Inhibition of α4 integrin and ICAM-1 markedly attenuate macrophage homing to atherosclerotic plaques in ApoE-deficient mice

Circulation

Volumn 97, Issue 1, 1998, Pages 75-81

  Patel, Shilpesh S ^a   Thiagarajan, Ram ^a   Willerson, James T ^a,c   Yeh, Edward T H ^a,b,c,d  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^c ST LUKE S EPISCOPAL HOSPITAL   (United States)

^d UT Houston Dental Branch   (United States)

Author keywords

Adhesion; Atherosclerosis; Cells; Integrins; Macrophages; Molecules; Monocytes

Indexed keywords

APOLIPOPROTEIN E; HOMING RECEPTOR; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; MICROSPHERE; MONOCLONAL ANTIBODY; SELECTIN; VASCULAR CELL ADHESION MOLECULE 1; ALPHA4 INTEGRIN; CELL ADHESION MOLECULE; LEUKOCYTE ANTIGEN;

ANIMAL CELL; ARTICLE; ATHEROSCLEROTIC PLAQUE; CELL ADHESION; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; HYPERCHOLESTEROLEMIA; IMMUNOHISTOCHEMISTRY; LIPOPROTEIN DEFICIENCY; MACROPHAGE ACTIVATION; MONOCYTE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; ANIMAL; ARTERIOSCLEROSIS; C57BL MOUSE; FEMALE; IMMUNOLOGY; PATHOLOGY; PERITONEUM MACROPHAGE; PHYSIOLOGY;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; APOLIPOPROTEINS E; ARTERIOSCLEROSIS; CELL ADHESION MOLECULES; FEMALE; INTEGRIN ALPHA4; INTEGRINS; INTERCELLULAR ADHESION MOLECULE-1; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; RECEPTORS, LYMPHOCYTE HOMING;

EID: 0031594872     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.97.1.75     Document Type: Article

References (34)

1. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801-808.
2. Joris I, Zand T, Nunnari JJ, Krolikowski FJ, Majno G. Studies on the pathogenesis of atherosclerosis, I: adhesion and emigration of mononuclear cells in the aorta of hypercholesterolemic rats. Am J Pathol. 1983;113: 341-358.
3. Gerrity RG. The role of the monocyte in atherogenesis, I: transition of blood-borne monocytes into foam cells in fatty lesions. Am J Pathol. 1973;103:181-191.
4. Munro JM, van der Walt JD, Munro CS, Chalmers JA, Cox EL. An immunohistochemical analysis of human aortic fatty streaks. Hum Pathol. 1987;18:375-380.
5. Assoian RK, Fleurdelys BE, Stevenson HC, Miller PJ, Madtes DK, Raines EW, Ross R, Sporn MB. Expression and secretion of type beta transforming growth factor by activated human macrophages. Proc Natl Acad Sci U{ths}S{ths}A.. 1987;84:6020-6024.
6. Bjorkerud S. Effects of transforming growth factor-B1 on human arterial smooth muscle cells in vitro. Arterioscler Thromb. 1991;11:892-902.
7. Heichendorff L. Laminin, fibronectin and type IV collagen in BM-like material from cultured arterial smooth muscle cells. Int J Biochem. 1988;20: 381-386.
8. Falk E, Shah PK, Fuster V. Coronary plaque disruption. Circulation. 1995; 92:657-671.
9. Libby P. Molecular bases of the acute coronary syndromes. Circulation. 1995;91:2844-2850.
10. Berliner JA, Navab M, Fogelman AM, Frank JS, Demer LL, Edwards PA, Watson AD, Lusis AJ. Atherosclerosis: basic mechanisms: oxidation, inflammation, and genetics. Circulation. 1995;91:2488-2496.
11. Shah PK, Falk E, Badimon JJ, Fernandez-Ortiz A, Mailhac A, Villareal-Levy G, Fallon JT, Regnstrom J, Fuster V. Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques: potential role of matrix-degrading metalloproteinases and implications for plaque rupture. Circulation. 1995;92:1565-1569.
12. Galis ZS, Sukhova GK, Lark MW, Libby P. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest. 1994;94:2493-2503.
13. Lendon CL, Davies MJ, Born GVR, Richardson PD. Atherosclerotic plaque caps are locally weakened when macrophages density is increased. Atherosclerosis. 1991;87:87-90.
14. Moreno PR, Falk E, Palacios IF, Newell JB, Fuster V, Fallon JT. Macrophage infiltration in acute coronary syndromes: Implications for plaque rupture. Circulation. 1994;90:775-778.
15. Moreno PR, Bernardi VH, Lopez-Cuellar J, Murcia AM, Palacios IF, Gold HK, Mehran R, Sharma SK, Nemerson Y, Fuster V, Fallon JT. Macrophages, smooth muscle cells, and tissue factor in unstable angina: implications for cell-mediated thrombogenicity in acute coronary syndromes. Circulation. 1996;94:3090-3097.
16. Carlos R, Kovach M, Schwartz B, Rosa M, Newman B, Wayner E, Benjamin C, Osborn L, Lobb R, Harlan J. Human monocytes bind to two cytokine-induced adhesive ligands on cultured human endothelial cells: endothelial-leukocyte adhesion molecule-1 and vascular cell adhesion molecule-1. Blood. 1991;77:2266-2271.
17. Hakkert BC, Kiujpers TW, Leeuwenberg JFM, van Mourik JA, Roos D. Neutrophil and monocyte adherence to and migration across monolayers of cytokine-activated endothelial cells: the contribution of CD 18, ELAM-1 and VLA-4. Blood. 1991;78:2721-2726.
18. Rice GE, Munro JM, Bevilacqua MP. Inducible cell adhesion molecule 110 (INCAM-110) is an endothelial adhesion molecule for lymphocytes: A CD11/CD18 independent adhesion mechanism. J Exp Med. 1990;171: 1369-1374.
19. Dustin ML, Rothlein R, Bhan AK, Dinarello DA, Sringer TA. Induction by IL-1 and interferon-J. Immunol. 1986;137:245-254.
20. Boyd AW, Wawaryk SO, Burns GF, Fecondo JV. Intercellular adhesion molecule 1 (ICAM-1) has a central role in cell-cell contact-mediated immune mechanisms. Proc Natl Acad Sci U{ths}S{ths}A. 1988;85: 3095-3099.
21. Munro JM, Pober JS, Cotran RS. Tumor necrosis factor and interferon-Papio anubis. Am J Pathol. 1989;135:121-133.
22. Cybulsky MI, Gimbone MA. Endothelial expression of a mononuclear adhesion molecule during atherogenesis. Science. 1991;251:788-791.
23. Poston RN, Haskard DO, Coucher JR, Gall NP, Johnson-Tidey RR. Expression of intercellular adhesion molecule-1 in atherosclerotic plaques. Am J Pathol. 1992;140:665-673.
24. Poston RN, Johnson-Tidey RR. Localized adhesion of monocytes to human atherosclerotic plaques demonstrated in vitro: implications for atherogenesis. Am J Pathol 1996;149:73-80.
25. Osborn L, Hession C, Tizard R, Vassallo C, Luhowskyj S, Chi-Russo G, Lobb R. Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell. 1989;59:1203-1211.
26. Plump AS, Smith JD, Hayek T, Aalto-Setala K, Walsh A, Verstuyft JG, Rubin EM, Breslow JL. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell. 1992;71:343-353.
27. Zhang SH, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science. 1992;258:468-471.
28. Reddick RL, Zhang SH, Maeda N. Atherosclerosis in mice lacking ApoE: evaluation of lesional development and progression. Arterioscler Thromb. 1994;14:141-147.
29. Robbins SL, Cotran RS, Kumar V. Pathologic basis of disease. Philadelphia, Pa: WB Saunders; 1984:697-698.
30. Nakashima Y, Plump AS, Raines EW, Breslow JL, Ross R. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb. 1994;14:133-140.
31. Springer TA. Adhesion receptors of the immune system. Nature. 1990;346: 425-434.
32. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte migration: the multistep paradigm. Cell. 1994;76:301-314.
33. Mojicik CF, Shevach EM. Adhesion molecules. Arthritis Rheum. 1997;40: 991-1004.
34. Varki A. Selectin ligands: will the real ones please stand up? J Clin Invest. 1997;99:158-162