Brain-derived neurotrophic factor reduces TrkB protein and mRNA in the normal retina and following optic nerve crush in adult rats

Brain Research

Volumn 1011, Issue 1, 2004, Pages 99-106

  Chen, Hao ^a   Weber, Arthur J ^b  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Brain derived neurotrophic factor; Cell death; Development and regeneration; Neurotrophic factors: expression and regulation; Retinal ganglion cell; TrkB

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; MESSENGER RNA; NEUROPROTECTIVE AGENT; RECOMBINANT BRAIN DERIVED NEUROTROPHIC FACTOR; RIBONUCLEASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; ENZYME ASSAY; NERVE CRUSH; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; OPTIC NERVE; OPTIC NERVE INJURY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; RECEPTOR DOWN REGULATION; RETINA; RETINA GANGLION CELL; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; BRAIN-DERIVED NEUROTROPHIC FACTOR; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HUMANS; NERVE CRUSH; OPTIC NERVE INJURIES; RATS; RECEPTOR, TRKB; RETINA; TIME FACTORS;

EID: 2342446469     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2004.03.024     Document Type: Article

References (39)

1. Atwal J.K., Massie B., Miller F.D., Kaplan D.R. The TrkB-Shc site signals neuronal survival and local axon growth via MEK and P13-kinase. Neuron. 27:2000;265-277
2. Baxter G.T., Radeke M.J., Kuo R.C., Makrides V., Hinkle B., Hoang R., Medina-Selby A., Coit D., Valenzuela P., Feinstein S.C. Signal transduction mediated by the truncated trkB receptor isoforms, trkB. T1 and trkB. T2. J. Neurosci. 17:1997;2683-2690
3. Canals J.M., Checa N., Marco S., Michels A., Perez N.E., Alberch J. The neurotrophin receptors trkA, trkB and trkC are differentially regulated after excitotoxic lesion in rat striatum. Brain Res. Mol. Brain Res. 69:1999;242-248
4. Cellerino A., Kohler K. Brain-derived neurotrophic factor/neurotrophin-4 receptor TrkB is localized on ganglion cells and dopaminergic amacrine cells in the vertebrate retina. J. Comp. Neurol. 386:1997;149-160
5. Chen H., Weber A.J. BDNF enhances retinal ganglion cell survival in cats with optic nerve damage. Invest. Ophthalmol. Vis. Sci. 42:2001;966-974
6. Chen G., Gharib T.G., Huang C.C., Taylor J.M., Misek D.E., Kardia S.L., Giordano T.J., Iannettoni M.D., Orringer M.B., Hanash S.M., Beer D.G. Discordant protein and mRNA expression in lung adenocarcinomas. Mol. Cell. Proteomics. 1:2002;304-313
7. Cheng L., Sapieha P., Kittlerová P., Hauswirth W.W., Di Polo A. TrkB gene transfer protects retinal ganglion cells from axotomy-induced death in vivo. J. Neurosci. 22:2002;3977-3986
8. Clarke D.B., Bray G.M., Aguayo A.J. Prolonged administration of NT-4/5 fails to rescue most axotomized retinal ganglion cells in adult rats. Vis. Res. 38:1998;1517-1524
9. Cohen A., Bray G.M., Aguayo A.J. Neurotrophin-4/5 (NT-4/5) increases adult rat retinal ganglion cell survival and neurite outgrowth in vitro. J. Neurobiol. 25:1994;953-959
10. Di Polo A., Aigner L.J., Dunn R.J., Bray G.M., Aguayo A.J. Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Muller cells temporarily rescues injured retinal ganglion cells. Proc. Natl. Acad. Sci. U. S. A. 95:1998;3978-3983
11. Frank L., Ventimiglia R., Anderson K., Lindsay R.M., Rudge J.S. BDNF down-regulates neurotrophin responsiveness, TrkB protein and TrkB mRNA levels in cultured rat hippocampal neurons. Eur. J. Neurosci. 8:1996;1220-1230
12. Frank L., Wiegand S., Siuciak J.A., Lindsay R.M., Rudge J.S. Effects of BDNF infusion on the regulation of TrkB protein and message in adult rat brain. Exp. Neurol. 145:1997;62-70
13. Galcheva-Gargova Z., Theroux S.J., Davis R.J. The epidermal growth factor receptor is covalently linked to ubiquitin. Oncogene. 11:1995;2649-2655
14. Gygi S.P., Rochon Y., Franza B.R., Aebersold R. Correlation between protein and mRNA abundance in yeast. Mol. Cell. Biol. 19:1999;1720-1730
15. Han B.H., Holtzman D.M. BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway. J. Neurosci. 20:2000;5775-5781
16. Hicks R.R., Li C., Zhang L., Dhillon H.S., Prasad M.R., Seroogy K.B. Alterations in BDNF and trkB mRNA levels in the cerebral cortex following experimental brain trauma in rats. J. Neurotrauma. 16:1999;501-510
17. Hicks R.R., Martin V.B., Zhang L., Seroogy K.B. Mild experimental brain injury differentially alters the expression of neurotrophin and neurotrophin receptor mRNAs in the hippocampus. Exp. Neurol. 160:1999;469-478
