Regional-specific regulation of BDNF and trkB correlates with nigral dopaminergic cell sprouting following unilateral nigrostriatal axotomy

Journal of Neuroscience Research

Volumn 86, Issue 9, 2008, Pages 2016-2027

  Garcia Navia J T ^a   Burguillos, M A ^a   Ramon Cueto A ^b   Machado, A ^a   Cano, J ^a   Venero, Jose L ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

^b INSTITUTO DE BIOMEDICINA DE VALENCIA   (Spain)

Author keywords

Axotomy; BDNF; GAP 43; Medial forebrain bundle; Neurotrophins; Nogo A; Substantia nigra

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; DYE; FLUORO JADE B; MESSENGER RNA; NEUROMODULIN; PROTEIN NOGO A; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOPAMINERGIC NERVE CELL; DOWN REGULATION; FEMALE; FOREBRAIN; GLIA; IMMUNOHISTOCHEMISTRY; NERVE FIBER GROWTH; NERVE FIBER TRANSECTION; NICK END LABELING; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; RAT; SIGNAL TRANSDUCTION; SUBSTANTIA NIGRA; UPREGULATION;

ANIMALS; AXOTOMY; BRAIN-DERIVED NEUROTROPHIC FACTOR; CORPUS STRIATUM; FEMALE; FUNCTIONAL LATERALITY; IN SITU HYBRIDIZATION; IN SITU NICK-END LABELING; MODELS, ANIMAL; RATS; RATS, WISTAR; RECEPTOR, TRKB; SUBSTANTIA NIGRA; TRANSCRIPTION, GENETIC;

EID: 48249144456     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21654     Document Type: Article

References (41)

