메뉴 건너뛰기




Volumn 150, Issue 9, 2004, Pages 3013-3023

Cryptococcus neoformans methionine synthase: Expression analysis and requirement for virulence

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; CYCLOSPORIN A; FLUCONAZOLE; HOMOCYSTEINE; MELANIN; METHIONINE SYNTHASE; TACROLIMUS;

EID: 4844231595     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.27235-0     Document Type: Article
Times cited : (62)

References (55)
  • 1
    • 0030668723 scopus 로고    scopus 로고
    • Cryptococcus neoformans mating and virulence are regulated by the G-protein α subunit GPA1 and cAMP
    • Alspaugh, J. A., Perfect, J. R. & Heitman, J. (1997). Cryptococcus neoformans mating and virulence are regulated by the G-protein α subunit GPA1 and cAMP. Genes Dev 11, 3206-3217.
    • (1997) Genes Dev. , vol.11 , pp. 3206-3217
    • Alspaugh, J.A.1    Perfect, J.R.2    Heitman, J.3
  • 3
    • 0025228772 scopus 로고
    • Cobalamin-dependent methionine synthase
    • Banerjee, R. V. & Matthews, R. G. (1990). Cobalamin-dependent methionine synthase. FASEB J 4, 1450-1459.
    • (1990) FASEB J. , vol.4 , pp. 1450-1459
    • Banerjee, R.V.1    Matthews, R.G.2
  • 4
    • 0037130295 scopus 로고    scopus 로고
    • From natural products to clinically useful antifungals
    • Barrett, D. (2002). From natural products to clinically useful antifungals. Biochim Biophys Acta 1587, 224-233.
    • (2002) Biochim. Biophys. Acta , vol.1587 , pp. 224-233
    • Barrett, D.1
  • 5
    • 0018354230 scopus 로고
    • Aspects of physiology of Histoplasma capsulatum
    • Boguslawski, G. & Stetler, D. A. (1979). Aspects of physiology of Histoplasma capsulatum. Mycopathologia 67, 17-24.
    • (1979) Mycopathologia , vol.67 , pp. 17-24
    • Boguslawski, G.1    Stetler, D.A.2
  • 6
    • 0036150323 scopus 로고    scopus 로고
    • Sulphur amino acid synthesis in Schizosaccharomyces pombe represents a specific variant of sulphur metabolism in fungi
    • Brzywczy, J., Sieânko, M., Kucharska, A. & Paszewski, A. (2002). Sulphur amino acid synthesis in Schizosaccharomyces pombe represents a specific variant of sulphur metabolism in fungi. Yeast 19, 29-35.
    • (2002) Yeast , vol.19 , pp. 29-35
    • Brzywczy, J.1    Sieânko, M.2    Kucharska, A.3    Paszewski, A.4
  • 7
    • 0014148109 scopus 로고
    • Cryptococcus neoformans. I. Nonencapsulated mutants
    • Bulmer, G. S., Sans, M. D. & Gunn, C. M. (1967). Cryptococcus neoformans. I. Nonencapsulated mutants. J Bacteriol 94, 1475-1479.
    • (1967) J Bacteriol , vol.94 , pp. 1475-1479
    • Bulmer, G.S.1    Sans, M.D.2    Gunn, C.M.3
  • 9
    • 0033986998 scopus 로고    scopus 로고
    • Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin
    • & 7 other authors
    • Cruz, M. C., Del Poeta, M., Wang, P. & 7 other authors (2000). Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin. Antimicrob Agents Chemother 44, 143-149.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 143-149
    • Cruz, M.C.1    Del Poeta, M.2    Wang, P.3
  • 12
    • 0028004384 scopus 로고
    • Antibiotics that inhibit fungal cell wall development
    • Debono, M. & Gordee, R. S. (1994). Antibiotics that inhibit fungal cell wall development. Annu Rev Microbiol 48, 471-497.
