Down-regulation of FKBP12.6 and SERCA2a contributes to acute heart failure in septic shock and is related to an up-regulated endothelin signalling pathway

Journal of Pharmacy and Pharmacology

Volumn 59, Issue 7, 2007, Pages 977-984

  He, Hai Bo ^a   Yu, Feng ^a   Dai, De Zai ^a   Dai, Yin ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); CPU 0213; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN CONVERTING ENZYME; ENDOTHELIN RECEPTOR ANTAGONIST; FK 506 BINDING PROTEIN; MESSENGER RNA; NITRIC OXIDE SYNTHASE; PHOSPHOLAMBAN; PROTEIN CALSTABIN 2; SARCOPLASMIC ENDOPLASMIC RETICULUM CALCIUM ATPASE 2A; UNCLASSIFIED DRUG;

ACUTE HEART FAILURE; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG STRUCTURE; HEART PERFORMANCE; HEART RATE; HEART WEIGHT; HEMODYNAMICS; MALE; MORBIDITY; MORTALITY; NONHUMAN; OXIDATION REDUCTION REACTION; PROTEIN EXPRESSION; RAT; SEPTIC SHOCK; SURVIVAL RATE; UPREGULATION;

ACUTE DISEASE; ANIMALS; ASPARTIC ENDOPEPTIDASES; BLOTTING, WESTERN; CALCIUM; CALCIUM-BINDING PROTEINS; DOWN-REGULATION; HEART FAILURE, CONGESTIVE; HEART RATE; MALE; METALLOENDOPEPTIDASES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; PYRAZOLES; RATS; RATS, WISTAR; RECEPTORS, ENDOTHELIN; RNA, MESSENGER; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SHOCK, SEPTIC; SIGNAL TRANSDUCTION; TACROLIMUS BINDING PROTEINS; UP-REGULATION; VASOCONSTRICTOR AGENTS;

EID: 34447310530     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.59.7.0010     Document Type: Article

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