Effects of four Fusarium toxins (fumonisin B1, α-zearalenol, nivalenol and deoxynivalenol) on porcine whole-blood cellular proliferation

Toxicon

Volumn 52, Issue 1, 2008, Pages 156-162

  Luongo, D ^a,b   De Luna, R ^c   Russo, R ^a   Severino, L ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b CNR   (Italy)

^c ASL AV2   (Italy)

Author keywords

Combined effects; Fusarium toxins; Porcine whole blood lymphocytes

Indexed keywords

ALPHA ZEARALENOL; FUMONISIN B1; MYCOTOXIN; NIVALENOL; VOMITOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; FUSARIUM; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; SWINE;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FUMONISINS; LYMPHOCYTE ACTIVATION; MALE; SWINE; TRICHOTHECENES; ZERANOL;

FUSARIUM; SUIDAE; SUS;

EID: 47849117947     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2008.04.162     Document Type: Article

References (56)

1. Accensi F., Pinton P., Callu P., Abella-Bourges N., Guelfi J.F., Grosjean F., and Oswald I.P. Ingestion of low doses of deoxynivalenol does not affect haematological, biochemical, or immune responses of piglets. J. Anim. Sci. 84 7 (2006) 1935-1942
2. Berenbaum M.C. What is synergy?. Pharmacol. Rev. 41 2 (1989) 93-141
3. Bernhoft A., Keblys M., Morrison E., Larsen H.J., and Flaoyen A. Combined effects of selected Penicillium mycotoxins on in vitro proliferation of porcine lymphocytes. Mycopathologia 158 3 (2004) 441-450
4. Bloemena E., Roos M.T., Van Heeijst J.L., Vossen J.M., and Schelleken P.T. Whole-blood lymphocyte cultures. J. Immunol. Methods 122 2 (1989) 161-167
5. Bondy G.S., and Pestka J.J. Immunomodulation by fungal toxins. J. Toxicol. Environ. Health Crit. Rev. 3 2 (2000) 109-143
6. 1 alters the proliferation and the barrier function of porcine intestinal epithelial cells. Toxicol. Sci. 77 1 (2004) 165-171
7. 1 selectively down-regulates the basal IL-8 expression in pig intestine: in vivo and in vitro studies. Food Chem. Toxicol. 44 10 (2006) 1768-1773
8. Cheng Y.H., Ding S.T., and Chang M.H. Effects of fumonisins on macrophage immune functions and gene expression of cytokines in broilers. Arch. Anim. Nutr. 60 4 (2006) 267-276
9. Colvin M.B., and Harrison R.L. Fumonisin induced pulmonary edema and hydrothorax in swine. Mycopathologia 117 1-2 (1992) 79-82
10. Creppy E.E. Update of survey, regulation and toxic effects of mycotoxins in Europe. Toxicol. Lett. 127 1-3 (2002) 19-28
11. D'Mello J.P.F., and MacDonalds A.M.C. Mycotoxins. Anim. Feed Sci. Technol. 69 (1997) 155-166
12. Dieckman M.A., and Green M.L. Mycotoxins and reproduction in domestic livestock. J. Anim. Sci. 70 5 (1992) 1615-1627
13. 1. Immunopharmacology 49 3 (2000) 401-409
14. 1 affects viability and alters nitric oxide production of a murine macrophage cell line. Int. Immunopharmacol. 2 8 (2002) 1087-1093
15. Dresden-Osborne C., Pittman Noblet G., Enongene E.N., Bacon C.W., Riley R.T., and Voss K.A. Host resistance to Trypanosoma cruzi infection is enhanced in mice fed Fusarium verticilloides (=F. moniliforme) culture material containing fumonisins. Food Chem. Toxicol. 40 12 (2002) 1789-1798
16. Edfors-Lilja I., Wattrang E., Marklund L., Moller M., Andersson-Eklund L., Andersson L., and Fossum C. Mapping quantitative trait loci for immune capacity in the pig. J. Immunol. 161 2 (1998) 829-835
17. Fasanmade A.A., and Jusko W.J. Optimizing whole blood lymphocyte proliferation in the rat. J. Immunol. Methods 184 2 (1995) 163-167
