Notch signaling in osteoblasts

Science Signaling

Volumn 1, Issue 17, 2008, Pages

  Canalis, Ernesto ^a,b  

^a SAINT FRANCIS HOSPITAL AND MEDICAL CENTER   (United States)

^b UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NOTCH RECEPTOR;

ANIMAL; BIOLOGICAL MODEL; BONE REMODELING; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOLOGY; HUMAN; METABOLISM; MUTATION; OSTEOBLAST; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; BONE REMODELING; CELL DIFFERENTIATION; CELL PROLIFERATION; HUMANS; MODELS, BIOLOGICAL; MUTATION; OSTEOBLASTS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

EID: 48149109123     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/stke.117pe17     Document Type: Review

References (40)

1. E. Canalis, A. Giustina, J. P. Bilezikian, Mechanisms of anabolic therapies for osteoporosis. N. Engl. J. Med. 357, 905-916 (2007).
2. E. Canalis, The fate of circulating osteoblasts. N. Engl. J. Med. 352, 2014-2016 (2005).
3. P. Bianco, R. P. Gehron, Marrow stromal stem cells. J. Clin. Invest. 105, 1663-1668 (2000).
4. E. Gazzerro, E. Canalis, Bone morphogenetic proteins and their antagonists. Rev. Endocr. Metab. Disord. 7, 51-65 (2006).
5. V. Krishnan, H. U. Bryant, O. A. MacDougald, Regulation of bone mass by Wnt signaling. J. Clin. Invest. 116, 1202-1209 (2006).
6. V. Deregowski, E. Gazzerro, L. Priest, S. Rydziel, E. Canalis, Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/β-catenin but not bone morphogenetic protein signaling. J. Biol. Chem. 281, 6203-6210 (2006).
7. F. Engin, Z.Yao, T.Yang, G. Zhou, T. Bertin, M. M. Jiang, Y. Chen, L. Wang, H. Zheng, R. E. Sutton, B. F. Boyce, B. Lee, Dimorphic effects of Notch signaling in bone homeostasis. Nat. Med. 14, 299-305 (2008).
8. M. J. Hilton, X. Tu, X. Wu, S. Bai, H. Zhao, T. Kobayashi, H. M. Kronenberg, S. L. Teitelbaum, F. P. Ross, R. Kopan, F. Long, Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat. Med. 14, 306-314 (2008).
9. J. S. Mumm, R. Kopan, Notch signaling: From the outside in. Dev. Biol. 228, 151-165 (2000).
10. S. E. Pursglove, J. P. Mackay, CSL: A Notch above the rest. Int. J. Biochem. Cell Biol. 37, 2472-2477 (2005).
11. C. Sahlgren, U. Lendahl, Notch signaling and its integration with other signaling mechanisms. Regen. Med. 1, 195-205 (2006).
12. E. H. Schroeter, J. A. Kisslinger, R. Kopan, Notch- 1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 393, 382-386 (1998).
13. Y. Nam, P. Sliz, L. Song, J. C. Aster, S. C. Blacklow, Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell 124, 973-983 (2006).
14. J. J. Wilson, R. A. Kovall, Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA. Cell 124, 985-996 (2006).
15. T. Iso, L. Kedes, Y. Hamamori, HES and HERP families: Multiple effectors of the Notch signaling pathway. J. Cell. Physiol. 194, 237-255 (2003).
16. T. Iso, V. Sartorelli, G. Chung, T. Shichinohe, L. Kedes, Y. Hamamori, HERP, a new primary target of Notch regulated by ligand binding. Mol. Cell. Biol. 21, 6071-6079 (2001).
17. N. Yamamoto, S. Yamamoto, F. Inagaki, M. Kawaichi, A. Fukamizu, N. Kishi, K. Matsuno, K. Nakamura, G. Weinmaster, H. Okano, M. Nakafuku, Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor. J. Biol. Chem. 276, 45031-45040 (2001).
18. N. Ohno, A. Izawa, M. Hattori, R. Kageyama, T. Sudo, dlk inhibits stem cell factor-induced colony formation of murine hematopoietic progenitors: Hes-1- independent effect. Stem Cells 19, 71-79 (2001).
19. R. M. Pereira, A. M. Delany, D. Durant, E. Canalis, Cortisol regulates the expression of Notch in osteoblasts. J. Cell. Biochem. 85, 252-258 (2002).
20. M. Nobta, T. Tsukazaki, Y. Shibata, C. Xin, T. Moriishi, S. Sakano, H. Shindo, A. Yamaguchi, Critical regulation of bone morphogenetic proteininduced osteoblastic differentiation by Delta1/Jagged1-activated Notch1 signaling. J. Biol. Chem. 280, 15842-15848 (2005).
