Inhibition of Th1- and enhancement of Th2-initiating cytokines and chemokines in trichosanthin-treated macrophages

Biochemical and Biophysical Research Communications

Volumn 284, Issue 1, 2001, Pages 168-172

  Xu, Weifeng ^a   Hou, Wanqiu ^a   Yao, Gang ^a   Ji, Yongyong ^a   Yeh, Ming ^a   Sun, Bing ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

Immunoglobulin E; Interleukin 10; Interleukin 12; Lipopolysaccharide; Macrophage; Monocyte chemoattractant protein 1; T helper 1; T helper 2; Trichosanthin; Tumor necrosis factor

Indexed keywords

ALLERGEN; CHEMOKINE; CYTOKINE; IMMUNOGLOBULIN E; INTERLEUKIN 10; INTERLEUKIN 12; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; TRICHOSANTHIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PLANT; PRIORITY JOURNAL; TH1 CELL; TH2 CELL; TRICHOSANTHES KIRILOWII MAXIM;

TRICHOSANTHES KIRILOWII;

EID: 0034805216     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.4940     Document Type: Article

References (19)

1. The safety and pharmacokinetics of GLQ223 in subjects with AIDS and AIDA-related complex: A phase I study
2. A phase I/II study of trichosanthin treatment of HIV disease
3. Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G protein activation, and this is mediated through interaction of trichosanthin and chemokine receptors
4. The influence of trichosanthin on the induction if IgE responses to ovalbumin under adjuvant-free condition
5. The kinetics of IL-4 and IFN-γ gene expression in mice after trichosansin immunization
6. Development of TH1 CD4+T cells through IL-12 produced by Listeria-induced macrophages
7. Effects of IL-12 on helper T cell-dependent immune responses in vivo
8. Interleukin 12 acts directly on CD4+T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming
9. IL-1 alpha and TNF-alpha are required for IL-12-induced development of Th1 cells producing high levels of IFN-gamma in BALB/c but not C57BL/6 mice
10. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression
11. Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+T cells
12. Differential CC chemokine-induced enhancement of T helper cell cytokine production
13. High-level monocyte chemoattractant protein-1 expression in transgenic mice increases their susceptibility to intracellular pathogens. High-level monocyte chemoattractant protein-1 expression in transgenic mice increases their susceptibility to intracellular pathogens
14. Adenoviral-mediated overexpression of monocyte chemoattractant protein-1 differentially alters the development of Th1 and Th2 type responses in vivo
15. Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1
16. The vasoactive peptide maxadilan from sand fly saliva inhibits TNF-alpha and induces IL-6 by mouse macrophages through interaction with the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor
17. Induction of Th1 cell-mediated protective immunity to Schistosoma mansoni by co-administration of larval antigens and IL-12 as an adjuvant
18. CpG oligodeoxynucleotides act as adjuvants that switch on T-helper 1 (Th-1) immunity
19. Effects of cholera toxin on macrophage production of co-stimulatory cytokines