Aqueous extract of rhubarb stabilizes vulnerable atherosclerotic plaques due to depression of inflammation and lipid accumulation

Phytotherapy Research

Volumn 22, Issue 7, 2008, Pages 935-942

  Liu, Yunfang ^a   Yan, Fangfang ^a   Liu, Yan ^a   Zhang, Cheng ^b   Yu, Huiming ^b   Zhang, Yun ^b   Zhao, Yuxia ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

Atherosclerosis; Plaque stability; Rhubarb

Indexed keywords

CHOLESTEROL; HISTAMINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; RHUBARB EXTRACT; SIMVASTATIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; VIPER VENOM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTERIAL WALL THICKNESS; ARTICLE; ATHEROSCLEROTIC PLAQUE; CHINESE MEDICINE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; COMPARATIVE STUDY; CONTROLLED STUDY; ECHOGRAPHY; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; INCIDENCE; INFLAMMATION; LIPID STORAGE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; RABBIT; SEROLOGY;

ANIMALS; ANTICHOLESTEREMIC AGENTS; AORTA, ABDOMINAL; AORTIC RUPTURE; ATHEROSCLEROSIS; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CONSTRICTION, PATHOLOGIC; DISEASE MODELS, ANIMAL; GENE EXPRESSION; HISTAMINE; MEDICINE, CHINESE TRADITIONAL; NF-KAPPA B; PHYTOTHERAPY; PLANT EXTRACTS; RABBITS; RHEUM; RNA, MESSENGER; SIMVASTATIN; TOLL-LIKE RECEPTORS; VIPER VENOMS;

ORYCTOLAGUS CUNICULUS; RHEUM X HYBRIDUM; VIPERINAE;

EID: 48749128521     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2429     Document Type: Article

References (32)

