Undernutrition in elderly patients with cancer: Target for diagnosis and intervention

Critical Reviews in Oncology/Hematology

Volumn 67, Issue 3, 2008, Pages 243-254

  Blanc Bisson, Christèle ^a   Fonck, Marianne ^b   Rainfray, Muriel ^a,d   Soubeyran, Pierre ^b,c,d   Bourdel Marchasson, Isabelle ^a,e  

^a Ctr Geriatrie Ctr Hosp Univ B   (France)

^b INSTITUT BERGONIÉ   (France)

^c INSTITUT CLAUDIUS REGAUD   (France)

^d UNIVERSITÉ DE BORDEAUX   (France)

^e CNRS University Bordeaux Segalen   (France)

Author keywords

Cancer; Comprehensive geriatric assessment; Dietary intervention; Elderly; Survival; Undernutrition

Indexed keywords

AGED; ANOREXIA; CACHEXIA; CALORIC INTAKE; CANCER PATIENT; CANCER SURVIVAL; CARBOHYDRATE INTAKE; DENTAL CARE; ELDERLY CARE; FAT INTAKE; GERIATRIC CARE; HUMAN; HYPOXEMIA; MALIGNANT NEOPLASTIC DISEASE; MOUTH HYGIENE; NUTRITIONAL REQUIREMENT; NUTRITIONAL SUPPORT; PATHOPHYSIOLOGY; PROGNOSIS; PROTEIN INTAKE; REVIEW;

EID: 48749116024     PISSN: 10408428     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2008.04.005     Document Type: Review

References (106)

