Immortal ALT+ human cells do not require telomerase reverse transcriptase for malignant transformation

Cancer Research

Volumn 65, Issue 15, 2005, Pages 6512-6515

  Sun, Beicheng ^a,b   Chen, Meizhen ^a   Hawks, Christina L ^a   Hornsby, Peter J ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

RAS PROTEIN; RASV12G PROTEIN; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG;

ALTERNATIVE LENGTHENING OF TELOMERE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INVASION; CANCER TRANSPLANTATION; CARCINOGENICITY; CELL IMMORTALIZATION; CONTROLLED STUDY; ENZYME ACTIVITY; FIBROBLAST; HUMAN; HUMAN CELL; KIDNEY CAPSULE; LUNG METASTASIS; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; ONCOGENE RAS; ONCOGENE RASV12G; PRIORITY JOURNAL; TELOMERE;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; DNA-BINDING PROTEINS; FIBROBLASTS; GENES, RAS; HUMANS; IMMUNOCOMPROMISED HOST; MICE; SIMIAN VIRUS 40; SUBRENAL CAPSULE ASSAY; TELOMERASE; TELOMERE;

EID: 23044498872     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-1210     Document Type: Article

References (17)

1. Shay JW, Wright WE. Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis 2005; 26:867-74.
2. Bryan TM, Englezou A, Gupta J, Bacchetti S, Reddel RR. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J 1995;14:4240-8.
3. Neumann AA, Reddel RR. Telomere maintenance and cancer: look, no telomerase. Nat Rev Cancer 2002;2:879-84.
4. Hahn WC, Counter CM, Lundberg AS, Beijersbergen RL, Brooks MW, Weinberg RA. Creation of human tumour cells with defined genetic elements. Nature 1999;400:464-8.
5. Hahn WC, Dessain SK, Brooks MW, et al. Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol Cell Biol 2002;22:2111-23.
6. Stewart SA, Hahn WC, O'Connor BF, et al. Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proc Natl Acad Sci U S A 2002;99:12606-11.
7. Chang S, DePinho RA. Telomerase extracurricular activities. Proc Natl Acad Sci U S A 2002;99:12520-2.
8. Sun B, Huang Q, Liu S, et al. Progressive loss of malignant behavior in telomerase-negative tumorigenic adrenocortical cells and restoration of tumorigenicity by human telomerase reverse transcriptase. Cancer Res 2004;64:6144-51.
9. Croce CM, Knowles BB, Koprowski H. Preferential retention of the human chromosome C-7 in human-(thymidine kinase deficient) mouse hybrid cells. Exp Cell Res 1973;82:457-61.
10. Benn PA, Shows TB, D'Ancona GG, Croce CM, Orkwiszewski KG, Mellman WJ. Assignment of a gene for uridine diphosphate galactose-4-epimerase to human chromosome 1 by somatic cell hybridization, with evidence for a regional assignment to Ipter-Ip21. Cytogenet Cell Genet 1979;24:138-42.
11. Girardi AJ, Weinstein D, Moorhead PS. SV40 transformation of human diploid cells. A parallel study of viral and karyologic parameters. Ann Med Exp Biol Fenn 1966;44:242-54
12. Miller AD, Rosman GJ. Improved retroviral vectors for gene transfer and expression. Biotechniques 1989;7: 980-2.
13. Pear WS, Nolan GP, Scott ML, Baltimore D. Production of high-titer helper-free retroviruses by transient transfection. Proc Natl Acad Sci U S A 1993;90:8392-6.
14. Thomas M, Northrup SR, Hornsby PJ. Adrenocortical tissue formed by transplantation of normal clones of bovine adrenocortical cells in scid mice replaces the essential functions of the animals' adrenal glands. Nat Med 1997;3:978-83.
15. Thomas M, Yang L, Hornsby PJ. Formation of functional tissue from transplanted adrenocortical cells expressing telomerase reverse transcriptase. Nat Biotechnol 2000;18:39-42.
16. Thomas M, Wang X, Hornsby PJ. Human adrenocortical cell xenotransplantation: model of cotransplantation of human adrenocortical cells and 3T3 cells in scid mice to form vascularized functional tissue and prevent adrenal insufficiency. Xenotransplantation 2002;9:58-67.
17. Ott CE, Knox FG. Tissue pressures and fluid dynamics in the kidney. Fed Proc 1976;35:1872-5.