메뉴 건너뛰기




Volumn 21, Issue 2, 2008, Pages 169-180

Short inhalation exposures of the isolated and perfused rat lung to respirable dry particle aerosols; The detailed pharmacokinetics of budesonide, formoterol, and terbutaline

Author keywords

dry powder aerosol; particle deposition; pharmacokinetics; pulmonary absorption

Indexed keywords

BRONCHODILATING AGENT; BUDESONIDE; ETHANOLAMINE DERIVATIVE; FORMOTEROL; TERBUTALINE;

EID: 48249148338     PISSN: 19412711     EISSN: 19412703     Source Type: Journal    
DOI: 10.1089/jamp.2007.0654     Document Type: Article
Times cited : (19)

References (33)
  • 1
    • 0030848618 scopus 로고    scopus 로고
    • Drug delivery takes a deep breath
    • DOI 10.1126/science.277.5330.1199
    • Service RF: Drug delivery takes a deep breath. Science. 1997;277:1199-1200. (Pubitemid 27449046)
    • (1997) Science , vol.277 , Issue.5330 , pp. 1199-1200
    • Service, R.F.1
  • 2
    • 33845906339 scopus 로고    scopus 로고
    • Inhaling medicines: Delivering drugs to the body through the lungs
    • DOI 10.1038/nrd2153, PII NRD2153
    • Patton JS, and Byron PR: Inhaling medicines: delivering drugs to the body through the lungs. Nat Rev Drug Discov. 2007;6:67-74. (Pubitemid 46020287)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.1 , pp. 67-74
    • Patton, J.S.1    Byron, P.R.2
  • 4
    • 33748544596 scopus 로고    scopus 로고
    • 2-agonists
    • DOI 10.2174/138161206778194187
    • Miller-Larsson A, and Selroos O: Advances in asthma and COPD treatment: combination therapy with inhaled corticosteroids and long-acting beta2-agonists. Curr Pharm Des. 2006;12:3261-3279. (Pubitemid 44364136)
    • (2006) Current Pharmaceutical Design , vol.12 , Issue.25 , pp. 3261-3279
    • Miller-Larsson, A.1    Selroos, O.2
  • 5
    • 0035513523 scopus 로고    scopus 로고
    • Pharmacokinetics and systemic activity of fluticasone via Diskus and pMDI, and of budesonide via Turbuhaler
    • Thorsson L, Edsbacker S, Kallen A, and Lofdahl CG: Pharmacokinetics and systemic activity of fluticasone via Diskus and pMDI, and of budesonide via Turbuhaler. Br J Clin Pharmacol. 2001;52:529-538.
    • (2001) Br J Clin Pharmacol. , vol.52 , pp. 529-538
    • Thorsson, L.1    Edsbacker, S.2    Kallen, A.3    Lofdahl, C.G.4
  • 6
    • 33744825733 scopus 로고    scopus 로고
    • Increasing exposure levels cause an abrupt change in the absorption and metabolism of acutely inhaled benzo(a)pyrene in the isolated, ventilated, and perfused lung of the rat
    • DOI 10.1093/toxsci/kfj104
    • Ewing P, Blomgren B, Ryrfeldt A, and Gerde P: Increasing exposure levels cause an abrupt change in the absorption and metabolism of acutely inhaled benzo(a)pyrene in the isolated, ventilated, and perfused lung of the rat. Toxicol Sci. 2006;91:332-340. (Pubitemid 43827286)
    • (2006) Toxicological Sciences , vol.91 , Issue.2 , pp. 332-340
    • Ewing, P.1    Blomgren, B.2    Ryrfeldt, A.3    Gerde, P.4
  • 7
    • 0035035883 scopus 로고    scopus 로고
    • The rapid alveolar absorption of diesel soot-adsorbed benzo [α]pyrene: Bioavailability, metabolism and dosimetry of an inhaled particle-borne carcinogen
    • Gerde P, Muggenburg BA, Lundborg M, and Dahl AR: The rapid alveolar absorption of diesel-soot adsorbed benzo(a)pyrene - bioavailability, metabolism, and dosimetry of an inhaled carcinogen. Carcinogenesis. 2001;22:741-749. (Pubitemid 32447922)