1. Zampini. Les aquitains âgés de 60 ans ou plus. INSEE Aquitaine 2004; 126.
2. Repetto L., Fratino L., Audisio R.A., et al. Comprehensive geriatric assessment adds information to Eastern Cooperative Oncology Group performance status in elderly cancer patients: an Italian Group for Geriatric Oncology Study. J Clin Oncol 20 (2002) 494-502
3. Skirvin J.A., and Lichtman S.M. Pharmacokinetic considerations of oral chemotherapy in elderly patients with cancer. Drugs Aging 19 (2002) 25-42
4. Pasetto L.M., Rossi E., Jirillo A., and Monfardini S. Colorectal cancer adjuvant treatment in elderly patients. Crit Rev Oncol Hematol 55 (2005) 201-206
5. Colorectal Cancer Collaborative Group, and Simmonds P.C. Palliative chemotherapy for advanced colorectal cancer: systematic review and meta-analysis. BMJ 321 (2000) 531-535
6. Gridelli C., Aapro M., Ardizzoni A., et al. Treatment of advanced non-small-cell lung cancer in the elderly: results of an international expert panel. J Clin Oncol 23 (2005) 3125-3137
7. Guigoz Y., Lauque S., and Vellas B.J. Identifying the elderly at risk for malnutrition. The Mini Nutritional Assessment. Clin Geriatr Med 18 (2002) 737-757
8. Bourdel-Marchasson I., and Berrut G. Caring the elderly diabetic patient with respect to concepts of successful aging and frailty. Diabetes Metab 31 Spec No 2 (2005) 5S13-15S19
9. Van Cutsem E., and Arends J. The causes and consequences of cancer-associated malnutrition. Eur J Oncol Nurs 9 Suppl. 2 (2005) S51-S63
10. Esper D.H., and Harb W.A. The cancer cachexia syndrome: a review of metabolic and clinical manifestations. Nutr Clin Pract 20 (2005) 369-376
11. Sun X.F., and Zhang H. Clinicopathological significance of stromal variables: angiogenesis, lymphangiogenesis, inflammatory infiltration, MMP and PINCH in colorectal carcinomas. Mol Cancer 5 (2006) 43
12. Nikolic-Paterson D.J., Main I.W., Tesch G.H., et al. Interleukin-1 in renal fibrosis. Kidney Int Suppl 54 (1996) S88-S90
13. Boucher D., Gogusev J., and Droz D. Expression of IL6 and TNF-alpha in normal and pathological kidney. C R Seances Soc Biol Fil 187 (1993) 425-433
14. Ellis M.J., Singer C., Hornby A., et al. Insulin-like growth factor mediated stromal-epithelial interactions in human breast cancer. Breast Cancer Res Treat 31 (1994) 249-261
15. Tiggelman A.M., Boers W., Linthorst C., et al. Interleukin-6 production by human liver (myo)fibroblasts in culture. Evidence for a regulatory role of LPS, IL-1 beta and TNF alpha. J Hepatol 23 (1995) 295-306
16. Lesourd B. Nutrition: a major factor influencing immunity in the elderly. J Nutr Health Aging 8 (2004) 28-37
17. Lesourd B. Nutritional factors and immunological ageing. Proc Nutr Soc 65 (2006) 319-325
18. Lesourd B., and Mazari L. Nutrition and immunity in the elderly. Proc Nutr Soc 58 (1999) 685-695
19. Lesourd B.M. Nutrition and immunity in the elderly: modification of immune responses with nutritional treatments. Am J Clin Nutr 66 (1997) 478S-484S
20. Segura A., Pardo J., Jara C., et al. An epidemiological evaluation of the prevalence of malnutrition in Spanish patients with locally advanced or metastatic cancer. Clin Nutr 24 (2005) 801-814
21. Arends J., Bodoky G., Bozzetti F., et al. ESPEN Guidelines on enteral nutrition: non-surgical oncology. Clin Nutr 25 (2006) 245-259
22. Argiles J.M. Cancer-associated malnutrition. Eur J Oncol Nurs 9 Suppl. 2 (2005) S39-S50
23. Hutton J.L., Martin L., Field C.J., et al. Dietary patterns in patients with advanced cancer: implications for anorexia-cachexia therapy. Am J Clin Nutr 84 (2006) 1163-1170
24. Eastern Cooperative Oncology Group, Dewys W.D., Begg C., Lavin P.T., et al. Prognostic effect of weight loss prior to chemotherapy in cancer patients. Am J Med 69 (1980) 491-497
25. van Halteren H.K., Bongaerts G.P., and Wagener D.J. Cancer cachexia: what is known about its etiology and what should be the current treatment approach?. Anticancer Res 23 (2003) 5111-5115
26. Fearon K.C., Voss A.C., and Hustead D.S. Definition of cancer cachexia: effect of weight loss, reduced food intake, and systemic inflammation on functional status and prognosis. Am J Clin Nutr 83 (2006) 1345-1350
27. Davis M.P., Dreicer R., Walsh D., et al. Appetite and cancer-associated anorexia: a review. J Clin Oncol 22 (2004) 1510-1517
28. Shimizu Y., Nagaya N., Isobe T., et al. Increased plasma ghrelin level in lung cancer cachexia. Clin Cancer Res 9 (2003) 774-778
29. Aleman M.R., Santolaria F., Batista N., et al. Leptin role in advanced lung cancer. A mediator of the acute phase response or a marker of the status of nutrition?. Cytokine 19 (2002) 21-26
30. Zarkesh-Esfahani H., Pockley A.G., Wu Z., et al. Leptin indirectly activates human neutrophils via induction of TNF-alpha. J Immunol 172 (2004) 1809-1814