    • (1994) Annu. Rev. Microbiol. , vol.48 , pp. 471-497
    • Debono, M.1    Gordee, R.S.2
  • 13
    • 0033998663 scopus 로고    scopus 로고
    • 1, fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans
    • 1, fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans. Antimicrob Agents Chemother 44, 739-746.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 739-746
    • Del Poeta, M.1    Cruz, M.C.2    Cardenas, M.E.3    Perfect, J.R.4    Heitman, J.5
  • 14
    • 0020452610 scopus 로고
    • Decreased virulence in stable, acapsular mutants of Cryptococcus neoformans
    • Fromtling, R. A., Shadomy, H. J. & Jacobson, E. S. (1982). Decreased virulence in stable, acapsular mutants of Cryptococcus neoformans. Mycopathologia 79, 23-29.
    • (1982) Mycopathologia , vol.79 , pp. 23-29
    • Fromtling, R.A.1    Shadomy, H.J.2    Jacobson, E.S.3
  • 15
    • 0031027261 scopus 로고    scopus 로고
    • In vitro studies of activities of the antifungal triazoles SCH56592 and itraconazole against Candida albicans, Cryptococcus neoformans, and other pathogenic yeasts
    • Galgiani, J. N. & Lewis, M. L. (1997). In vitro studies of activities of the antifungal triazoles SCH56592 and itraconazole against Candida albicans, Cryptococcus neoformans, and other pathogenic yeasts. Antimicrob Agents Chemother 41, 180-183.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 180-183
    • Galgiani, J.N.1    Lewis, M.L.2
  • 18
    • 0026630973 scopus 로고
    • Comparison of cobalamin-independent and cobalamin-dependent methionine synthases from Escherichia coli: Two solutions to the same chemical problem
    • Gonzâalez, J. C., Banerjee, R. V., Huang, S., Sumner, J. S. & Matthews, R. G. (1992). Comparison of cobalamin-independent and cobalamin-dependent methionine synthases from Escherichia coli: two solutions to the same chemical problem. Biochemistry 31, 6045-6056.
    • (1992) Biochemistry , vol.31 , pp. 6045-6056
    • Gonzâalez, J.C.1    Banerjee, R.V.2    Huang, S.3    Sumner, J.S.4    Matthews, R.G.5
  • 19
    • 0021997066 scopus 로고
    • Virulence of Cryptococcus neoformans. Regulation of capsule synthesis by carbon dioxide
    • Granger, D. L., Perfect, J. R. & Durack, D. T. (1985). Virulence of Cryptococcus neoformans. Regulation of capsule synthesis by carbon dioxide. J Clin Invest 76, 508-516.
    • (1985) J. Clin. Invest. , vol.76 , pp. 508-516
    • Granger, D.L.1    Perfect, J.R.2    Durack, D.T.3
  • 20
    • 0016235319 scopus 로고
    • Accumulation of a sterol intermediate during reaction in the presence of homocysteine with cell-free extract of yeast
    • Hatanaka, H., Ariga, N., Nagai, J. & Katsuki, H. (1974). Accumulation of a sterol intermediate during reaction in the presence of homocysteine with cell-free extract of yeast. Biochem Biophys Res Commun 60, 787-793.
    • (1974) Biochem. Biophys. Res. Commun. , vol.60 , pp. 787-793
    • Hatanaka, H.1    Ariga, N.2    Nagai, J.3    Katsuki, H.4
  • 21
    • 0023481280 scopus 로고
    • A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli
    • Hoffman, C. S. & Winston, F. (1987). A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. Gene 57, 267-272.
    • (1987) Gene , vol.57 , pp. 267-272
    • Hoffman, C.S.1    Winston, F.2
  • 22
    • 0025974977 scopus 로고
    • Proofreading in vivo: Editing of homocysteine by methionyl-tRNA synthetase in the yeast Saccharomyces cerevisiae
    • Jakubowski, H. (1991). Proofreading in vivo: editing of homocysteine by methionyl-tRNA synthetase in the yeast Saccharomyces cerevisiae. EMBO J 10, 593-598.