21. M. Schnabel, I. Fichtel, L. Gotzen, J. Schlegel, Differential expression of Notch genes in human osteoblastic cells. Int. J. Mol. Med. 9, 229-232 (2002).
22. C. Liu, Y. Li, M. Semenov, C. Han, G. H. Baeg, Y. Tan, Z. Zhang, X. Lin, X. He, Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108, 837-847 (2002).
23. B. M. Gumbiner, Propagation and localization of Wnt signaling. Curr. Opin. Genet. Dev. 8, 430-435 (1998).
24. A.Wodarz, R. Nusse, Mechanisms of Wnt signaling in development. Annu. Rev. Cell Dev. Biol. 14, 59-88 (1998).
25. J. D. Axelrod, K. Matsuno, S. Artavanis-Tsakonas, N. Perrimon, Interaction between Wingless and Notch signaling pathways mediated by dishevelled. Science 271, 1826-1832 (1996).
26. B. De Strooper, W. Annaert, Where Notch and Wnt signaling meet. The presenilin hub. J. Cell Biol. 152, F17-F20 (2001).
27. L. Espinosa, J. Ingles-Esteve, C. Aguilera, A. Bigas, Phosphorylation by glycogen synthase kinase-3β downregulates Notch activity: A link for notch and Wnt pathways. J. Biol. Chem. 278, 32227-32235 (2003).
28. C. S. Wesley, Notch and wingless regulate expression of cuticle patterning genes. Mol. Cell. Biol. 19, 5743-5758 (1999).
29. T. Kitamura, Y. I. Kitamura, Y. Funahashi, C. J. Shawber, D. H. Castrillon, R. Kollipara, R. A. De- Pinho, J. Kitajewski, D. Accili, A Foxo/Notch pathway controls myogenic differentiation and fiber type specification. J. Clin. Invest. 117, 2477-2485 (2007).
30. Y. G. Ni, K. Berenji, N. Wang, M. Oh, N. Sachan, A. Dey, J. Cheng, G. Lu, D. J. Morris, D. H. Castrillon, R. D. Gerard, B. A. Rothermel, J. A. Hill, Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling. Circulation 114, 1159-1168 (2006).
31. M. M. Winslow, M. Pan, M. Starbuck, E. M. Gallo, L. Deng, G. Karsenty, G. R. Crabtree, Calcineurin/ NFAT signaling in osteoblasts regulates bone mass. Dev. Cell 10, 771-782 (2006).
32. F. Ikeda, R. Nishimura, T. Matsubara, K. Hata, S. V. Reddy, T. Yoneda, Activation of NFAT signal in vivo leads to osteopenia associated with increased osteoclastogenesis and bone-resorbing activity. J. Immunol. 177, 2384-2390 (2006).
33. S. Bai, R. Kopan, W. Zou, M. J. Hilton, C. T. Ong, F. Long, F. P. Ross, S. L. Teitelbaum, Notch1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells. J. Biol. Chem. 283, 6509-6518 (2007).
34. G. R. Crabtree, E. N. Olson, NFAT signaling: Choreographing the social lives of cells. Cell 109, S67-S79 (2002).
35. I. Kalajzic, Z. Kalajzic, M. Kaliterna, G. Gronowicz, S. H. Clark, A. C. Lichtler, D. Rowe, Use of type I collagen green fluorescent protein transgenes to identify subpopulations of cells at different stages of the osteoblast lineage. J. Bone Miner. Res. 17, 15-25 (2002).
36. K. Tezuka, M.Yasuda, N.Watanabe, N. Morimura, K. Kuroda, S. Miyatani, N. Hozumi, Stimulation of osteoblastic cell differentiation by Notch. J. Bone Miner. Res. 17, 231-239 (2002).
37. R. A. Oldershaw, S. R. Tew, A. M. Russell, K. Meade, R. Hawkins, T. R. McKay, K. R. Brennan, T. E. Hardingham, Notch signaling through Jagged-1 is necessary to initiate chondrogenesis in human bone marrow stromal cells, but must be switched off to complete chondrogenesis. Stem Cells 26, 666-674 (2008).
38. L. Li, I. D. Krantz, Y. Deng, A. Genin, A. B. Banta, C. C. Collins, M. Qi, B. J. Trask, W. L. Kuo, J. Cochran, T. Costa, M. E. Pierpont, E. B. Rand, D. A. Piccoli, L. Hood, N. B. Spinner, Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Nat. Genet. 16, 243-251 (1997).
39. T. Oda, A. G. Elkahloun, B. L. Pike, K. Okajima, I. D. Krantz, A. Genin, D. A. Piccoli, P. S. Meltzer, N. B. Spinner, F. S. Collins, S. C. Chandrasekharappa, Mutations in the human Jagged1 gene are responsible for Alagille syndrome. Nat. Genet. 16, 235-242 (1997).
40. Supported by National Institute of Diabetes and Digestive and Kidney Diseases grant DK045227