Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 22, 2006, Pages 5773-5777

  Hwang, Sung Hee ^a   Morisseau, Christophe ^a   Do, Zung ^a   Hammock, Bruce D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Anti inflammation; Hypertension; Soluble epoxide hydrolase; Urea

Indexed keywords

ADAMANTANE DERIVATIVE; ENZYME INHIBITOR; EPOXIDE HYDROLASE; EPOXIDE HYDROLASE INHIBITOR; FUNCTIONAL GROUP; PHENYL GROUP; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG SOLUBILITY; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; IC 50; IONIZATION; SOLID PHASE SYNTHESIS; SUBSTITUTION REACTION;

COMBINATORIAL CHEMISTRY TECHNIQUES; ENZYME INHIBITORS; EPOXIDE HYDROLASES; INHIBITORY CONCENTRATION 50; KINETICS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 33749251458     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.08.078     Document Type: Article

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