Colloidal carriers for the enhanced delivery through the skin

Expert Opinion on Drug Delivery

Volumn 5, Issue 7, 2008, Pages 737-755

  Cosco, D ^a   Celia, C ^a   Cilurzo, F ^a   Trapasso, E ^a   Paolino, D ^a  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

Ethosomes; Liposomes; Niosomes; Polymeric particles; Skin delivery; Solid lipid nanoparticles; Transfersomes

Indexed keywords

ACICLOVIR; BACITRACIN; BETAMETHASONE VALERATE; CANNABIDIOL; CARBOMER; CHOLESTEROL; COLLOIDAL CARRIER; CORTICOSTEROID; DICLOFENAC; DRUG CARRIER; DRUG VEHICLE; ENOXACIN; ESTRADIOL; FINASTERIDE; FLUOROURACIL; INSULIN; LIPOSOME; MINOXIDIL; NANOPARTICLE; NIOSOME; PERGOLIDE; PHOSPHATIDYLCHOLINE; PLASMID DNA; POLYMER; RETINOIC ACID; ROTIGOTINE; SOLID LIPID NANOPARTICLE; TESTOSTERONE; TRIHEXYPHENIDYL; UNINDEXED DRUG;

ALLERGIC REACTION; ANTIINFLAMMATORY ACTIVITY; AREA UNDER THE CURVE; ATOPIC DERMATITIS; BIOMEDICAL ENGINEERING; CLINICAL TRIAL; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG FORMULATION; DRUG METABOLISM; DRUG PENETRATION; DRUG RELEASE; DRUG TARGETING; DRUG TRANSPORT; DYSTONIA; GENETIC IMMUNIZATION; HUMAN; MATERIAL STATE; NANOENCAPSULATION; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARKINSONISM; PHASE TRANSITION; REVIEW; RHEUMATIC DISEASE; SKIN PENETRATION; SKIN PERMEABILITY; THERMODYNAMICS; TOPICAL TREATMENT; UNSPECIFIED SIDE EFFECT;

ADMINISTRATION, TOPICAL; ANIMALS; COLLOIDS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HUMANS; LIPOSOMES; NANOPARTICLES; SKIN; SKIN ABSORPTION;

EID: 48449105065     PISSN: 17425247     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425247.5.7.737     Document Type: Review

References (97)

