Immune response to Toxoplasma gondii

Annali dell'Istituto Superiore di Sanita

Volumn 40, Issue 1, 2004, Pages 71-80

  Filisetti, Denis ^a   Candolfi, Ermanno ^a  

^a Institut de Parasitologie   (France)

Author keywords

Cytochine; Humoral immune response; Pathology; Toxoplasma

Indexed keywords

GAMMA INTERFERON;

ANIMAL TISSUE; BLOOD BRAIN BARRIER; BLOOD PLACENTA BARRIER; BLOOD RETINA BARRIER; CYTOKINE RELEASE; CYTOSOL; DISEASE COURSE; HOST; HUMAN; IMMUNE RESPONSE; MOUSE; NONHUMAN; REVIEW; SPOROZOITE; SURVIVAL; T LYMPHOCYTE; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ACUTE DISEASE; ANIMALS; BRAIN; CYTOKINES; HUMANS; INTERFERON TYPE II; MUSCLES; T-LYMPHOCYTES; TOXOPLASMA; TOXOPLASMOSIS;

EID: 4744365859     PISSN: 00212571     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (125)

1. Johnson J, Suzuki Y, Mack D, Mui E, Estes R, David C, Skamene E, Forman J, McLeod R. Genetic analysis of influences on survival following Toxoplasma gondii infection. Int J Parasitol 2002;32(2):179-85.
2. Suzuki Y, Remington JS. Toxoplasmic encephalitis in AIDS patients and experimental models for study of the disease and its treatment. Res Immunol 199;144(1):66-7.
3. Subauste CS, Remington JS. Immunity to Toxoplasma gondii. Curr Opin Immunol 1993;5(4):532-7.
4. Lindberg RE, Frenkel JK. Cellular immunity to toxoplasma and besnoitia in hamsters: specificity and the effects of cortisol. Infect Immun 1977;15(3):855-62.
5. Schluter D, Lohler J, Deckert M, Hof H, Schwendemann G. Toxoplasma encephalitis of immunocompetent and nude mice: immunohistochemical characterisation of Toxoplasma antigen, infiltrates and major histocompatibility complex gene products. J Neuroimmunol 1991;31(3):185-98.
6. Hauser W, Sharma S, Remington J. Augmentation of NK cell activity by soluble and particulate fractions of Toxoplasma gondii. J Immunol 1983;131(1):458-63.
7. Sibley LD, Adams LB, Krahenbuhl JL. Macrophage interactions in toxoplasmosis. Res Immunol 1993;144(1):38-40.
8. Murray HW, Cohn ZA. Macrophage oxygen-dependent anti microbial activity. I. Susceptibility of Toxoplasma gondii to oxygen intermediates. J Exp Med 1979;150:938-49.
9. Hughes HPA. Oxidative killing of intracellular parasites mediated by macrophages. Parasitol Today 1988;4:340-7.
10. Drapier J, Wietzerbin J, Hibbs J. Interferon-gamma and tumor necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages. Eur J Immunol 1988;18:1587-92.
11. Ding A, Nathan C, Stuher D. Release of reactives nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. J Immunol 1988;141(7):2407-12.
12. Adams L, Hibbs J, Taintor R, Krahenbuhl J. Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. J Immunol 1990;144(7):2725-9.
13. Schluter D, Deckert-Schluter M, Lorenz E, Meyer T, Rollinghoff M, Bogdan C. Inhibition of inducible nitric oxide synthase exacerbates chronic cerebral toxoplasmosis in Toxoplasma gondii-susceptible C57BL/6 mice but does not reactivate the latent disease in T. gondii-resistant BALB/c mice. J Immunol 1999;162(6):3512-8.
14. Pfefferkorn ER, Rebhun S, Eckel M. Characterization of an indoleamine 2,3-dioxygenase induced by gamma-interferon in cultured human fibroblasts. J Interferon Res 1986;6(3):267-79.