    • (1991) EMBO J. , vol.10 , pp. 593-598
    • Jakubowski, H.1
  • 23
    • 0036750807 scopus 로고    scopus 로고
    • The determination of homocysteine-thiolactone in biological samples
    • Jakubowski, H. (2002). The determination of homocysteine-thiolactone in biological samples. Anal Biochem 308, 112-119.
    • (2002) Anal. Biochem. , vol.308 , pp. 112-119
    • Jakubowski, H.1
  • 24
    • 1542373560 scopus 로고    scopus 로고
    • Molecular basis of homocysteine toxicity in humans
    • Jakubowski, H. (2004). Molecular basis of homocysteine toxicity in humans. Cell Mol Life Sci 61, 470-487.
    • (2004) Cell Mol. Life Sci. , vol.61 , pp. 470-487
    • Jakubowski, H.1
  • 25
    • 0348143466 scopus 로고    scopus 로고
    • Transcriptional regulation of methionine synthase by homocysteine and choline in Aspergillus nidulans
    • Kacprzak, M. M., Lewandowska, I., Matthews, R. G. & Paszewski, A. (2003). Transcriptional regulation of methionine synthase by homocysteine and choline in Aspergillus nidulans. Biochem J 376, 517-524.
    • (2003) Biochem. J. , vol.376 , pp. 517-524
    • Kacprzak, M.M.1    Lewandowska, I.2    Matthews, R.G.3    Paszewski, A.4
  • 26
    • 2942595896 scopus 로고    scopus 로고
    • Cryptococcus neoformans Ilv2p confers resistance to sulfometuron methyl and is required for survival at 37°C and in vivo
    • Kingsbury, J. M., Yang, Z., Ganous, T. M., Cox, G. M. & McCusker, J. H. (2004a). Cryptococcus neoformans Ilv2p confers resistance to sulfometuron methyl and is required for survival at 37°C and in vivo. Microbiology 150, 1547-1558.
    • (2004) Microbiology , vol.150 , pp. 1547-1558
    • Kingsbury, J.M.1    Yang, Z.2    Ganous, T.M.3    Cox, G.M.4    McCusker, J.H.5
  • 27
    • 2942635960 scopus 로고    scopus 로고
    • Novel chimeric spermidine synthase-saccharopine dehydrogenase gene (SPE3-LYS9) in the human pathogen Cryptococcus neoformans
    • Kingsbury, J. M., Yang, Z., Ganous, T. M., Cox, G. M. & McCusker, J. H. (2004b). Novel chimeric spermidine synthase-saccharopine dehydrogenase gene (SPE3-LYS9) in the human pathogen Cryptococcus neoformans. Eukaryot Cell 3, 752-763.
    • (2004) Eukaryot. Cell , vol.3 , pp. 752-763
    • Kingsbury, J.M.1    Yang, Z.2    Ganous, T.M.3    Cox, G.M.4    McCusker, J.H.5
  • 28
    • 0002427193 scopus 로고
    • Cryptococcus
    • Edited by C. Cann. Philadelphia, PA: Lea & Febiger
    • Kwon-Chung, K. J. & Bennett, J. E. (1992). Cryptococcus. In Medical Mycology, pp. 397-446. Edited by C. Cann. Philadelphia, PA: Lea & Febiger.
    • (1992) Medical Mycology , pp. 397-446
    • Kwon-Chung, K.J.1    Bennett, J.E.2
  • 29
    • 0022635758 scopus 로고
    • Encapsulation and melanin formation as indicators of virulence in Cryptococcus neoformans
    • Kwon-Chung, K. J. & Rhodes, J. C. (1986). Encapsulation and melanin formation as indicators of virulence in Cryptococcus neoformans. Infect Immun 51, 218-223.
