In silico prediction of novel phosphodiesterase type-5 inhibitors derived from Sildenafil, Vardenafil and Tadalafil

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 16, 2008, Pages 7599-7606

  Antunes, João E ^a   Freitas, Matheus P ^a   da Cunha, Elaine F F ^a   Ramalho, Teodorico C ^a   Rittner, Roberto ^b  

^a FEDERAL UNIVERSITY OF LAVRAS   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Docking studies; Erectile dysfunction; MIA QSAR; PDE 5 inhibitors

Indexed keywords

PHOSPHODIESTERASE V INHIBITOR; SILDENAFIL; TADALAFIL; VARDENAFIL; ZAPRINAST;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACTIVITY; DRUG BINDING SITE; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG STRUCTURE; GENOTOXICITY; LD 50; MOLECULAR DOCKING; MOUSE; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT;

ANIMALS; CARBOLINES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; IMIDAZOLES; MICE; MODELS, MOLECULAR; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PURINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; SULFONES; TRIAZINES;

EID: 49149108488     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.07.022     Document Type: Article

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