15. MacKenzie CR, Langen R, Takikawa O, Daubener W. Inhibition of indoleamine 2,3-dioxygenase in human macrophages inhibits interferon-gamma-induced bacteriostasis but does not abrogate toxoplasmastasis. Eur J Immunol 1999;29(10):3254-61.
16. Sher A, Oswald IP, Hieny S, Gazzinelli RT. Toxoplasma gondii induces a T-independent IFN-gamma response in natural killer cells that requires both adherent accessory cells and tumor necrosis factor-alpha. J Immunol 1993;150(9):3982-9.
17. Hunter C, Subauste C, Van Cleave V, Remington J. Production of gamma interferon by natural killer cells from Toxoplasma gondii-infected SCID mice: regulation by interleukin-10, interleukin-12, and tumor necrosis factor alpha. Infect Immunity 1994;62(7):2818-24.
18. Gazzinelli R, Hieny S, Wynn T, Wolf S, Sher A. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon g by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc Natl Acad Sci USA 1993;90:6115-9.
19. Cai G, Kastelein R, Hunter CA. Interleukin-18 (IL-18) enhances innate IL-12 mediated resistance to Toxoplasma gondii. Infect Immun 2000;68(12):6932-8.
20. Cai G, Radzanowski T, Villegas EN, Kastelein R, Hunter CA. Identification of STAT4-dependent and independent mechanisms of resistance to Toxoplasma gondii. J Immunol 2000;165(5):2619-27.
21. Subauste X, Chung J, Koniaris A, Hunter C, Montoya J, Porcelli S, Remington J. Preferential activation and expansion of human peripheral blood gamma-delta T cells in response to Toxoplasma gondii in vitro and their cytokine production and cytotoxic activity against T. gondii-infected cells. J Clin Invest 1995;96(july):610-9.
22. Scalise F, Gerli R, Castellucci G, Spinozzi F, Fabietti G, Crupi S, Sensi L, Britta R, Vaccaro R, Bertotto A. Lymphocytes bearing the gamma-delta T-cell receptor in acute toxoplasmosis. Immunol 1992;76:668-70.
23. De Paoli P, Basaglia G, Gennari D, Crovatto M, Modolo M, Santini G. Phenotypic profile and functional characteristics of human gamma and delta T cells during acute toxoplasmosis. J Clin Microbiol 1992;30(3):729-31.
24. Hisaeda H, Nagasawa H, Maeda KI, Maekawa Y, Ishikawa H, Ito Y, Good RA, Himeno K. Gamma-delta T cells play an important role in Hsp65 expression and in acquiring protective immune response against infection with Toxoplasma gondii. J Immunol 1995;154:244-51.
25. Lepage AC, Buzoni-Gatel D, Bout DT, Kasper LH. Gut-derived intraepithelial lymphocytes induce long term immunity against Toxoplasma gondii. J Immunol 1998;161(9):4902-8.
26. Sayles PC, Rakhmilevich AL, Johnson LL. Gamma delta T cells and acute primary Toxoplasma gondii infection in mice. J Infect Dis 1995;171(1):249-52.
27. Yong EC, Chi EY, Fritsche TR, Henderson WR, Jr. Human platelet-mediated cytotoxicity against Toxoplasma gondii: role of thromboxane. J Exp Med 1991;173(1):65-78.
28. Chumpitazi BF, Simon J, Polack B, Peyron F, Picot S, Ricard J, Ambroise-Thomas P. Human platelet inhibition of Toxoplasma gondii growth. Clin Exp Immunol 1998;111(2):325-33.
29. Henderson WR, Jr., Chi EY. The importance of leukotrienes in mast cell-mediated Toxoplasma gondii cytotoxicity. J Infect Dis 1998;177(5):1437-43.
30. Bliss SK, Butcher BA, Denkers EY. Rapid recruitment of neutrophils containing prestored IL-12 during microbial infection. J Immunol 2000;165(8):4515-21.
