Minodronic acid, a third-generation bisphosphonate, antagonizes purinergic P2X2/3 receptor function and exerts an analgesic effect in pain models

European Journal of Pharmacology

Volumn 589, Issue 1-3, 2008, Pages 98-101

  Kakimoto, Shuichiro ^a   Nagakura, Yukinori ^a   Tamura, Seiji ^a   Watabiki, Tomonari ^a   Shibasaki, Kumiko ^a   Tanaka, Shohei ^a   Mori, Masamichi ^a   Sasamata, Masao ^a   Okada, Masamichi ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Analgesia; Bisphosphonate; Minodronic acid; P2X2 3 receptor; Pain

Indexed keywords

ACETIC ACID; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; BISPHOSPHONIC ACID DERIVATIVE; CLODRONIC ACID; FORMALDEHYDE; MINODRONIC ACID; PAMIDRONIC ACID; PURINERGIC P2X2 RECEPTOR; PURINERGIC P2X3 RECEPTOR; SURAMIN; ZOLEDRONIC ACID;

ANALGESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE METASTASIS; BONE PAIN; BONE TURNOVER; CONTROLLED STUDY; DRUG POTENCY; IC 50; MALE; MOUSE; NEUROTRANSMITTER RELEASE; NOCICEPTION; NONHUMAN; OSTEOLYSIS; PAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACETIC ACID; ADENOSINE TRIPHOSPHATE; ANALGESICS, NON-NARCOTIC; ANIMALS; BONE DENSITY CONSERVATION AGENTS; CHO CELLS; CRICETINAE; CRICETULUS; DIPHOSPHONATES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FORMALDEHYDE; IMIDAZOLES; INJECTIONS, SUBCUTANEOUS; MALE; MICE; MICE, INBRED ICR; PAIN; PAIN MEASUREMENT; RECEPTORS, PURINERGIC P2; TIME FACTORS; TRANSFECTION;

EID: 47549090957     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.05.011     Document Type: Article

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