Cancer cachexia demonstrates the energetic impact of gluconeogenesis in human metabolism

Medical Hypotheses

Volumn 67, Issue 5, 2006, Pages 1213-1222

  Bongaerts, G P A ^a   van Halteren, H K ^a   Verhagen, C A M ^a   Wagener, D J Th ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; LACTIC ACID; PYRUVATE DEHYDROGENASE;

ARTICLE; BODY ARMOR; CACHEXIA; CANCER PATIENT; ENERGY METABOLISM; FOOD INTAKE; GLUCONEOGENESIS; HUMAN; LIVER; MAMMAL CELL; METABOLISM; PATHOGENESIS; PRIORITY JOURNAL; TUMOR CELL; TUMOR GROWTH; WEIGHT REDUCTION;

ADENOSINE TRIPHOSPHATE; CACHEXIA; ENERGY METABOLISM; GLUCONEOGENESIS; HUMANS; HYDROGEN-ION CONCENTRATION; LACTIC ACID; LIVER; NEOPLASMS; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; REFERENCE VALUES;

MAMMALIA;

EID: 33748054296     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2006.04.048     Document Type: Article

References (24)

1. Tisdale M.J. Cachexia in cancer patients. Nature Rev Cancer 2 (2002) 862-871
2. Tisdale M.J. Biology of cachexia. JNCI 89 (1997) 1763-1773
3. Gold J. Proposed treatment of cancer by inhibition of gluconeogenesis. Oncology 22 (1968) 185-207
4. Dills W.L. Nutritional and physiological consequences of tumour glycolysis. Parasitology 107 (1993) S177-S186
5. Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 (2000) 57-70
6. Michalides R. Cell cycle regulators: mechanisms and their role in aetiology, prognosis treatment of cancer. J Clin Path 52 (1999) 555-568
7. Koea J.B., and Shaw J.H.F. The effect of tumor bulk on the metabolic response to cancer. Ann Surg 215 (1992) 282-288
8. Costa G., Lane W.W., Vincent R.G., Siebold J.A., Aragon M., and Bewley P.T. Weight loss and cachexia in lung cancer. Nutr Cancer 2 (1980) 98-103
9. Harris A.L. Hypoxia: a key regulatory factor in tumour growth. Nature Rev Cancer 2 (2002) 38-47
10. Höckel M., and Vaupel P. Tumor hypoxia: definitions and current clinical, biologic and molecular aspects. J Natl Cancer Inst 93 (2001) 266-276
11. Jerusalem G., Hustinx R., Beguin E., and Fillet G. The value of positron emission tomography (PET) imaging in disease staging and therapy assessment. Ann Oncol 13 Suppl. 4 (2002) 227-234
12. Holm E., Hagmüller E., and Staedt U. Substrate balances across colonic carcinomas in humans. Cancer Res 55 (1995) 1373-1378
13. Holroyde C., Gabuzda T.G., Putnam R.C., Paul P., and Reichard G.A. Altered glucose metabolism in metastatic carcinoma. Cancer Res 35 (1975) 3710-3714
14. Holroyde C.P., Axelrod R.S., Skutches C.L., Haff A.C., Paul P., and Reichard G.A. Lactate metabolism in patients with metastatic colorectal cancer. Cancer Res 39 (1979) 4900-4904
15. Holroyde C.P., Skutches C.L., Boden G., and Reichard G.A. Glucose metabolism in cachectic patients with colorectal cancer. Cancer Res 44 (1984) 5910-5913
16. Roh M.S., Ekman L., Jeevanandum M., and Brennan M.F. Gluconeogenesis in tumor-influenced hepatocytes. Surgery 96 (1984) 427-434
17. Vaupel P., Kallinowski F., and Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 49 (1989) 6449-6465
18. Höckel M., Schlenger K., Aral B., Mitze M., Schaffer U., and Vaupel P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56 (1996) 4509-4515
19. Höckel M., and Vaupel P. Biological consequences of tumor hypoxia. Sem Oncol 28 Suppl. 8 (2001) 36-41
20. Luft F.C. Lactic acidosis update for critical care clinicians. J Am Soc Nephrol 12 (2001) S15-S19
21. Lowry S.F., Foster D.M., Norton J.A., Berman M., and Brennan M.F. Glucose disposal and gluconeogenesis from alanine in tumor-bearing fischer 344 rats. JNCI 66 (1981) 653-658
22. Inculet R.I., Peacock J.L., Gorschboth C.M., and Norton J.A. Gluconeogenesis in the tumor-influenced rat hepatocyte: importance of tumor burden, lactate, insulin and glucagon. JNCI 79 (1987) 1039-1046
23. Cersosimo E., Pisters P.W.T., Pesola G., Rogatko A., Vydelingum N.A., Bajorunas D., and Brennan M.F. The effect of graded doses of insulin on peripheral glucose uptake and lactate release in cancer cachexia. Surgery 109 (1991) 459-467
24. Van Halteren H.K., Bongaerts G.P.A., Verhagen C.A.M., Kamm Y.J.L., Willems J.L., Grutters G.J., Koopman J.P., and Wagener D.J.Th. Recombinant human erythropoietin attenuates weight loss in a murine cancer cachexia model. J Cancer Res Clin Oncol 130 (2004) 211-216