Serum prohepcidin reflects the degree of liver function impairment in liver cirrhosis

Biomarkers

Volumn 13, Issue 5, 2008, Pages 478-485

  Jaroszewicz, Jerzy ^a   Rogalska, Magdalena ^a   Flisiak, Robert ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

Hepcidin; Iron metabolism; Liver cirrhosis; Liver insufficiency

Indexed keywords

ACUTE PHASE PROTEIN; BIOCHEMICAL MARKER; IRON; PROHEPCIDIN;

ADULT; AGED; ALCOHOL LIVER CIRRHOSIS; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ACTIVITY; DISEASE SEVERITY; FEMALE; HEPATITIS C; HUMAN; IMMUNOASSAY; IRON METABOLISM; LIVER CIRRHOSIS; LIVER FAILURE; MAJOR CLINICAL STUDY; MALE; PRIMARY BILIARY CIRRHOSIS; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL;

ADULT; AGED; AGED, 80 AND OVER; ANTIMICROBIAL CATIONIC PEPTIDES; BIOLOGICAL MARKERS; FEMALE; HUMANS; LIVER CIRRHOSIS; LIVER FUNCTION TESTS; MALE; MIDDLE AGED; PROTEIN PRECURSORS;

HEPATITIS C VIRUS;

EID: 47949131516     PISSN: 1354750X     EISSN: 13665804     Source Type: Journal    
DOI: 10.1080/13547500802033391     Document Type: Article

References (21)

1. Choi, SO, Cho, YS, Kim, HL and Park, JW (2007) ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPalpha and STAT-3. Biochemical & Biophysical Research Communications, 356, pp. 312-317.
2. De Domenico, I., Ward, DM, Langelier, C., Vaughn, MB, Nemeth, E. Sundquist, WI et al. (2007) The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Molecular Biology of the Cell, 18, pp. 2569-2578.
3. Friedman, SL (1995) Parenchymal Fe and collagen gene expression: An iron-clad association?. Hepatology, 21, pp. 1197-1199.
4. Fujita, N., Sugimoto, R., Takeo, M., Urawa, N., Mifuji, R. Tanaka, H. et al. (2007) Hepcidin expression in the liver: Relatively low level in patients with chronic hepatitis C. Molecular Medicine, 13, pp. 97-104.
5. Guo, L., Enzan, H., Hayashi, Y., Miyazaki, E., Jin, Y., Toi, M., Kuroda, N. and Hiroi, M. (2006) Increased iron deposition in rat liver fibrosis induced by a high-dose injection of dimethylnitrosamine. Experimental & Molecular Pathology, 81, pp. 255-261.
6. Harrison-Findik, DD, Klein, E., Crist, C., Evans, J., Timchenko, N. and Gollan, J. (2007) Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol. Hepatology, 46, pp. 1979-1985.
7. Kulaksiz, H., Gehrke, SG, Janetzko, A., Rost, D., Bruckner, T. Kallinowski, B. et al. (2004) Pro-hepcidin: Expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia. Gut, 53, pp. 735-743.
8. Nagashima, M., Kudo, M., Chung, H., Ishikawa, E., Hagiwara, S. Nakatani, T. et al. (2006) Regulatory failure of serum prohepcidin levels in patients with hepatitis C. Hepatology Research, 36, pp. 288-293.
9. Nemeth, E., Tuttle, MS, Powelson, J., Vaughn, MB, Donovan, A. Ward, DM et al. (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science, 306, pp. 2090-2093.
10. Nemeth, E., Valore, EV, Territo, M., Schiller, G., Lichtenstein, A. and Ganz, T. (2003) Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood, 101, pp. 2461-2463.
11. Nicolas, G., Bennoun, M., Devaux, I., Beaumont, C., Grandchamp, B. Kahn, A. et al. (2001) Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proceedings of the National Academy of Sciences USA, 98, pp. 8780-8785.
12. Nicolas, G., Chauvet, C., Viatte, L., Danan, JL, Bigard, X. Devaux, I. et al. (2002) The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. Journal of Clinical Investigation, 110, pp. 1037-1044.
13. Ohtake, T., Saito, H., Hosoki, Y., Inoue, M., Miyoshi, S. Suzuki, Y. et al. (2007) Hepcidin is down-regulated in alcohol loading. Alcoholism. Clinical & Experimental Research, 31, pp. S2-S8.
14. Park, CH, Valore, EV, Waring, AJ and Ganz, T. (2001) Hepcidin, a urinary antimicrobial peptide synthesized in the liver. Journal of Biological Chemistry, 276, pp. 7806-7810.
15. Peyssonnaux, C., Zinkernagel, AS, Schuepbach, RA, Rankin, E., Vaulont, S. Haase, VH et al. (2007) Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). Journal of Clinical Investigation, 117, pp. 1926-1932.
16. Pigeon, C., Ilyin, G., Courselaud, B., Leroyer, P., Turlin, B. Brissot, P. et al. (2001) A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Journal of Biological Chemistry, 276, pp. 7811-7819.
17. Piperno, A., Girelli, D., Nemeth, E., Trombini, P., Bozzini, C. Poggiali, E. et al. (2007) Blunted hepcidin response to oral iron challenge in HFE-hemochromatosis. Blood, 110, pp. 4096-4100.
18. Pugh, RN, Murray-Lyon, IM, Dawson, JL, Pietroni, MC and Williams, R. (1973) Transection of the oesophagus for bleeding oesophageal varices. British Journal of Surgery, 60, pp. 646-649.
19. Shaw, S., Jayatilleke, E. and Lieber, CS (1988) Lipid peroxidation as a mechanism of alcoholic liver injury: Role of iron mobilization and microsomal induction. Alcohol, 5, pp. 135-140.
20. Valenti, L., Pulixi, EA, Arosio, P., Cremonesi, L., Biasiotto, G. Dongiovanni, P. et al. (2007) Relative contribution of iron genes, dysmetabolism and hepatitis C virus (HCV) in the pathogenesis of altered iron regulation in HCV chronic hepatitis. Haematologica, 92, pp. 1037-1042.
21. Valore, EV and Ganz, T. (2008) Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin. Blood. Cells Molecules & Diseases, 40, pp. 132-138.