Less Na +/H +-exchanger to treat heart failure: A simple solution for a complex problem?

Cardiovascular Research

Volumn 65, Issue 1, 2005, Pages 10-12

  Stagg, Mark A ^a   Terracciano, Cesare M N ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN INHIBITOR; SODIUM PROTON EXCHANGE PROTEIN 1;

ACIDOSIS; EDITORIAL; HEART FAILURE; HEART FUNCTION; HEART MUSCLE ISCHEMIA; HUMAN; INHIBITION KINETICS; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TARGETING; REGULATORY MECHANISM; REPERFUSION INJURY;

CALCIUM; CARDIOMEGALY; GUANIDINES; HEART FAILURE, CONGESTIVE; HUMANS; MYOCARDIUM; SODIUM; SODIUM-HYDROGEN ANTIPORTER; SULFONES;

EID: 11144322100     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2004.10.028     Document Type: Editorial

References (16)

1. +-exchanger attenuates cardiac hypertrophy and prevents cellular remodeling in heart failure Cardiovasc. Res. 65 2005 83 92
2. M. Karmazyn, X.T. Gan, RA. Humphreys, H. Yoshida, and K. Kusumoto The myocardial Na(+)-H(+) exchange: structure, regulation, and its role in heart disease Circ. Res. 85 1999 777 786
3. + exchange isoform 1 mRNA expression in isolated rat hearts Am. J. Physiol. 277 1999 H993 H998
4. C. Peiro, J. Angulo, J.L. Llergo, L. Rodriguez-Manas, J. Marin, and CF. Sanchez-Ferrer Angiotensin II mediates cell hypertrophy in vascular smooth muscle cultures from hypertensive Ren-2 transgenic rats by an amiloride- and furosemide-sensitive mechanism Biochem. Biophys. Res. Commun. 240 1997 367 371
5. + exchanger activity: signalling and significance Cardiovasc. Res. 57 2003 942 952
6. K.D. Schluter, M. Schafer, C. Balser, G. Taimor, and H.M. Piper Influence of pHi and creatine phosphate on alpha-adrenoceptor-mediated cardiac hypertrophy J. Mol. Cell. Cardiol. 30 1998 763 771
7. + exchanger attenuates the deterioration of ventricular function during pacing-induced heart failure in rabbits Cardiovasc. Res. 63 2004 273 282
8. H.E. Cingolani, and M.C. Camilion de Hurtado Na(+)-H(+) exchanger inhibition: a new antihypertrophic tool Circ. Res. 90 2002 751 753
9. i and underlies disturbed calcium handling in the rabbit pressure and volume overload heart failure model Cardiovasc. Res. 57 2003 1015 1024
10. D.J. Beuckelmann, M. Nabauer, and E. Erdmann Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure Circulation 85 1992 1046 1055
11. G. Hasenfuss, M. Meyer, W. Schillinger, M. Preuss, B. Pieske, and H. Just Calcium handling proteins in the failing human heart Basic Res. Cardiol. 92 Suppl 1 1997 87 93
12. F. del Monte, S.E. Harding, U. Schmidt, T. Matsui, Z.B. Kang, and G.W. Dec Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a Circulation 100 1999 2308 2311
13. Y. Iwanaga, M. Hoshijima, Y. Gu, M. Iwatate, T. Dieterle, and Y. Ikeda Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats J. Clin. Invest. 113 2004 727 736
14. I.A. Hobai, C. Maack, and B. O'Rourke Partial inhibition of sodium/calcium exchange restores cellular calcium handling in canine heart failure Circ. Res. 95 2004 292 299
15. i handling in the failing human heart Cardiovasc. Res. 57 2003 874 886
16. B.J. Wilkins, and J.D. Molkentin Calcium-calcineurin signaling in the regulation of cardiac hypertrophy Biochem. Biophys. Res. Commun. 322 2004 1178 1191