Binding mode analysis of 2, 4-diamino-5-methyl-5-deaza-6-substituted pteridines with mycobacterium tuberculosis and human dihydrofolate reductases

Journal of Biomolecular Structure and Dynamics

Volumn 25, Issue 4, 2008, Pages 377-385

  da Cunha, Elaine F F ^a   Ramalho, Teodorico C ^a   Reynolds, Robert C ^b  

^a FEDERAL UNIVERSITY OF LAVRAS   (Brazil)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINO 5 METHYL 5 DEAZAPTERIDINE DERIVATIVE; BACTERIAL ENZYME; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; METHOTREXATE; PTERIDINE DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG SELECTIVITY; DRUG TARGETING; ENZYME STRUCTURE; HUMAN; HYDROGEN BOND; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR MODEL; MULTIDRUG RESISTANCE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; THREE DIMENSIONAL IMAGING; TUBERCULOSIS; VIRTUAL REALITY; X RAY CRYSTALLOGRAPHY;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; COMPUTER SIMULATION; FOLIC ACID ANTAGONISTS; HUMANS; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; PROTEIN BINDING; PTERIDINES; TETRAHYDROFOLATE DEHYDROGENASE;

MYCOBACTERIUM TUBERCULOSIS;

EID: 38349152543     PISSN: 07391102     EISSN: 15380254     Source Type: Journal    
DOI: 10.1080/07391102.2008.10507186     Document Type: Article

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