Peptides with antihypertensive activity obtained from milk and egg proteins;Péptidos antihipertensivos derivados de proteínas de leche y huevo

Nutricion Hospitalaria

Volumn 23, Issue 4, 2008, Pages 313-318

  Aleixandre, A ^a   Miguel, M ^a   Muguerza, B ^b  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b Natraceutical Group   (Spain)

Author keywords

Angiotensin converting enzyme; Bioactive peptides; Egg; Hypertension; Milk

Indexed keywords

ANTIHYPERTENSIVE AGENT; ARGINYLALANYLASPARTYLHISTIDYLPROLYLPHENYLALANYLLEUCINE; BETA CASEIN; BETA LACTOGLOBULIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EGG PROTEIN; EGG WHITE; ISOLEUCYLPROLYLPROLINE; LEUCYLHISTIDYLLEUCYLPROLYLLEUCYLPROLINE; MILK PROTEIN; OVALBUMIN; OVOKININ; OXYGENASE; PEPTIDE DERIVATIVE; PHENYLALANYLARGINYLALANYLASPARTYLHISTIDYLPROLYLPHENYLALANYLLEUCINE; PROTEIN HYDROLYSATE; VALYLPROLYLPROLINE;

AMINO ACID SEQUENCE; ANTIHYPERTENSIVE ACTIVITY; DRUG ISOLATION; ENTEROCOCCUS FAECALIS; FERMENTATION; HUMAN; HYPERTENSION; LACTOBACILLUS HELVETICUS; NONHUMAN; REVIEW; VASODILATATION;

EGG PROTEINS; HYPERTENSION; MILK PROTEINS; PEPTIDES;

ENTEROCOCCUS FAECALIS; LACTOBACILLUS HELVETICUS;

EID: 47749093537     PISSN: 02121611     EISSN: 16995198     Source Type: Journal    
DOI: None     Document Type: Review

References (50)

