a compound from sesame oil) increases tocopherol levels in rats fed ad libitum
    • KAMAL-ELDIN, A, D. PETTERSSON & L.-A. APPELQUIST. 1995. Sesamin (a compound from sesame oil) increases tocopherol levels in rats fed ad libitum. Lipids 30: 499-505.
    • (1995) Lipids , vol.30 , pp. 499-505
    • Kamal-Eldin, A.1    Pettersson, D.2    Appelquist, L.-A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.