31. Morris H. Dysphagia in the elderly-a management challenge for nurses. Br J Nurs 15 (2006) 558-562
32. Grant J.P., Chapman G., and Russell M.K. Malabsorption associated with surgical procedures and its treatment. Nutr Clin Pract 11 (1996) 43-52
33. Martin R.E., and Sessle B.J. The role of the cerebral cortex in swallowing. Dysphagia 8 (1993) 195-202
34. Shaker R., and Lang I.M. Effect of aging on the deglutitive oral, pharyngeal, and esophageal motor function. Dysphagia 9 (1994) 221-228
35. Knox L.S., Crosby L.O., Feurer I.D., et al. Energy expenditure in malnourished cancer patients. Ann Surg 197 (1983) 152-162
36. Bongaerts G.P., van Halteren H.K., Verhagen C.A., and Wagener D.J. Cancer cachexia demonstrates the energetic impact of gluconeogenesis in human metabolism. Med Hypotheses 67 (2006) 1213-1222
37. Todorov P.T., McDevitt T.M., Cariuk P., et al. Induction of muscle protein degradation and weight loss by a tumor product. Cancer Res 56 (1996) 1256-1261
38. Russell S.T., and Tisdale M.J. Effect of a tumour-derived lipid-mobilising factor on glucose and lipid metabolism in vivo. Br J Cancer 87 (2002) 580-584
39. Chaudary N., and Hill R.P. Hypoxia and metastasis in breast cancer. Breast Dis 26 (2006) 55-64
40. Pouyssegur J., Dayan F., and Mazure N.M. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441 (2006) 437-443
41. Wincewicz A., Sulkowska M., Koda M., and Sulkowski S. Clinicopathological significance and linkage of the distribution of HIF-1alpha and GLUT-1 in human primary colorectal cancer. Pathol Oncol Res 13 (2007) 15-20
42. Buzby G.P., Knox L.S., Crosby L.O., et al. Study protocol: a randomized clinical trial of total parenteral nutrition in malnourished surgical patients. Am J Clin Nutr 47 (1988) 366-381
43. Buzby G.P., Williford W.O., Peterson O.L., et al. A randomized clinical trial of total parenteral nutrition in malnourished surgical patients: the rationale and impact of previous clinical trials and pilot study on protocol design. Am J Clin Nutr 47 (1988) 357-365
44. Bouillanne O., Morineau G., Dupont C., et al. Geriatric Nutritional Risk Index: a new index for evaluating at-risk elderly medical patients. Am J Clin Nutr 82 (2005) 777-783
45. Buccheri G., and Ferrigno D. Importance of weight loss definition in the prognostic evaluation of non-small-cell lung cancer. Lung Cancer 34 (2001) 433-440
46. Read J.A., Choy S.T., Beale P.J., and Clarke S.J. Evaluation of nutritional and inflammatory status of advanced colorectal cancer patients and its correlation with survival. Nutr Cancer 55 (2006) 78-85
47. Lecleire S., Di Fiore F., Antonietti M., et al. Undernutrition is predictive of early mortality after palliative self-expanding metal stent insertion in patients with inoperable or recurrent esophageal cancer. Gastrointest Endosc 64 (2006) 479-484
48. Miki C., Inoue Y., Toiyama Y., et al. Deficiency in systemic interleukin-1 receptor antagonist production as an operative risk factor in malnourished elderly patients with colorectal carcinoma. Crit Care Med 33 (2005) 177-180
49. Martin F., Santolaria F., Batista N., et al. Cytokine levels (IL-6 and IFN-gamma), acute phase response and nutritional status as prognostic factors in lung cancer. Cytokine 11 (1999) 80-86
50. Bouillanne O., Golmard J.L., Coussieu C., et al. Leptin a new biological marker for evaluating malnutrition in elderly patients. Eur J Clin Nutr 61 (2007) 647-654
51. Andreyev H.J., Norman A.R., Oates J., and Cunningham D. Why do patients with weight loss have a worse outcome when undergoing chemotherapy for gastrointestinal malignancies?. Eur J Cancer 34 (1998) 503-509
52. Toliusiene J., and Lesauskaite V. The nutritional status of older men with advanced prostate cancer and factors affecting it. Support Care Cancer 12 (2004) 716-719
53. Hickman D.M., Miller R.A., Rombeau J.L., et al. Serum albumin and body weight as predictors of postoperative course in colorectal cancer. JPEN J Parenter Enteral Nutr 4 (1980) 314-316
54. Bozzetti F., Gavazzi C., Miceli R., et al. Perioperative total parenteral nutrition in malnourished, gastrointestinal cancer patients: a randomized, clinical trial. JPEN J Parenter Enteral Nutr 24 (2000) 7-14
55. Lobato-Mendizabal E., Ruiz-Arguelles G.J., and Marin-Lopez A. Leukaemia and nutrition. I: Malnutrition is an adverse prognostic factor in the outcome of treatment of patients with standard-risk acute lymphoblastic leukaemia. Leuk Res 13 (1989) 899-906
56. Bartali B., Frongillo E.A., Bandinelli S., et al. Low nutrient intake is an essential component of frailty in older persons. J Gerontol A Biol Sci Med Sci 61 (2006) 589-593
