Endothelin receptor antagonist CPU0213 and vitamin E reverse downregulation of FKBP12.6 and SERCA2a: A role of hyperphosphorylation of PKCε

European Journal of Pharmacology

Volumn 591, Issue 1-3, 2008, Pages 211-218

  Li, Na ^a   Jia, Nan ^a   Dai, De Zai ^a   Dai, Yin ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

CPU0213; Endothelin receptor antagonist; FKBP12.6; H2O2; PKCe open ; SERCA2a; Vitamin E

Indexed keywords

1 BUTYL 3 [2,4 BIS(4 CHLOROBENZYLOXY)PHENYL]PYRAZOLE 5 CARBOXYLIC ACID; ALPHA TOCOPHEROL; BETA ADRENERGIC RECEPTOR; BIOLOGICAL MARKER; CPU 0213; ENDOTHELIN 1; ENDOTHELIN RECEPTOR ANTAGONIST; FLUORESCENT DYE; HYDROGEN PEROXIDE; ISOPRENALINE; MESSENGER RNA; MOLECULAR MARKER; PROPRANOLOL; PROTEIN FKBP12.6; PROTEIN KINASE C EPSILON; REACTIVE OXYGEN METABOLITE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ATPASE 2A; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BETA ADRENERGIC STIMULATION; CONTROLLED STUDY; DIASTOLE; DRUG PROTEIN BINDING; ENZYME PHOSPHORYLATION; HEART ARRHYTHMIA; HEART FAILURE; HEART VENTRICLE WALL; MALE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; RAT; SUDDEN DEATH;

ANIMALS; ANTIOXIDANTS; BIOMARKERS, PHARMACOLOGICAL; CALCIUM; DEATH, SUDDEN, CARDIAC; DOWN-REGULATION; GENE EXPRESSION REGULATION; HEART FAILURE; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTEIN KINASE C-EPSILON; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ENDOTHELIN; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; TACROLIMUS BINDING PROTEINS; VITAMIN E;

EID: 48749097820     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.06.080     Document Type: Article

References (45)

