Studies of the melatonin binding site location onto quinone reductase 2 by directed mutagenesis

Archives of Biochemistry and Biophysics

Volumn 477, Issue 1, 2008, Pages 12-19

  Boutin, Jean A ^a   Saunier, Carine ^a   Guenin, Sophie Pénélope ^a   Berger, Sylvie ^a   Moulharat, Natacha ^a   Gohier, Arnaud ^a   Delagrange, Philippe ^b   Cogé, Francis ^a   Ferry, Gilles ^a  

^a INSTITUT DE RECHERCHES SERVIER   (France)

^b INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

Binding; Catalytic activity; Human quinone oxidoreductase 2 (hQR2); Melatonin; MT3; Site directed mutagenesis

Indexed keywords

5 METHOXYCARBONYLAMINO N ACETYLTRYPTAMINE; FLAVINE ADENINE NUCLEOTIDE; G PROTEIN COUPLED RECEPTOR; IODINE 125; ISOLEUCINE; MELATONIN; MELATONIN 1 RECEPTOR; MELATONIN 2 RECEPTOR; MELATONIN DERIVATIVE; OXIDOREDUCTASE; PHENYLALANINE; QUINONE DERIVATIVE; QUINONE REDUCTASE 2; TYROSINE; UBIQUINONE 1;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVITY; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BINDING SITES; BLOTTING, WESTERN; CATALYSIS; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; MELATONIN; MOLECULAR SEQUENCE DATA; MUTAGENESIS; QUINONE REDUCTASES; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 48749117271     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2008.04.040     Document Type: Article

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