Regulation of metal transporters by dietary iron, and the relationship between body iron levels and cadmium uptake

Archives of Toxicology

Volumn 81, Issue 5, 2007, Pages 327-334

  Kim, Dong Won ^a   Kim, Ki Young ^a   Choi, Byung Sun ^a   Youn, Pilju ^b   Ryu, Doug Young ^b   Klaassen, Curtis D ^c   Park, Jung Duck ^a  

^a Chung Ang University   (South Korea)

^b Seoul National University   (South Korea)

^c UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

Cadmium (Cd); Divalent metal transporter 1 (DMT1); Duodenum; Iron (Fe); Metal transporter protein 1 (MTP1)

Indexed keywords

CADMIUM; FERROPORTIN 1; FERROUS SULFATE; IRON; MESSENGER RNA; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BODY BURDEN; BRAIN; CONTROLLED STUDY; DUODENUM; IRON BLOOD LEVEL; IRON DEFICIENCY; IRON INTAKE; IRON RESPONSIVE ELEMENT; IRON STORAGE; IRON TRANSPORT; KIDNEY; LIVER; MESSENGER RNA SYNTHESIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN VARIANT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN; TESTIS; TISSUE DISTRIBUTION; UPREGULATION;

ANIMALS; BODY COMPOSITION; BRAIN; CADMIUM CHLORIDE; CATION TRANSPORT PROTEINS; GENE EXPRESSION REGULATION; INTESTINE, SMALL; IRON; IRON, DIETARY; IRON-REGULATORY PROTEINS; KIDNEY; LIVER; MALE; MICE; MICE, INBRED ICR; MYOCARDIUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPLEEN; TESTIS; UP-REGULATION; WEIGHT GAIN;

ANIMALIA; MAMMALIA; MUS;

EID: 34247874547     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-006-0160-7     Document Type: Article

References (34)

