Bone cancer pain: From model to mechanism to therapy

Journal of Pain and Symptom Management

Volumn 29, Issue 5 SUPPL., 2005, Pages 32-46

  Luger, Nancy M ^a   Mach, David B ^a   Sevcik, Molly A ^a   Mantyh, Patrick W ^a,b,c  

^a UNIVERSITY OF MINNESOTA   (United States)

^b VA MEDICAL CENTER   (United States)

^c 18 208 Moos Tower ^*  (United States)

Author keywords

Metastases; Morphine; Pain

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; FREUND ADJUVANT; MORPHINE; MORPHINE SULFATE; NALOXONE; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE;

ACUTE DRUG ADMINISTRATION; ANALGESIA; ANIMAL EUTHANASIA; BEHAVIOR; BONE CANCER; BONE DESTRUCTION; BREAST CANCER; CANCER INVASION; CANCER MODEL; CANCER PAIN; CANCER PATIENT; CANCER TRANSPLANTATION; CHRONIC PAIN; CLINICAL FEATURE; COMPARATIVE STUDY; CONFERENCE PAPER; CONSTIPATION; CORRELATION ANALYSIS; CORTICAL BONE; DISEASE COURSE; DISEASE MODEL; DISEASE SEVERITY; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; DRUG TARGETING; DRUG TOLERANCE; FEMUR; HINDLIMB; HUMAN; INFLAMMATION; INJECTION; LUNG CANCER; NOCICEPTION; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; OSTEOSARCOMA; PROSTATE CANCER; QUALITY OF LIFE; SEDATION; SENSITIZATION; SENSORY NERVE; SIDE EFFECT; SOMNOLENCE; STATISTICAL ANALYSIS;

EID: 19344372093     PISSN: 08853924     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpainsymman.2005.01.008     Document Type: Conference Paper

References (82)