    • (2001) Carcinogenesis , vol.22 , Issue.5 , pp. 741-749
    • Gerde, P.1    Muggenburg, B.A.2    Lundborg, M.3    Dahl, A.R.4
  • 8
    • 0020589977 scopus 로고
    • Relation between molecular weight and pulmonary absorption rate of lipid-insoluble compounds in neonatal and adult rats
    • DOI 10.1016/0006-2952(83)90025-4
    • Schanker LS, and Hemberger JA: Relation between molecular weight and pulmonary absorption rate of lipid-insoluble compounds in neonatal and adult rats. Biochem Pharmacol. 1983;32:2599-2601. (Pubitemid 13007874)
    • (1983) Biochemical Pharmacology , vol.32 , Issue.17 , pp. 2599-2601
    • Schanker, L.S.1    Hemberger, J.A.2
  • 13
    • 0036771091 scopus 로고    scopus 로고
    • Biochemical evidence for transcytotic absorption of polyaspartamide from the rat lung: Effects of temperature and metabolic inhibitors
    • DOI 10.1002/jps.10188
    • Sakagami M, Byron PR, and Rypacek F: Biochemical evidence for transcytotic absorption of polyaspartamide from the rat lung: effects of temperature and metabolic inhibitors. J Pharm Sci. 2002;91:1958-1968. (Pubitemid 36254932)
    • (2002) Journal of Pharmaceutical Sciences , vol.91 , Issue.9 , pp. 1958-1968
    • Sakagami, M.1    Byron, P.R.2    Rypacek, F.3
  • 16
    • 0035042689 scopus 로고    scopus 로고
    • Pharmacokinetics of budesonide and its major ester metabolite after inhalation and intravenous administration of budesonide in the rat
    • Jendbro M, Johansson CJ, Strandberg P, Falk-Nilsson H, and Edsbacker S: Pharmacokinetics of budesonide and its major ester metabolite after inhalation and intravenous administration of budesonide in the rat. Drug Metab Dispos. 2001;29:769-776. (Pubitemid 32374581)
    • (2001) Drug Metabolism and Disposition , vol.29 , Issue.5 , pp. 769-776
    • Jendbro, M.1    Johansson, C.-J.2    Strandberg, P.3    Falk-Nilsson, H.4    Edsbacker, S.5
  • 17
    • 0032583937 scopus 로고    scopus 로고
    • Lung as reservoir for antidepressants in pharmacokinetic drug interactions
    • DOI 10.1016/S0140-6736(97)07336-4
    • Suhara T, Sudo Y, Yoshida K, Okubo Y, Fukuda H, Obata T, Yoshikawa K, Suzuki K, and Sasaki Y: Lung as reservoir for antidepressants in pharmacokinetic drug interactions. Lancet. 1998;351:332-335. (Pubitemid 28052699)
    • (1998) Lancet , vol.351 , Issue.9099 , pp. 332-335
    • Suhara, T.1    Sudo, Y.2    Yoshida, K.3    Okubo, Y.4    Fukuda, H.5    Obata, T.6    Yoshikawa, K.7    Suzuki, K.8    Sasaki, Y.9
  • 18
    • 0141630489 scopus 로고    scopus 로고
    • In vivo efficacy in airway disease models of N-(3,5-dichloro-pyrid-4-yl)- [1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl] -glyoxylic acid amide (AWD 12-281), a selective phosphodiesterase 4 inhibitor for inhaled administration
    • DOI 10.1124/jpet.103.053942
    • Kuss H, Hoefgen N, Johanssen S, Kronbach T, and Rundfeldt C: In vivo efficacy in airway disease models of N-(3,5-dichloropyrid-4-yl)-[1-(4- fluorobenzyl)- 5-hydroxy-indole-3-yl]-glyo xylic acid amide (AWD 12-281), a selective phosphodiesterase 4 inhibitor for inhaled administration. J Pharmacol Exp Ther. 2003; 307:373-385. (Pubitemid 37151930)
    • (2003) Journal of Pharmacology and Experimental Therapeutics , vol.307 , Issue.1 , pp. 373-385