1. Abboud S, Haile DJ (2000) A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem 275:19906-19912
2. Andrews NC (1999) Disorders of iron metabolism. N Engl J Med 341:1986-1995
3. Bannon DI, Portnoy ME, Olivi L, Lees PS, Culotta VC, Bressler JP (2002) Uptake of lead and iron by divalent metal transporter 1 in yeast and mammalian cells. Biochem Biophys Res Commun 295:978-984
4. Berglund M, Akesson A, Nermell B, Vahter M (1994) Intestinal absorption of dietary cadmium in women depends on body iron stores and fiber intake. Environ Health Perspect 102:1058-1066
5. Bradman A, Eskenazi B, Sutton P, Athanasoulis M, Goldman LR (2001) Iron deficiency associated with higher blood lead in children living in contaminated environments. Environ Health Perspect 109:1079-1084
6. Canonne-Hergaux F, Gros P (2002) Expression of the iron transporter DMT1 in kidney from normal and anemic mk mice. Kidney Int 62:147-156
7. Canonne-Hergaux F, Gruenheid S, Ponka P, Gros P (1999) Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron. Blood 12:4406-4417
8. Canonne-Hergaux F, Zhang AS, Ponka P, Gros P (2001) Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice. Blood 98:3823-3830
9. Ferguson CJ, Wareing M, Ward DT, Green R, Smith CP, Riccardi D (2001) Cellular localization of divalent metal transporter DMT-1 in rat kidney. Am J Physiol Renal Physiol 280:F803-F814
10. Flanagan PR, McLellan JS, Haist J, Cherian G, Chamberlain MJ, Valberg LS (1978) Increased dietary cadmium absorption in mice and human subjects with iron deficiency. Gastroenterology 74:841-846
11. Fleming MD, Trenor CC III, Su MA, Foernzler D, Beier DR, Dietrich WF, Andrews NC (1997) Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet 16:383-386
12. Fox MR, Tao SH, Stone CL, Fry BE Jr (1984) Effects of zinc, iron and copper deficiencies on cadmium in tissues of Japanese quail. Environ Health Perspect 54:57-65
13. Griffin KP, Ward DT, Liu W, Stewart G, Morris ID, Smith CP (2005) Differential expression of divalent metal transporter DMT1 (Slc11a2) in the spermatogenic epithelium of the developing and adult rat testis. Am J Physiol Cell Physiol 288:C176-C184
14. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, Hediger MA (1997) Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388:482-488
15. Kido T, Nogawa K, Yamada Y, Honda R, Tsuritani I, Ishizaki M, Yamaya H (1989) Osteopenia in inhabitants with renal dysfunction induced by exposure to environmental cadmium. Int Arch Occup Environ Health 61:271-276
16. Knutson M, Menzies S, Connor J, Wessling-Resnick M (2004) Developmental, regional, and cellular expression of SFT/UbcH5A and DMT1 mRNA in brain. J Neurosci Res 76:633-641
17. Lee PL, Gelbart T, West C, Holloran C, Beutler E (1998) The human Nramp2 gene: characterization of the gene structure, alternative splicing, promoter region and polymorphisms. Blood Cells Mol Dis 24:199-215
18. McKie AT, Barlow DJ (2004) The SLC40 basolateral iron transporter family (IREG1/ferroportin/MTP1). Pflügers Arch 447:801-806
19. Moos T, Morgan EH (2004) The metabolism of neuronal iron and its pathogenic role in neurological disease: review. Ann NY Acad Sci 1012:14-26
20. Okubo M, Yamada K, Hosoyamada M, Shibasaki T, Endou H (2003) Cadmium transport by human Nramp 2 expressed in Xenopus laevis oocytes. Toxicol Appl Pharmacol 187:162-167
21. Park JD, Cherrington NJ, Klaassen CD (2002) Intestinal absorption of cadmium is associated with divalent metal transporter 1 in rats. Toxicol Sci 68:288-294
22. Ragan HA (1977) Effects of iron deficiency on the absorption and distribution of lead and cadmium in rats. J Lab Clin Med 90:700-706
23. Ryu DY, Lee SJ, Park DW, Choi BS, Klaassen CD, Park JD (2004) Dietary iron regulates intestinal cadmium absorption through iron transporters in rats. Toxicol Lett 152:19-25
24. Shigematsu I (1984) The epidemiological approach to cadmium pollution in Japan. Ann Acad Med Singapore 13:231-236
25. Stuart KA, Anderson GJ, Frazer DM, Powell LW, McCullen M, Fletcher LM, Crawford DH (2003) Duodenal expression of iron transport molecules in untreated haemochromatosis subjects. Gut 52:953-959
26. Sugita M, Tsuchiya K (1995) Estimation of variation among individuals of biological half-time of cadmium calculated from accumulation data. Environ Res 68:31-37
27. Tchernitchko D, Bourgeois M, Martin ME, Beaumont C (2002) Expression of the two mRNA isoforms of the iron transporter Nrmap2/DMTI in mice and function of the iron responsive element. Biochem J 363:449-455
28. Valberg LS, Sorbie J, Hamilton DL (1976) Gastrointestinal metabolism of cadmium in experimental iron deficiency. Am J Physiol 231:462-467
29. Wang X, Ghio AJ, Yang F, Dolan KG, Garrick MD, Piantadosi CA (2002) Iron uptake and Nramp2/DMT1/DCT1 in human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 282:L987-L995
30. Williams K, Wilson MA, Bressler J (2000) Regulation and developmental expression of the divalent metal-ion transporter in the rat brain. Cell Mol Biol 46:563-571
31. World Health Organization (2003) Micronutrient deficiencies: battling iron deficiency anemia
32. Yang F, Liu XB, Quinones M, Melby PC, Ghio A, Haile DJ (2002a) Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation. J Biol Chem 277:39786-39791
33. Yang F, Wang X, Haile DJ, Piantadosi CA, Ghio AJ (2002b) Iron increases expression of iron-export protein MTP1 in lung cells. Am J Physiol Lung Cell Mol Physiol 283:L932-L939
34. Zhang AS, Xiong S, Tsukamoto H, Enns CA (2004) Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes. Blood 103:1509-1514