18. Jelsma T.N., Friedman H.H, Berkelaar M., Bray G.M., Aguayo A.J. Different forms of the neurotrophin receptor trkB mRNA predominate in rat retina and optic nerve. J. Neurobiol. 24:1993;1207-1214
19. Kashiwagi F., Kashiwagi K., Iizuka Y., Tsukahara S. Effects of brain-derived neurotrophic factor and neurotrophin-4 on isolated cultured retinal ganglion cells: evaluation by flow cytometry. Invest. Ophthalmol. Vis. Sci. 41:2000;2373-2377
20. Klein R., Nanduri V., Jing S.A., Lamballe F., Tapley P., Bryant S., Cordon C.C., Jones K.R., Reichardt L.F., Barbacid M. The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. Cell. 66:1991;395-403
21. Klöcker N., Cellerino A., Bähr M. Free radical scavenging and inhibition of nitric oxide synthase potentiates the neurotrophic effects of brain-derived neurotrophic factor on axotomized retinal ganglion cells In vivo. J. Neurosci. 18:1998;1038-1046
22. Klöcker N., Kermer P., Weishaupt J.H., Labes M., Ankerhold R., Bähr M. Brain-derived neurotrophic factor-mediated neuroprotection of adult rat retinal ganglion cells In vivo does not exclusively depend on phosphatidyl-inositol-3′-Kinase/Protein kinase B signaling. J. Neurosci. 20:2000;6962-6967
23. Knusel B., Gao H., Okazaki T., Yoshida T., Mori N., Hefti F., Kaplan D.R. Ligand-induced down-regulation of Trk messenger RNA, protein and tyrosine phosphorylation in rat cortical neurons. Neuroscience. 78:1997;851-862
24. Lom B., Cohen-Cory S. Brain-derived neurotrophic factor differentially regulates retinal ganglion cell dendritic and axonal arborization in vivo. J. Neurosci. 19:1999;9928-9938
25. Mansour-Robaey S., Clarke D.B., Wang Y.C., Bray G.M., Aguayo A.J. Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells. Proc. Natl. Acad. Sci. U. S. A. 91:1994;1632-1636
26. Mey J., Thanos S. Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivo. Brain Res. 602:1993;304-317
27. Mori S., Heldin C.H., Claesson-Welsh L. Ligand-induced polyubiquitination of the platelet-derived growth factor beta-receptor. J. Biol. Chem. 267:1992;6429-6434
28. Mori S., Tanaka K., Omura S., Saito Y. Degradation process of ligand-stimulated platelet-derived growth factor beta-receptor involves ubiquitin-proteasome proteolytic pathway. J. Biol. Chem. 270:1995;29447-29452
29. Offenhäuser N., Muzio V., Biffo S. BDNF binding to truncated trkBT.1 does not affect gene expression. Mol. Neurosci. 13:2002;1189-1193
30. Peinado-Ramón P., Salvador M., Villegas-Pérez M.P., Vidal-Sanz M. Effects of axotomy and intraocular administration of NT-4, NT-3, and brain-derived neurotrophic factor on the survival of adult rat retinal ganglion cells. A quantitative in vivo study. Invest. Ophthalmol. Vis. Sci. 37:1996;489-500
31. Perez M.T., Caminos E. Expression of brain-derived neurotrophic factor and of its functional receptor in neonatal and adult rat retina. Neurosci. Lett. 183:1995;96-99
32. Sawai H., Clarke D.B., Kittlerová P., Bray G.M., Aguayo A.J. Brain-derived neurotrophic factor and neurotrophin-4/5 stimulate growth of axonal branches from regenerating retinal ganglion cells. J. Neurosci. 16:1996;3887-3894
33. Sommerfeld M.T., Schweigreiter R., Barde Y.A., Hoppe E. Down-regulation of the neurotrophin receptor TrkB following ligand binding. Evidence for an involvement of the proteasome and differential regulation of TrkA and TrkB. J. Biol. Chem. 275:2000;8982-8990
34. Stoflet E.S., Koeberl D.D., Sarkar G., Sommer S.S. Genomic amplification with transcript sequencing. Science. 239:1988;491-494
35. Suzuki A., Nomura S., Morii E., Fukuda Y., Kosaka J. Localization of mRNAs for trkB isoforms and p75 in rat retinal ganglion cells. J. Neurosci. Res. 54:1998;27-37
36. Ugolini G., Cremisi F., Maffei L. TrkA, TrkB and p75 mRNA expression is developmentally regulated in the rat retina. Brain Res. 704:1995;121-124
37. Villegas-Pérez M.P., Vidal-Sanz M., Rasminsky M., Bray G.M., Aguayo A.J. Rapid and protracted phases of retinal ganglion cell loss follow axotomy in the optic nerve of adult rats. J. Neurobiol. 24:1993;23-36
38. Watson F.L., Heerssen H.M., Moheban D.B., Lin M.Z., Sauvageot C.M., Bhattacharyya A., Pomeroy S.L., Segal R.A. Rapid nuclear responses to target-derived neurotrophins require retrograde transport of ligand-receptor complex. J. Neurosci. 19:1999;7889-7900
39. Wong J.Y., Liberatore G.T., Donnan G.A., Howells D.W. Expression of brain-derived neurotrophic factor and TrkB neurotrophin receptors after striatal injury in the mouse. Exp. Neurol. 148:1997;83-91