1. Abreu MT, Arditi M. 2004. Innate immunity and toll-like receptors: clinical implications of basic science research. J Pediatr 144: 421-429.
2. Brand K, Page S, Walli AK, Neumeier D, Baeuerle PA. 1997. Role of nuclear factor-kappa B in atherogenesis. Exp Physiol 82: 297-304.
3. Bulut Y, Faure E, Thomas L et al. 2002. Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway. J Immunol 168: 1435-1440.
4. Cai J, Xuan ZR, Wei YP, Yang HB, Wang H. 2005. Effects of perioperative administration of rhubarb on acute inflammatory response in patients with gastric cancer. Chin J Integr Med 11: 195-198.
5. Castrillo A, Joseph SB, Vaidya SA et al. 2003. Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism. Mol Cell 12: 805-816.
6. Chang CH, Lin CC, Yang JJ, Namba T, Hattori M. 1996. Antiinflammatory effects of emodin from Ventilago leiocarpa. Am J Chin Med 24: 139-142.
7. Chen WQ, Zhang L, Liu YF et al. 2007. Prediction of atherosclerotic plaque ruptures with high frequency ultrasound imaging and serum inflammatory markers. Am J Physiol Heart Circ Physiol 293: H2836-H2844.
8. Cleland SJ, Sattar N, Petrie JR, Forouhi NG, Elliott HL, Connell JM. 2000. Endothelial dysfunction as a possible link between C-reactive protein levels and cardiovascular disease. Clin Sci Lond 98: 531-535.
9. Constantinides P, Chakravarti RN. 1961. Rabbit arterial thrombosis production by systemic procedures. Arch Pathol 72: 197-208.
10. Edfeldt K, Swedenborg J, Hansson GK, Yan ZQ. 2002. Expression of toll-like receptors in human atherosclerotic lesions: a possible pathway for plaque activation. Circulation 105: 1158-1161.
11. Goel V, Ooraikul B, Basu TK. 1997. Cholesterol lowering effects of rhubarb stalk fiber in hypercholesterolemic men. J Am Coll Nutr 16: 600-604.
12. Jackson LA, Yu O, Heckbert SR et al. 2002. Influenza vaccination is not associated with a reduction in the risk of recurrent coronary events. Am J Epidemiol 156: 634-640.
13. Kolodgie FD, Gold HK, Burke AP et al. 2003. Intraplaque hemorrhage and progression of coronary atheroma. N Engl J Med 349: 2316-2325.
14. Libby P. 2001. Current concepts of the pathogenesis of the acute coronary syndromes. Circulation 104: 365-372.
15. Libby P, Egan D, Skarlatos S. 1997. Roles of infectious agents in atherosclerosis and restenosis: an assessment of the evidence and need for future research. Circulation 96: 4095-4103.
16. Libby P, Ridker PM. 2004. Inflammation and atherosclerosis: role of C-reactive protein in risk assessment. Am J Med 116: 9S-16S.
17. Liu YF, Yu HM, Zhang C et al. 2007. Treatment with rhubarb improves brachial artery endothelial function in patients with atherosclerosis: a randomized, double-blind, placebo-controlled clinical trial. Am J Chin Med 35: 583-595.
18. Mendes AF, Caramona MM, de Carvalho AP, Lopes MC. 2002. Diacerhein and rhein prevent interleukin-1beta-induced nuclear factor-kappaB activation by inhibiting the degradation of inhibitor kappaB-alpha. Pharmacol Toxicol 91: 22-28.
19. Michelsen KS, Wong MH, Shah PK et al. 2004. Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci USA 101: 10679-10684.
20. Miller Yl, Viriyakosol S, Binder CJ, Feramisco JR, Kirkland TN, Witztum JL. 2003. Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells. J Biol Chem 278: 1561-1568.
21. Mintz GS, Nissen SE, Anderson WD et al. 2001. American College of Cardiology clinical expert consensus document on standards for acquisition, measurement and reporting of intravascular ultrasound studies (IVUS): a report of the American College of Cardiology Task Force on clinical expert consensus documents. J Am Coll Cardiol 37: 1478-1492.
22. Moon MK, Kang DG, Lee JK, Kim JS, Lee HS. 2006. Vasodilatory and anti-inflammatory effects of the aqueous extract of rhubarb via a NO-cGMP pathway. Life Sci 78: 1550-1557.
23. Naghavi M, Libby P, Falk E et al. 2003. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation 108: 1664-1672.
24. National Pharmacopoeia Committee. 2005. Pharmacopoeia of China. 1st part. Chinese Publishing Company of Chemical Industry: Beijing, China.
25. Okamura Y, Watari M, Jerud ES et al. 2001. The extra domain A of fibronectin activates Toll-like receptor 4. J Biol Chem 276: 10229-10233.
26. Olsson AG, McTaggart F, Raza A. 2002. Rosuvastatin: a highly effective new HMG-CoA reductase inhibitor. Cardiovasc Drug Rev 20: 303-328.
27. Peng SM, Wang SZ, Zhao JP. 2002. Effect of rhubarb on inflammatory cytokines and complements in patients with systemic inflammation reaction syndrome and its significance. Zhongguo Zhong Xi Yi Jie He Za Zhi 22: 264-266.
28. Sander D, Winbeck K, Klingelhofer J, Etgen T, Conrad B. 2002. Reduced progression of early carotid atherosclerosis after antibiotic treatment and Chlamydia pneumoniae seropositivity. Circulation 106: 2428-2433.
29. Spencer CM, Wilde Ml. 1997. Diacerhein. Drugs 53: 98-106.
30. Vabulas RM, Ahmad-Nejad P, da Costa C et al. 2001. Endo-cytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells. J Biol Chem 276: 31332-31339.
31. Xu XH, Shah PK, Faure E et al. 2001. Toll-like receptor-4 is expressed by macrophages in murine and human lipid-rich atherosclerotic plaques and upregulated by oxidized LDL. Circulation 104: 3103-3108.
32. Zhu W, Wang XM, Zhang L, Li XY, Wang BX. 2005. Pharmacokinetic of rhein in healthy male volunteers following oral and retention enema administration of rhubarb extract: a single dose study. Am J Chin Med 33: 839-850.