Structure-activity relationships of bifunctional cyclic disulfide peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors

Peptides

Volumn 29, Issue 8, 2008, Pages 1413-1423

  Agnes, Richard S ^a   Ying, Jinfa ^a   Kövér, Katalin E ^b   Lee, Yeon Sun ^a   Davis, Peg ^c   Ma, Shou wu ^c   Badghisi, Hamid ^c   Porreca, Frank ^c   Lai, Josephine ^c   Hruby, Victor J ^a  

^a University of Arizona   (United States)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Bifunctional peptides; G Protein coupled receptors; Multivalent ligands; NMR conformation; Overlapping pharmacophores; Pain; Tolerance

Indexed keywords

CHOLECYSTOKININ A RECEPTOR; CHOLECYSTOKININ B RECEPTOR; CHOLECYSTOKININ RECEPTOR; CYCLOPEPTIDE; DELTA OPIATE RECEPTOR; MU OPIATE RECEPTOR; RECEPTOR BLOCKING AGENT;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CYCLIZATION; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE; PHARMACOPHORE; PRIORITY JOURNAL; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; DISULFIDES; DRUG DESIGN; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES, CYCLIC; RECEPTORS, CHOLECYSTOKININ; RECEPTORS, OPIOID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 47649130291     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2008.03.022     Document Type: Article

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