31. Bliss SK, Gavrilescu LC, Alcaraz A, Denkers EY. Neutrophil depletion during Toxoplasma gondii infection leads to impaired immunity and lethal systemic pathology. Infect Immun 2001;69(8):4898-905.
32. Khan IA, Murphy PM, Casciotti L, Schwartzman JD, Collins J, Gao JL, Yeaman GR. Mice lacking the chemokine receptor CCR1 show increased susceptibility to Toxoplasma gondii infection. J Immunol 2001;166(3):1930-7.
33. Bout D, Moretto M, Dimier-Poisson I, Gatel DB. Interaction between Toxoplasma gondii and enterocyte. Immunobiol 1999;201(2):225-8.
34. Yap GS, Sher A. Effector cells of both nonhemopoietic and hemopoietic origin are required for interferon (IFN)-gamma- and tumor necrosis factor (TNF)- alpha-dependent host resistance to the intracellular pathogen, Toxoplasma gondii. J Exp Med 1999;189(7):1083-92.
35. Reichmann G, Walker W, Villegas EN, Craig L, Cai G, Alexander J, Hunter CA. The CD40/CD40 ligand interaction is required for resistance to toxoplasmic encephalitis. Infect Immun 2000;68(3):1312-8.
36. Seguin R, Kasper LH. Sensitized lymphocytes and CD40 ligation augment interleukin-12 production by human dendritic cells in response to Toxoplasma gondii. J Infect Dis 1999;179(2):467-74.
37. Subauste CS, Wessendarp M. Human dendritic cells discriminate between viable and killed Toxoplasma gondii tachyzoites: dendritic cell activation after infection with viable parasites results in CD28 and CD40 ligand signaling that controls IL-12-dependent and -independent T cell production of IFN- gamma. J Immunol 2000;165(3):1498-505.
38. Hunter C, Subauste C, Remington J. The role of cytokines in toxoplasmosis. Biotherapy 1994;7:237-47.
39. Suzuki Y, Remington J. Dual regulation of resistance against Toxoplasma gondii infection by Lyt-2+ and Lyt-1+, L3T4+ T cells in mice. J Immunol 1988;140:3943-6.
40. Gazzinelli RT, Hakim FT, Hieny S, Shearer GM, Sher A. Synergistic role CD4+ and CD8+ T lymphocytes in INF-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine. J Immunol 1991;146(1):286-92.
41. Araujo F. Depletion of the L3T4+ (CD4+) T lymphocytes prevents development of resistance to Toxoplasma gondii in mice. Infect Immun 1991;59(5):1614-9.
42. Brinkmann V, Remington JS, Sharma SD. Vaccination of mice with the protective F3G3 antigen of Toxoplasma gondii activates CD4+ but not CD8+ T cells and induces Toxoplasma specific IgG antibody. Mol Immunol 1993;30(4):353-8.
43. Sharma SD, Hofflin JM, Remington JS. In vivo recombinant interleukin 2 administration enhances survival against a lethal challenge with Toxoplasma gondii. J Immunol 1985;135(6): 4160-3.
44. Suzuki Y, Orellana MA, Schreiber RD, Remington JS. Interferon-gamma: the major mediator of resistance against Toxoplasma gondii. Science 1988;240(4851):516-8.
45. Nagasawa H, Manabe T, Maekawa Y, Oka M, Himeno K. Role of L3T4+ and Lyt-2+ T cell subsets in protective immune responses of mice against infection with a low or high virulent strain of Toxoplasma gondii. Microbiol Immunol 1991;35(3):215-22.
46. Kasper L, Khan I, Ely K, Buelow R, Boothroyd J. Antigen-specific (p30) mouse CD8+ T cells are cytotoxic against Toxoplasma gondii infected peritoneal macrophages. J Immunol 1992;148(5):1493-8.
47. Subauste C, Koniaris A, Remington J. Murine CD8+ cytotoxic T lymphocytes lyse Toxoplasma gondii infected cells. J Immunol 1991;147(11):3955-9.