57. Field C.J. Use of T cell function to determine the effect of physiologically active food components. Am J Clin Nutr 71 (2000) 1720S-1725S [discussion 1726S-1727S]
58. Bourdel-Marchasson I., Dumas F., Pinganaud G., et al. Audit of percutaneous endoscopic gastrostomy in long-term enteral feeding in a nursing home. Int J Qual Health Care 9 (1997) 297-302
59. Howard L., and Malone M. Clinical outcome of geriatric patients in the United States receiving home parenteral and enteral nutrition. Am J Clin Nutr 66 (1997) 1364-1370
60. Alvarez-Fernandez B., Garcia-Ordonez M.A., Martinez-Manzanares C., and Gomez-Huelgas R. Survival of a cohort of elderly patients with advanced dementia: nasogastric tube feeding as a risk factor for mortality. Int J Geriatr Psychiatry 20 (2005) 363-370
61. Callahan C.M., Haag K.M., Weinberger M., et al. Outcomes of percutaneous endoscopic gastrostomy among older adults in a community setting. J Am Geriatr Soc 48 (2000) 1048-1054
62. Bourdel-Marchasson I., Barateau M., Rondeau V., et al. A multi-center trial of the effects of oral nutritional supplementation in critically ill older inpatients. Nutrition 16 (2000) 1-5
63. Volkert D., Hubsch S., Oster P., and Schlierf G. Nutritional support and functional status in undernourished geriatric patients during hospitalization and 6-month follow-up. Aging (Milano) 8 (1996) 386-395
64. Bruce D., Laurance I., McGuiness M., et al. Nutritional supplements after hip fracture: poor compliance limits effectiveness. Clin Nutr 22 (2003) 497-500
65. Potter J.M., Roberts M.A., McColl J.H., and Reilly J.J. Protein energy supplements in unwell elderly patients-a randomized controlled trial. JPEN J Parenter Enteral Nutr 25 (2001) 323-329
66. Houwing R.H., Rozendaal M., Wouters-Wesseling W., et al. A randomised, double-blind assessment of the effect of nutritional supplementation on the prevention of pressure ulcers in hip-fracture patients. Clin Nutr 22 (2003) 401-405
67. Espaulella J., Guyer H., Diaz-Escriu F., et al. Nutritional supplementation of elderly hip fracture patients. A randomized, double-blind, placebo-controlled trial. Age Ageing 29 (2000) 425-431
68. Lauque S., Arnaud-Battandier F., Gillette S., et al. Improvement of weight and fat-free mass with oral nutritional supplementation in patients with Alzheimer's disease at risk of malnutrition: a prospective randomized study. J Am Geriatr Soc 52 (2004) 1702-1707
69. Beck A.M., Ovesen L., and Schroll M. Home-made oral supplement as nutritional support of old nursing home residents, who are undernourished or at risk of undernutrition based on the MNA. A pilot trial. Mini Nutritional Assessment. Aging Clin Exp Res 14 (2002) 212-215
70. Hickson M., Bulpitt C., Nunes M., et al. Does additional feeding support provided by health care assistants improve nutritional status and outcome in acutely ill older in-patients? A randomised control trial. Clin Nutr 23 (2004) 69-77
71. Boige V., and Ducreux M. Prevention and treatment of chemotherapy-induced digestive toxicities. Bull Cancer 88 (2001) 163-173
72. Maduro J.H., Pras E., Willemse P.H., and de Vries E.G. Acute and long-term toxicity following radiotherapy alone or in combination with chemotherapy for locally advanced cervical cancer. Cancer Treat Rev 29 (2003) 471-488
73. Feeney K., Cain M., and Nowak A.K. Chemotherapy induced nausea and vomiting-prevention and treatment. Aust Fam Physician 36 (2007) 702-706
74. Hogle W.P. The state of the art in radiation therapy. Semin Oncol Nurs 22 (2006) 212-220
75. Mendenhall W.M., Amdur R.J., and Palta J.R. Intensity-modulated radiotherapy in the standard management of head and neck cancer: promises and pitfalls. J Clin Oncol 24 (2006) 2618-2623
76. Isenring E.A., Bauer J.D., and Capra S. Nutrition support using the American Dietetic Association medical nutrition therapy protocol for radiation oncology patients improves dietary intake compared with standard practice. J Am Diet Assoc 107 (2007) 404-412
77. Vagianos K., Bector S., McConnell J., and Bernstein C.N. Nutrition assessment of patients with inflammatory bowel disease. JPEN J Parenter Enteral Nutr 31 (2007) 311-319
78. Daly J.M., Weintraub F.N., Shou J., et al. Enteral nutrition during multimodality therapy in upper gastrointestinal cancer patients. Ann Surg 221 (1995) 327-338
79. van Bokhorst-De Van Der Schueren M.A., Quak J.J., von Blomberg-van der Flier B.M., et al. Effect of perioperative nutrition, with and without arginine supplementation, on nutritional status, immune function, postoperative morbidity, and survival in severely malnourished head and neck cancer patients. Am J Clin Nutr 73 (2001) 323-332