18. Forsell J.H., and Pestka J.J. Relation of 8-ketotrichothecene and zearalenone analog structure to inhibition of mitogen-induced human lymphocyte blastogenesis. Appl. Environ. Microbiol. 50 5 (1985) 1304-1307
19. 1, in rats. Carcinogenesis 12 7 (1991) 1247-1251
20. 1 transiently activates nuclear factor-kappa B, tumor necrosis factor alpha and caspase 3 via protein kinase C alpha dependent pathway in porcine renal epithelial cells. Cell Biol. Toxicol. 20 4 (2004) 197-212
21. Goyarts T., Danicke S., Tiemann U., and Rothkotter H.J. Effects of the Fusarium toxins deoxynivalenol (DON) on IgA, IgM and IgG concentrations and proliferation of porcine blood lymphocytes. Toxicol. In Vitro 20 6 (2006) 858-867
22. Grove J.F. Non macrocylic trichothecenes. Nat. Prod. Rep. 5 2 (1988) 187-209
23. 1-containing culture material on growing barrows. Am. J. Vet. Res. 56 12 (1995) 1668-1672
24. Igarashi H., Kouro T., Yokota T., Comp P.C., and Kincade P.W. Age and stage dependency of estrogen receptor expression by lymphocytes precursors. Proc. Natl. Acad. Sci. U.S.A. 98 26 (2001) 15131-15136
25. Koshinsky H.A., and Khachatourians G.G. Trichothecenes synergism, additivity and antagonism: the significance of the maximally quiescent ratio. Nat. Toxins 1 1 (1992) 38-47
26. Kuiper-Goodman T. Food safety: mycotoxins and phytotoxins in perspective. In: Miraglia M., ven Egmond H., Brera C., and Gilbert J. (Eds). Mycotoxins and Phytotoxins. Developments in Chemistry, Toxicology and Food Safety (1998), Alaken Ink, Fort Collins, CO 25-48
27. Li M., Cuff C.F., and Pestka J.J. Modulation of murine host response to enteric reovirus infection by the trichothecene doeoxynivalenol. Toxicol. Sci. 87 1 (2005) 134-145
28. 1 and moniliformin on performance and selected immune parameters in turkey poults. Poult. Sci. 79 6 (2000) 871-878
29. Lioi M.B., Santoro A., Barbieri R., Salzano S., and Ursini M.V. Ochratoxin A and zearalenone: a comparative study on genotoxic effects and cell death induced in bovine lymphocytes. Mutat. Res. 557 1 (2004) 19-27
30. 1 on primary swine alveolar macrophages. Toxicol. Appl. Pharmacol. 180 3 (2002) 197-204
31. 1 and α-zearalenol on proliferation and cytokine expression in Jurkat T cells. Toxicol. In vitro 20 8 (2006) 1403-1410
32. Madhyastha M.S., Marquardt R.R., and Abramson D. Structure-activity relationships and interactions among trichothecene mycotoxins as assessed by yeast bioassay. Toxicon 32 9 (1994) 1147-1152
33. Marin D.E., Taranu I., Pascale F., Lionide A., Burlacu R., Bailly J.D., and Oswald I.P. Sex-related differences in the immune response of weanling piglets exposed to low doses of fumonisin extract. Br. J. Nutr. 95 6 (2006) 1185-1192
34. Meky F.A., Hardie L.J., Evans S.W., and Wild C.P. Deoxynivalenol-induced immunomodulation of human lymphocyte proliferation and cytokine production. Food Chem. Toxicol. 39 8 (2001) 827-836
35. Minervini F., Dell'Aquila M.E., Maritato F., Minoia P., and Visconti A. Toxic effects of the mycotoxin zearalenone and its derivates on in vitro maturation of bovine oocytes and 17 beta-estradiol levels in mural granulosa cell cultures. Toxicol. In Vitro 15 4-5 (2001) 489-495
36. Oswald I.P., Marin D.E., Bouhet S., Pinton P., Taranu I., and Accensi F. Immunotoxicological risk of mycotoxins for domestic animals. Food Addit. Contam. 22 4 (2005) 354-360
37. Osweiler G.D., Kehrli M.E., Stabel J.R., Thurston J.R., Ross P.F., and Wilson T.M. Effects of fumonisin contaminated corn screenings on growth and health of feeder calves Asian-Austral. J. Anim. Sci. 71 (2003) 459-466
