Interactive effects of fumonisin B1 and α-zearalenol on proliferation and cytokine expression in Jurkat T cells

Toxicology in Vitro

Volumn 20, Issue 8, 2006, Pages 1403-1410

  Luongo, D ^a,b   Severino, L ^a   Bergamo, P ^b   De Luna, R ^a   Lucisano, A ^a   Rossi, M ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b CNR   (Italy)

Author keywords

zearalenol; Fumonisin B1; Immunotoxicity; Jurkat T cells

Indexed keywords

ALPHA ZEARALENOL; FUMONISIN B1;

ARTICLE; CELL PROLIFERATION; COMORBIDITY; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HUMAN CELL; IMMUNE FUNCTION TEST; LEUKEMIA CELL LINE; LYMPHOBLASTOID CELL;

APOPTOSIS; CASPASES; CELL PROLIFERATION; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FUMONISINS; HUMANS; INDICATORS AND REAGENTS; JURKAT CELLS; L-LACTATE DEHYDROGENASE; MYCOTOXINS; NECROSIS; RNA, MESSENGER; ZERANOL;

FUNGI;

EID: 33749574371     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2006.06.006     Document Type: Article

References (47)

1. Abid-Essefi S., Ouanes Z., Hassen W., Baudrimont I., Creppy E., and Bacha H. Cytotoxicity, inhibition of DNA and protein syntheses and oxidative damage in cultured cells exposed to zearalenone. Toxicol. In Vitro 18 (2004) 467-474
2. Abnet C.C., Borkowf C.B., Qiao Y.L., Albert P.S., Wang E., Merrill Jr. A.H., Mark S.D., Dong Z.W., Taylor P.R., and Dawsey S.M. Sphingolipids as biomarkers of fumonisin exposure and risk of esophageal squamous cell carcinoma in China. Can. Cause. Control 12 (2001) 821-828
3. Astoul E., Edmunds C., Cantrell D.A., and Ward S.G. PI 3-K and T-cell activation: limitations of T-leukemic cell lines as signaling models. Trends Immunol. 22 (2001) 490-496
4. Berek L., Petri I.B., Mesterhazy A., Teren J., and Molnar J. Effects of mycotoxins on human immune functions in vitro. Toxicol. In Vitro 15 (2001) 25-30
5. Berenbaum M.C. What is synergy?. Pharmacol. Rev. 41 (1989) 93-141
6. Bernhoft A., Keblys M., Morrison E., Larsen H.J., and Flaoyen A. Combined effects of selected Penicillium mycotoxins on in vitro proliferation of porcine lymphocytes. Mycopathologia 158 (2004) 441-450
7. Bhandari N., Brown C.C., and Sharma R.P. Fumonisin B1-induced localized activation of cytokine network in mouse liver. Food Chem. Toxicol. 40 (2002) 1483-1491
8. Bondy G.S., and Pestka J.J. Immunomodulation by fungal toxins. J. Toxicol. Environ. Health. B, Crit. Rev. 3 (2000) 109-143
9. Bouhet S., Hourcade E., Loiseau N., Fikry A., Martinez S., Roselli M., Galtier P., Mengheri E., and Oswald I.P. The mycotoxin fumonisin B1 alters the proliferation and the barrier function of porcine intestinal epithelial cells. Toxicol. Sci. 77 (2004) 165-171
10. Calemine J., Zalenka J., Karpuzoglu-Sahin E., Ward D.L., Lengi A., and Ahmed S.A. The immune system of geriatric mice is modulated by estrogenic endocrine disruptors (diethylstilbestrol, alpha-zearalanol, and genistein): effects on interferon-gamma. Toxicology 194 (2003) 115-128
11. Cheeke P.R. Mycotoxins in cereal grains and supplements. In: Cheeke P.R. (Ed). Natural Toxicants in Feeds Forages and Poisonous plants (1998), Interstate Publishers Inc, Danville, IL 87-136
12. Colvin B.M., and Harrison L.R. Fumonisin-induced pulmonary edema and hydrothorax in swine. Mycopathologia 117 (1992) 79-82
13. Creppy E.E. Update of survey, regulation and toxic effects of mycotoxins in Europe. Toxicol. Lett. 127 (2002) 19-28