48. Denkers EY, Sher A, Gazzinelli RT. CD8+ T-cell interactions with Toxoplasma gondii: implications for processing of antigen for class-I-restricted recognition. Res Immunol 1993;144(1): 51-7.
49. Yano A, Aosai F, Ohta M, Hasekura H, Sugane K, Hayashi S. Antigen presentation by Toxoplasma gondii-infected cells to CD4+ proliferative T cells and CD8+ cytotoxic cells. J Parasitol 1989;75(3):411-6.
50. Vollmer T, Waldor M, Steinman L, Conley F. Depletion of T-4+ lymphocytes with monoclonal antibody reactivates toxoplasmosis in the central nervous system: a model of superinfection in AIDS. J Immunol 1987;138(11):3737-41.
51. Gazzinelli R, Xu Y, Hieny S, Cheever A, Sher A. Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii. J Immunol 1992;149(1):175-80.
52. Caamano J, Tato C, Cai G, Villegas EN, Speirs K, Craig L, Alexander J, Hunter CA. Identification of a role for NF-kappa B2 in the regulation of apoptosis and in maintenance of T cell-mediated immunity to Toxoplasma gondii. J Immunol 2000;165(10):5720-8.
53. Prigione I, Facchetti P, Lecordier L, Deslee D, Chiesa S, Cesbron-Delauw MF, Pistoia V. T cell clones raised from chronically infected healthy humans by stimulation with Toxoplasma gondii excretory-secretory antigens cross- react with live tachyzoites: characterization of the fine antigenic specificity of the clones and implications for vaccine development. J Immunol 2000;164(7):374-8.
54. Villegas EN, Elloso MM, Reichmann G, Peach R, Hunter CA. Role of CD28 in the generation of effector and memory responses required for resistance to Toxoplasma gondii. J Immunol 1999;163(6):3344-53.
55. Rytel MW, Jones TC. Induction of interferon in mice infected with Toxoplasma gondii. Proc Soc Exp Biol Med 1966;123(3): 859-62.
56. McCabe RE, Luft BJ, Remington JS. Effect of murine interferon gamma on murine toxoplasmosis. J Infect Dis 1984;150(6): 961-2.
57. Raymond J, Poissonnier M, Thulliez P, Forestier F, Daffos F, Lebon P. Presence of gamma interferon in human acute and congenital toxoplasmosis. J Clin Microbiol 1990;28(6): 1434-7.
58. Ely KH, Kasper LH, Khan IA. Augmentation of the CD8+ T cell response by IFN-gamma in IL-12- deficient mice during Toxoplasma gondii infection. J Immunol 1999;162(9): 5449-54.
59. Jones C, Bienz A, Erb P. In vitro cultivation of Toxoplasma gondii cyts in astrocytes in the presence of gamma infection. Infect Immun 1985;51(1):147-156.
60. Bohne W, Heesemann J, Gross U. Induction of bradyzoite-specific Toxoplasma gondii antigens in gamma interferon treated mouse macrophages. Infect Immun 1993;61(3): 1141-5.
61. Soete M, Camus D, Dubremetz J. Experimental induction of bradyzoite-specific antigen expression and cyst formation by the RH strain of Toxoplasma gondii in vitro. Exp Parasitol 1994;78:361-70.
62. Gavrilescu LC, Denkers EY. IFN-gamma overproduction and high level apoptosis are associated with high but not low virulence Toxoplasma gondii infection. J Immunol 2001;167(2): 902-9.
63. Liesenfeld O, Kosek J, Remington JS, Suzuki Y. Association of CD4+ T cell-dependent, interferon-gamma-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondii. J Exp Med 1996;184(2): 597-607.
64. Suzuki Y, Sher A, Yap G, Park D, Neyer LE, Liesenfeld O, Fort M, Kang H, Gufwoli E. IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB/c and susceptible C57BL/6 mice following peroral infection with Toxoplasma gondii. J Immunol 2000;164(10):5375-82.