1. Chen J.K., and Chow S.E. Antioxidants and myocardial ischemia: reperfusion injuries. Chang Gung Med. J. 28 (2005) 369-377
2. Choi G.R., Porter C.B., and Ackerman M.J. Sudden cardiac death and channelopathies: a review of implantable defibrillator therapy. Pediatr. Clin. North. Am. 51 (2004) 1289-1303
3. Curran J., Hinton M.J., Rios E., Bers D.M., and Shannon T.R. Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase. Circ. Res. 100 (2007) 391-398
4. Dai D.Z. CPU86017: a novel Class III antiarrhythmic agent with multiple actions at ion channels. Cardiovasc. Drug Rev. 24 (2006) 101-115
5. Dong F., Zhang X., Wold L.E., Ren Q., Zhang Z., and Ren J. Endothelin-1 enhances oxidative stress, cell proliferation and reduces apoptosis in human umbilical vein endothelial cells: role of ETB receptor, NADPH oxidase and caveolin-1. Br. J. Pharmacol. 145 (2005) 323-333
6. Dorn G.W., and Force T. Protein kinase cascades in the regulation of cardiac hypertrophy. J. Clin. Invest. 115 (2005) 527-537
7. El-Demerdash E., Awad A.S., Taha R.M., El-Hady A.M., and Sayed-Ahmed M.M. Probucol attenuates oxidative stress and energy decline in isoproterenol-induced heart failure in rat. Pharmacol. Res. 51 (2005) 311-318
8. Erkasap N. SERCA in genesis of arrhythmias: what we already know and what is new?. Anadolu. Kardiyol. Derg. 7 Suppl 1 (2007) 43-46
9. Feng Y., Dai D.Z., Na T., Cui B., Wang T., Zhang Y., and Dai Y. Endothelin receptor antagonist CPU0213 suppresses ventricular fibrillation in L-thyroxin induced cardiomyopathy. Pharmacol. Rep. 59 (2007) 306-314
10. Feng Y., Tang X.Y., Dai D.Z., and Dai Y. Reversal of isoproterenol induced downregulation of phospholamban and FKBP12.6 is mediated by antagonism of endothelin receptors of CPU0213. Acta Pharmacol. Sinica 28 (2007) Proofs
11. Goette A., Bukowska A., and Lendeckel U. Non-ion channel blockers as anti-arrhythmic drugs (reversal of structural remodeling). Curr. Opin. Pharmacol. 7 (2007) 219-224
12. Gupta S.K., Saxena A., Singh U., and Arya D.S. Bosentan, the mixed ETA-ETB endothelin receptor antagonist, attenuated oxidative stress after experimental myocardial ischemia and reperfusion. Mol. Cell Biochem. 275 (2005) 67-74
13. He H.B., Yu F., Dai D.Z., and Dai Y. Down-regulation of FKBP12.6 and SERCA2a contributes to acute heart failure in septic shock and is related to an up-regulated endothelin signalling pathway. J. Pharm. Pharmacol. 59 (2007) 977-984
14. Hicks J.J., Montes-Cortes D.H., Cruz-Dominguez M.P., Medina-Santillan R., and Olivares-Corichi I.M. Antioxidants decrease reperfusion induced arrhythmias in myocardial infarction with ST-elevation. Front. Biosci. 12 (2007) 2029-2037
15. Horkay F., Geller L., Kiss O., Szabo T., Vago H., Kekesi V., Juhasz-Nagy A., and Merkely B. Bosentan the mixed endothelin-A- and -B-receptor antagonist suppresses intrapericardial endothelin-1-induced ventricular arrhythmias. J. Cardiovasc. Pharmacol. 36 (2000) S320-322
16. Kao J.P., Harootunian A.T., and Tsien R.Y. Photochemically generated cytosolic calcium pulses and their detection by fluo-3. J. Biol. Chem. 264 (1989) 8179-8184
17. Kim J.Y., and Saffen D. Activation of M1 muscarinic acetylcholine receptors stimulates the formation of a multiprotein complex centered on TRPC6 channels. J. Biol. Chem. 280 (2005) 32035-32047
18. Lehnart S.E., Wehrens X.H., Laitinen P.J., Reiken S.R., Deng S.X., Cheng Z., Landry D.W., Kontula K., Swan H., and Marks A.R. Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak. Circulation 109 (2004) 3208-3214
19. Minamisawa S., and Ikeda Y. Sarcoplasmic reticulum function and heart failure: a novel therapeutic target for heart failure. Clin. Calcium 16 (2006) 37-44
20. Na T., Huang Z.J., Dai D.Z., Zhang Y., and Dai Y. Abrupt changes in FKBP12.6 and SERCA2a expression contribute to sudden occurrence of ventricular fibrillation on reperfusion and are prevented by CPU86017. Acta Pharmacol. Sinica 28 (2007) 773-782
21. Neuman R.B., Bloom H.L., Shukrullah I., Darrow L.A., Kleinbaum D., Jones D.P., and Dudley Jr. S.C. Oxidative stress markers are associated with persistent atrial fibrillation. Clin. Chem. 53 (2007) 1652-1657
22. Ortega R.M. Importance of functional foods in the Mediterranean diet. Public Health Nutr. 9 (2006) 1136-1140
23. Papparella I., Ceolotto G., Berto L., Cavalli M., Bova S., Cargnelli G., Ruga E., Milanesi O., Franco L., Mazzoni M., Petrelli L., Nussdorfer G.G., and Semplicini A. Vitamin C prevents zidovudine-induced NAD(P)H oxidase activation and hypertension in the rat. Cardiovasc. Res. 73 (2007) 432-438
24. Pedersen H.S., Elming H., Seibaek M., Burchardt H., Brendorp B., Torp-Pedersen C., and Kober L. Risk factors and predictors of Torsade de pointes ventricular tachycardia in patients with left ventricular systolic dysfunction receiving Dofetilide. Am. J. Cardiol. 100 (2007) 876-880
