Intracellular signaling mechanisms mediating the antiproliferative and apoptotic effects of γ-tocotrienol in neoplastic mammary epithelial cells

Journal of Plant Physiology

Volumn 162, Issue 7, 2005, Pages 803-810

  Sylvester, Paul W ^a   Shah, Sumit J ^a   Samant, Ganesh V ^a  

^a UNIVERSITY OF LOUISIANA AT MONROE   (United States)

Author keywords

Akt; Apoptosis; Caspase; FLIP; Mammary cancer; PI3K; Tocotrienol; Vitamin E

Indexed keywords

CELLS; CHROMOSOMES; ENZYME KINETICS; GROWTH KINETICS; PHENOLS; PROTEINS;

APOPTOTIC ACTIVITY; CELL GROWTH; EPITHELIAL CELLS; INTRACELLULAR SIGNALING;

VITAMINS;

CELLS; CHROMOSOMES; GROWTH; PHENOLS; PROTEINS; VITAMINS;

EID: 20144363212     PISSN: 01761617     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jplph.2005.04.014     Document Type: Conference Paper

References (24)

1. A.S. Baldwin The NF-kappa B and I kappa B proteins: new discoveries and insights Annu Rev Immunol 14 1996 649 683
2. D.K. Biswas, A.P. Cruz, E. Gansberger, and A.B. Pardee Epidermal growth factor-induced nuclear factor kappa B activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells Proc Natl Acad Sci USA 97 2000 8542 8547
3. R.C. Cottrell Introduction: nutritional aspects of palm oil Am J Clin Nutr 53 1991 989S 1009S
4. K.G. Danielson, L.W. Anderson, and H.L. Hosick Selection and characterization in culture of mammary tumor cells with distinctive growth properties in vivo Cancer Res 40 1980 1812 1819
5. J. Downward Mechanisms and consequences of activation of protein kinase B/Akt Curr Opin Cell Biol 10 1998 262 267
6. U. Hermanto, C.S. Zong, and L.H. Wang ErbB2-overexpressing human mammary carcinoma cells display an increased requirement for the phosphatidylinositol 3-kinase signaling pathway in anchorage-independent growth Oncogene 20 2001 7551 7562
7. S.J. Hughes, Y. Nambu, O.S. Soldes, D. Hamstra, A. Rehemtulla, M.D. Iannettoni, M.B. Orringer, and D.G. Beer Fas/APO-1 (CD95) is not translocated to the cell membrane in esophageal adenocarcinoma Cancer Res 57 1997 5571 5578
8. E.S. Kandel, and N. Hay The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB Exp Cell Res 253 1999 210 229
9. B.S. McIntyre, K.P. Briski, A. Gapor, and P.W. Sylvester Antiproliferative and apoptotic effects of tocopherols and tocotrienols on preneoplastic and neoplastic mouse mammary epithelial cells Proc Soc Exp Biol Med 224 2000 292 301
10. B.S. McIntyre, K.P. Briski, M.A. Tirmenstein, M.W. Fariss, A. Gapor, and P.W. Sylvester Antiproliferative and apoptotic effects of tocopherols and tocotrienols on normal mouse mammary epithelial cells Lipids 35 2000 171 180
11. L. Packer, S.U. Weber, and G. Rimbach Molecular aspects of a-tocotrienol antioxidant action and cell signaling J Nutr 131 2001 369S 373S
12. D.J. Panka, T. Mano, T. Suhara, K. Walsh, and J.W. Mier Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells J Biol Chem 276 2001 6893 6896
13. C. Scaffidi, I. Schmitz, P.H. Krammer, and M.E. Peter The role of c-FLIP in modulation of CD95-induced apoptosis J Biol Chem 274 1999 1541 1548
14. S. Shah, and P.W. Sylvester Tocotrienol-induced caspase-8 activation is unrelated to death receptor apoptotic signaling in neoplastic mammary epithelial cells Exp Biol Med 229 2004 745 755
15. S. Shah, A. Gapor, and P.W. Sylvester Role of caspase-8 activation in mediating vitamin E-induced apoptosis in murine mammary cancer cells Nutr Cancer 45 2003 236 246
16. D. Sliva, M.T. Rizzo, and D. English Phosphatidylinositol 3-kinase and NF-kappaB regulate motility of invasive MDA-MB-231 human breast cancer cells by the secretion of urokinase-type plasminogen activator J Biol Chem 277 2002 3150 3157
17. T. Suhara, T. Mano, B.E. Oliverira, and K. Walsh Phosphatidylinositol 3-kinase/Akt signaling controls endothelial cell sensitivity to Fas-mediated apoptosis via regulation of FLICE-inhibitory protein (FLIP) Circ Res 89 2001 13 19
18. P.W. Sylvester, and S.J. Shah Mechanisms mediating the antiproliferative and apoptotic effects of vitamin E in mammary cancer cells Front Biosci 10 2005 699 709
19. P.W. Sylvester, and A. Theriault Role of tocotrienols in the prevention of cardiovascular disease and breast cancer Curr Top Nutraceutical Res 1 2003 121 136
20. P.W. Sylvester, B.S. McIntyre, A. Gapor, and K.P. Briski Vitamin E inhibition of normal mammary epithelial cell growth is associated with a reduction in protein kinase C(alpha) activation Cell Prolif 34 2001 347 357
21. P.W. Sylvester, A. Nachnani, S. Shah, and K.P. Briski Role of GTP-binding proteins in reversing the antiproliferative effects of tocotrienols in preneoplastic mammary epithelial cells Asia Pacific J Clin Nutr 11 2002 S452 S459
22. A. Toker Protein kinases as mediators of phosphoinositide 3-kinase signaling Mol Pharmacol 57 2000 652 688
23. J. Tschopp, M. Irmler, and M. Thome Inhibition of fas death signals by FLIPs Curr Opin Immunol 10 1998 552 558
24. S.P. Yap, K.H. Yuen, and J.W. Wong Pharmacokinetics and bioavailability of alpha-, gamma-, and delta-tocotrienols under different food status J Pharm Pharmacol 53 2001 67 71