Design and synthesis of novel oxazole containing 1,3-Dioxane-2-carboxylic acid derivatives as PPAR α/γ dual agonists

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 15, 2008, Pages 7117-7127

  Pingali, Harikishore ^a,b   Jain, Mukul ^a   Shah, Shailesh ^b   Makadia, Pankaj ^a   Zaware, Pandurang ^a   Goel, Ashish ^a   Patel, Megha ^a   Giri, Suresh ^a   Patel, Harilal ^a   Patel, Pankaj ^a  

^a ZYDUS RESEARCH CENTRE   (India)

^b M S UNIVERSITY OF BARODA   (India)

Author keywords

1,3 Dioxane carboxylic acid; Oxazole; PPAR agonist; Type 2 diabetes

Indexed keywords

2 METHYL 5 [4 (5 METHYL 2 (METHYLPHENYL)OXAZOL 4 YLMETHOXY)BENZYL] 1,3 DIOXANE 2 CARBOXYLIC ACID; 2 METHYL 5 [4 (5 METHYL 2 PHENYLOXAZOL 4 YLMETHOXY)BENZYL] 1,3 DIOXANE 2 CARBOXYLIC ACID; 2 METHYL 5 [4 (5 METHYL 2 PHENYLOXAZOL 4 YLMETHOXY)PHENYL] 1,3 DIOXANE 2 CARBOXYLIC ACID; 2 METHYL 5 [4 [2 (5 METHYL 2 (4 METHYLPHENYL)OXAZOL 4 YL)ETHOXY]BENZYL] 1,3 DIOXANE 2 CARBOXYLIC ACID; 2 METHYL 5 [4 [2 (5 METHYL 2 (4 METHYLPHENYL)OXAZOL 4 YL)ETHOXY]PHENYL] 1,3 DIOXANE 2 CARBOXYLIC ACID; 2 METHYL 5 [4 [2 (5 METHYL 2 (5 METHYLTHIOPHEN 2 YL)OXAZOL 4 YL)ETHOXY]BENZYL] 1,3 DIOXANE 2 CARBOXYLIC ACID; 2 METHYL 5 [4 [2 (5 METHYL 2 PHENYLOXAZOL 4 YL)ETHOXY]BENZYL] 1,3 DIOXANE 2 CARBOXYLIC ACID; 2 METHYL 5 [4 [3 (5 METHYL 2 (4 METHYLPHENYL)OXAZOL 4 YL)PROPOXY]BENZYL] 1,3 DIOXANE 2 CARBOXYLIC ACID; 2 METHYL 5 [4 [5 METHYL 2 (5 METHYLTHIOPHEN 2 YL)OXAZOL 4 YLMETHOXY]BENZYL] 1,3 DIOXANE 2 CARBOXYLIC ACID; 5 [4 (2 TERT BUTYL 5 METHYLOXAZOL 4 YLMETHOXY)BENZYL] 1,3 DIOXANE 2 CARBOXYLIC ACID; 5 [4 [2 (2 TERT BUTYL 5 METHYLOXAZOL 4 YL)ETHOXY]BENZYL] 2 METHYL 1,3 DIOXANE 2 CARBOXYLIC ACID; [2 METHYL 5 [4 (2 (5 METHYL 2 PHENYLOXAZOL 4 YL)ETHOXY)PHENYL]] 1,3 DIOXANE 2 CARBOXYLIC ACID; [2 METHYL 5 [4 (5 METHYL 2 (4 METHYLPHENYL)OXAZOL 4 YLMETHOXY)PHENYL]] 1,3 DIOXANE 2 CARBOXYLIC ACID; BEZAFIBRATE; CARBOXYLIC ACID DERIVATIVE; CLOFIBRATE; FARGLITAZAR; FENOFIBRATE; MURAGLITAZAR; OXAZOLE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; PIRINIXIC ACID; RAGAGLITAZAR; ROSIGLITAZONE; TESAGLITAZAR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYPOGLYCEMIA; HYPOLIPEMIA; LIPOPHILICITY; MALE; MOUSE; NONHUMAN; PHARMACOPHORE; RAT;

ANIMALS; CARBOXYLIC ACIDS; DIABETES MELLITUS; DRUG DESIGN; HYPOGLYCEMIC AGENTS; MICE; MICE, INBRED NOD; MOLECULAR STRUCTURE; OXAZOLES; PPAR ALPHA; PPAR GAMMA; RATS; RATS, ZUCKER; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; MUS; RATTUS;

EID: 48449090661     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.06.050     Document Type: Article

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