65. Hunter C, Candolfi E, Subauste C, Van Cleave V, Remington J. Studies on the role of interleukin-12 in acute murine toxoplasmosis. Immunol 1995;84:16-20.
66. Letscher-Bru V, Villard O, Risse B, Zauke M, Klein JP, Kien TT. Protective effect of vaccination with a combination of recombinant surface antigen 1 and interleukin-12 against toxoplasmosis in mice. Infect Immun 1998;66(9): 4503-6.
67. Yap G, Pesin M, Sher A. Cutting edge: IL-12 is required for the maintenance of IFN-gamma production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii. J Immunol 2000;165(2):628-31.
68. Aliberti J, Reis e Sousa C, Schito M, Hieny S, Wells T, Huffnagle GB, Sher A. CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha+ dendritic cells. Nat Immunol 2000;1(1):83-87.
69. Aliberti J, Hieny S, Reis e Sousa C, Serhan CN, Sher A. Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity. Nat Immunol 2002;3(1):76-82.
70. Chang HR, Grau GE, Pechere JC. Role of TNF and IL1 in infections with Toxoplasma gondii. Immunol 1990;69:37-37.
71. Langermans J, Van der Hulst M, Nibbering P, Hiemstra P, Fransen P, Van Furth R. IFN-gamma induced L-arginine dependent toxoplasmastatic activity in murine peritoneal macrophages is mediated by endogenous tumor necrosis factor. J Immunol 1992;148(2):568-74.
72. Johnson L. A Protective role for endogenous tumor necrosis factor in Toxoplasma gondii infection. Infect Immun 1992;60(5):1979-83.
73. Tripp C, Wolf S, Unanue E. Interleukin 12 and tumor necrosis factor a are costimulators of interferon g production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc Nat Acad Sci USA 1993;90:3725-9.
74. Black CM, Israelski DM, Suzuki Y, Remington J. Effect of recombinant tumour necrosis factor on acute infection in mice with Toxoplasma gondii or Trypanosoma cruzi. Immunol 1989;68:570-4.
75. Beaman M, Remington J. Cytokines and resistance against Toxoplasma gondii: evidence from in vivo and in vitro studies. 1992:111-119.
76. Marshall AJ, Brunet LR, van Gessel Y, Alcaraz A, Bliss SK, Pearce EJ, Denkers EY. Toxoplasma gondii and Schistosoma mansoni synergize to promote hepatocyte dysfunction associated with high levels of plasma TNF-alpha and early death in C57BL/6 mice. J Immunol 1999;163(4):2089-97.
77. Grau G, Tacchini-Cottier F, Piguet P. Is TNF beneficial or deleterious in Toxoplasmic encephalitis? Parasitol Today 1992;8:322-4.
78. Yamamoto JH, Vallochi AL, Silveira C, Filho JK, Nussenblatt RB, Cunha-Neto E, Gazzinelli RT, Belfort R, Jr., Rizzo LV. Discrimination between patients with acquired toxoplasmosis and congenital toxoplasmosis on the basis of the immune response to parasite antigens. J Infect Dis 2000;181(6): 2018-22.
79. Suzuki Y, Yang Q, Conley F, JS A, Remington J. Antibody against interleukin-6 reduces inflammation and numbers of cysts in brains of mice with toxoplasmic encephalitis. Infect Immun 1994;62:2773-8.
80. Lyons RE, Anthony JP, Ferguson DJ, Byrne N, Alexander J, Roberts F, Roberts CW. Immunological studies of chronic ocular toxoplasmosis: up-regulation of major histocompatibility complex class I and transforming growth factor beta and a protective role for interleukin-6. Infect Immun 2001;69(4):2589-95.
81. Beaman M, Hunter C, Remington J. Enhancement of intracellular replication of T. gondii by IL-6. Interaction with IFN-γ and TNF-α. J Immunol 1994;153:4583-7.