1. Cancer Statistics 2005, Jan-Feb issue, CA: Cancer Journal for Clinicians.
2. S. Mercadante Malignant bone pain: pathophysiology and treatment Pain 69 1997 1 18
3. S. Mercadante, and E. Arcuri Breakthrough pain in cancer patients: pathophysiology and treatment Cancer Treat Rev 24 1998 425 432
4. R.K. Portenoy, and P. Lesage Management of cancer pain Lancet 353 1999 1695 1700
5. A. Banning, P. Sjogren, and H. Henriksen Pain causes in 200 patients referred to a multidisciplinary cancer pain clinic Pain 45 1991 45 48
6. R.E. Coleman How can we improve the treatment of bone metastases further? Curr Opin Oncol 10 1998 S7 S13
7. R.E. Coleman, S. Houston, and O.P. Purohit A randomised phase II study of oral pamidronate for the treatment of bone metastases from breast cancer Eur J Cancer 34 1998 820 824
8. R.E. Coleman Skeletal complications of malignancy Cancer 80 1997 1588 1594
9. F. Fulfaro, A. Casuccio, C. Ticozzi, and C. Ripamonti The role of bisphosphonates in the treatment of painful metastatic bone disease: a review of phase III trials Pain 78 1998 157 169
10. A. Lipton Bisphosphonates and breast carcinoma Cancer 80 1997 1668 1673
11. M. Pecherstorfer, and M. Vesely Diagnosis and monitoring of bone metastases: clinical means J.J. Body Tumor bone diseases and osteoporosis in cancer patients 2000 Marcel Dekker, Inc. New York 97 129
12. D. Preston, K. Baxter, M. Schiefelbein, and J. Spicer Palliation of painful bone metastases: radioactive isotopes J.J. Body Tumor bone diseases and osteoporosis in cancer patients 2000 Marcel Dekker, Inc. New York 287 304
13. R. Rosier Bone pain Am J Hosp Palliat Care 9 1992 37
14. R.K. Portenoy, and N.A. Hagen Breakthrough pain: definition, prevalence and characteristics Pain 41 1990 273 281
15. S. Mercadante Controversies over spinal treatment in advanced cancer patients [see comments] Support Care Cancer 6 1998 495 502
16. R.K. Portenoy Managing cancer pain poorly responsive to systemic opioid therapy Oncology 13 1999 25 29
17. N.I. Cherny The management of cancer pain [see comments] Ca Cancer J Clin 50 2000 70 116 quiz 117-120
18. M.H. Levy Pharmacologic treatment of cancer pain N Engl J Med 335 1996 1124 1132
19. R.C. Koshy, and S.A. Grossman Treatment of bone pain J.J. Body Tumor bone diseases and osteoporosis in cancer patients 2000 Marcel Dekker, Inc New York 245 261
20. K.B. Olson, and K.J. Pienta Pain management in patients with advanced prostate cancer Oncology (Huntington) 13 1999 1537 1549 discussion 1549-1550 passim
21. A. Serafini Therapy of metastatic bone pain J Nuclear Medicine 42 2001 895 906
22. P. Honore, N.M. Luger, and M.C. Sabino Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemcial reorganization of the spinal cord Nature Med 6 2000 521 528
23. N.M. Luger, P. Honore, and M.C. Sabino Osteoprotegerin diminishes advanced bone cancer pain Cancer Res 61 2001 4038 4047
24. M.J. Schwei, P. Honore, and S.D. Rogers Neurochemical and cellular reorganization of the spinal cord in a murine model of bone cancer pain J Neurosci 19 1999 10886 10897
25. D.R. Clohisy, C.M. Ogilvie, and M.L. Ramnaraine Tumor osteolysis in osteopetrotic mice J Orthopaedic Research 13 1995 892 897
26. D.R. Clohisy, D. Palkert, and M.L. Ramnaraine Human breast cancer induces osteoclast activation and increases the number of osteoclasts at sites of tumor osteolysis J Orthopaed Res 14 1996 396 402
27. J.L. Bloem, and H.M. Kroon Osseous lesions Rad Clin North Am 32 1993 265 278
28. M. Parsa, and M. Murphey Radiographic diagnosis and monitoring of bone metastases J.J. Body Tumor bone disease and osteoporosis in cancer patients 2000 Marcel Dekker, Inc New York 155 195
29. T. Taube, I. Elomaa, and C. Blomqvist Histomorphometric evidence for osteoclast-mediated bone resorption in metastatic breast cancer Bone 15 1994 161 166
30. N.M. Luger, M.C. Sabino, and M.J. Schwei Efficacy of systemic morphine suggests a fundamental difference in the mechanisms that generate bone cancer vs inflammatory pain Pain 99 2002 397 406