14. Creppy E.E., Chiarappa P., Baudrimont I., Borracci P., Moukha S., and Carratu M.R. Synergistic effects of fumonisin B1 and ochratoxin A: are in vitro cytotoxicity data predictive of in vivo acute toxicity?. Toxicology 201 (2004) 115-123
15. Diekman M.A., and Green M.L. Mycotoxins and reproduction in domestic livestock. J. Animal Sci. 70 (1992) 1615-1627
16. D'Mello J.P.F., and Mac Donald A.M.C. Mycotoxins. Animal Feed Sci. Technol. 69 (1997) 155-166
17. Dombrink-Kurtzman M.A., Gomez-Flores R., and Weber R.J. Activation of rat splenic macrophage and lymphocyte functions by fumonisin B1. Immunopharmacology 49 (2000) 401-409
18. Dresden-Osborne C., and Noblet G.P. Fumonisin B1 affects viability and alters nitric oxide production of a murine macrophage cell line. Int. Immunopharmacol. 2 (2002) 1087-1093
19. Gelderblom W.C., Kriek N.P., Marasas W.F., and Thiel P.G. Toxicity and carcinogenicity of the Fusarium moniliforme metabolite, fumonisin B1, in rats. Carcinogenesis 12 (1991) 1247-1251
20. Gopee N.V., and Sharma R.P. The mycotoxin fumonisin B1 transiently activates nuclear factor-kappaB, tumor necrosis factor alpha and caspase 3 via protein kinase C alpha-dependent pathway in porcine renal epithelial cells. Cell Biol. Toxicol. 20 (2004) 197-212
21. Harvey R.B., Edrington T.S., Kubena L.F., Elissalde M.H., and Rottinghaus G.E. Influence of aflatoxin and fumonisin B1-containing culture material on growing barrows. Am. J. Vet. Res. 56 (1995) 1668-1672
22. He Q., Riley R.T., and Sharma R.P. Fumonisin-induced tumor necrosis factor-alpha expression in a porcine kidney cell line is independent of sphingoid base accumulation induced by ceramide synthase inhibition. Toxicol. Appl. Pharmacol. 174 (2001) 69-77
23. Heussner A.H., Dietrich D.R., and O'Brien E. In vitro investigation of individual and combined cytotoxic effects of ochratoxin A and other selected mycotoxins on renal cells. Toxicol. In Vitro 20 (2006) 332-341
24. Igarashi H., Kouro T., Yokota T., Comp P.C., and Kincade P.W. Age and stage dependency of estrogen receptor expression by lymphocyte precursors. Proc. Natl. Acad. Sci. USA 98 (2001) 15131-15136
25. Koshinsky H.A., and Khachatourians G.G. Trichothecene synergism, additivity, and antagonism: the significance of the maximally quiescent ratio. Nat. Toxins 1 (1992) 38-47
26. Kouadio J.H., Mobio T.A., Baudrimont I., Moukha S., Dano S.D., and Creppy E.E. Comparative study of cytotoxicity and oxidative stress induced by deoxynivalenol, zearalenone or fumonisin B1 in human intestinal cell line Caco-2. Toxicology 213 (2005) 56-65
27. Kuiper-Goodman T. Food Safety: Mycotoxins and Phytotoxins in Perspective. In: Miraglia M., van Egmond H., Brera C., and Gilbert J. (Eds). Mycotoxins and phycotoxins. Developments in Chemistry, Toxicology and Food Safety (1998), Alaken Inc, Fort Collins, CO 25-48
28. Lemmer E.R., de la Motte Hall P., Omori N., Omori M., Shephard E.G., Gelderblom W.C., Cruse J.P., Barnard R.A., Marasas W.F., Kirsch R.E., and Thorgeirsson S.S. Histopathology and gene expression changes in rat liver during feeding of fumonisin B1, a carcinogenic mycotoxin produced by Fusarium moniliforme. Carcinogenesis 20 (1999) 817-824
29. Li Y.C., Ledoux D.R., Bermudez A.J., Fritsche K.L., and Rottinghaus G.E. The individual and combined effects of fumonisin B1 and moniliformin on performance and selected immune parameters in turkey poults. Poultry Sci. 79 (2000) 871-878