1. Martínez Agustín O, Martínez de Victoria Muñoz E. Proteínas y péptidos en nutrición enteral. Nutr Hosp 2006; 21(Supl. 2):1-14.
2. Gobbetti M, Stepaniak L, De Angelis M, Corsetti A, Di Cagno R. Latent bioactive peptides in milk proteins: proteolytic activation and significance in dairy processing. Crit Rev Food Sci Nutr 2002; 42:223-39.
3. Maeno M, Yamamoto N, Takano T. Identification of an antihypertensive peptide from casein hydrolysate produced by a proteinase from Lactobacillus helveticus CP790. J Dairy Sci 1996; 79:1316-321.
4. Mullaly MM, Meisel H, FitzGerald RJ. Identification of a novel angiotensin-I-converting enzyme inhibitory peptide corresponding to a tryptic fragment of bovine β-lactoglobulin. FEBS Lett 1997; 402:99-101.
5. Abubakar A, Saito T, Kitazawa H, Kawai Y, Itoh T. Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion. J Dairy Sci 1998; 81:3131-138.
6. Saito T, Nakamura T, Kitazawa H, Kawai Y, Itoh T. Isolation and structural analysis of antihypertensive peptides that exist naturally in Gouda cheese. J Dairy Sci 2000; 83:1434-440.
7. Fujita H, Yamagami T, Ohshima K. Effects of an ACE-inhibitory agent, katsuobushi oligopeptide, in the spontaneously hypertensive rat and in borderline and mildly hypertensive subjects. Nutr Res 2001; 21:1149-158.
8. Wu J, Ding X. Hypotensive and physiological effect of angiotensin converting enzyme inhibitory peptides derived from soy protein on spontaneously hypertensive rats. J Agric Food Chem 2001; 49:501-06.
9. Soares de Moura R, Costa Viana FS, Souza MAV, Kovary K, Guedes DC, Oliveira EPB, Rubenich LSM, Carvalho LC, Oliveira RM, Tano RM, Gusmão T, Correia ML. Antihypertensive, vasodilator and antioxidant effects of a vinifiera grape skin extract. J Pharmacy Pharmacol 2002; 54:1515-520.
10. Yang Y, Marczak ED, Usui H, Kawamura Y, Yoshikawa M. Antihypertensive properties of spinach leaf protein digests. J Agric Food Chem 2004; 52:2223-225.
11. Sekiya S, Kobayashi Y, Kita E, Imamura Y, Toyama S. Antihypertensive effects of tryptic hydrolysate of casein on normotensive and hypertensive volunteers. J Nutr Food Sci 1992; 45:513-17.
12. Sugai, R. ACE inhibitors and functional foods. Bulletin of the IDF. 1998; 336:17-20.
13. Karaki H, Doi K, Sugano S, Uchiya H, Sugai R, Murakami U, Takemoto S. Antihypertensive effect of tryptic hydrolysate of milk casein in spontaneously hypertensive rats. Comp Biochem Physiol 1990; 96C:367-71.
14. Townsend RR, McFadden CB, Ford V, Cadeé JA. A randomized, doubled-blind, placebo controlled trial of casein protein hydrolysate (C12 peptide) in human essential hypertension. Am J Hyperten 2004; 17:1056-1058.
15. Pins JJ, Keenan JM. The antihypertensive effects of a hydrolysated whey protein isolate supplement (Biozate® 1). Cardiovasc Drugs Ther 2002; 16:68.
16. Pins JJ, Keenan JM. The antihypertensive effects of a hydrolysated whey protein isolate supplement (Biozate® 1): a pilot study. FASEB J 2003; 17:A1110.
17. Nakamura Y, Yamamoto N, Sakai K, Takano T, Okubo A, Yamazaki S. Purification and characterization of angiotensin-converting enzyme inhibitors from sour milk. J Dairy Sci 1995; 78:777-783.
18. Nakamura Y, Yamamoto N, Sakai K, Okubo A, Yamazaki S, Takano TJ. Antihypertensive effect of sour milk and peptides isolated from it that are inhibitors to angiotensin I-converting enzyme. J Dairy Sci 1995; 78:1253-1257.
19. Nakamura Y, Masuda O, Takano T. Decrease of tissue angiotensin I-converting enzyme activity upon feeding sour milk in spontaneously hypertensive rats. Biosci Biotech Biochem 1996; 60:488-489.
20. Masuda O, Nakamura Y, Takano T. Antihypertensive peptides are present in aorta after oral administration of sour milk containing these peptides to spontaneously hypertensive rats. J Nutr 1996; 126:3063-3068.
21. Hata Y, Yamamoto M, Ohni M, Nakajima K, Nakamura Y, Takano T. A placebo-controlled study of the effect of sour milk on blood pressure in hypertensive subjects. Am J Clin Nutr 1996; 64:767-71.
22. Mizushima S, Ohshige K, Watanabe J, Kimura M, Kadowaki T, Nakamura Y, Tochikubo O, Ueshima H. Randomized controlled trial of sour milk on blood pressure in borderline hypertensive men. Am J Hypertens 2004; 17:701-706.
23. Sipola M, Finckenberg P, Santisteban J, Korpela R, Vapaatalo H, Nurminen M-L. Long-term intake of milk peptides attenuates development of hypertension in spontaneously hypertensive rats. J Phys Pharm 2001; 52:745-54.
24. Sipola MP, Finckenberg P, Korpela R, Vapaatalo H, Nurminen MA. Effect of long-term intake of milk products on blood pressure in hypertensive rats. J Dairy Res 2002; 69:103-11.
25. Seppo L, Kerojoki O, Suomalainen T, Korpela R. The effect of a Lactobacillus helveticus LBK-16 H fermented milk on hypertension: a pilot study on humans. Milchwissenschaft 2002; 57:124-27.
26. Seppo L, Jauhiainen T, Poussa T, Korpela R. A fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects. Am J Clin Nutr 2003; 77:326-30.
