Dermal dendritic cells, and not Langerhans cells, play an essential role in inducing an immune response

Journal of Immunology

Volumn 180, Issue 5, 2008, Pages 3057-3064

  Fukunaga, Atsushi ^a   Khaskhely, Noor M ^a   Sreevidya, Coimbatore S ^a   Byrne, Scott N ^a,b   Ullrich, Stephen E ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b ROYAL PRINCE ALFRED HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

1 FLUORO 2,4 DINITROBENZENE; FLUORESCEIN ISOTHIOCYANATE; HAPTEN; THROMBOCYTE ACTIVATING FACTOR; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; THROMBOCYTE ACTIVATING FACTOR RECEPTOR; FIBRINOGEN RECEPTOR; G PROTEIN COUPLED RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CELL MIGRATION; CELL STIMULATION; CONTACT ALLERGY; CONTROLLED STUDY; DENDRITIC CELL; LANGERHANS CELL; LYMPH NODE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN; SKIN CELL; TRANSGENIC MOUSE; WILD TYPE; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; CELL MOTION; COMPARATIVE STUDY; CONTACT DERMATITIS; CYTOLOGY; EPIDERMIS; GENETICS; IMMUNOLOGY; KERATINOCYTE; METABOLISM; MOLECULAR GENETICS; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY;

AMINO ACID SEQUENCE; ANIMALS; CELL MOVEMENT; DERMATITIS, CONTACT; EPIDERMIS; KERATINOCYTES; LANGERHANS CELLS; LYMPH NODES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PLATELET ACTIVATING FACTOR; PLATELET MEMBRANE GLYCOPROTEINS; RECEPTORS, G-PROTEIN-COUPLED; SKIN;

EID: 49149101883     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.5.3057     Document Type: Article

References (37)

