A multivalent combination of experimental antituberculosis DNA vaccines based on Ag85B and regions of difference antigens

Microbes and Infection

Volumn 8, Issue 9-10, 2006, Pages 2390-2399

  Grover, Ajay ^a   Ahmed, Mir Fayaz ^b   Singh, Balwan ^b   Verma, Indu ^a   Sharma, Pawan ^b   Khuller, G K ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

^b INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

DNA vaccines; Regions of difference; Tuberculosis

Indexed keywords

BACTERIAL ANTIGEN; BCG VACCINE; DNA VACCINE; EPITOPE; GAMMA INTERFERON; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY; INTERLEUKIN 12P40; PROTEIN AG85B; PROTEIN CFP10; PROTEIN CFP21; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; BACTERICIDAL ACTIVITY; BACTERIUM COLONY; BCG VACCINATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; FEMALE; HUMORAL IMMUNITY; IMMUNE RESPONSE; LUNG; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MOUSE; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; SPLEEN; TH1 CELL; TUBERCULOSIS; VACCINE PRODUCTION;

ANIMALS; ANTIBODY FORMATION; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; FEMALE; IMMUNOPHENOTYPING; MICE; MICE, INBRED C57BL; MYCOBACTERIUM TUBERCULOSIS; T-LYMPHOCYTES, CYTOTOXIC; TUBERCULOSIS; TUBERCULOSIS VACCINES; VACCINES, DNA;

MYCOBACTERIUM BOVIS BCG; MYCOBACTERIUM TUBERCULOSIS;

EID: 33749332099     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2006.04.025     Document Type: Article

References (30)