    • (1986) Infect. Immun. , vol.51 , pp. 218-223
    • Kwon-Chung, K.J.1    Rhodes, J.C.2
  • 30
    • 0032216576 scopus 로고    scopus 로고
    • Synergistic effects of tacrolimus and azole antifungal agents against azole-resistant Candida albicans strains
    • Maesaki, S., Marichal, P., Ashraf Hossain, M., Sanglard, D., Bossche, H. V. & Kohno, S. (1998). Synergistic effects of tacrolimus and azole antifungal agents against azole-resistant Candida albicans strains. J Antimicrob Chemother 42, 747-753.
    • (1998) J. Antimicrob. Chemother. , vol.42 , pp. 747-753
    • Maesaki, S.1    Marichal, P.2    Ashraf Hossain, M.3    Sanglard, D.4    Bossche, H.V.5    Kohno, S.6
  • 32
    • 0033751965 scopus 로고    scopus 로고
    • Fluconazole plus cyclosporine: A fungicidal combination effective against experimental endocarditis due to Candida albicans
    • Marchetti, O., Entenza, J. M., Sanglard, D., Bille, J., Glauser, M. P. & Moreillon, P. (2000b). Fluconazole plus cyclosporine: a fungicidal combination effective against experimental endocarditis due to Candida albicans. Antimicrob Agents Chemother 44, 2932-2938.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 2932-2938
    • Marchetti, O.1    Entenza, J.M.2    Sanglard, D.3    Bille, J.4    Glauser, M.P.5    Moreillon, P.6
  • 33
    • 0037659374 scopus 로고    scopus 로고
    • Fungicidal synergism of fluconazole and cyclosporine in Candida albicans is not dependent on multidrug efflux transporters encoded by the CDR1, CDR2, CaMDR1, and FLU1 genes
    • Marchetti, O., Moreillon, P., Entenza, J. M., Vouillamoz, J., Glauser, M. P., Bille, J. & Sanglard, D. (2003). Fungicidal synergism of fluconazole and cyclosporine in Candida albicans is not dependent on multidrug efflux transporters encoded by the CDR1, CDR2, CaMDR1, and FLU1 genes. Antimicrob Agents Chemother 47, 1565-1570.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 1565-1570
    • Marchetti, O.1    Moreillon, P.2    Entenza, J.M.3    Vouillamoz, J.4    Glauser, M.P.5    Bille, J.6    Sanglard, D.7
  • 34
    • 0024369757 scopus 로고
    • Dimorphism in Histoplasma capsulatum: A model for the study of cell differentiation in pathogenic fungi
    • Maresca, B. & Kobayashi, G. S. (1989). Dimorphism in Histoplasma capsulatum: a model for the study of cell differentiation in pathogenic fungi. Microbiol Rev 53, 186-209.
    • (1989) Microbiol. Rev. , vol.53 , pp. 186-209
    • Maresca, B.1    Kobayashi, G.S.2
  • 35
    • 0030845895 scopus 로고    scopus 로고
    • Molecular genetics of sulfur assimilation in filamentous fungi and yeast
    • Marzluf, G. A. (1997). Molecular genetics of sulfur assimilation in filamentous fungi and yeast. Annu Rev Microbiol 51, 73-96.
    • (1997) Annu. Rev. Microbiol. , vol.51 , pp. 73-96
    • Marzluf, G.A.1
  • 36
    • 0019464724 scopus 로고
    • Inhibition of sterol transmethylation by S-adenosylhomocysteine analogs
    • McCammon, M. T. & Parks, L. W. (1981). Inhibition of sterol transmethylation by S-adenosylhomocysteine analogs. J Bacteriol 145, 106-112.