1. Wolff, K. 1967. The fine structure of the Langerhans cell granule. J. Cell Biol. 35: 468-473.
2. Valladeau, J., O. Ravel, C. Dezutter-Dambuyant, K. Moore, M. Kleijmeer, Y. Liu, V. Duvert-Frances, C. Vincent, D. Schmitt, J. Davoust, et al. 2000. Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity 12: 71-81.
3. Kripke, M. L., C. G. Munn, A. Jeevan, J. M. Tang, and C. Bucana. 1990. Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization. J. Immunol. 145: 2833-2838.
4. Cumberbatch, M., S. J. Gould, S. W. Peters, and I. Kimber. 1991. MHC class II expression by Langerhans' cells and lymph node dendritic cells: possible evidence for maturation of Langerhans' cells following contact sensitization. Immunology 74: 414-419.
5. Moodycliffe, A. M., I. Kimber, and M. Norval. 1992. The effect of ultraviolet B irradiation and urocanic acid isomers on dendritic cell migration. Immunology 77: 394-399.
6. Fukunaga, A., H. Nagai, T. Noguchi, H. Okazawa, T. Matozaki, X. Yu, C. F. Lagenaur, N. Honma, M. Ichihashi, M. Kasuga, et al. 2004. Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 regulates the migration of Langerhans cells from the epidermis to draining lymph nodes. J. Immunol. 172: 4091-4099.
7. Bennett, C. L., E. van Rijn, S. Jung, K. Inaba, R. M. Steinman, M. L. Kapsenberg, and B. E. Clausen. 2005. Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity. J. Cell Biol. 169: 569-576.
8. Kaplan, D. H., M. C. Jenison, S. Saeland, W. D. Shlomchik, and M. J. Shlomchik. 2005. Epidermal Langerhans cell-deficient mice develop enhanced contact hypersensitivity. Immunity 23: 611-620.
9. Kissenpfennig, A., S. Henri, B. Dubois, C. Laplace-Builhe, P. Perrin, N. Romani, C. H. Tripp, P. Douillard, L. Leserman, D. Kaiserlian, et al. 2005. Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 22: 643-654.
10. Stoecklinger, A., I. Grieshuber, S. Scheiblhofer, R. Weiss, U. Ritter, A. Kissenpfennig, B. Malissen, N. Romani, F. Koch, F. Ferreira, et al. 2007. Epidermal Langerhans cells are dispensable for humoral and cell-mediated immunity elicited by gene gun immunization. J. Immunol. 179: 886-893.
11. Lenz, A., M. Heine, G. Schuler, and N. Romani. 1993. Human and murine dermis contain dendritic cells: isolation by means of a novel method and phenotypical and functional characterization. J. Clin. Invest. 92: 2587-2596.
12. Ishii, S., and T. Shimizu. 2000. Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice. Prog. Lipid Res. 39: 41-82.
13. Walterscheid, J. P., S. E. Ullrich, and D. X. Nghiem. 2002. Platelet-activating factor, a molecular sensor for cellular damage, activates systemic immune suppression. J. Exp. Med. 195: 171-179.
14. Zhang, Q., N. Mousdicas, Q. Yi, M. Al-Hassani, S. D. Billings, S. M. Perkins, K. M. Howard, S. Ishii, T. Shimizu, and J. B. Travers. 2005. Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptor. J. Clin. Invest. 115: 2855-2861.
15. Wolf, P., D. X. Nghiem, J. P. Walterscheid, S. Byrne, Y. Matsumura, Y. Matsumura, C. Bucana, H. N. Ananthaswamy, and S. E. Ullrich. 2006. Platelet-activating factor is crucial in psoralen and ultraviolet A-induced immune suppression, inflammation, and apoptosis. Am. J. Pathol. 169: 795-805.
16. Ramos, G., N. Kazimi, D. X. Nghiem, J. P. Walterscheid, and S. E. Ullrich. 2004. Platelet activating factor receptor binding plays a critical role in jet fuel-induced immune suppression. Toxicol. Appl. Pharmacol. 195: 331-338.
17. Pei, Y., L. A. Barber, R. C. Murphy, C. A. Johnson, S. W. Kelley, L. C. Dy, R. H. Fertel, T. M. Nguyen, D. A. Williams, and J. B. Travers. 1998. Activation of the epidermal platelet-activating factor receptor results in cytokine and cyclooxygenase-2 biosynthesis. J. Immunol. 161: 1954-1961.
18. Dy, L. C., Y. Pei, and J. B. Travers. 1999. Augmentation of ultraviolet B radiation-induced tumor necrosis factor production by the epidermal platelet-activating factor receptor. J. Biol. Chem. 274: 26917-26921.
19. Lou, Y. P., K. Takeyama, K. M. Grattan, J. A. Lausier, I. F. Ueki, C. Agusti, and J. A. Nadel. 1998. Platelet-activating factor induces goblet cell hyperplasia and mucin gene expression in airways. Am. J. Respir. Crit. Care Med. 157: 1927-1934.
20. Ishii, S., T. Kuwaki, T. Nagase, K. Maki, F. Tashiro, S. Sunaga, W. H. Cao, K. Kume, Y. Fukuchi, K. Ikuta, et al. 1998. Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor. J. Exp. Med. 187: 1779-1788.
21. Douillard, P., P. Stoitzner, C. H. Tripp, V. Clair-Moninot, S. Ait-Yahia, A. D. McLellan, A. Eggert, N. Romani, and S. Saeland. 2005. Mouse lymphoid tissue contains distinct subsets of langerin/CD207 dendritic cells, only one of which represents epidermal-derived Langerhans cells. J. Invest. Dermatol. 125: 983-994.
22. Fukunaga, A., H. Nagai, X. Yu, S. Oniki, H. Okazawa, S. Motegi, R. Suzuki, N. Honma, T. Matozaki, C. Nishigori, and T. Horikawa. 2006. Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 regulates the induction of Langerhans cell maturation. Eur. J. Immunol. 36: 3216-3226.
23. Merad, M., M. G. Manz, H. Karsunky, A. Wagers, W. Peters, I. Charo, I. L. Weissman, J. G. Cyster, and E. G. Engleman. 2002. Langerhans cells renew in the skin throughout life under steady-state conditions. Nat. Immunol. 3: 1135-1141.
24. Yu, X., A. Fukunaga, H. Nagai, S. Oniki, N. Honma, M. Ichihashi, T. Matozaki, C. Nishigori, and T. Horikawa. 2006. Engagement of CD47 inhibits the contact hypersensitivity response via the suppression of motility and B7 expression by Langerhans cells. J. Invest. Dermatol. 126: 797-807.
25. Moodycliffe, A. M., D. Nghiem, G. Clydesdale, and S. E. Ullrich. 2000. Immune suppression and skin cancer development: regulation by NKT cells. Nat. Immunol. 1: 521-525.
26. Griffiths, C. E., R. J. Dearman, M. Cumberbatch, and I. Kimber. 2005. Cytokines and Langerhans cell mobilisation in mouse and man. Cytokine 32: 67-70.
27. + cell-derived dendritic cells express functional receptors for platelet activating factor. FEBS Lett. 418: 98-100.
28. Cumberbatch, M., and I. Kimber. 1992. Dermal tumour necrosis factor-α induces dendritic cell migration to draining lymph nodes, and possibly provides one stimulus for Langerhans' cell migration. Immunology 75: 257-263.
29. + epidermal cells. J. Immunol. 137: 2460-2467.
30. Bacci, S., P. Alard, R. Dai, T. Nakamura, and J. W. Streilein. 1997. High and low doses of haptens dictate whether dermal or epidermal antigen-presenting cells promote contact hypersensitivity. Eur. J. Immunol. 27: 442-448.
31. Barber, L. A., D. F. Spandau, S. C. Rathman, R. C. Murphy, C. A. Johnson, S. W. Kelley, S. A. Hurwitz, and J. B. Travers. 1998. Expression of the platelet-activating factor receptor results in enhanced ultraviolet B radiation-induced apoptosis in a human epidermal cell line. J. Biol. Chem. 273: 18891-18897.
32. Ishii, S., and T. Shimizu. 2000. Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice. Prog. Lipid Res. 39: 41-82.
33. Silberberg-Sinakin, I., and G. J. Thorbecke. 1980. Contact hypersensitivity and Langerhans cells. J. Invest. Dermatol. 75: 61-67.
34. Olson, E. N., H. H. Arnold, P. W. Rigby, and B. J. Wold. 1996. Know your neighbors: three phenotypes in null mutants of the myogenic bHLH gene MRF4. Cell 85: 1-4.
35. Ullrich, S. E. 2005. Mechanisms underlying UV-induced immune suppression. Mutat. Res. 571: 185-205.
36. Itano, A. A., S. J. McSorley, R. L. Reinhardt, B. D. Ehst, E. Ingulli, A. Y. Rudensky, and M. K. Jenkins. 2003. Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. Immunity 19: 47-57.
37. Guttman-Yassky, E., M. A. Lowes, J. Fuentes-Duculan, J. Whynot, I. Novitskaya, I. Cardinale, A. Haider, A. Khatcherian, J. A. Carucci, R. Bergman, and J. G. Krueger. 2007. Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis. J. Allergy Clin. Immunol. 119: 1210-1217.