Bosentan the mixed endothelin-A- and -B-receptor antagonist suppresses intrapericardial endothelin-1-induced ventricular arrhythmias

Journal of Cardiovascular Pharmacology

Volumn 36, Issue 5 SUPPL. 1, 2000, Pages

  Horkay, F ^a   Geller, L ^a   Kiss, O ^a   Szabo, T ^a   Vago, H ^a   Kekesi, V ^a   Juhasz Nagy, A ^a   Merkely, B ^a  

^a SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

Author keywords

Bosentan; Endothelin (ET); Monophasic action potential duration (MAPD); Ventricular arrhythmia

Indexed keywords

ANTIARRHYTHMIC AGENT; BOSENTAN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR ANTAGONIST;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG INFUSION; ELECTROCARDIOGRAM; ENDOCARDIUM; EPICARDIUM; HEART DEPOLARIZATION; HEART LEFT VENTRICLE; HEART MUSCLE ISCHEMIA; HEART OUTFLOW TRACT OBSTRUCTION; HEART RIGHT VENTRICLE; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; MEAN ARTERIAL PRESSURE; NONHUMAN; PERICARDIUM; PRIORITY JOURNAL; ST SEGMENT ELEVATION;

EID: 0033734714     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200036001-00064     Document Type: Article

References (8)

1. Electrophysiological effects of intrapericardial infusion of endothelin-1
2. Mechanism of endothelin-induced malignant ventricular arrhythmias in dogs
3. Proarrhythmic activity of intracoronary endothelin in dogs; relation to the site of administration and to changes in regional flow
4. Endothelin and ischaemic arrhythmias - Antiarrhythmic or arrhythmogenic?
5. Intrapericardial infusion of endothelin-1 induces ventricular arrhythmias in dogs
6. Evidence for direct arrhythmic action of endothelin
7. Endothelin antagonism with bosentan: A review of potential applications
8. Role of endogenous endothelin in myocardial and coronary endothelial injury after ischemia and reperfusion in rats: Studies with bosentan a mixed ETA/B antagonist