Intravesical electromotive mitomycin C versus passive transport mitomycin C for high risk superficial bladder cancer: A prospective randomized study

Journal of Urology

Volumn 170, Issue 3, 2003, Pages 777-782

  Di Stasi, Savino M ^a   Giannantoni, Antonella ^a   Stephen, Robert L ^a   Capelli, Giovanni ^a   Navarra, Pierluigi ^a   Massoud, Renato ^a   Vespasiani, Giuseppe ^a  

^a NONE

Author keywords

Bladder; Bladder neoplasms; Chemotherapy; Electricity; Mitomycin

Indexed keywords

BCG VACCINE; MITOMYCIN C;

ADULT; AGED; ARTHRALGIA; ARTHRITIS; ARTICLE; BLADDER CANCER; CANCER CHEMOTHERAPY; CANCER RECURRENCE; CANCER STAGING; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; CYSTITIS; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HYPERSENSITIVITY; DRUG INSTILLATION; DRUG UPTAKE; ELECTRIC CURRENT; FATIGUE; FEMALE; FEVER; HIGH RISK POPULATION; HUMAN; LIVER TOXICITY; LUNG INFECTION; MALAISE; MALE; PASSIVE TRANSPORT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RASH; SEPSIS; SUPERFICIAL CANCER; TRANSPORT KINETICS; TRANSURETHRAL RESECTION; TREATMENT OUTCOME;

EID: 0043240101     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ju.0000080568.91703.18     Document Type: Article

References (20)

1. Jakse, G., Loidl, W., Seeber, G., and Hofstädter, F.: Stage T1, grade 3 transitional cell carcinoma of the bladder: an unfavorable tumor? J Urol, 137: 39, 1987
2. Abel, P. D.: Follow-up of patients with "superficial" transitional cell carcinoma of the bladder: the case for a change in policy. Br J Urol, 72: 135, 1993
3. Bostwick, D. G.: Natural history of early bladder cancer. J Cell Biochem, suppl., 161: 31, 1992
4. Cookson, M. S., Herr, H. W., Zhang, Z.-F., Soloway, S., Sogani, P. C. and Fair, W. R.: The treated natural history of high risk superficial bladder cancer: 15-year outcome. J Urol, 158: 62, 1997
5. Kim, J. C. and Steinberg, G. D.: The limits of bacillus Calmette-Guérin for carcinoma in situ of the bladder. J Urol, 165: 745, 2001
6. Wientjes, M. G., Badalament, R. A. and Au, J. L.: Use of pharmacologic data and computer simulations to design an efficacy trial of intravesical mitomycin C therapy for superficial bladder cancer. Cancer Chemother Pharmacol, 32: 255, 1993
7. Gao, X., Au, J. L., Badalament, R. A. and Wientjes, M. G: Bladder tissue uptake of mitomycin C during intravesical therapy is linear with drug concentration in urine. Clin Cancer Res, 4: 139, 1998
8. Au, J. L., Badalament, R. A., Wientjes, M. G., Young, D. C., Warner, J. A., Venema, P. L. et al: Methods to improve efficacy of intravesical mitomycin C: results of a randomized phase III trial. J Natl Cancer Inst, 93: 597, 2001
9. Herr, H. W.: The value of a second transurethral resection in evaluating patients with bladder tumors. J Urol, 162: 74, 1999
10. Schmittgen, T. D., Wientjes, M. G., Badalament, R. A. and Au, J. L.: Pharmacodynamics of mitomycin C in cultured human bladder tumors. Cancer Res, 51: 3849, 1991
11. Phipps, J. B., Padmanabhan, R. V. and Lattin, G. A.: Iontophoretic delivery of model inorganic and drug ions. J Pharm Sci, 78: 365, 1989
12. Di Stasi, S. M., Giannantoni, A., Massoud, R., Dolci, S., Navarra, P., Vespasiani, G. et al: Electromotive versus passive diffusion of mitomycin C into human bladder wall: concentration-depth profiles studies. Cancer Res, 59: 4912, 1999
13. Soloway, M. S.: Editorial comment. J Urol, 143: 36, 1990
14. Lamm, D. L.: Carcinoma in situ. Urol Clin North Am, 19: 499, 1992
15. Lugnani, F., Mazza, G., Cerulli, N., Rossi, C. and Stephen, R. L.: Iontophoresis of drugs in the bladder wall: equipment and preliminary studies. Artif Org, 17: 8, 1993
16. Katchalsky, A. and Curran, P. F.: Nonequilibrium Thermodynamics in Biophysics. Cambridge: Harvard University Press, 1965
17. Henderson, L. W.: Peritoneal ultrafiltration dialysis: enhanced urea transfer using hypertonic peritoneal dialysis fluid. J Clin Invest, 45: 950, 1966
18. Stephen, R. L., Novak, J. M., Jensen, E. M., Kablitz, C. and Buys, S. S.: Effect of osmotic pressure on uptake of chemotherapeutic agents by carcinoma cells. Cancer Res, 50: 4704, 1990
19. Montie, J. E.: Intravesical therapy for bladder cancer: empiricism at the helm. J Natl Cancer Inst, 93: 572, 2001
20. Herr, H. W. and Reuter, V. E.: Progression of T1 bladder tumors: better staging or better biology? Cancer, 86: 908, 1999