Ribosomal protein S6 is a selective mediator of TRAIL-apoptotic signaling

Oncogene

Volumn 27, Issue 31, 2008, Pages 4344-4352

  Jeon, Y J ^a   Kim, I K ^b   Hong, S H ^a   Nan, H ^a   Kim, H J ^a   Lee, H J ^a   Masuda, E S ^c   Meyuhas, O ^d   Oh, B H ^e   Jung, Y K ^a  

^a Seoul National University   (South Korea)

^b BURNHAM INSTITUTE   (United States)

^c RIGEL PHARMACEUTICALS INC   (United States)

^d HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^e Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

Apoptosis; DR4; Ribosomal protein S6; S6 kinase 1; TRAIL; Tumor cell

Indexed keywords

COMPLEMENTARY DNA; CYCLOHEXIMIDE; DEATH RECEPTOR 4; DEATH RECEPTOR 5; DOXORUBICIN; ETOPOSIDE; PROTEIN S6; STAUROSPORINE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TUNICAMYCIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; EMBRYO; FIBROBLAST; FLUORESCENCE ACTIVATED CELL SORTING; GENETIC SCREENING; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; DNA, COMPLEMENTARY; HELA CELLS; HUMANS; JURKAT CELLS; MICE; MICE, TRANSGENIC; PHOSPHORYLATION; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RECEPTORS, TUMOR NECROSIS FACTOR; RIBOSOMAL PROTEIN S6; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 47549095202     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2008.73     Document Type: Article

References (24)

1. Ashkenazi A, Pai RC, Fong S, Leung S, Lawrence DA, Marsters SA et al. (1999). Safety and antitumor activity of recombinant soluble Apo2 ligand. J Clin Invest 104: 155-162.
2. Beuvink I, Boulay A, Fumagalli S, Zilbermann F, Ruetz S, O'Reilly T et al. (2005). The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation. Cell 120: 747-759.
3. Fesik SW. (2005). Promoting apoptosis as a strategy for cancer drug discovery. Nat Rev Cancer 5: 876-885.
4. Franco R, Rosenfeld MG. (1990). Hormonally inducible phosphorylation of a nuclear pool of ribosomal protein S6. J Biol Chem 265: 4321-4325.
5. Harada H, Andersen JS, Mann M, Terada N, Korsmeyer SJ. (2001). p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Proc Natl Acad Sci USA 98: 9666-9670.
6. Inoki K, Corradetti MN, Guan KL. (2005). Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet 37: 19-24.
7. Jefferies HB, Fumagalli S, Dennis PB, Reinhard C, Pearson RB, Thomas G. (1997). Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k. EMBO J 16: 3693-3704.
8. Kim IK, Chung CW, Woo HN, Hong GS, Nagata S, Jung YK. (2000). Reconstitution of caspase-8 sensitizes JB6 cells to TRAIL. Biochem Biophy Res Commun 277: 311-316.
9. Kim IK, Jung YK, Noh DY, Song YS, Choi CH, Oh BH et al. (2003). Functional screening of genes suppressing TRAIL-induced apoptosis: distinct inhibitory activities of Bcl-XL and Bcl-2. Br J Cancer 88: 910-917.
10. Krieg J, Hofsteenge J, Thomas G. (1988). Identification of the 40S ribosomal protein S6 phosphorylation sites induced by cycloheximide. J Biol Chem 263: 11473-11477.
11. Nebbioso A, Clarke N, Voltz E, Germain E, Ambrosino C, Bontempo P et al. (2005). Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells. Nat Med 1: 77-84.
12. Pan G, Ni J, Wei YF, Yu G, Gentz R, Dixit VM. (1997a). An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 277: 815-818.
13. Pan G, O'Rouke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J et al. (1997b). The receptor for the cytotoxic ligand TRAIL. Science 276: 111-113.
14. Panner A, James CD, Berger MS, Pieper RO. (2005). mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells. Mol Cell Biol 25: 8809-8823.
15. Pende M, Um SH, Mieulet V, Sticker M, Goss VL, Mestan J et al. (2004). S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Mol Cell Biol 24: 3112-3124.
16. Pitti RM, Marsters SA, Ruppert A, Donahue CJ, Moore A, Ashkenazi A. (1996). Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J Biol Chem 271: 12687-12690.
17. Raymond AD, Helen T, Fiona CK, Xue SL, Juthathip M, Paul CE et al. (2005). Expression of TRAIL and TRAIL receptors in normal and malignant tissues. Cell Res 15: 430-438.
18. Ren YG, Klaus WW, Deborah AK, Pedro AB, Marc N, Quinn LD. (2004). Differential regulation of the TRAIL death receptors DR4 and DR5b y the signal recognition particle. Mol Cell Biol 15: 5064-5074.
19. Ruvinsky I, Sharon N, Lerer T, Cohen H, Stolovich-Rain M, Nir T et al. (2005). Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. Genes Dev 19: 2199-2211.
20. Shashirekha S, Bonnie AG, Jennifer GB, Xiaojie H, Nicolette VY, Gary H et al. (2005). Transcription factor NF-κB differentially regulates death receptor 5expression involving histone deacetylase 1. Mol Cell Biol 25: 5404-5416.
21. Sheridan JP, Marsters SE, Pitti RM, Gurney A, Skubatch M, Baldwin D et al. (1997). Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 277: 818-821.
22. Stromberg T, Dimberg A, Hammarberg A, Carlson K, Osterborg A, Nilsson K et al. (2004). Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone. Blood 103: 3138-3147.
23. Wiley SR, Schooley K, Smolak PJ, Din WS, Huang CP, Nicholl JK. (1995). Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3: 673-682.
24. Wu GS, Burns TF, McDonald III ER, Jiang W, Meng R, Krantz ID et al. (1997). KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene. Nat Genet 17: 141-143.