1. Bähr M, Bonhoeffer F. 1994. Perspectives on axonal regeneration in the mammalian CNS. Trends Neurosci 17:473-479.
2. Barbacid M. 1995. Neurotrophic factors and their receptors. Curr Opin Cell Biol 7:148-155.
3. Basi GS, Jacobson RD, Virag I, Schilling J, Skene JH. 1987. Primary structure and transcriptional regulation of GAP-43, a protein associated with nerve growth. Cell 49:785-791.
4. Batchelor PE, Liberatore GT, Porritt MJ, Donnan GA, Howells DW. 2000. Inhibition of brain-derived neurotrophic factor and ghal cell line-derived neurotrophic factor expression reduces dopaminergic sprouting in the injured striatum. Eur J Neurosci 12:3462-3468.
5. Batchelor PE, Liberatore GT, Wong JY, Porritt MJ, Frerichs F, Donnan GA, Howells DW. 1999. Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and ghal cell line-derived neurotrophic factor. J Neurosci 19:1708-1716.
6. Batchelor PE, Porritt MJ, Martinello P, Parish CL, Liberatore GT, Donnan GA, Howells DW. 2002. Macrophages and microglia produce local trophic gradients that stimulate axonal sprouting toward but not beyond the wound edge. Mol Cell Neurosci 21:436-453.
7. Brecknell JE, Dunnett SB, Fawcett JW. 1995. A quantitative study of cell death in the SN following a mechanical lesion of the medial forebrain bundle. Neuroscience 64:219-227.
8. Caroni P, Schwab ME. 1988. Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter. Neuron 1:85-96.
9. Chen MS, Huber AB, van der Haar ME, Frank M, Schnell L, Spillmann AA, Christ F, Schwab ME. 2000. Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 403:434-439.
10. Chen H, Weber AJ. 2004. Brain-derived neurotrophic factor reduces TrkB protein and mRNA in the normal retina and following optic nerve crush in adult rats. Brain Res 1011:99-106.
11. Díaz J, Levesque D, Lammers CH, Griffon N, Martres MP, Schwartz JC, Sokoloff P. 1995. Phenotypical characterization of neurones expressing the dopamine D3 receptor in the rat brain. Neuroscience 65:731-745.
12. Fawcett JW, Asher RA. 1999. The glial scar and central nervous system repair. Brain Res Bull 49:377-391.
13. Frank L, Ventimiglia R, Anderson K, Lindsay RM, Rudge JS. 1996. BDNF down-regulates neurotrophin responsiveness, TrkB protein and TrkB mRNA levels in cultured rat hippocampal neurons. Eur J Neurosci 8:1220-1230.
14. Gavrieli Y, Sherman Y, Ben-Sasson SA. 1992. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119:493-501.
15. Giros B, Jaber M, Jones SR, Wightman RM, Caron MG. 1996. Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 379:606-612.
16. Jones SR, Gainetdinov RR, Jaber M, Giros B, Wightman RM, Caron MG. 1998. Profound neuronal plasticity in response to inactivation of the dopamine transporter. Proc Natl Acad Sci U S A 95:4029-4034.
17. Klein R, Parada LF, Coulier F, Barbacid M. 1989. trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. EMBO J 8:3701-3709.
18. Knusel B, Gao H, Okazaki T, Yoshida T, Mori N, Hefti F, Kaplan DR. 1997. Ligand-induced down-regulation of Trk messenger RNA, protein and tyrosine phosphorylation in rat cortical neurons. Neuroscience 78:851-862.
19. Moon LD, Asher RA, Rhodes KE, Fawcett JW. 2002. Relationship between sprouting axons, proteoglycans and glial cells following unilateral nigrostriatal axotomy in the adult rat. Neuroscience 109:101-117.
20. Morgenstern DA, Asher RA, Fawcett JW. 2002. Chondroitin sulphate proteoglycans in the CNS injury response. Prog Brain Res 137:313-332.
21. Patapoutian A, Reichardt LF. 2001. Trk receptors: mediators of neurotrophin action. Curr Opin Neurobiol 11:272-280.
22. Paxinos G, Watson C. 1986. The Rat Brain in Stereotaxic Coordinates. San Diego, CA: Academic Press.
23. Plunkett RJ, Ip NY, Asada H, Friedman B, Pan L, Kaseloo PA, Parfitt MM. 1997. Trauma-induced striatal CNTF and BDNF mRNA in hemiparkinsonian rats. Neuroreport 20:507-511.
24. Revueita M, Venero JL, Machado A, Cano J. 1999. Serotonin hyperin-nervation in the adult rat ventral mesencephalon following unilateral transection of the medial forebrain bundle. Correlation with reactive microglial and astroglial populations. Neuroscience 91:567-577.
25. Ribeiro MJ, Vidailhet M, Loc'h C, Dupel C, Nguyen JP, Ponchant M, Dollé F, Peschanski M, Hantraye P, Cesaro P, Samson Y, Remy P. 2002. Dopaminergic function and dopamine transporter binding assessed with positron emission tomography in Parkinson disease. Arch Neurol 59:580-586.
26. Rinne JO, Ruottinen H, Bergman J, Haaparanta M, Sonninen P, Solin O. 1999. Usefulness of a dopamine transporter PET ligand [(18)F]beta-CFT in assessing disability in Parkinson's disease. J Neurol Neurosurg Psychiatr 67:737-741.
27. Rite I, Machado A, Cano J, Venero JL. 2005. Divergent regulatory mechanisms governing BDNF mRNA expression in cerebral cortex and SN in response to striatal target ablation. Exp Neurol 192:142-155.
28. Rite I, Venero JL, Tomas-Camardiel M, Machado A, Cano J. 2003. Expression of BDNF mRNA in SN is dependent on target integrity and independent of neuronal activation. J Neurochem 87:709-721.
29. Schmued LC, Hopkins KJ. 2000. Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res 874:123-130.
30. Schwab ME. 2004. Nogo and axon regeneration. Curr Opin Neurobiol 14:118-124.
31. Snider WD, Zhou FQ, Zhong J, Markus A. 2002. Signaling the pathway to regeneration. Neuron 35:13-16.
32. Uhl GR. 2003. Dopamine transporter: basic science and human variation of a key molecule for dopaminergic function, locomotion, and parkinsonism. Mov Disord 18 Suppl 7:S71-S80.
33. Venero JL, Hefti F. 1998. Regionally specific induction of BDNF and truncated trkB.T1 receptors in the hippocampal formation after intraseptal injection of kainic acid. Brain Res 790:270-277.
34. Venero JL, Hefti F, Knusel B. 1996. Trophic effect of exogenous nerve growth factor on rat striatal cholinergic neurons: comparison between intraparenchymal and intraventricular administration. Mol Pharmacol 49:303-310.
35. Venero JL, Machado A, Cano J. 2004. Importance of aquaporins in the physiopathology of brain edema. Curr. Pharm Des 10:2153-2161.
36. Venero JL, Revuelta M, Atiki L, Santiago M, Tomas-Camardiel MC, Cano J, Machado A. 2003. Evidence for dopamine-derived hydroxyl radical formation in the nigrostriatal system in response to axotomy. Free Radic Biol Med 34:111-123.
37. Venero JL, Revuelta M, Cano J, Machado A. 1997. Time course changes in the dopaminergic nigrostriatal system following transection of the medial forebrain bundle: detection of oxidatively modified proteins in substantia nigra. J Neurochem 68:2458-2468
38. Venero JL, Vizuete ML, Revuelta M, Vargas C, Cano J, Machado A. 2000. Upregulation of BDNF mRNA and trkB mRNA in the nigrostriatal system and in the lesion site following unilateral transection of the medial forebrain bundle. Exp Neurol 161:38-48.
39. Vizuete ML, Venero JL, Vargas C, Ilundain AA, Echevarria M, Machado A, Cano J. 1999. Differential upregulation of aquaporin-4 mRNA expression in reactive astrocytes after brain injury: potential role in brain edema. Neurobiol Dis 6:245-258.
40. Wisden W, Morris BJ. 2002. In situ hybridization with oligonucleotide probes. Int Rev Neurobiol 47:3-59.
41. Wong JY, Liberatore GT, Donnan GA, Howells DW. 1997. Expression of brain-derived neurotrophic factor and TrkB neurotrophin receptors after striatal injury in the mouse. Exp Neurol 148:83-91.