30. Lioi M.B., Santoro A., Barbieri R., Salzano S., and Ursini M.V. Ochratoxin A and zearalenone: a comparative study on genotoxic effects and cell death induced in bovine lymphocytes. Mutat. Res. 557 (2004) 19-27
31. Loewe S. The problem of synergism and antagonism of combined drugs. Arzneimittelforschung 3 (1953) 285-290
32. Luongo D., Bergamo P., and Rossi M. Effects of conjugated linoleic acid on growth and cytokine expression in Jurkat T cells. Immunol. Lett. 90 (2003) 195-201
33. Marasas W.F. Fumonisins: their implications for human and animal health. Nat. Toxins 3 (1995) 193-198
34. McMurray R.W., Ndebele K., Hardy K.J., and Jenkins J. K17-beta-estradiol suppresses IL-2 and IL-2 receptor. Cytokine 14 (2001) 324-333
35. Merrill J.E., and Murphy S.P. Inflammatory events at the blood brain barrier: regulation of adhesion molecules, cytokines, and chemokines by reactive nitrogen and oxygen species. Brain Behav. Immun. 11 (1997) 245-263
36. Oswald I.P., Marin D.E., Bouchet S., Pinton P., Taranu I., and Accensi F. Immunotoxicological risk of mycotoxins for domestic animals. Food Addit. Contam. 22 (2005) 354-360
37. Osweiler G.D., Kehrli M.E., Stabel J.R., Thurston J.R., Ross P.F., and Wilson T.M. Effects of fumonisin-contaminated corn screenings on growth and health of feeder calves. Asian-Austral. J. Animal Sci. 71 (2003) 459-466
38. Pestka J.J., Uzarski R.L., and Islam Z. Induction of apoptosis and cytokine production in the Jurkat human T cells by deoxynivalenol: role of mitogen-activated protein kinases and comparison to other 8-ketotrichothecenes. Toxicology 206 (2005) 207-219
39. Ramasamy S., Wang E., Hennig B., and Merrill Jr. A.H. Fumonisin B1 alters sphingolipid metabolism and disrupts the barrier function of endothelial cells in culture. Toxicol. Appl. Pharmacol. 133 (1995) 343-348
40. Schroeder J.J., Crane H.M., Xia J., Liotta D.C., and Merrill Jr. A.H. Disruption of sphingolipid metabolism and stimulation of DNA synthesis by fumonisin B1. A molecular mechanism for carcinogenesis associated with Fusarium moniliforme. J. Biol. Chem. 269 (1994) 3475-3481
41. Sharma N., He Q., and Sharma R.P. Augmented fumonisin B1 toxicity in co-cultures: evidence for crosstalk between macrophages and non-parenchymatous liver epithelial cells involving proinflammatory cytokines. Toxicology 203 (2004) 239-251
42. Speijers G.J.A., and Speijers M.H.M. Combined toxic effects of mycotoxins. Toxicol. Lett. 153 (2004) 91-98
43. Tajima O., Schoen E.D., Feron V.J., and Groten J.P. Statistically designed experiments in a tiered approach to screen mixtures of Fusarium mycotoxins for possible interactions. Food Chem. Toxicol. 40 (2002) 685-695
44. Taranu I., Marin D.E., Bouhet S., Pascale F., Bailly J.D., Miller J.D., Pinton P., and Oswald I.P. Mycotoxin fumonisin B1 alters the cytokine profile and decreases the vaccinal antibody titer in pigs. Toxicol. Sci. 84 (2005) 301-307
45. Theumer M.G., Lopez A.G., Masih D.T., Chulze S.N., and Rubistein H.R. Immunobiological effects of AFB1 and AFB1-FB1 mixture in experimental subchronic mycotoxicoses in rats. Toxicology 186 (2003) 159-170
46. Tipton D.A., Lyle B., Babich H., and Dabbous M.K. In vitro cytotoxic and anti-inflammatory effects of myrrh oil on human gingival fibroblasts and epithelial cells. Toxicol. In Vitro 17 (2003) 301-310
47. Yoo H.S., Norred W.P., Showker J., and Riley R.T. Elevated sphingoid bases and complex sphingolipid depletion as contributing factors in fumonisin-induced cytotoxicity. Toxicol. Appl. Pharmacol. 138 (1996) 211-218