Lung as reservoir for antidepressants in pharmacokinetic drug interactions

Lancet

Volumn 351, Issue 9099, 1998, Pages 332-335

  Suhara, Tetsuya ^a   Sudo, Yasuhiko ^b   Yoshida, Katsuya ^a   Okubo, Yoshiro ^b   Fukuda, Hiroshi ^a   Obata, Takayuki ^b   Yoshikawa, Kyosan ^a   Suzuki, Kazutoshi ^a   Sasaki, Yasuhito ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; CARBON 11; CIANOPRAMINE; CLOMIPRAMINE; IMIPRAMINE; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT;

ADULT; ARTICLE; BRAIN; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG UPTAKE; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; LUNG; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

EID: 0032583937     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(97)07336-4     Document Type: Article

References (21)

1. 3H]imipramine binding sites in rat lung are associated with a non-neuronal uptake site for serotonin. Eur J Pharmacol 1983; 94: 345-48.
2. 14C-imipramine in isolated perfused rat lungs. J Pharmacol Exp Ther 1972; 183: 182-87.
3. 3H] imipramine binding sites in human lung. Biochem Biophys Res Commun 1984; 120: 926-32.
4. 4 Taylor D. Selective serotonin reuptake inhibitors and tricyclic antidepressants in combination: interaction and therapeutic uses. Br J Psychiatry 1995; 167: 575-80.
5. 5 Lemberger L, Bergstrom RF, Wolen RL, Farid NA, Enas GG, Aronoff GR. Fluoxetine: clinical pharmacology and physiologic disposition. J Clin Psychiatry 1985; 46: 14-19.
6. 11C]fluoxetine in a monkey brain. Nucl Med Biol 1995; 22: 613-16.
7. 7 Downs JM, Downs AD. Effect of fluoxetine on metabolism of tricyclic antidepressants in the lungs. Am J Psychiatry 1989; 146: 814-15.
8. 8 Junod AF. Mechanisms of drug accumulation in the lung. In: Junod AF, de Haller R, eds. Lung metabolism. New York: Academic Press, 1975: 219-31.
9. 3H]cyanoimipramine. J Pharmacol Exp Ther 1987; 241: 196-203.
10. 11C] cyanoimipramine. Nucl Med Biol 1987; 14: 587-92.
11. 11 Ramamoorthy S, Bauman AL, Moore KR, et al. Antidepressant-and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci USA 1993; 90: 2542-46.
12. 12 Hoffman BJ, Mezey E, Brownstein MJ. Cloning of a serotonin transporter affected by antidepressants. Science 1991; 254: 579-80.
13. 11C] β-CIT uptake in the primate peripheral organs measured by PET. Ann Nucl Med 1996; 10: 85-88.
14. 3H]norepinephrine in vivo: effects of pretreatment with imipramine or cocaine. J Pharmacol Exp Ther 1980; 213: 120-27.
15. 15 Iwasawa Y, Gillis CN, Aghajanian G. Hypothermie inhibition of 5-hydroxytryptamine and norepinephrine uptake by lung: cellular location of amines after uptake. J Pharmacol Exp Ther 1973; 186: 498-507.
16. 16 Anderson MW, Orton TC, Pickett RD, Eling TE. Accumulation of amines in the isolated perfused rabbit lung. J Pharmacol Exp Ther 1974; 189: 456-66.
17. 17 Vestal RE, Kornhauser DM, Shand DG. Active uptake of propranolol by isolated rabbit alveolar macrophages and its inhibition by other basic amines. J Pharmacol Exp Ther 1980; 214; 106-11.
18. 18 Wilson AGE, Sar M, Stumpf WE. Autoradiographic study of imipramine localization in the isolated perfused rabbit lung. Drug Metab Dispos 1982; 10: 281-83.
19. 19 Pistolesi M, Miniati M, Petruzzelli S, et al. Pulmonary retention of iodobenzyl-propanediamine in humans: effect of cigarette smoking. Am Rev Respir Dis 1988; 138: 1429-33.
20. 3H] imipramine on human platelets. Life Sci 1980; 26: 953-59.
21. 18F]haloperidol. Synapse 1992; 11: 10-19.