New 4-aminoquinoline Mannich base antimalarials. 1. Effect of an alkyl substituent in the 5'-position of the 4'-hydroxyanilino side chain

Journal of Medicinal Chemistry

Volumn 42, Issue 15, 1999, Pages 2747-2751

  Raynes, Kaylene J ^a   Stocks, Paul A ^a   O'Neill, Paul M ^a   Park, B Kevin ^a   Ward, Stephen A ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOQUINOLINE DERIVATIVE; 7 CHLORO 4 [5' ISOPROPYL 4' HYDROXYL 3' [(TERT BUTYLAMINO)METHYL]PHENYL]AMINOQUINOLINE; 7 CHLORO 4 [5' PROPYL 4' HYDROXYL 3' [(TERT BUTYLAMINO)METHYL]PHENYL]AMINOQUINOLINE; AMODIAQUINE; AMOPYROQUINE; ANTIMALARIAL AGENT; CHLOROQUINE; TEBUQUINE; TERT BUTYLAMODIAQUINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DRUG ACCUMULATION; DRUG POTENCY; DRUG RESISTANCE; DRUG STRUCTURE; MALARIA; NONHUMAN; ORAL DRUG ADMINISTRATION; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; STRAIN DIFFERENCE; STRUCTURE ACTIVITY RELATION;

ANILINE COMPOUNDS; ANIMALS; ANTIMALARIALS; INHIBITORY CONCENTRATION 50; MALARIA; MALE; MANNICH BASES; MICE; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033614986     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9901374     Document Type: Article

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