1. Hadgraft J. Skin deep. Eur J Pharm Biopharm 2004;58:291-9
2. Foldvari M. Non-invasive administration of drugs through the skin: challenges in delivery system design. Pharm Sci Technol Today 2000;3(12):417-25
3. Lasic DD. Novel applications of liposomes. TIBTECH 1998;16:307-21
4. Torchilin V, Weissing V. Liposomes. The Practical Approach Series, 2nd ed. New York: Oxford University Press; 2003
5. Takino T, Konishi K, Takakura Y, Hashida M. Long circulating emulsion carrier systems for highly lipophilic drugs. Biol Pharm Bull 1994;17:121-5
6. Moutardier V, Tosini F, Vlieghe P, et al. Colloidal anticancer drugs bioavailabilities in oral administration models. Int J Pharm 2003;260(1):23-38
7. Verma DD, Verma S, Blume G, Fahr A. Liposomes increase skin penetration of entrapped and non-entrapped hydrophilic substances into human skin: a skin penetration and confocal laser scanning microscopy study. Eur J Pharm Biopharm 2003;55:271-7
8. Manosroi A, Kongkaneramit LL, Manosroi F. Stability and transdermal absorption of topical amphotericin B liposome formulations. Int J Pharm 2004;270:279-86
9. Verma DD, Verma S, Blume G, Fahr A. Particle size of liposomes influences dermal delivery of substances into skin. Int J Pharm 2003;258:141-51
10. Gregoriadis G. Liposomes as drug carriers. In: Gregoriadis G, editor, Recent trend and progress. Wiley, Chichester; 1988; p. 3-18
11. Betz G, Aeppli A, Menshutina N, Leuenberger H. In vivo comparison of various liposome formulations for cosmetic application. Int J Pharm 2005;296:44-54
12. Maestrelli F, Gonzalez-Rodryguez ML, Rabasco AM, Mura P. Preparation and characterization of liposomes encapsulating ketoprofen-cyclodextrin complexes for transdermal drug delivery. Int J Pharm 2005;298:55-67
13. Sharma BB, Jain SK, Vyas SP. Topical liposome system bearing local anasthetic lignocaine: preparation and evaluation. J Microencapsul 1994;11:279-86
14. Bhatia A, Kumar R, Katare OP. Tamoxifen in topical liposomes: development, characterization and in vitro evaluation. J Pharm Pharm Sci 2004;7(2):252-9
15. Jia-You F, Yann-Lii L, Chia-Chun C, et al. Lipid nano/submicron emulsion as vehicle for topical flurbiprofen delivery. Drug Deliv 2004;11:97-105
16. Arsic I, Vidovic A, Vuleta G. Influence of liposomes on the stability of vitamin A incorporated in polyacrylate hydrogel. Int J Cosm Sci 1999;21:219-25
17. El Maghraby GM, Williams AC, Barry BW. Can drug-bearing liposomes penetrate intact skin? J Pharm Pharmacol 2006;58:415-29
18. Cevc G, Blume G. Lipid vesicles penetrate into intact skin owing to the transdermal osmotic gradients and hydration force. Biochim Biophys Acta 1992;104:226-32
19. Mezei M, Gulasekharam V. Liposomes: a selective drug delivery system for the topical route of administration. 1. Lotion dosage form. Life Sci 1980;26:1473-7
20. Zellmer S, Pfiel W, Lasch J. Interaction of phosphatidylcholine liposomes with the human stratum corneum. Biochim Biophys Acta 1995;237:176-82
21. Hofland HEJ, Bouwstra JA, Bodde HE, et al. Interactions of liposomes with human skin in vitro: freeze fracture electron microscopial visualization and small angle X-ray scattering studies. Br J Dermatol 1995;132:853-66
22. Kirjavainen M, Urtti A, Jaaskelainen I, et al. Interaction of liposomes with human skin in vitro: the influence of lipid composition and structure. Biochim Biophys Acta 1996;1304:179-89
23. Bouwstra JA, Honeywell-Nguyen PL, Gooris GS, Ponec M. Structure of the skin barrier and its modulation by vesicular formulations. Prog Lipid Res 2003;42:1-36
24. Honeywell-Nguyen PL, De Graff AM, Wouter Groenink HW, Bouwstra JA. The in vivo and in vitro interactions of elastic and rigid vesicles with human skin. Biochim Biophys Acta 2002;1573:130-40
25. Jacobs M, Martin GP, Marriott C. Effects of phosphatidylcholine in the topical bioavailability of corticosteroids assessed by the human skin blanching assay. J Pharm Pharmacol 1988;40:829-33
26. Sinico C, Manconi M, Peppi M, et al. Liposomes as carriers for dermal delivery of tretinoin: in vitro evaluation of drug permeation and vesicle-skin interaction. J Control Release 2005;103:123-36