27. Tuomilehto J, Lindstrom J, Hyyrynen J, Korpela R, Karhunen ML, Mikkola L, Jauhiainen T, Seppo L, Nissinen A. Effect of ingesting sour milk fermented using Lactobacillus helveticus bacteria producing tripeptides on blood pressure in subjects with mild hypertension. J Hum Hypertens 2004; 18;705-802.
28. Fitzgerald, RJ, Murria BA, Walsh GJ. Hypotensive peptides from milk proteins. J Nutr 2004; 134:980S-988S.
29. Quirós A, Ramos M, Muguerza B, Delgado MA, Miguel M, Aleixandre A, Recio I. Identification of novel antihypertensive peptides in milk fermented with Enterococus faecalis. Int Dairy J 2007; 17:33-41.
30. Muguerza B, Ramos M, Sánchez E, Manso MA, Miguel M, Aleixandre A, Delgado MA, Recio I. Antihypertensive activity of milks fermented by Enterococcus faecalis strains isolated from raw milk. Int Dairy J 2006; 16:61-9.
31. Miguel M, Recio I, Ramos M, Delgado MA, Aleixandre MA. Effect of ACE-Inhibitory Peptides Obtained from Enterococcus faecalis Fermented Milk in Hypertensive Rats. J Dairy Sci 2006; 89:3352-359.
32. Miguel M, Muguerza B, Sánchez E, Delgado MA, Recio I, Ramos M, Aleixandre MA. Changes in arterial blood pressure of milk fermented by Enterococcus faecalis CECT 5728 in spontaneously hypertensive rats. British J Nutr 2005; 93:1-9.
33. Pihlanto-Leppala A, Koskinen P, Piilola K, Tupasela T, Korhonen H. Angiotensin I-converting enzyme inhibitory properties of whey protein digests: concentration and characterization of active peptides. J Dairy Res 2000; 1:53-64.
34. Chobert JM, El-Zahar K, Sitohy M, Dalgalarrondo M, Metro F, Choiset Y, Haertle T. Angiotensin I-converting-enzyme (ACE)-inhibitory activity of tryptic peptides of ovine beta-lactoglobulin and of milk yoghurts obtained by using different starters. Lait 2005; 85(3):141-52.
35. Nurmeinin ML, Sipola M, Kaarto H, Pihlanto-Leppala A, Piilola K, Korpela R, Tossavainen O, Kohonen H, Vapaatalo H. alactorphin lowers blood pressure measured by radiotelelmetry in normotensive and spontaneously hypertensive rats. Life Sci 2000; 66:535-43.
36. Mullaly MM, Meisel H, FitGerald RJ. Synthetic peptides corresponding to α-lactalbumin and β-lactoglobulin sequences with angiotensn-I- converting enzyme inhibitory activity. Biol Chem 1996; 377:259-60.
37. Hernández-Ledesma B, Recio I, Ramos M, Amigo L. Preparation of ovine and caprine β-lactoglobulin hydrolysates with ACE-inhibitory activity. Identification of active peptides from caprine β-lactoglobulin hydrolysed with thermolysin. Int Dairy J 2002;12:805-12.
38. Hernández-Ledesma B, Miguel M, Amigo L, Aleixandre MA, Recio I. Effect of simulated gastrointestinal digestion on the antihypertensive properties of β-lactoglobulin peptides. J Dairy Res 2007; 74(3):336-39.
39. Fujita H, Usui H, Kurahashi K, Yoshikawa M. Isolation and characterization of Ovokinin, a bradykinin B1 agonist peptide derived from ovalbumin. Peptides 1995; 16:785-90.
40. Fujita H, Sasaki R, Yoshikawa M. Potentiation of the antihypertensive activity of orally administered Ovokinin, a vasorelaxing peptide derived from ovalbumin, by emulsification in egg phosphatidyl-choline. Biosci Biotech Biochem 1995; 59:2344-345.
41. Matoba N, Usui H, Fujita H, Yoshikawa M. A novel anti-hypertensive peptide derived from ovalbumin induces nitric oxidemediated vasorelaxation in an isolated SHR mesenteric artery. FEBS Lett 1999; 452:181-84.
42. Matoba N, Yamada Y, Usui H, Nakagiri R, Yoshikawa M. Designing potent derivatives of Ovokinin (2-7), an anti-hypertensive peptidederived from ovalbumin. Biosci Biotech Biochem 2001; 65:636-39.
43. Scruggs P, Filipeanu CM, Yang J, Kang Chang J, Dun NJ. Interaction of ovokinin (2-7) with vascular bradykinin 2 receptors. Reg Pep 2004; 120:85-91.
44. Yamada Y, Matoba N, Usiu H, Onishi K, Yoshikawa M. Design of a highly potent anti-hypertensive peptide based on Ovokinin (2-7). Biosci Biotech Biochem 2002; 66:1213-217.
45. Fujita H, Yokoyama K, Yoshikawa M. Classification and antihypertensive activity of angiotensin I- converting enzyme inhibitory peptides derived from food proteins. J Food Sci 2000; 65:564-69.
46. Miguel M, Recio I, Gómez-Ruiz JA, Ramos M, López- Fandiño R. Angiotensin I-converting enzyme inhibitory activity of peptides derived from egg white proteins by enzymatic hydrolysis. J Food Prot 2004; 67:1914-920.
47. Miguel M, López-Fandiño R, Ramos M, Aleixandre MA. Short-term effect of egg white hydrolysate products on the arterial blood pressure of hypertensive rats. British J Nutr 2005; 94:731-37.
48. Miguel M, López-Fandiño R, Ramos M, Aleixandre MA. Long-term antihypertensive effect of egg white treated with pepsin in hypertensive rats. Life Sci 2006; 78:2960-966.
49. Miguel M, Ramos M, Aleixandre MA, López-Fandiño R. Antihypertensive peptides obtained from egg white proteins by enzymatic hydrolysis. Stability under simulated gastrointestinal digestion. J Agric Food Chem 2006; 54:726-31.
50. Yoshii H, Tachi N, Ohba R, Sakamura O, Takemaya H, Itani T. Antihypertensive effect of ACE inhibitory oligopeptides from chicken egg yolks. Com Biochem Physiol Part C 2001; 128:27-33.