Inhibition of Endothelial Nitric Oxide Synthase activity by Proline-Rich Tyrosine Kinase 2 in response to fluid shear stress and insulin

Circulation Research

Volumn 102, Issue 12, 2008, Pages 1520-1528

  Fisslthaler, Beate ^a   Loot, Annemarieke E ^a   Mohamed, Annisuddin ^a   Busse, Rudi ^a   Fleming, Ingrid ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Blood flow; Insulin; Mechanotransduction; Nitric oxide; Nitric oxide synthases; Phosphorylation

Indexed keywords

ASPARTIC ACID; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FOCAL ADHESION KINASE 2; GLUTAMIC ACID; INSULIN; IONOMYCIN; MUTANT PROTEIN; NITRIC OXIDE; PHENYLALANINE; SMALL INTERFERING RNA; HYBRID PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; NOS3 PROTEIN, HUMAN; NOS3 PROTEIN, MOUSE; PTK2B PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTERY BLOOD FLOW; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTICLE; CAROTID ARTERY; CELL STRAIN HEK293; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SHEAR STRESS; SWINE; WILD TYPE; ANIMAL; AORTA; BIOSYNTHESIS; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; EPITHELIUM CELL; FLOW KINETICS; GENETICS; LUNG; MECHANICAL STRESS; MISSENSE MUTATION; PHYSIOLOGY; POINT MUTATION; RNA INTERFERENCE;

ANIMALS; AORTA; CELLS, CULTURED; ENDOTHELIAL CELLS; ENZYME ACTIVATION; EPITHELIAL CELLS; FOCAL ADHESION KINASE 2; INSULIN; IONOMYCIN; LUNG; MICE; MUTATION, MISSENSE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; POINT MUTATION; RECOMBINANT FUSION PROTEINS; RHEOLOGY; RNA INTERFERENCE; RNA, SMALL INTERFERING; STRESS, MECHANICAL; SUS SCROFA;

EID: 48249126446     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.108.172072     Document Type: Article

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