82. Friedland JS, Shattock RJ, Johnson JD, Remick DG, Holliman RE, Griffin GE. Differential cytokine gene expression and secretion after phagocytosis by a human monocytic cell line of Toxoplasma gondii compared with Mycobacterium tuberculosis. Clin Exp Immunol 1993;91:282-6.
83. Pelloux H, Pernod G, Ricard J, Renversez TC, Ambroise-Thomas P. Interleukin-6 is secreted by human monocytes after stimulation with anti-Toxoplasma gondii sera. J Infect Dis 1994;169(5):1181-2.
84. Pelloux H, Ricard J, Bracchi V, Markowicz Y, Verna JM, Ambroise-Thomas P. Tumor necrosis factor alpha, interleukin 1 alpha, and interleukin 6 mRNA expressed by human astrocytoma cells after infection by three different strains of Toxoplasma gondii. Parasitol Res 1994;80(4):271-6.
85. Zhang Y, Denkers EY. Protective role for interleukin-5 during chronic Toxoplasma gondii infection. Infect Immun 1999;67(9):4383-92.
86. Nickdel MB, Roberts F, Brombacher F, Alexander J, Roberts CW. Counter-protective role for interleukin-5 during acute Toxoplasma gondii infection. Infect Immun 2001;69(2):1044-52.
87. Arnaud JP, Griscelli C, Couvreur J, Desmonts G. Anomalies hématologiques et immunologiques et immunologiques dans la toxoplasmose congénitale. Nouv Rev Fr Hematol 1975;15(4):496-505.
88. Nakazaki S, Saeki N, Itoh S, Osato K, Watanabe O, Hamada N, Mitsuhashi H, Shin H, Kiuchi I, Kobayashi C, Yano A, Yamaura A. Toxoplasmic encephalitis in patients with acquired immunodeficiency syndrome-four case reports. Neurol Med Chir (Tokyo) 2000;40(2):120-3.
89. Doherty TM, Seder RA, Sher A. Induction and regulation of IL-15 expression in murine macrophages. J Immunol 1996;156(2):735-41.
90. Khan IA, Kasper LH. IL-15 augments CD8+ T cell-Mediated immunity against Toxoplasma gondii infection in Mice. J Immunol 1996;157:2103-8.
91. Khan IA, Casciotti L. IL-15 prolongs the duration of CD8+ T cell-mediated immunity in mice infected with a vaccine strain of Toxoplasma gondii. J Immunol 1999;163(8):4503-9.
92. Denkers EY, Scharton-Kersten T, Barbieri S, Caspar P, Sher A. A role for CD4+ NK1.1+ T lymphocytes as major histocompatibility complex class II independent helper cells in the generation of CD8+ effector function against intracellular infection. J Exp Med 1996;184(1):131-9.
93. Appelberg R, Orme I, Pinto de Souza M, Silva M. In vitro effects of interleukin-4 on interferon-gamma induced macrophage activation. Immunol 1992;76:553-9.
94. Villard O, Candolfi E, Despringre J, Derouin F, Marcellin L, Viville S, Kien T. Protective effect of low doses of an anti-IL-4 monoclonal antibody in a murine model of acute toxoplasmosis. Parasite Immunol 1995;17:233-6.
95. Thouvenin M, Candolfi E, Villard O, Klein JP, Kien T. Immune response in a murine model of congenital toxoplasmosis: increased susceptibility of pregnant mice and transplacental passage of Toxoplasma gondii are type 2-dependent. Parassitologia 1997;39(4):279-83.
96. Alexander J, Jebbari H, Bluethmann H, Brombacher F, Roberts CW. The role of IL-4 in adult acquired and congenital toxoplasmosis. Int J Parasitol 1998;28(1):113-20.
97. Hunter CA, Abrams JS, Beaman MH, Remington JS. Cytokine mRNA in the central nervous system of SCID mice infected with Toxoplasma gondii: importance of T-cell-independent regulation of resistance to T. gondii. Infect Immun 1993;61(10):4038-44.
