Distribution of DT-diaphorase and reduced nicotinamide adenine dinucleotide phosphate: Cytochrome P450 oxidoreductase in bladder tissues and tumors

Journal of Urology

Volumn 166, Issue 6, 2001, Pages 2500-2505

  Li, Dong ^a   Gan, Yuebo ^a   Wientjes, M Guill ^a   Badalament, Robert A ^a   Au, Jessie L S ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Bladder; Bladder neoplasms; Mitomycin; NADPH ferrihemoprotein reductase; Oxioreductases

Indexed keywords

BETA ACTIN; CYTOCHROME P450; MITOMYCIN C; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANIMAL TISSUE; ARTICLE; BLADDER TUMOR; CANCER INVASION; DOG; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN TISSUE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE DISTRIBUTION; TRANSURETHRAL RESECTION; TUMOR LOCALIZATION; TUMOR XENOGRAFT; VASCULAR ENDOTHELIUM;

EID: 0035173676     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(05)65624-8     Document Type: Article

References (42)

1. Cancer statistics, 1999
2. Intravesical chemotherapy. Treatment selection, techniques, and results
3. Reductive metabolism and alkylating activity of mitomycin C induced by rat liver microsomes
4. Bioreductive activation of mitomycin C by DT-diaphorase
5. DT diaphorase: Purification, properties, and function
6. Immunodetection of NAD(P)H:Quinone oxidoreductase 1 (NQO1) in human tissues
7. DT-diaphorase as a critical determinant of sensitivity to mitomycin C in human colon and gastric carcinoma cell lines
8. Immunological quantitation of DT-diaphorase in carcinoma cell lines and clinical colon cancers: Advanced tumors express greater levels of DT-diaphorase
9. Establishment and characterization of non-small cell lung cancer cell lines resistant to mitomycin C under aerobic conditions
10. Chemosensitivity to the indoloquinone EO9 is correlated with DT-diaphorase activity and its gene expression
11. Biochemical characterization of a mitomycin C-resistant human bladder cancer cell line
12. Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: Relationship to the response of lung tumor xenografts to mitomycin C1
13. Non-enzymatic and enzymatic activation of mitomycin C: Identification of a unique cystolic activity
14. Decreased NADPH:cytochrome P-450 reductase activity and impaired drug activation in a mammalian cell line resistant to mitomycin under aerobic but not hypoxic conditions
15. Activation of mitomycin C by NADPH:Cytochrome P-450 reductase
16. Relative importance of DT-diaphorase and hypoxia in the bioactivation of EO9 by human lung tumor cell lines
17. Bladder wall penetration of intravesical mitomycin C in dogs
18. Penetration of mitomycin C in human bladder
19. Use of pharmacologic data and computer simulations to design an efficacy trial of intravesical mitomycin C therapy for superficial bladder cancer
20. Pharmacodynamics of mitomycin C in cultured human bladder tumors
21. Correlation of human bladder tumor histoculture proliferation and sensitivity to mitomycin C with tumor pathobiology
22. Expression of DT-diaphorase and cytochrome P450 reductase correlates with mitomycin C activity in human bladder tumors
23. Characterization of a polymorphism in NAD(P)H:quinone oxidoreductase (DT-diaphorase)
24. NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: Characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity
25. Increased activity and expression of NAD(P)H:quinone acceptor oxidoreductase in confluent cell cultures and within multicellular spheroids
26. Quantitation of thymidylate synthase, dihydrofolate reductase, and DT diaphorase gene expression in human tumors using the polymerase chain reaction
27. Protein measurement with the folin phenol reagent
28. Increased NAD(P)H.: (quinone-acceptor)oxidoreductase activity is associated with density-dependent growth inhibition of normal but not transformed cells
29. Increase of NAD(P)H:quinone reductase by dietary antioxidants: Possible role in protection against carcinogenesis and toxicity
30. DT-diaphorase and cancer chemotherapy
31. Regulation of genes encoding NAD(P)H:quinone oxidoreductases
32. Bioactivation of quinones by DT-diaphorase, molecular, biochemical, and chemical studies
33. DT diaphorase: Possible roles in cancer chemotherapy and carcinogenesis
34. Metabolism of mitomycin C by DT-diaphorase: Role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells
35. DT-diaphorase and cytochrome B5 reductase in human lung and breast tumors
36. Biochemical and quantitative histochemical study of reduced pyridine nucleotide dehydrogenation by human colonic carcinomas
37. DT-diaphorase activity in various cells in culture with emphasis on induction in ascites hepatoma cells
38. Mitomycin C sensitivity in human bladder cancer cells: Possible role of glutathione and glutathione transferase in resistance
39. 5-Year followup of a randomized prospective study comparing mitomycin C and bacillus Calmette-Guerin in patients with superficial bladder carcinoma
40. Selective inhibition of cyclooxygenase-2 enhances mitomycin-C-induced apoptosis
41. Methods to improve efficacy of intravesical mitomycin C: Results of a randomized phase III trial