Simulation modelling of human intestinal absorption using caco-2 permeability and kinetic solubility data for early drug discovery

Journal of Pharmaceutical Sciences

Volumn 97, Issue 10, 2008, Pages 4557-4574

  Thomas, Simon ^a   Brightman, Frances ^a   Gill, Helen ^a   Lee, Sally ^a   Pufong, Boris ^a  

^a CYPROTEX DISCOVERY LTD   (United Kingdom)

Author keywords

Caco 2 cells; Gastrointestinal transit; In silico modeling; In vitro in vivo correlations (IVIVC); Intestinal absorption; Mathematical model; Nonlinear pharmacokinetics; Pharmacokinetics; Physiological model; Solubility

Indexed keywords

ARTICLE; CANCER CELL CULTURE; CELL MEMBRANE PERMEABILITY; DRUG ABSORPTION; DRUG IDENTIFICATION; DRUG PENETRATION; DRUG RESEARCH; DRUG SOLUBILITY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; INTESTINE FLUID; MATHEMATICAL MODEL; SIMULATION; STOMACH JUICE; STRUCTURE ACTIVITY RELATION;

EID: 48049089223     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21305     Document Type: Article

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