98. Candolfi E, Hunter CA, Remington JS. Role of gamma interferon and other cytokines in suppression of the spleen cell proliferative response to Concanavaline A and toxoplasma antigen during acute toxoplasmosis. Infect Immun 1995;63:751-6.
99. Gazzinelli R, Oswald I, James S, Sher A. IL-10 inhibits parasite killing and nitrogen oxide production by interferon-gamma activated macrophages. J Immunol 1992;148:1792-6.
100. Liesenfeld O. Immune responses to Toxoplasma gondii in the gut. Immunobiol 1999;201(2):229-39.
101. Villegas EN, Wille U, Craig L, Linsley PS, Rennick DM, Peach R, Hunter CA. Blockade of costimulation prevents infection-induced immunopathology in interleukin-10-deficient mice. Infect Immun 2000;68(5):2837-44.
102. Hunter CA, Bermudez L, Beernink H, Waegell W, Remington JS. Transforming growth factor-beta inhibits interleukin-12-induced production of interferon-gamma by natural killer cells: a role for transforming growth factor-beta in the regulation of T cell-independent resistance to Toxoplasma gondii. Eur J Immunol 1995;25(4):994-1000.
103. Langermans JA, Nibbering PH, Van Vuren-Van Der Hulst ME, Van Furth R. Transforming growth factor-beta suppresses interferon-gamma-induced toxoplasmastatic activity in murine macrophages by inhibition of tumour necrosis factor-alpha production. Parasite Immunol 2001;23(4): 169-75.
104. Buzoni-Gatel D, Debbabi H, Mennechet FJ, Martin V, Lepage AC, Schwartzman JD, Kasper LH. Murine ileitis after intracellular parasite infection is controlled by TGF-beta-producing intraepithelial lymphocytes. Gastroenterology 2001;120(4):914-24.
105. Schluter D, Bertsch D, Frei K, Hubers SB, Wiestler OD, Hof H, Fontana A, Deckert-Schluter M. Interferon-gamma antagonizes transforming growth factor-beta2-mediated immunosuppression in murine Toxoplasma encephalitis. J Neuroimmunol 1998;91(1-2):38-48.
106. Nagineni CN, Detrick B, Hooks JJ. Transforming growth factor-beta expression in human retinal pigment epithelial cells is enhanced by Toxoplasma gondii: a possible role in the immunopathogenesis of retinochoroiditis. Clin Exp Immunol 2002;128(2):372-8.
107. Amichay D, Gazzinelli RT, Karupiah G, Moench TR, Sher A, Farber JM. Genes for chemokines MuMig and Crg-2 are induced in protozoan and viral infections in response to IFN-gamma with patterns of tissue expression that suggest nonredundant roles in vivo. J Immunol 1996;157(10):4511-20.
108. Khan IA, MacLean JA, Lee FS, Casciotti L, DeHaan E, Schwartzman JD, Luster AD. IP-10 is critical for effector T cell trafficking and host survival in Toxoplasma gondii infection. Immunity 2000;12(5):483-94.
109. Pinon J, Foudrinier F, Mougeot G, Niel G, Marx C, Barnin A, Tirard V, Bessières M, Danis M, Camerlinck P, Seguela J, Remy G, Frottier J. Pic-Elisa et isotypes spécifiques IgA ou IgE dans l'évaluation des risques toxoplasmiques chez les sujets immunodéprimés. Rev Fr Lab 1991;223:103-7.
110. Pinon JM, Dumon H, Chemla C, Franck J, Petersen E, Lebech M, Zufferey J, Bessieres MH, Marty P, Holliman R, Johnson J, Luyasu V, Lecolier B, Guy E, Joynson DH, Decoster A, Enders G, Pelloux H, Candolfi E. Strategy for diagnosis of congenital toxoplasmosis: evaluation of methods comparing mothers and newborns and standard methods for postnatal detection of immunoglobulin G, M, and A antibodies. J Clin Microbiol 2001;39(6):2267-71.