1. Huygen K. On the use of DNA vaccines for the prophylaxis of mycobacterial diseases. Infect. Immun. 71 (2003) 1613-1621
2. Horwitz M.A., Harth G., Dillon B.J., and Maslesa-Galic S. Recombinant bacillus calmette-guerin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 13853-13858
3. Behr M.A., Wilson M.A., Gill W.P., Salamon H., Schoolnik G.K., Rane S., and Small P.M. Comparative genomics of BCG vaccines by whole-genome DNA microarray. Science 284 (1999) 1520-1523
4. Andersen P. TB vaccines: progress and problems. Trends Immunol. 22 (2001) 160-168
5. Brandt L., Elhay M., Rosenkrands I., Lindblad E.B., and Andersen P. ESAT-6 subunit vaccination against Mycobacterium tuberculosis. Infect. Immun. 68 (2000) 791-795
6. Weinrich Olsen A., van Pinxteren L.A., Meng Okkels L., Birk Rasmussen P., and Andersen P. Protection of mice with a tuberculosis subunit vaccine based on a fusion protein of antigen 85b and esat-6. Infect. Immun. 69 (2001) 2773-2778
7. Weldingh K., Rosenkrands I., Jacobsen S., Rasmussen P.B., Elhay M.J., and Andersen P. Two-dimensional electrophoresis for analysis of Mycobacterium tuberculosis culture filtrate and purification and characterization of six novel Mycobacterium tuberculosis. Infect. Immun. 66 (1998) 3492-3500
8. Kamath A.T., Feng C.G., Macdonald M., Briscoe H., and Britton W.J. Differential protective efficacy of DNA vaccines expressing secreted proteins of combinations expressing either tissue plasminogen activator signal sequence fusion proteins or ubiquitin-conjugated antigens induce sustained protective immunity in a mouse model of pulmonary tuberculosis. Infect. Immun. 67 (1999) 1702-1707
9. Delogu G., Li A., Repique C., Collins F., and Morris S.L. DNA vaccine combinations expressing either tissue plasminogen activator signal sequence fusion proteins or ubiquitin-conjugated antigens induce sustained protective immunity in a mouse model of pulmonary tuberculosis. Infect. Immun. 70 (2002) 292-302
10. Cai H., Tian X., Hu X.D., Zhuang Y.H., and Zhu Y.X. Combined DNA vaccines formulated in DDA enhance protective immunity against tuberculosis. DNA Cell Biol. 23 (2004) 450-456
11. Denis O., Lozes E., and Huygen K. Induction of cytotoxic T-cell responses against culture filtrate antigens in Mycobacterium bovis bacillus Calmette-Guerin-infected mice. Infect. Immun. 65 (1997) 676-684
12. Demissie A., Ravn P., Olobo J., Doherty T.M., Eguale T., Geletu M., Hailu W., Andersen P., and Britton S. T-cell recognition of Mycobacterium tuberculosis culture filtrate fractions in tuberculosis patients and their household contacts. Infect. Immun. 67 (1999) 5967-5971
13. Ravn P., Demissie A., Eguale T., Wondwosson H., Lein D., Amoudy H.A., Mustafa A.S., Jensen A.K., Holm A., Rosenkrands I., Oftung F., Olobo J., von Reyn F., and Andersen P. Human T cell responses to the ESAT-6 antigen from Mycobacterium tuberculosis. J. Infect. Dis. 179 (1999) 637-645
14. Vekemans J., Lienhardt C., Sillah J.S., Wheeler J.G., Lahai G.P., Doherty M.T., Corrah T., Andersen P., McAdam K.P., and Marchant A. Tuberculosis contacts but not patients have higher gamma interferon responses to ESAT-6 than do community controls in The Gambia. Infect. Immun. 69 (2001) 6554-6557
15. Olsen A.W., Hansen P.R., Holm A., and Andersen P. Efficient protection against Mycobacterium tuberculosis by vaccination with a single subdominant epitope from the ESAT-6 antigen. Eur. J. Immunol. 30 (2000) 1724-1732
16. Horwitz M.A., Lee B.W., Dillon B.J., and Harth G. Protective immunity against tuberculosis induced by vaccination with major extracellular proteins of Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 1530-1534
17. Huygen K., Content J., Denis O., Montgomery D.L., Yawman A.M., Deck R.R., DeWitt C.M., Orme I.M., Baldwin S., D'Souza C., Drowart A., Lozes E., Vandenbussche P., Van Vooren J.P., Liu M.A., and Ulmer J.B. Immunogenicity and protective efficacy of a tuberculosis DNA vaccine. Nat. Med. 2 (1996) 893-898
18. Delogu G., Howard A., Collins F.M., and Morris S.L. DNA vaccination against tuberculosis: expression of a ubiquitin-conjugated tuberculosis protein enhances antimycobacterial immunity. Infect. Immun. 68 (2000) 3097-3102
19. Bhardwaj D., Hora B., Singh N., Puri S.K., Lalitha P., Rupa P., and Chauhan V.S. Immunogenicity and protective efficacy of three DNA vaccines encoding pre-erythrocytic- and erythrocytic-stage antigens of Plasmodium cynomolgi in rhesus monkeys. FEMS Immunol. Med. Microbiol. 34 (2002) 33-43
20. Frelin L., Alheim M., Chen A., Soderholm J., Rozell B., Barnfield C., Liljestrom P., and Sallberg M. Low dose and gene gun immunization with a hepatitis C virus non-structural (NS) 3 DNA-based vaccine containing NS4A inhibit NS3/4A-expressing tumors in vivo. Gene Ther. 10 (2003) 686-699
21. Li Z., Howard A., Kelley C., Delogu G., Collins F., and Morris S. Immunogenicity of DNA vaccines expressing tuberculosis proteins fused to tissue plasminogen activator signal sequences. Infect. Immun. 67 (1999) 4780-4786
22. Leal I.S., Smedegard B., Andersen P., and Appelberg R. Interleukin-6 and interleukin-12 participate in induction of a type 1 protective T-cell response during vaccination with a tuberculosis subunit vaccine. Infect. Immun. 67 (1999) 5747-5754
23. He Y., Vemulapalli R., Zeytun A., and Schurig G.G. Induction of specific cytotoxic lymphocytes in mice vaccinated with Brucella abortus RB51. Infect. Immun. 69 (2001) 5502-5508
24. Bunce C., and Bell E.B. CD45RC isoforms define two types of CD4 memory T cells, one of which depends on persisting antigen. J. Exp. Med. 185 (1997) 767-776
25. Colston M.J. The cellular and molecular basis of immunity against mycobacterial diseases. Soc. Appl. Bacteriol. Symp. Ser. 25 (1996) 33S-39S
26. Lozes E., Huygen K., Content J., Denis O., Montgomery D.L., Yawman A.M., Vandenbussche P., Van Vooren J.P., Drowart A., Ulmer J.B., and Liu M.A. Immunogenicity and efficacy of a tuberculosis DNA vaccine encoding the components of the secreted antigen 85 complex. Vaccine 15 (1997) 830-833
27. D'Souza S., Denis O., Scorza T., Nzabintwali F., Verschueren H., and Huygen K. CD4 + T cells contain Mycobacterium tuberculosis infection in the absence of CD8 + T cells in mice vaccinated with DNA encoding Ag85A. Eur. J. Immunol. 30 (2000) 2455-2459
28. Tanghe A., Lefevre P., Denis O., D'Souza S., Braibant M., Lozes E., Singh M., Montgomery D., Content J., and Huygen K. Immunogenicity and protective efficacy of tuberculosis DNA vaccines encoding putative phosphate transport receptors. J. Immunol. 162 (1999) 1113-1119
29. D'Souza S., Rosseels V., Denis O., Tanghe A., De Smet N., Jurion F., Palfliet K., Castiglioni N., Vanonckelen A., Wheeler C., and Huygen K. Improved tuberculosis DNA vaccines by formulation in cationic lipids. Infect. Immun. 70 (2002) 3681-3688
30. Singh H., and Raghava G.P. ProPred1: prediction of promiscuous MHC Class-I binding sites. Bioinformatics 19 (2003) 1009-1014