27. Betz G, Aeppli A, Menshutina N, Leuenberger H. In vivo comparison of various liposome formulations for cosmetic application. Int J Pharm 2005;296:44-54
28. Padamwar MN, Pokharkar VB. Development of vitamin loaded topical liposomal formulation using factorial design approach: drug deposition and stability. Int J Pharm 2006;320:37-44
29. Maestrelli F, Gonzalez-Rodryguez ML, Rabasco AM, Mura P. Effect of preparation technique on the properties of liposomes encapsulating ketoprofen-cyclodextrin complexes aimed for transdermal delivery. Int J Pharm 2006;312:53-60
30. Uchegbu IF, Vyas SP. Non-ionic surfactant based vesicles (niosomes) in drug delivery. Int J Pharm 1998;172:33-70
31. Handjani-Vila RM, Rlbier A, Rondot B, Vanlerberghe G. Dispersion of lamellar phases of non-ionic lipids in cosmetic products. Int J Cosmetic Sci 1979;1:303-14
32. Manconi M, Sinico C, Valenti D, et al. Niosomes as carriers for tretinoin III. A study into the in vitro cutaneous delivery of vesicle-incorporated tretinoin. Int J Pharm 2006;311:11-9
33. Agarwal R, Katare OP, Vyas SP. Preparation and in vitro evaluation of liposomal/niosoma delivery systems for antipsoriatic drug dithranol. Int J Pharm 2001;228:43-52
34. Fang JY, Hong CT, Chiu WT, Wang YY. Effect of liposomes and niosomes on skin permeation of enoxacin. Int J Pharm 2001;219:61-72
35. Junginger HE, Hofland HEJ, Bouwstra JA. Liposomes and niosomes interactions with human skin. Cosmet Toil 1991;106:45-50
36. Grams YY, Alaruikka S, Lashley L, et al. Permeant lipophilicity and vehicle composition influence accumulation of dyes in hair follicles of human skin. Eur J Pharm Sci 2003;18:329-36
37. Tabbakhian M, Tavakoli N, Jaafari MR, Daneshamouz S. Enhancement of follicular delivery of finasteride by liposomes and niosomes. 1. In vitro permeation and in vivo deposition studies using hamster flank and ear models. Int J Pharm 2006;323:1-10
38. Uchegbu IF, McCarthy D, Schatzlein A, Florence AT. Phase transitions in aqueous dispersions of the hexadecyl diglycerol ether (C16G2) non-ionic surfactants, cholesterol and cholesteryl poly-24-oxyethylene ether: vesicles, tubules, discomes and micelles. STP Pharm Sci 1996;6:33-43
39. Uchegbu IF, Schatzlein A, Vanlerberghe G, et al. Polyhedral non-ionic surfactant vesicles. J Pharm Pharmacol 1997;49:606-10
40. Arunothayanun P, Uchegbu IF, Craig DQM, et al. In vitro/in vivo characterisation of polyhedra niosomes. Int J Pharm 1999;183:57-61
41. Manconi M, Valenti D, Sinico C, et al. Niosomes as carriers for tretinoin II. Influence of vesicular incorporation on tretinoin photostability. Int J Pharm 2003;260:261-72
42. Yoshioka T, Sternberg B, Florence AT. Preparation and properties of vesicles (niosomes) of sorbitan monoesters (span-20, span-40, span-60 and span-80) and a sorbitan triester (span-85). Int J Pharm 1994;105:1-6
43. Ganesan MG, Weiner ND, Flynn GL, Ho NFH. Influence of liposomal drug entrapment on percutaneous absorption. Int J Pharm 1984;20:139-54
44. Sarpotdar PP, Zatz JL. Percutaneous absorption enhancement by non-ionic surfactants. Drug Dev Ind Pharm 1986;12:1625-47
45. Hofland HEJ, Geest R, Bodde HE, et al. Estradiol permeation from nonionic surfactant vesicles through human stratum corneum in vitro. Pharm Res 1994;11:659-64
46. Verma DD, Verma S, Blume G, Fahr A. Particle size of liposomes influences dermal delivery of substances into skin. Int J Pharm 2003;258:141-51
47. Blume G, Cevc G. Liposomes for the sustained drug release in vivo Biochim Biophys Acta 1990;1029(1):91-7
48. Cevc G, Blume G. Hydrocortisone and dexamethasone in very deformable drug carriers have increased biological potency, prolonged effect, and reduced therapeutic dosage. Biochim Biophys Acta 2004;1663(1-2):61-73
49. Cevc G. Transfersomes, liposomes and other lipid suspensions on the skin: permeation enhancement, vesicle penetration, and transdermal drug delivery. Crit Rev Ther Drug Carrier Syst 1996;13(3-4):257-388