    • (1981) J. Bacteriol. , vol.145 , pp. 106-112
    • McCammon, M.T.1    Parks, L.W.2
  • 37
    • 0035119757 scopus 로고    scopus 로고
    • A new dominant selectable marker for use in Cryptococcus neoformans
    • McDade, H. C. & Cox, G. M. (2001). A new dominant selectable marker for use in Cryptococcus neoformans. Med Mycol 39, 151-154.
    • (2001) Med. Mycol. , vol.39 , pp. 151-154
    • McDade, H.C.1    Cox, G.M.2
  • 38
    • 0023200281 scopus 로고
    • Mycelial- to yeast-phase transitions of the dimorphic fungi Blastomyces dermatitidis and Paracoccidioides brasiliensis
    • Medoff, G., Painter, A. & Kobayashi, G. S. (1987). Mycelial- to yeast-phase transitions of the dimorphic fungi Blastomyces dermatitidis and Paracoccidioides brasiliensis. J Bacteriol 169, 4055-4060.
    • (1987) J. Bacteriol. , vol.169 , pp. 4055-4060
    • Medoff, G.1    Painter, A.2    Kobayashi, G.S.3
  • 39
    • 0031028176 scopus 로고    scopus 로고
    • The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein
    • Odom, A., Del Poeta, M., Perfect, J. & Heitman, J. (1997a). The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein. Antimicrob Agents Chemother 41, 156-161.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 156-161
    • Odom, A.1    Del Poeta, M.2    Perfect, J.3    Heitman, J.4
  • 40
    • 0031008864 scopus 로고    scopus 로고
    • Calcineurin is required for virulence of Cryptococcus neoformans
    • Odom, A., Muir, S., Lim, E., Toffaletti, D. L., Perfect, J. & Heitman, J. (1997b). Calcineurin is required for virulence of Cryptococcus neoformans. EMBO J 16, 2576-2589.
    • (1997) EMBO J. , vol.16 , pp. 2576-2589
    • Odom, A.1    Muir, S.2    Lim, E.3    Toffaletti, D.L.4    Perfect, J.5    Heitman, J.6
  • 41
    • 0345489076 scopus 로고    scopus 로고
    • Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei
    • Onyewu, C., Blankenship, J. R., Del Poeta, M. & Heitman, J. (2003). Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei. Antimicrob Agents Chemother 47, 956-964.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 956-964
    • Onyewu, C.1    Blankenship, J.R.2    Del Poeta, M.3    Heitman, J.4
  • 42
    • 0028847265 scopus 로고
    • Physiological implications of sterol biosynthesis in yeast
    • Parks, L. W. & Casey, W. M. (1995). Physiological implications of sterol biosynthesis in yeast. Annu Rev Microbiol 49, 95-116.
    • (1995) Annu. Rev. Microbiol. , vol.49 , pp. 95-116
    • Parks, L.W.1    Casey, W.M.2
  • 43
    • 0027372019 scopus 로고
    • The gene encoding phosphoribosylaminoimidazole carboxylase (ADE2) is essential for growth of Cryptococcus neoformans in cerebrospinal fluid
    • Perfect, J. R., Toffaletti, D. L. & Rude, T. H. (1993). The gene encoding phosphoribosylaminoimidazole carboxylase (ADE2) is essential for growth of Cryptococcus neoformans in cerebrospinal fluid. Infect Immun 61, 4446-4451.
    • (1993) Infect. Immun. , vol.61 , pp. 4446-4451
    • Perfect, J.R.1    Toffaletti, D.L.2    Rude, T.H.3
  • 44
    • 0015934089 scopus 로고
    • An Aspergillus nidulans mutant lacking cystathionine synthase: Identity of L-serine sulfhydrylase with cystathionine synthase and its distinctness from O-acetyl-L-serine sulfhydrylase
    • Pieniazek, N., Stepieân, P. P. & Paszewski, A. (1973). An Aspergillus nidulans mutant lacking cystathionine synthase: identity of L-serine sulfhydrylase with cystathionine synthase and its distinctness from O-acetyl-L-serine sulfhydrylase. Biochim Biophys Acta 297, 37-47.