111. Villena I, D., Brodard V, Queureux C, Leroux B, Dupouy D, Remy G, Foudrinier F, Chemla C, Gomez-Marin JE, Pinon JM. Detection of specific immunoglobulin E during maternal, fetal, and congenital toxoplasmosis. J Clin Microbiol 1999;37(11):3487-3490.
112. Sayles PC, Gibson GW, Johnson LL. B cells are essential for vaccination-induced resistance to virulent Toxoplasma gondii. Infect Immun 2000;68(3):1026-33.
113. Mordue DG, Desai N, Dustin M, Sibley LD. Invasion by Toxoplasma gondii establishes a moving junction that selectively excludes host cell plasma membrane proteins on the basis of their membrane anchoring. J Exp Med 1999;190(12):1783-92.
114. Tomavo S. The differential expression of multiple isoenzyme forms during stage conversion of Toxoplasma gondii: an adaptive developmental strategy. Int J Parasitol 2001;31(10): 1023-31.
115. Birner P, Gatterbauer B, Drobna D, Bernheimer H. Molecular mimicry in infectious encephalitis and neuritis: binding of antibodies against infectious agents on Western blots of human nervous tissue. J Infect 2000;41(1):32-8.
116. Yolken RH, Bachmann S, Ruslanova I, Lillehoj E, Ford G, Torrey EF, Schroeder J, Rouslanova I. Antibodies to Toxoplasma gondii in individuals with first-episode schizophrenia. Clin Infect Dis 2001;32(5):842-4.
117. Candolfi E, Hunter C, Remington J. Mitogen and antigen specific proliferation of T cells in murine toxoplasmosis is inhibited by rective nitrogen intermediates. Infect Immun 1994;62(5):1995-2001.
118. Neyer LE, Kang H, Remington JS, Suzuki Y. Mesenteric lymph node T cells but not splenic T cells maintain their proliferative response to concanavalin-A following peroral infection with Toxoplasma gondii. Parasite Immunol 1998;20(12):573-81.
119. Seng S, Nagasawa H, Maki Y, Yokoyama M, Inoue N, Xuan X, Igarashi I, Saito A, Fujisaki K, Mikami T, Suzuki N, Toyoda Y. Increased susceptibility to Toxoplasma gondii infection in SAG-1 transgenic mice. Int J Parasitol 1999;29(9):1433-6.
120. Reis e Sousa C, Yap G, Schulz O, Rogers N, Schito M, Aliberti J, Hieny S, Sher A. Paralysis of dendritic cell IL-12 production by microbial products prevents infection-induced immunopathology. Immunity 1999;11(5):637-47.
121. Mordue DG, Monroy F, La Regina M, Dinarello CA, Sibley LD. Acute toxoplasmosis leads to lethal overproduction of Thl cytokines. J Immunol 2001;167(8):4574-84.
122. Khan IA, Matsuura T, Kasper LH. Activation-mediated CD4+ T cell unresponsiveness during acute Toxoplasma gondii infection in mice. Int Immunol 1996;8(6):887-96.
123. Goebel S, Gross U, Luder CG. Inhibition of host cell apoptosis by Toxoplasma gondii is accompanied by reduced activation of the caspase cascade and alterations of poly(ADP-ribose) polymerase expression. J Cell Sci 2001;114(Pt 19):3495-505.
124. Darde ML, Villena I, Pinon JM, Beguinot I. Severe toxoplasmosis caused by a Toxoplasma gondii strain with a new isoenzyme type acquired in French Guyana. J Clin Microbiol 1998;36(1):324.
125. Ajzenberg D, Banuls AL, Tibayrenc M, Darde ML. Microsatellite analysis of Toxoplasma gondii shows considerable polymorphism structured into two main clonal groups. Int J Parasitol 2002;32(1):27-38.