    • Kuss, H.1    Hoefgen, N.2    Johanssen, S.3    Kronbach, T.4    Rundfeldt, C.5
  • 19
    • 0038408540 scopus 로고    scopus 로고
    • Drug absorption from the isolated perfused rat lung - Correlations with drug physicochemical properties and epithelial permeability
    • DOI 10.1080/1061186031000086117
    • Tronde A, Norden B, Jeppsson AB, Brunmark P, Nilsson E, Lennernäs H, and Bengtsson UH: Drug absorption from the isolated perfused rat lung - correlations with drug physicochemical properties and epithelial permeability. J Drug Target. 2003;11:61-74. (Pubitemid 36527397)
    • (2003) Journal of Drug Targeting , vol.11 , Issue.1 , pp. 61-74
    • Tronde, A.1    Norden, B.2    Jeppsson, A.-B.3    Brunmark, P.4    Nilsson, E.5    Lennernas, H.6    Bengtsson, U.H.7
  • 20
    • 0020409435 scopus 로고
    • Pharmacokinetics and metabolism of budesonide, a selective glucocorticoid
    • Ryrfeldt A, Andersson P, Edsbacker S, Tonnesson M, Davies D, and Pauwels R: Pharmacokinetics and metabolism of budesonide, a selective glucocorticoid. Eur J Respir Dis Suppl. 1982;122:86-95. (Pubitemid 13235843)
    • (1982) European Journal of Respiratory Diseases , vol.63 , Issue.SUPPL. 122 , pp. 86-95
    • Ryrfeldt, A.1    Andersson, P.2    Edsbacker, S.3
  • 21
    • 0034107229 scopus 로고    scopus 로고
    • Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: Uses and limitations
    • Driscoll KE, Costa DL, Hatch G, Henderson R, Oberdorster G, Salem H, and Schlesinger RR: Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: uses and limitations. Toxicol Sci. 2000;55:24-35. (Pubitemid 30252432)
    • (2000) Toxicological Sciences , vol.55 , Issue.1 , pp. 24-35
    • Driscoll, K.E.1    Costa, D.L.2    Hatch, G.3    Henderson, R.4    Oberdorster, G.5    Salem, H.6    Schlesinger, R.B.7
  • 22
    • 0022598247 scopus 로고
    • An isolated perfused rat lung preparation for the study of aerosolized drug deposition and absorption
    • DOI 10.1002/jps.2600750214
    • Byron PR, Roberts NS, and Clark AR: An isolated perfused rat lung preparation for the study of aerosolized drug deposition and absorption. J Pharm Sci. 1986; 75:168-171. (Pubitemid 16162541)
    • (1986) Journal of Pharmaceutical Sciences , vol.75 , Issue.2 , pp. 168-171
    • Byron, P.R.1    Roberts, N.S.R.2    Clark, A.R.3
  • 23
    • 0347763791 scopus 로고    scopus 로고
    • A novel method to aerosolize powder for short inhalation exposures at high concentrations: Isolated rat lungs exposed to respirable diesel soot
    • DOI 10.1080/08958370490258381
    • Gerde P, Ewing P, Lastbom L, Ryrfeldt A, Waher J, and Liden G: A novel method to aerosolize powder for short inhalation exposures at high concentrations: isolated rat lungs exposed to respirable diesel soot. Inhal Toxicol. 2004;16:45-52. (Pubitemid 38101401)
    • (2004) Inhalation Toxicology , vol.16 , Issue.1 , pp. 45-52
    • Gerde, P.1    Ewing, P.2    Lastbom, L.3    Ryrfeldt, A.4    Waher, J.5    Liden, G.6
  • 24
    • 0025818847 scopus 로고
    • Difference in pulmonary absorption of inhaled terbutaline in healthy smokers and non-smokers
    • Schmekel B, Borgstrom L, and Wollmer P: Difference in pulmonary absorption of inhaled terbutaline in healthy smokers and non-smokers. Thorax. 1991;46: 225-228.