38. Pestka J.J., Yan D., and King L.E. Flow cytometric analysis of the effects of the in vitro exposure to vomitoxin (deoxynivalenol) on apoptosis in murine T, B and IgA cells. Food Chem. Toxicol. 32 12 (1994) 1125-1136
39. Pestka J.J., and Smolinski A.T. Deoxynivalenol: toxicology and potencial effects on humans. J. Toxicol. Environ. Health B Crit. Rev. 8 1 (2005) 39-69
40. 1 alters sphingoilipid metabolism and disrupts the barrier function of endothelial cells in culture. Toxicol. Appl. Pharmacol. 133 2 (1995) 343-348
41. Rocha O., Ansari K., and Doohan F.M. Effects of Trichothecene mycotoxins on eukaryotic cells: a review. Food Addit. Contam. 22 4 (2005) 369-378
42. Rotter B.A., Prelusky D.B., and Pestka J.J. Toxicology of deoxynivalenol (vomitoxin). J. Toxicol. Environ. Health 48 1 (1996) 1-34
43. Schothorst R.C., and van Egmond H.P. Report from SCOOP task 3.2.10 "Collection of occurrence data of fusarium toxins in food and assessment of dietary intake by the population of EU member States". Subtask: trichothecenes. Toxicol. Lett. 153 (2004) 133-143
44. Severino L., Luongo D., Bergamo P., Lucisano A., and Rossi M. Mycotoxins nivalenol and deoxynivalenol differently modulate cytokine mRNA expression in Jurkat T cells. Cytokine 36 1-2 (2006) 75-82
45. 1 toxicity in co-cultures: evidence for crosstalk between macrophages and non-parenchymatous liver epithelial cells involving in proinflammatory cytokines. Toxicology 203 1-3 (2004) 239-251
46. Speijers G.J.A., and Speijers M.H.M. Combined toxic effects of mycotoxins. Toxicol. Lett. 153 1 (2004) 91-98
47. 1 contamination on home-grown corn in high-risk areas for esophageal and liver cancer in China. Food Addit. Contam. 24 2 (2007) 181-185
48. Tajima O., Schoen E.D., Feron V.J., and Groten J.P. Statistically designed experiments in a tiered approach to screen mixtures of Fusarium mycotoxsins for possible interactions. Food Chem. Toxicol. 40 5 (2002) 685-695
49. 1 alters the cytokine profile and decreases the vaccinal antibody titer in pigs. Toxicol. Sci. 84 2 (2005) 301-307
50. 1 mixture in experimental subchronic mycotoxicoses in rats. Toxicology 186 1-2 (2003) 159-170
51. Thies F., Peterson L.D., Powell J.R., Nebe-von-Caron G., Hurst T.L., Matthews K.R., Newsholme E.A., and Calder P.C. Manipulation of the type of fat consumed by growing pigs affects plasma and mononuclear cell fatty acid compositions and lymphocyte and phagocyte functions. J. Anim. Sci. 77 1 (1999) 137-147
52. Thuvander A., Wikman C., and Gadhasson I. In vitro exposure of human lymphocytes to trichothecenes: individual variation in sensitivity and effects of combined exposure on lymphocyte function. Food Chem. Toxicol. 37 6 (1999) 639-648
53. 1 on certain immune parameters of weaned pigs. Acta Vet. Hung. 51 3 (2003) 171-179
54. Yancy H., Ayers S.L., Farrell D.E., Day A., and Myers M.J. Differential cytokine mRNA exspression in swine whole blood and peripheral blood mononuclear cell cultures. Vet. Immunol. Immunopathol. 79 1-2 (2001) 41-52
55. Yoo H.S., Norred W.P., Showker J., and Riley R.T. Elevated sphingoid bases and complex sphingolipid depletion as contributing factors in fumonisin-induced cytotoxicity. Toxicol. Appl. Pharmacol. 138 2 (1996) 211-218
56. Yu Z., Zhang L., Wu D., and Liu F. Anti-apoptotic action of zearalenone in MCF-7 cells. Ecotoxicol. Environ. Saf. 62 3 (2005) 441-446