    • (1973) Biochim. Biophys. Acta , vol.297 , pp. 37-47
    • Pieniazek, N.1    Stepieân, P.P.2    Paszewski, A.3
  • 47
    • 0036342893 scopus 로고    scopus 로고
    • Resistance of human fungal pathogens to antifungal drugs
    • Sanglard, D. (2002). Resistance of human fungal pathogens to antifungal drugs. Curr Opin Microbiol 5, 379-385.
    • (2002) Curr. Opin. Microbiol. , vol.5 , pp. 379-385
    • Sanglard, D.1
  • 48
    • 0038016755 scopus 로고    scopus 로고
    • Calcineurin A of Candida albicans: Involvement in antifungal tolerance, cell morphogenesis and virulence
    • Sanglard, D., Ischer, F., Marchetti, O., Entenza, J. M. & Bille, J. (2003). Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence. Mol Microbiol 48, 959-976.
    • (2003) Mol. Microbiol. , vol.48 , pp. 959-976
    • Sanglard, D.1    Ischer, F.2    Marchetti, O.3    Entenza, J.M.4    Bille, J.5
  • 50
    • 0031457095 scopus 로고    scopus 로고
    • Metabolism of sulfur amino acids in Saccharomyces cerevisiae
    • Thomas, D. & Surdin-Kerjan, Y. (1997). Metabolism of sulfur amino acids in Saccharomyces cerevisiae. Microbiol Mol Biol Rev 61, 503-532.
    • (1997) Microbiol. Mol. Biol. Rev. , vol.61 , pp. 503-532
    • Thomas, D.1    Surdin-Kerjan, Y.2
  • 51
    • 0027467293 scopus 로고
    • Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA
    • Toffaletti, D. L., Rude, T. H., Johnston, S. A., Durack, D. T. & Perfect, J. R. (1993). Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA. J Bacteriol 175, 1405-1411.
    • (1993) J. Bacteriol. , vol.175 , pp. 1405-1411
    • Toffaletti, D.L.1    Rude, T.H.2    Johnston, S.A.3    Durack, D.T.4    Perfect, J.R.5
  • 52
    • 3142752754 scopus 로고    scopus 로고
    • The RAM1 gene encoding a protein-farnesyltransferase β-subunit homolog is essential in Cryptococcus neoformans
    • Vallim, M. A., Fernandes, L. & Alspaugh, J. (2004). The RAM1 gene encoding a protein-farnesyltransferase β-subunit homolog is essential in Cryptococcus neoformans. Microbiology 150, 1925-1935.
    • (2004) Microbiology , vol.150 , pp. 1925-1935
    • Vallim, M.A.1    Fernandes, L.2    Alspaugh, J.3
  • 53
    • 0031969879 scopus 로고    scopus 로고
    • Clinical, cellular, and molecular factors that contribute to antifungal drug resistance
    • White, T. C., Marr, K. A. & Bowden, R. A. (1998). Clinical, cellular, and molecular factors that contribute to antifungal drug resistance. Clin Microbiol Rev 11, 382-402.
    • (1998) Clin. Microbiol. Rev. , vol.11 , pp. 382-402
    • White, T.C.1    Marr, K.A.2    Bowden, R.A.3
  • 54
    • 0036667450 scopus 로고    scopus 로고
    • Molecular and genetic analysis of the Cryptococcus neoformans MET3 gene and a met3 mutant
    • Yang, Z., Pascon, R. C., Alspaugh, A., Cox, G. M. & McCusker, J. H. (2002). Molecular and genetic analysis of the Cryptococcus neoformans MET3 gene and a met3 mutant. Microbiology 148, 2617-2625.
    • (2002) Microbiology , vol.148 , pp. 2617-2625
    • Yang, Z.1    Pascon, R.C.2    Alspaugh, A.3    Cox, G.M.4    McCusker, J.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.