25. Porter M.J., Heidkamp M.C., Scully B.T., Patel N., Martin J.L., and Samarel A.M. Isoenzyme-selective regulation of SERCA2 gene expression by protein kinase C in neonatal rat ventricular myocytes. Am J Physiol. Cell Physiol. 285 (2003) C39-C47
26. Pratt C.M., Al-Khalidi H.R., Brum J.M., Holroyde M.J., Schwartz P.J., Marcello S.R., Borggrefe M., Dorian P., and Camm A.J. Cumulative experience of azimilide-associated torsades de pointes ventricular tachycardia in the 19 clinical studies comprising the azimilide database. J. Am. Coll. Cardiol. 48 (2006) 471-477
27. Pratt C.M., and Moye L.A. The Cardiac Arrhythmia Suppression Trial: background, interim results and implications. Am. J. Cardiol. 65 (1990) 20B-29B
28. Qi M.Y., Xia H.J., Dai D.Z., and Dai Y. A novel endothelin receptor antagonist CPU0213 improves diabetic cardiac insufficiency attributed to up-regulation of the expression of FKBP12.6, SERCA2a, and PLB in rats. J. Cardiovasc. Pharmacol. 47 (2006) 729-735
29. Rah D.K., Han D.W., Baek H.S., Hyon S.H., Park B.Y., and Park J.C. Protection of rabbit kidney from ischemia/reperfusion injury by green tea polyphenol pretreatment. Arch. Pharm. Res. 30 (2007) 1447-1454
30. Sasser J.M., Sullivan J.C., Hobbs J.L., Yamamoto T., Pollock D.M., Carmines P.K., and Pollock J.S. Endothelin A receptor blockade reduces diabetic renal injury via an anti-inflammatory mechanism. J. Am. Soc. Nephrol. 18 (2007) 143-154
31. Sen-Chowdhry S., and McKenna W.J. Sudden cardiac death in the young: a strategy for prevention by targeted evaluation. Cardiology 105 (2006) 196-206
32. Tajima M., Weinberg E.O., Bartunek J., Jin H., Yang R., Paoni N.F., and Lorell B.H. Treatment with growth hormone enhances contractile reserve and intracellular calcium transients in myocytes from rats with postinfarction heart failure. Circulation 99 (1999) 127-134
33. Tokuhisa T., Yano M., Obayashi M., Noma T., Mochizuki M., Oda T., Okuda S., Doi M., Liu J., Ikeda Y., Yamamoto T., Ohkusa T., and Matsuzaki M. AT1 receptor antagonist restores cardiac ryanodine receptor function, rendering isoproterenol-induced failing heart less susceptible to Ca2+-leak induced by oxidative stress. Circ. J. 70 (2006) 777-786
34. VerNooy R.A., and Mangrum J.M. Azimilide, a novel oral class III antiarrhythmic for both supraventricular and ventricular arrhythmias. Curr. Drug Targets Cardiovasc. Haematol. Disord. 5 (2005) 75-84
35. Virag L., Scott G.S., Antal-Szalmas P., O'Connor M., Ohshima H., and Szabo C. Requirement of intracellular calcium mobilization for peroxynitrite-induced poly(ADP-ribose) synthetase activation and cytotoxicity. Mol. Pharmacol. 56 (1999) 824-833
36. Waldo A.L., Camm A.J., deRuyter H., Friedman P.L., MacNeil D.J., Pauls J.F., Pitt B., Pratt C.M., Schwartz P.J., and Veltri E.P. Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival With Oral d-Sotalol. Lancet 348 (1996) 7-12
37. Wang H.L., Dai D.Z., Gao E., Zhang Y.P., and Lu F. Dispersion of ventricular mRNA of RyR2 and SERCA2 associated with arrhythmogenesis in rats. Acta Pharmacol. Sinica 25 (2004) 738-743
38. Wehrens X.H., Lehnart S.E., Huang F., Vest J.A., Reiken S.R., Mohler P.J., Sun J., Guatimosim S., Song L.S., Rosemblit N., D'Armiento J.M., Napolitano C., Memmi M., Priori S.G., Lederer W.J., and Marks A.R. FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell 113 (2003) 829-840
39. Wehrens X.H., and Marks A.R. Molecular determinants of altered contractility in heart failure. Ann. Med. 36 Suppl 1 (2004) 70-80
40. Wilson L.D., Wan X., and Rosenbaum D.S. Cellular alternans: a mechanism linking calcium cycling proteins to cardiac arrhythmogenesis. Ann. N.Y. Acad. Sci. 1080 (2006) 216-234
41. Xia H.J., Dai D.Z., and Dai Y. Up-regulated inflammatory factors endothelin, NFkappaB, TNFalpha and iNOS involved in exaggerated cardiac arrhythmias in l-thyroxine-induced cardiomyopathy are suppressed by darusentan in rats. Life Sci. 79 (2006) 1812-1819
42. Xu F.P., Chen M.S., Wang Y.Z., Yi Q., Lin S.B., Chen A.F., and Luo J.D. Leptin induces hypertrophy via endothelin-1-reactive oxygen species pathway in cultured neonatal rat cardiomyocytes. Circulation 110 (2004) 1269-1275
43. Yano M., Kobayashi S., Kohno M., Doi M., Tokuhisa T., Okuda S., Suetsugu M., Hisaoka T., Obayashi M., Ohkusa T., Kohno M., and Matsuzaki M. FKBP12.6-mediated stabilization of calcium-release channel (ryanodine receptor) as a novel therapeutic strategy against heart failure. Circulation 107 (2003) 477-484
44. Yaras N., Bilginoglu A., Vassort G., and Turan B. Restoration of diabetes-induced abnormal local Ca2+ release in cardiomyocytes by angiotensin II receptor blockade. Am. J. Physiol. Heart Circ. Physiol. 292 (2007) H912-920
45. Zorov D.B., Juhaszova M., and Sollott S.J. Mitochondrial ROS-induced ROS release: an update and review. Biochim. Biophys. Acta 1757 (2006) 509-517