50. Cevc G, Blume G. New, highly efficient formulation of diclofenac for the topical, transdermal administration in ultradeformable drug carriers, Transfersomes. Biochim Biophys Acta 2001;1514:191-205
51. Jain S, Sapre R, Tiwary AK, Jain NK. Proultraflexible lipid vesicles for effective transdermal delivery of levonorgestrel: development, characterization, and performance evaluation. AAPS Pharm Sci Tech 2005;6:E513-522
52. Cevc G, Gebauer D, Stieber J, et al. Ultraflexible vesicles, Transfersomes, have an extremely low pore penetration resistance and transport therapeutic amounts of insulin across the intact mammalian skin. Biochim Biophys Acta 1998;1368:201-15
53. Cevc G. Transdermal drug delivery of insulin with ultradeformable carriers. Clin Pharmacokinet 2003;42(5):461-74
54. Paul A, Cevc G, Bachhawat BK. Transdermal immunization with large proteins by means of ultradeformable drug carriers. Eur J Immunol 1995;25:3521-4
55. Cevc G, Schätzlein A, Richardsen H. Ultradeformable lipid vesicles can penetrate the skin and other semi-permeable barriers unfragmented. Evidence from double label CLSM experiments and direct size measurements. Biochim Biophys Acta 2002;1564(1):21-30
56. Cevc G. Lipid vesicles and other colloids as drug carriers on the skin. Adv Drug Deliv Rev 2004;56:675-711
57. Elsayed MMA, Abdallah OY, Naggar VF, Khalafallah NM. Lipid vesicles for skin delivery of drugs: reviewing three decades of research. Int J Pharm 2007;332:1-16
58. Paul A, Cevc G, Bachhawat BK. Transdermal immunisation with an integral membrane component, gap junction protein, by means of ultradeformable drug carriers, transferosomes. Vaccine 1998;16:188-95
59. Gupta PN, Mishra V, Rawat A, et al. Non-invasive vaccine delivery in transfersomes, niosomes and liposomes: a comparative study. Int J Pharm 2005;293:73-82
60. Mishra D, Dubey V, Asthana A, et al. Elastic liposomes mediated transcutaneous immunization against Hepatitis B. Vaccine 2006;24:4847-55
61. El Maghraby GM, Williams AC, Barry BW. Skin delivery of 5-fluorouracil from ultradeformable and standard liposomes in vitro J Pharm Pharmacol 2001;53:1069-77
62. El Maghraby GM, Williams AC, Barry BW. Skin hydration and possible shunt route penetration in controlled estradiol delivery from ultradeformable and standard liposomes. J Pharm Pharmacol 2001;53:1311-22
63. Honeywell-Nguyen PL, Gooris GS, Bouwstra JA. Quantitative assessment of the transport of elastic and rigid vesicle components and a model drug from these vesicle formulations into human skin in vivo. J Invest Dermatol 2004;123:902-10
64. Trotta M, Peira E, Debernardi G, Gallarate M. Elastic liposomes for skin delivery of dipotassium, glycyrrhizinate. Int J Pharm 2002;241:319-27
65. Van Den Bergh B, Bouwstra JA, Junginger HE, Wertz PW. Elasticity of vesicles affects hairless mouse skin structure and permeability. J Control Rel 1999;62:367-79
66. Honeywell-Nguyen PL, Frederik PM, Bomans PH, et al. Transdermal delivery of pergolide from surfactant-based elastic and rigid vesicles: characterization and in vitro transport studies. Pharm Res 2002;19(7):991-7
67. Honeywell-Nguyen PL, De Graaff AM, Groenink HW, Bouwstra JA. The in vivo and in vitro interactions of elastic and rigid vesicles with human skin. Biochim Biophys Acta 2002;1573(2):130-40
68. Honeywell-Nguyen PL, Bouwstra JA. Vesicles as a tool for transdermal and dermal delivery. Drug Discov Today Technol 2005;2:67-74
69. Schatzlein A, Cevc C. Non-uniform cellular packing of the stratum corneum and permeability barrier function of intact skin: a high-resolution confocal laser scanning microscopy study using highly deformable vesicles (Transfersomes). Br J Dermatol 1998;138(4):583-92
70. Chiantia S, Giannola LI, Cordone L. Lipid phase transition in saccharide-coated cholate-containing liposomes: coupling to the surrounding matrix. Langmuir 2005;21(9):4108-16
71. Touitou E, Dayan N, Bergelson L, et al. Ethosomes - novel vesicular carriers for enhanced delivery: characterization and skin penetration properties. J Control Release 2000;65:403-18
72. Dayan N, Touitou E. Carriers for skin delivery of trihexyphenidyl HCI: ethosomes vs. liposomes. Biomaterials 2000;21:1879-85
