Structure-activity studies on 1,3-dioxane-2-carboxylic acid derivatives, a novel class of subtype-selective peroxisome proliferator-activated receptor α (PPARα) agonists

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 2, 2008, Pages 981-994

  Asaki, Tetsuo ^a   Aoki, Tomiyoshi ^a   Hamamoto, Taisuke ^a   Sugiyama, Yukiteru ^a   Ohmachi, Shinji ^a   Kuwabara, Kenji ^a   Murakami, Kohji ^a   Todo, Makoto ^a  

^a NIPPON SHINYAKU CO LTD   (Japan)

Author keywords

1,3 Dioxane carboxylic acid; Metabolic disorder; Selective PPAR agonist

Indexed keywords

2 METHYL C 5 [4 [2 (2,4 DIMETHYLPHENYL) 5 METHYL 1,3 OXAZOL 4 YL]BUTYL] 1,3 DIOXANE 2 CARBOXYLIC ACID; 2 METHYL C 5 [4 [2 (3 FLUORO 4 METHYLPHENYL) 5 METHYL 1,3 OXAZOL 4 YL]BUTYL] 1,3 DIOXANE 2 CARBOXYLIC ACID; 2 METHYL C 5 [4 [2 (3,4 DIMETHYLPHENYL) 5 METHYL 1,3 OXAZOL 4 YL]BUTYL] 1,3 DIOXANE 2 CARBOXYLIC ACID; 2 METHYL C 5 [4 [2 (4 CHLOROPHENYL) 5 METHYL 1,3 OXAZOL 4 YL]BUTYL] 1,3 DIOXANE 2 CARBOXYLIC ACID; 2 METHYL C 5 [4 [2 (4 ETHYLPHENYL) 5 METHYL 1,3 OXAZOL 4 YL]BUTYL] 1,3 DIOXANE 2 CARBOXYLIC ACID; 2 METHYL C 5 [4 [2 (4 METHOXYPHENYL) 5 METHYL 1,3 OXAZOL 4 YL]BUTYL] 1,3 DIOXANE 2 CARBOXYLIC ACID; 2 METHYL C 5 [4 [5 METHY1 2 (4 TRIFLUOROMETHYLPHENYL) 1,3 OXAZOL 4 YL]BUTYL] 1,3 DIOXANE 2 CARBOXYLIC ACID; 2 METHYL C 5 [4 [5 METHYL 2 (2 METHYLPHENY1) 1,3 OXAZOL 4 YL]BUTYL] 1,3 DIOXANE 2 CARBOXYLIC ACID; 2 METHYL C 5 [4 [5 METHYL 2 (3 METHYLPHENY1) 1,3 OXAZOL 4 YL]BUTYL] 1,3 DIOXANE 2 CARBOXYLIC ACID; 2 METHYL C 5 [4 [5 METHYL 2 (4 METHYLPHENYL) 1,3 OXAZOL 4 YL]BUTYL] 1,3 DIOXANE 2 CARBOXYLIC ACID; BEZAFIBRATE; CARBOXYLIC ACID DERIVATIVE; FENOFIBRATE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OXAZOLE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; METABOLIC DISORDER; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; STRUCTURE ACTIVITY RELATION; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; COMBINATORIAL CHEMISTRY TECHNIQUES; DIOXANES; HUMANS; MICE; MOLECULAR STRUCTURE; OXAZOLES; PPAR ALPHA; STRUCTURE-ACTIVITY RELATIONSHIP;

MUS;

EID: 38549092684     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.10.007     Document Type: Article

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