31. M.C. Sabino, J.R. Ghilardi, and J.L. Jonger Simultaneous reduction in cancer pain, bone destruction, and tumor growth by selective inhibition of cyclooxygenase-2 Cancer Res 62 2002 7343 7349
32. P. Honore, S.D. Rogers, and M.J. Schwei Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons Neuroscience 98 2000 585 598
33. W.H. McBride Phenotype and functions of intratumoral macrophages Biochim Biophys Acta 865 1986 27 41
34. F. Zhang, W. Lu, and Z. Dong Tumor-infiltrating macrophages are involved in suppressing growth and metastasis of human prostate cancer cells by INF-beta gene therapy in nude mice Clin Cancer Res 8 9 2002 2942 2951
35. L.R. Watkins, D. Martin, and P. Ulrich Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat Pain 71 1997 225 235
36. B. Safieh-Garabedian, S. Poole, and A. Allchorne Contribution of interleukin-1 beta to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia Brit J Pharmacology 115 1995 1265 1275
37. C.J. Woolf, A. Allchorne, B. Safieh-Garabedian, and S. Poole Cytokines, nerve growth factor and inflammatory hyperalgesia: the contribution of tumour necrosis factor alpha Brit J Pharmacol 121 1997 417 424
38. L.S. Sorkin, W.H. Xiao, R. Wagner, and R.R. Myers Tumour necrosis factor-alpha induces ectopic activity in nociceptive primary afferent fibres Neuroscience 81 1997 255 262
39. C.C. Pilbeam, J.R. Harrison, and L.G. Raisz Prostaglandins and bone metabolism J.P. Bilezikian L.G. Raisz G.A. Rodan Principles of bone biology 2002 Academic Press New York 979 994
40. A.B. Malmberg, and T.L. Yaksh Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat J Pharmacol Exper Ther 263 1992 136 146
41. T.H. Olson, M.S. Riedl, and L. Vulchanova An acid sensing ion channel (ASIC) localizes to small primary afferent neurons in rats Neuroreport 9 1998 1109 1113
42. D.B. Mach, S.D. Rogers, and M.C. Sabino Origins of skeletal pain: sensory and sympathetic innervation of the mouse femur Neurosci 113 2002 155 166
43. J. Insall, H. Shoji, and V. Mayer High tibial osteotomy. A five-year evaluation J Bone Joint Surg Am 56 1974 1397 1405
44. R. Rubens Clinical aspects of bone metastases J.J. Body Tumor bone diseases and osteoporosis in cancer patients 2000 Mercel Dekker, Inc New York 85 96
45. M.J. Millan, A. Czlonkowski, and B. Morris Inflammation of the hind limb as a model of unilateral, localized pain: influence on multiple opioid systems in the spinal cord of the rat Pain 35 1988 299 312
46. A.I. Basbaum, and J.M. Besson Towards a new pharmacotherapy of pain 1991 John Wiley & Sons Chichester
47. A.H. Dickenson Neurophysiology of opioid poorly responsive pain Cancer Surveys 21 1994 5 16
48. C. Stein Peripheral mechanisms of opioid analgesia Anesthesia Analgesia 76 1993 182 191
49. T.L. Yaksh Pharmacology and mechanisms of opioid analgesic activity Acta Anaesthesiol Scand 41 1997 94 111
50. J. Joris, A. Costello, R. Dubner, and K. Hargreaves Opioids supress carrageenan-induced edema and hyperthermia at doses that inhibit hyperalgesia Pain 43 1990 95 103
51. M.H. Ossipov, C.J. Kovelowski, and F. Porreca The increase in morphine antinociceptive potency produced by carrageenan-induced hindpaw inflammation is blocked by naltrindole, a selective delta-opioid antagonist Neurosci Lett 184 1995 173 176
52. L.C. Stanfa, A.F. Sullivan, and A.H. Dickenson Alterations in neuronal excitability and the potency of spinal mu, delta and kappa opioids after carrageenan-induced inflammation Pain 50 1992 345 354
53. D.M. Dirig, and T.L. Yaksh Differential right shifts in the dose-response curve for intrathecal morphine and sufentanil as a function of stimulus intensity Pain 62 1995 321 328
54. S. Saeki, and T.L. Yaksh Suppression of nociceptive responses by spinal mu opioid agonists: effects of stimulus intensity and agonist efficacy Anesth Analg 77 1993 265 274
55. S. Arner, and B.A. Meyerson Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain Pain 33 1988 11 23
56. D. Bridges, S.W.N. Thompson, and A.S. Rice Mechanisms of neuropathic pain Brit J Anaesth 87 2001 12 26
57. L. Stanfa, and A. Dickenson Spinal opioid systems in inflammation Inflamm Res 44 1995 231 241