80. Lundholm K., Daneryd P., Bosaeus I., et al. Palliative nutritional intervention in addition to cyclooxygenase and erythropoietin treatment for patients with malignant disease: effects on survival, metabolism, and function. Cancer 100 (2004) 1967-1977
81. Gianotti L., Braga M., Nespoli L., et al. A randomized controlled trial of preoperative oral supplementation with a specialized diet in patients with gastrointestinal cancer. Gastroenterology 122 (2002) 1763-1770
82. Bozzetti F., Cozzaglio L., Gavazzi C., et al. Nutritional support in patients with cancer of the esophagus: impact on nutritional status, patient compliance to therapy, and survival. Tumori 84 (1998) 681-686
83. Isenring E., Capra S., and Bauer J. Patient satisfaction is rated higher by radiation oncology outpatients receiving nutrition intervention compared with usual care. J Hum Nutr Diet 17 (2004) 145-152
84. Persson C.R., Johansson B.B., Sjoden P.O., and Glimelius B.L. A randomized study of nutritional support in patients with colorectal and gastric cancer. Nutr Cancer 42 (2002) 48-58
85. McGough C., Baldwin C., Frost G., and Andreyev H.J. Role of nutritional intervention in patients treated with radiotherapy for pelvic malignancy. Br J Cancer 90 (2004) 2278-2287
86. Bauer J., Capra S., Battistutta D., et al. Compliance with nutrition prescription improves outcomes in patients with unresectable pancreatic cancer. Clin Nutr 24 (2005) 998-1004
87. Evans W.K., Nixon D.W., Daly J.M., et al. A randomized study of oral nutritional support versus ad lib nutritional intake during chemotherapy for advanced colorectal and non-small-cell lung cancer. J Clin Oncol 5 (1987) 113-124
88. Cynober L AE, Arnaud-Battandier F, Bonnefoy M, et al. Apports nutritionnels conseillés pour la population française. In: Martin A, AFSSA, editors. Lassay les Châteaux, Tec&Doc 2001. p. 307-336.
89. Neary N.M., Small C.J., Wren A.M., et al. Ghrelin increases energy intake in cancer patients with impaired appetite: acute, randomized, placebo-controlled trial. J Clin Endocrinol Metab 89 (2004) 2832-2836
90. Baldwin C., McGough C., Norman A.R., et al. Failure of dietetic referral in patients with gastrointestinal cancer and weight loss. Eur J Cancer 42 (2006) 2504-2509
91. Hebuterne X., Schneider S., Peroux J.L., and Rampal P. Effects of refeeding by cyclic enteral nutrition on body composition: comparative study of elderly and younger patients. Clin Nutr 16 (1997) 283-289
92. Ottery F.D. Supportive nutrition to prevent cachexia and improve quality of life. Semin Oncol 22 (1995) 98-111
93. Mercadante S. Parenteral versus enteral nutrition in cancer patients: indications and practice. Support Care Cancer 6 (1998) 85-93
94. Nayel H., el-Ghoneimy E., and el-Haddad S. Impact of nutritional supplementation on treatment delay and morbidity in patients with head and neck tumors treated with irradiation. Nutrition 8 (1992) 13-18
95. Heys S.D., Walker L.G., Smith I., and Eremin O. Enteral nutritional supplementation with key nutrients in patients with critical illness and cancer: a meta-analysis of randomized controlled clinical trials. Ann Surg 229 (1999) 467-477
96. Bozzetti F. Nutrition and gastrointestinal cancer. Curr Opin Clin Nutr Metab Care 4 (2001) 541-546
97. Koretz R.L., Avenell A., Lipman T.O., et al. Does enteral nutrition affect clinical outcome? A systematic review of the randomized trials. Am J Gastroenterol 102 (2007) 412-429
98. Chumlea W.M., and Sun S.S. The availability of body composition reference data for the elderly. J Nutr Health Aging 8 (2004) 76-82
99. Salive M.E., Cornoni-Huntley J., Phillips C.L., et al. Serum albumin in older persons: relationship with age and health status. J Clin Epidemiol 45 (1992) 213-221
100. Folstein M.F., Folstein S.E., and McHugh P.R. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12 (1975) 189-198
101. Arthur A., Jagger C., Lindesay J., et al. Using an annual over-75 health check to screen for depression: validation of the short Geriatric Depression Scale (GDS15) within general practice. Int J Geriatr Psychiatry 14 (1999) 431-439
102. Inouye S.K., van Dyck C.H., Alessi C.A., et al. Clarifying confusion: the confusion assessment method. A new method for detection of delirium. Ann Intern Med 113 (1990) 941-948
103. Katz S. Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. J Am Geriatr Soc 31 (1983) 721-727
104. Lawton M.P., and Brody E.M. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 9 (1969) 179-186
105. Bergstrom N., Braden B.J., Laguzza A., and Holman V. The Braden Scale for Predicting Pressure Sore Risk. Nurs Res 36 (1987) 205-210
106. Cockcroft D.W., and Gault M.H. Prediction of creatinine clearance from serum creatinine. Nephron 16 (1976) 31-41