    • (1991) Thorax. , vol.46 , pp. 225-228
    • Schmekel, B.1    Borgstrom, L.2    Wollmer, P.3
  • 26
    • 14944368518 scopus 로고    scopus 로고
    • Size distribution of chromate paint aerosol generated in a bench-scale spray booth
    • DOI 10.1093/annhyg/meh080
    • Sabty-Daily RA, Hinds WC, and Froines JR: Size distribution of chromate paint aerosol generated in a bench-scale spray booth. Ann Occup Hyg. 2005;49: 33-45. (Pubitemid 40362517)
    • (2005) Annals of Occupational Hygiene , vol.49 , Issue.1 , pp. 33-45
    • Sabty-Daily, R.A.1    Hinds, W.C.2    Froines, J.R.3
  • 27
    • 0033974966 scopus 로고    scopus 로고
    • The effect of heterogeneity of lung structure on particle deposition in the rat lung
    • Hofmann W, Asgharian B, Bergmann R, Anjilvel S, and Miller FJ: The effect of heterogeneity of lung structure on particle deposition in the rat lung. Toxicol Sci. 2000;53:430-437. (Pubitemid 30100160)
    • (2000) Toxicological Sciences , vol.53 , Issue.2 , pp. 430-437
    • Hofmann, W.1    Asgharian, B.2    Bergmann, R.3    Anjilvel, S.4    Miller, F.J.5
  • 29
    • 33750845387 scopus 로고    scopus 로고
    • In vivo, in vitro and ex vivo models to assess pulmonary absorption and disposition of inhaled therapeutics for systemic delivery
    • DOI 10.1016/j.addr.2006.07.012, PII S0169409X06001463
    • Sakagami M: In vivo, in vitro and ex vivo models to assess pulmonary absorption and disposition of inhaled therapeutics for systemic delivery. Adv Drug Deliv Rev. 2006;58:1030-1060. (Pubitemid 44712023)
    • (2006) Advanced Drug Delivery Reviews , vol.58 , Issue.9-10 , pp. 1030-1060
    • Sakagami, M.1
  • 30
    • 0028300203 scopus 로고
    • Why are long-acting beta-adrenoceptor agonists long-acting?
    • Anderson GP, Linden A, and Rabe KF: Why are longacting beta-adrenoceptor agonists long-acting? Eur Respir J. 1994;7:569-578. (Pubitemid 24099018)
    • (1994) European Respiratory Journal , vol.7 , Issue.3 , pp. 569-578
    • Anderson, G.P.1    Linden, A.2    Rabe, K.F.3
  • 31
    • 0020260786 scopus 로고
    • Extrapulmonary effects of terbutaline during prolonged administration
    • Bengtsson B, and Fagerstrom PO: Extrapulmonary effects of terbutaline during prolonged administration. Clin Pharmacol Ther. 1982;31:726-732. (Pubitemid 13096686)
    • (1982) Clinical Pharmacology and Therapeutics , vol.31 , Issue.6 , pp. 726-732
    • Bengtsson, B.1    Fagerstrom, P.O.2
  • 32
    • 0016545293 scopus 로고
    • Deposition of inhaled monodisperse aerosols in small rodents
    • WH Walton (ed.) Pergamon Press, Oxford
    • Raabe OG, Yeh H-C, Newton GJ, Phalen RF, and Velasquez DJ: Deposition of inhaled monodisperse aerosols in small rodents. In: WH Walton (ed.). Inhaled Particles IV. Pergamon Press, Oxford; pp. 3-21, 1977.
    • (1977) Inhaled Particles , vol.4 , pp. 3-21
    • Raabe, O.G.1    Yeh, H.-C.2    Newton, G.J.3    Phalen, R.F.4    Velasquez, D.J.5
  • 33
    • 77957178470 scopus 로고
    • A multiple-path model of particle deposition in the rat lung
    • Anjilvel S, and Asgharian B: A multiple-path model of particle deposition in the rat lung. Fundam Appl Toxicol. 1995;28:41-50.
    • (1995) Fundam Appl Toxicol. , vol.28 , pp. 41-50
    • Anjilvel, S.1    Asgharian, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.