58. T.L. Yaksh Preclinical models of nociception T.L. Yaksh Anesthesia: biologic foundations 1997 Lippincott-Raven Publishers Philadephia 685 718
59. S.P. Hunt, A. Pini, and G. Evan Induction of c-fos-like protein in spinal cord neurons following sensory stimulation Nature 328 1987 632 634
60. C. Abbadie, J. Trafton, and H. Liu Inflammation increases the distribution of dorsal horn neurons that internalize the neurokinin-1 receptor in response to noxious and non-noxious stimulation J Neurosci 17 1997 8049 8060
61. A. Bjurholm, A. Kreicbergs, E. Brodin, and M. Schultzberg Substance P- and CGRP-immunoreactive nerves in bone PEPTIDES 9 1988 165 171
62. G. Catheline, S. Le Guen, P. Honore, and J.M. Besson Are there long-term changes in the basal or evoked Fos expression in the dorsal horn of the spinal cord of the mononeuropathic rat? Pain 80 1999 347 357
63. R.W. Colburn, A.J. Rickman, and J.A. DeLeo The effect of site and type of nerve injury on spinal glial activation and neuropathic pain behavior Exper Neurol 157 1999 289 304
64. E.L. Hill, and R. Elde Distribution of CGRP-, VIP-, D beta H-, SP-, and NPY-immunoreactive nerves in the periosteum of the rat Cell Tissue Res 264 1991 469 480
65. P. Honore, P.M. Menning, and S.D. Rogers Spinal substance P receptor expression and internalization in acute, short-term, and long-term inflammatory pain states J Neurosci 19 1999 7670 7678
66. T.M. Laughlin, T.W. Vanderah, and J. Lashbrook Spinally administered dynorphin A produces long-lasting allodynia: involvement of NMDA but not opioid receptors Pain 72 1997 253 260
67. K. Noguchi, K. Kowalski, and R. Traub Dynorphin expression and Fos-like immunoreactivity following inflammation induced hyperalgesia are colocalized in spinal cord neurons Mol Brain Res 10 1991 227 233
68. T.W. Vanderah, T. Laughlin, and J.M. Lashbrook Single intrathecal injections of dynorphin A or des-Tyr-dynorphins produce long-lasting allodynia in rats; blockade by MK-801 but not naloxone Pain 68 1996 275 281
69. T.W. Vanderah, M.H. Ossipov, and J. Lai Mechanisms of opioid-induced pain and antinociceptive tolerance: descending facilitation and spinal dynorphin [review] Pain 92 2001 5 9
70. R.W. Colburn, J.A. DeLeo, and A.J. Rickman Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat J Neuroimmunol 79 1997 163 175
71. C.J. Garrison, P.M. Dougherty, K.C. Kajander, and S.M. Carlton Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury Brain Res 565 1991 1 7
72. L.R. Watkins, and S.F. Maier Implications of immune-to-brain communication for sickness and pain Proc Nat Acad Sci USA 96 1999 7710 7713
73. N. Coyle, J. Adelhardt, K.M. Foley, and R.K. Portenoy Character of terminal illness in the advanced cancer patient: pain and other symptoms during the last four weeks of life [see comments] J Pain Symptom Manage 5 1990 83 93
74. M.K. Makin Strong opioids for cancer pain J Royal Soc Med 94 2001 17 21
75. R. Payne Mechanisms and management of bone pain Cancer 80 1997 1608 1613
76. R. Payne Practice guidelines for cancer pain therapy. Issues pertinent to the revision of national guidelines Oncology 12 1998 169 175
77. E. Collin, P. Poulain, and A. Gauvain-Piquard Is disease progression the major factor in morphine 'tolerance' in cancer pain treatment? Pain 55 1993 319 326
78. C.J. Woolf, G.J. Bennett, and M. Doherty Towards a mechanism-based classification of pain Pain 77 1998 227 229
79. J.J. Body, P. Greipp, and R.E. Coleman A phase 1 study of AMGN-0007, a recombinant osteoprotegrin construct, in patients with multiple myeloma or breast carcinoma related bone metastasis Cancer 97 2003 887 892
80. S.R. Chaplan, F.W. Bach, and J.W. Pogrel Quantitative assessment of tactile allodynia in the rat paw J Neurosci Meth 53 1994 55 63
81. J. Hasselstrom, J.O. Svensson, and J. Sawe Disposition and analgesic effects of systemic morphine, morphine-6-glucuronide and normorphine in rat Pharmacol Toxicol 79 1996 40 46
82. S. Siegel, and N. Castellan Nonparametric statistics for the behavioral sciences 1988 McGraw-Hill, Inc. New York