73. Touitou E. Compositions for applying active substances to or through the skin. US5540934; 1996
74. Godin B, Touitou E. Mechanism of bacitracin permeation enhancement through the skin and cellular membranes from an ethosomal carrier. J Control Release 2004;94:365-79
75. Paolino D, Lucania G, Mardente D, et al. Ethosomes for skin delivery of ammonium glycyrrhizinate: in vitro percutaneous permeation through human skin and in vivo anti-inflammatory activity on human volunteers. J Control Release 2005;106:99-110
76. Touitou E. Drug delivery across the skin. Expert Opin Biol Ther 2002;2:723-33
77. Paolino D, Cosco D, Cilurzo F, Fresta M. Innovative drug delivery systems for the administration of natural compounds. Curr Bioactive Compounds 2007;3:262-77
78. Horwitz E, Pisanty S, Czerninski R, et al. A clinical evaluation of a novel liposomal carrier for acyclovir in the topical treatment of recurrent herpes labialis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;87(6):700-5
79. Touitou E, Godin B, Dayan N, et al. Intracellular delivery mediated by an ethosomal carrier. Biomaterials 2001;22:3053-9
80. Lodzki M, Godin B, Rakou L, et al. Cannabidiol-transdermal delivery and anti-inflammatory effect in a murine model. J Control Release 2003;93:377-87
81. Couvreur P, Barratt G, Fattal E, et al. Nanocapsule technology: a review. Crit Rev Ther Drug Carrier Syst 2002;19:99-134
82. Paolino D, Sinha P, Fresta M, Ferrari M. Drug delivery systems. In: Webster JG, editor, The encyclopedia of medical devices and instrumentations. 2nd edition. John Wiley & Sons, New Jersey; 2006; 437-95
83. Ga De Jalòn E, Blanco-Prìeto MJ, Ygartua P, Santoyo S. Topical application of acyclovir-loaded microparticles: quantification of the drug in porcine skin layers. J Control Release 2001;75:191-7
84. Santoyo S, Ga De Jalòn E, Ygartua P, et al. Optimization of topical cidofovir penetration using microparticles. Int J Pharm 2002; 242:107-13
85. Simeonova M, Velichkova R, Ivanova G, et al. Poly(butylcyanoacrylate) nanoparticles for topical delivery of 5-fluorouracil. Int J Pharm 2003;263:133-40
86. Shim J, Seok Kang H, Park WS, et al. Transdermal delivery of minoxidil with block copolymer nanoparticles. J Control Release 2004;97:477-84
87. Lademann J, Richter H, Teichmann A, et al. Nanoparticles - an efficient carrier for drug delivery into the hair follicles. Eur J Pharm Biopharm 2007;66:159-64
88. Cui Z, Mumper RJ. Chitosan-based nanoparticles for topical genetic immunization. J Control Release 2001;75:409-19
89. Badea I, Wettig S, Verrall R, Foldvari M. Topical non-invasive gene delivery using gemini nanoparticles in interferon-γ-deficient mice. Eur J Pharm Biopharm 2007;65:414-22
90. Müller RH, Radtke M, Wissing SA. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv Drug Deliv Rev 2002;54(Suppl 1):131-55
91. Muller RH, Wissing S, Mader K. UV radiation reflecting or absorbing agents, protecting against harmful UV radiation and reinforcing the natural skin barrier. WO0103652; 2001
92. Jenning V, Schäfer-Korting M, Gohla S. Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties. J Control Release 2000;66:115-26
93. Song C, Liu S. A new healthy sunscreen system for human: solid lipid nanoparticles as carrier for 3,4,5-trimethoxybenzoylchitin and the improvement by adding vitamin E. Int J Biol Macrom 2005;36:116-9
94. Kramer KD, Schäfer-Korting M. Glucocorticoid entrapment into lipid carriers - characterisation by parelectric spectroscopy and influence on dermal uptake. J Control Release 2004;97:493-502
95. Longstaff E, Von Krogh G. Condyloma eradication: self-therapy with 0.15-0.5% podophyllotoxin versus 20-25% podophyllin preparations-an integrated safety assessment. Regul Toxicol Pharmacol 2001;33:117-37
96. Chen H, Chang X, Du D, et al. Podophyllotoxin-loaded solid lipid nanoparticles for epidermal targeting. J Control Release 2006;110:296-306
97. Mei Z, Chen H, Weng T, et al. Solid lipid nanoparticle and microemulsion for topical delivery of triptolide. Eur J Pharm Biopharm 2003;56:189-96